Abstract: A peritoneal dialysis (“PD”) system includes a PD fluid pump, a disinfection loop including the PD fluid pump, the disinfection loop including PD fluid used for disinfecting the disinfection loop, and an acid solution source positioned and arranged to supply an acid solution to the disinfection loop during disinfection using the PD fluid. The disinfection loop includes an airtrap and a pressure sensor positioned and arranged to sense PD fluid pressure during disinfection, the pressure sensor outputting to a control unit, the control unit configured to open at least one gas valve located along at least one gas line leading to an upper portion of the airtrap when the PD fluid pressure reaches or exceeds a threshold PD fluid pressure due to gas formation caused by mixing the acid solution with the PD fluid.

Abstract: A method of performing dialysis includes: recirculating a dialysis fluid from a patient or a dialyzer for at least two cycles, each cycle contacting the dialysis fluid first with a zirconium phosphate layer followed by at least one of a urease layer, a zirconium oxide layer, or a carbon layer; storing the recirculated dialysis fluid in a storage container; and transferring the dialysis fluid from the storage container to the patient or the dialyzer. In one example, the zirconium phosphate layer and the at least one of the urease layer, the zirconium oxide layer, or the carbon layer is provided by a sorbent cartridge.

Abstract: The safety device includes a tubular body extending along a longitudinal axis. The tubular body is configured to receive the medical container, a needle cover movable relative to said body between a retracted position, and an extended position in which the needle cover distally extends from the retracted position in order to shield the injection needle after activation of the safety device, a release element configured to move the needle cover from the retracted to the extended position after activation of the safety device, and a retainer for maintaining the release element in a compressed condition when the needle cover is in the retracted position. The retainer is configured to transmit a user's activation force to the needle cover once the injection operation is completed. The needle cover includes a distal abutment surface, said distal abutment surface abutting against a proximal abutment surface of a bump protruding from the body in the retracted position of the needle cover.

Abstract: Protein separation can be provided based on a High Performance Countercurrent Membrane Purification (HPCMP), which can exploit highly selective diffusive transport across thin walls of a hollow fiber membrane for separation of proteins. Embodiments of an HPCMP system can separate mixtures of multiple proteins (e.g. separate BSA and Mb) or other biological material and provide high yields (e.g. achieving greater than 98% yield of both proteins with purification factors greater than 100-fold, etc.). Embodiments of a HPCMP system can be configured for high resolution separations in the preparation of biopharmaceuticals and natural protein products. Other embodiments can be utilized in other protein separation environments or biological material separation environments.

Abstract: An integrated catheter includes a catheter adapter having a catheter and an inlet, the catheter configured to be inserted into a patient's vasculature. The integrated catheter also includes a near-patient access port having a first port at a first end and a female luer connector at a second end, as well as intermediate tubing extending between the inlet of the catheter adapter and the first port of the near-patient access port. Additionally, the integrated catheter includes a stabilization platform configured to stabilize at least the near-patient access port on a patient's skin.

Abstract: Disclosed is a balloon for a balloon catheter that can prevent kinking or buckling of the balloon and elongation of the balloon in the longitudinal direction. A balloon (2) for a balloon catheter has a balloon body (20); the balloon body (20) has an inflating part (20e), a distal sleeve part (25), and a proximal sleeve part (21); the distal sleeve part (25) has a fixed part (25f) fixed to the shaft (3); the balloon (2) has a reinforcing part (60) disposed on an inner surface of the distal sleeve part (25) at a part of a circumferential direction of the distal sleeve part (25); the reinforcing part (60) is located proximal to a distal end of the fixed part (25f); and the balloon (2) does not have the reinforcing part (60) on an inner surface of the proximal sleeve part (21).

Abstract: A peritoneal dialysis (“PD”) system includes a cycler having a peristaltic pump actuator; a disposable set including a pressure sensing manifold including first and second pressure sensing pods, a drain line and a first dialysis fluid/heater container line in fluid communication with the first pressure sensing pod, and at least one dialysis fluid container line and a patient line in fluid communication with the second pressure sensing pod; and a control unit programmed to operate the peristaltic pump actuator (i) in a first direction to pump fresh dialysis fluid along the at least one additional dialysis fluid container line into the first dialysis fluid/heater line and (ii) in a second direction to pump heated fresh dialysis fluid along the first dialysis fluid/heater line into the patient line. The pump actuator may be operated in the first direction again to pump used dialysis fluid from the patient to a drain.

Abstract: Compounds, systems, kits, methods, and/or apparatuses may be operative to reduce amyloid beta (A?) peptide in a patient, including a central nervous system (CNS) of the patient and/or a periphery (non-CNS portion) of the patient. In some embodiments, a displacer fluid comprising a A? displacer may be introduced to the patient to bind to a blood protein, such as albumin, that binds A? (for instance, A? peptide or non-plaque A?) in the patient periphery. Binding of the displacer to the blood protein may facilitate more free A? peptide (for instance, A? monomers) in the periphery for clearance via natural processes, such as through the liver or kidneys, and/or artificial processes, such as dialysis. Increased removal of the free A? peptide in the periphery may ultimately lead to less A? peptide in the CNS, which may decrease A? plaque formation in Alzheimer's Disease (AD) patients. Other embodiments are described.

Abstract: The present disclosure discloses a pet water filter cartridge, which specifically relates to the field of filtration technology for pet drinking water and aquatic aquaculture water, including a water filter cartridge carrier and a filter material. The water filter cartridge carrier is composed of a non-woven cotton hot pressed base and a non-woven cotton cover, the base is provided with an accommodation chamber. The accommodation chamber is provided with the filter material, the non-woven cotton cover is sealed at an opening of the accommodation chamber. The present disclosure directly uses non-woven cotton heat pressed filter cartridge carrier with various shapes, the entire filter cartridge is made of a filtering material. The materials used are all involved in water filtration, no excess plastic skeleton or trays are used as the filter cartridge carrier, which can reduce the pressure of emissions on the environment and be more environmentally friendly.

Abstract: Environmental barge with belt skimmer for spill response to oil pollution at sea. The environmental barge consists of an upper part with pontoons and a lower part with a bottom with an integrated hydrophilic filter. The environmental barge is designed so that at least four environmental barges can be stacked inside and on top of each other. Oil-mixed water is guided to the belt skimmer, which carries it up into the environmental barge, where the gravitational principle means that the oil pushes the water through the hydrophilic filter and back into the sea as the barge is filled with oil. The environmental barge can thus be completely filled with oil without increasing the draft. The environmental barge footprint is identical to a standard 20-foot container, and it has container corner castings, allowing significant spill response capacity to be quickly transported and deployed in areas where no other spill response capacity is available.

Abstract: A peritoneal dialysis fluid circuit comprising a patient line, a delivery line configured to supply fresh dialysis fluid towards the patient line, a withdrawal line configured to withdraw spent dialysis fluid from the patient line, a first pump arranged on the delivery line and configured to supply fresh dialysis fluid towards the patient line, and a second pump arranged on the withdrawal line and configured to withdraw spent dialysis fluid from the patient line. The fluid circuit further comprises a control unit configured to perform a peritoneal dialysis procedure. The peritoneal dialysis procedure comprises commanding activation of the first pump at a first flow rate, and activation of the second pump at a second flow rate different from the first flow rate: the first pump and the second pump are active simultaneously to provide the first flow rate and the second flow rate.

Abstract: A manifold assembly for a peritoneal dialysis apparatus, comprises: a casing delimiting internally a first compartment and a second compartment; a yielding pump tube having a first end connected or connectable to the first compartment and a second end connected or connectable to the second compartment. The yielding pump tube extends outside the casing to be coupled to a peristaltic pump of a cycler of a peritoneal dialysis apparatus. The second compartment delimits expansion chambers configured to attenuate pressure pulsations from the peristaltic pump.

Abstract: A peristaltic pumping device of linear type, includes a section of deformable tube crossed by a fluid whereon at least a peristaltic compression is implemented; and an actuator, including a rotating element provided with one or more helical ribs arranged projecting from its surface to interfere, along the rotation of the rotating element, with said deformable tube and, so as to determine thereon at least a localized, movable and continuous squeezing, moving along a predetermined direction, which implements peristaltic compression, the helical ribs are arranged along a helical axis with respect thereto they are fixed, the position thereof being tied with respect to the rotating element, wherein at least a portion of helical rib, which interferes with said deformable tube, is rotatable around the respective helical axis, thereby minimizing the friction thereof on the surface of the deformable tube, thereby allowing to reduce effectively the stress on the deformable tube.

Abstract: A peritoneal dialysis (“PD”) system includes a PD fluid pump, a dual lumen patient line including fresh and used PD fluid lumens, a filter set in fluid communication with the fresh and used PD fluid lumens, a valve provided either with a patient's transfer set or with the filter set, and a control unit configured, after a patient drain, to (i) prompt a patient or caregiver to close the valve when the valve is a manual valve, or (ii) cause the valve to close automatically when the valve is an electrically or pneumatically controlled valve. The control unit is further configured to cause the PD fluid pump, with the valve closed, to pump fresh, heated PD fluid into the fresh PD fluid lumen to displace unheated PD fluid from the fresh PD fluid lumen, through the filter set, into the used PD fluid lumen. A corresponding method is also disclosed.

Abstract: A manifold assembly for a peritoneal dialysis apparatus, comprises: a casing delimiting internally a first compartment and a second compartment; a yielding pump tube having a first end connected or connectable to the first compartment and a second end connected or connectable to the second compartment. The yielding pump tube extends outside the casing to be coupled to a peristaltic pump of a cycler of a peritoneal dialysis apparatus. A first pump port and a second pump port are placed on a first side of the casing and ports are placed on a second side of the casing, opposite the first side.

Abstract: The present disclosure generally relates to a device for analysing spent peritoneal dialysate from a peritoneal dialysis apparatus. The device comprises: a set of housings attachable to the peritoneal dialysis apparatus; a set of test components disposed in the housings, each test component and comprising one or more reagents for detecting one or more substances; and a set of fluidic conduits connected to the housings for communicating the dialysate from the peritoneal dialysis apparatus to the housings, wherein the test components are arranged for the reagents to react with the dialysate communicated to the housings and thereby detect the substances in the dialysate.

Abstract: A dialysis system and dialysis machine or cycler are provided that decrease a disposable set's cost and complexity. The dialysis machine or cycler includes a weigh scale on which multiple fluid supply containers containing dialysis fluid, and a drain trolley, are positioned. The fluid supply containers may be elevated relative to the drain trolley. The drain trolley is sized to contain all of the effluent drained from a patient during a dialysis treatment. The fluid supply containers are in fluid communication with one another and arranged one of top of the other. A control unit may control fill, dwell and drain cycles by controlling the operation of a pump and a valve. Dialysis fluid from the bottom-most fluid supply container may be pumped into a patient. The valve may be opened to allow effluent to drain from the patient to the drain trolley by way of gravity.

Abstract: A peritoneal dialysis (“PD”) system includes a housing; a dialysis fluid pump housed by the housing and including a reusable pump body that accepts PD fluid for pumping; a dialysis fluid inline heater housed by the housing and including a reusable heater body that accepts PD fluid for heating; at least one reusable PD fluid line extending from the housing; at least one disinfection connector supported by the housing and configured to accept one of the at least one reusable PD fluid line; and a control unit configured to run a disinfection sequence after a PD treatment, wherein each of the at least one reusable PD fluid line is connected to one of the at least one disinfection connectors, and wherein at least one of the dialysis fluid pump or the dialysis fluid inline heater is actuated by the control unit during the disinfection sequence.

Abstract: A system and method for producing fluid for peritoneal dialysis (PD) is disclosed. The system comprises a fluid path including one or more PD-concentrate connectors each connected to one or more sources of PD-concentrate fluid, and a water connector connected to a source of water. The system further includes a forward osmosis FO-unit including a draw side and a feed side separated by a FO-membrane. The FO-unit is fluidly connected to the fluid path. The FO-unit receives the one or more PD-concentrate fluids at the draw side, and receives the water at the feed side. Purified water is transported to one or more PD-concentrate fluids through the FO-membrane by means of an osmotic pressure gradient between the draw side and the feed side. The transported purified water is further purified by the FO-membrane and the one or more PD-concentrate fluids is diluted to produce a diluted PD-concentrate fluid.

Abstract: A dialysis system (10) comprising a dialysis machine (20) and a water purification system (30). The water purification system (30) comprising a pre-treatment system (10) and a primary treatment system (80). The water purification system (30) is provided within a portable unit (90) defining an enclosure. The dialysis machine (20) is removably provided on an upper surface of the enclosure of the portable unit (90).