Abstract: Computer-implemented methods and systems for intelligently controlling a reverse osmosis (RO) machine. The method (which can be executed by a system) can include a processor(s) determining variables related to operation of the membranes of an RO machine by measuring, over time, operating limits of the membranes. The processor(s) can iteratively determine variables (e.g., measured and inferred) related to operation of the membranes by applying an iterative mathematical model to determine a portion of the inferred variables. The portion includes one or more critical variables that cannot be measured directly. The processor(s) determines, based on the variables, an upper limit and a lower limit for various control parameters within the RO machine; control parameters are controlled by active components of the RO machine. The processor(s) derives, for each of the various control parameters, an adjustment. Implementing the adjustment obtains optimal permeate recovery in the RO machine within the operating limits.

Abstract: A fluid delivery device has a syringe barrel with reservoir chamber for fluid, a plunger that translates along a longitudinal axis to expel fluid, and a pusher dimensioned to translate within the barrel and coupled to a drive mechanism to controllably contact and move the plunger. The pusher contacts the plunger at its mechanical center to reduce tilt in the plunger. Contact faces of the pusher and plunger cooperate as a ball joint to minimize non-axial forces on the plunger face. The pusher can have a protrusion of various lengths extending toward and being at least partially received in a recess of various depths in the plunger. The pusher is rigidly connected to a drive mechanism for anti-rotation. The pusher can have scalloped edges for air venting, and apertures for cooperating with protrusions on the drive mechanism to prevent bottoming out the plunger when filling.

Abstract: A method of preparing reverse osmosis membrane with double network of charged hydrogel and polyamide includes the steps of: (a) preparing an aqueous phase polymer solution containing m-phenylenediamine, polymer monomer with ionic group and crosslinking agent, and an organic phase polymer solution containing trimesoyl chloride and photoinitiator; (b) preparing a reverse osmosis membrane by inducing reaction of the aqueous phase and the organic phase polymer solution under ultraviolet light to form a charged hydrogel layer and a polyamide layer respectively; and (c) cleaning the membrane. The hydrogel layer not only enhances the electrical properties, thereby limiting the dissolution of ions in water on the membrane surface and the diffusion of ions in the membrane, and reducing the ions passing through the membrane, but also improves the hydrophilicity, which is beneficial to the transmission of water molecules within the membrane and the improvement of the anti-fouling performance of the membrane.

Abstract: The present technology relates to a method for improved recovery of phosphorylated compounds (e.g., phosphorylated glycans). In particular, the present technology utilizes certain chelator additives in a solution to wash and elute the phosphorylated compounds from a solid phase extraction cartridge.

Abstract: The present invention relates to a method for automatically verifying correct setup of a blood treatment apparatus, in particular a gravimetric cycler for peritoneal dialysis having only one scale and a hose system, wherein the hose system comprises at least three line portions for connection to at least one drainage bag, at least one solution bag and a patient, wherein, by means of the scale, a change in weight of the solution bag and/or the drainage bag during a filling process of the hose system is detected and compared to an expected value. Furthermore, the invention relates to a corresponding blood treatment apparatus.

Abstract: A concentration apparatus including a negatively charged membrane, a sample water supply, a first solenoid valve on a flow path from the sample water supply to the negatively charged membrane, an acidic solution storage tank storing an acidic solution, a second solenoid valve on a flow path from the acidic solution storage tank to the negatively charged membrane, an alkaline solution storage tank storing an alkaline solution, a third solenoid valve on a flow path from the alkaline solution storage tank to the negatively charged membrane, an outlet to discharge fluid, a fourth solenoid valve and a first suction pump each on a flow path from the negatively charged membrane to the outlet, a collection container in which fluid is collected, a fifth solenoid valve on a flow path from the negatively charged membrane to the collection container, and a controller that controls opening and closing of the solenoid valves.

Abstract: The disclosure relates to a method including determining a treatment time of a dialysis treatment for a patient, receiving, from at least a sensor of a dialysis machine, a dialysate flow rate, the dialysate comprising bicarbonate pumped out of a bicarbonate source, wherein the bicarbonate source has an initial amount of bicarbonate, and predicting that by end of the dialysis treatment no more than a threshold amount of bicarbonate will be left in the bicarbonate source, and in response, determining that a clearance value during the treatment is or will be higher than the threshold clearance value, and sending, to a balancing system, an instruction to reduce the dialysate flow rate to a reduced rate, wherein the reduced rate results in reducing a rate of bicarbonate pumped out of the bicarbonate source while maintaining a clearance value of the treatment at no less than the threshold clearance value.

Abstract: A peritoneal dialysis (“PD”) system includes a housing, a PD fluid pump housed by the housing, and a reusable patient line extending from the housing. The reusable patient line includes a distal end configured to be connected to a patient line connector provided by the housing. The PD system also includes at least one reusable PD fluid line extending from the housing, the at least one reusable PD fluid line including a distal end configured to be connected to a PD fluid line connector provided by the housing. The PD system further includes a control unit configured to cause the PD fluid pump to apply a negative pressure to at least one of the reusable patient line or the at least one reusable PD fluid line when connected, respectively, to the patient line connector or the PD fluid line connector.

Abstract: An apparatus for extracorporeal blood treatment comprises a control unit (100) which, during the extracorporeal blood treatment, is programmed for: computing a mass balance rate (Jsoln) of a selected solute or solutes from a solute concentration (Csoln) in dialysis fluid and/or infusion fluids, from a patient solute concentration (Cpsoln), from a fluid flow rate or rates (Qpbp, Qpre, Qpost, Qdial, Qanc) and from a filtration flow rate (Qfil) or a patient fluid removal rate (Qpfr); computing, from the computed mass balance rate (Jsoln) and from a specific energy load (Emetsoln) of each solute, an energy balance (Esoln) due to the selected solute or solutes.

Abstract: The present invention relates to a pharmaceutical dosage form for application to a mucous membrane, in particular to a buccal, intestinal, rectal or vaginal mucous membrane, comprising at least one string-like or strip-like preparation comprising the active pharmaceutical ingredient, the dosage from consisting a first and a second halve-capsule shell, which jointly define the size of an aperture for releasing the preparation. The invention also relates to a method of producing the pharmaceutical dosage form.

Abstract: A water treatment system comprising filter and filter head is provided. The filter comprises: a cartridge; a cap attached to the cartridge; the cartridge comprises: first compartment comprising first water-treating medium/s; second compartment comprising second water-treating medium/s; the cap comprises a selector. The filter further comprises bypass/es extending from the selector and throughout first compartment and into second compartment, each of the bypass/es having an inlet and an outlet. In first state all water entering the filter passes through the first compartment; in second state all water entering the filter bypasses first compartment and passes through second compartment. In intermediate state/s first part of water enters the filter passing through the first compartment and a second part of water enters the filter bypassing the first compartment and passes through the second compartment. The filter head is reversibly attachable to the cap.

Abstract: A vascular access device with vessel accommodation includes a top portion and a bottom portion. The top portion includes a top vascular housing for encasing a top portion of a vessel when implanted and at least one hollow male member extending from the top vascular housing. The bottom portion includes a bottom vascular housing for encasing a bottom portion of the vessel when implanted and at least one female member disposed at an upward-facing coupling edge of the bottom vascular housing. The at least one female member receives the at least one hollow male member of the top portion to couple the top portion and the bottom portion together such that the top and bottom portions can move vertically with respect to one another but rotation and movement in the horizontal/longitudinal directions are inhibited.

Abstract: Embodiments pertain to a peritoneal dialysate production and delivery (PD) system configured to produce fresh dialysate for use in peritoneal dialysis of a patient, the system comprising: a water inlet, a water treatment device that is fluidly connectable or connected via the water inlet to a water source and configured to treat water received from the water source to generate treated water; a concentrate supply device that is in fluid communication with the at least one water treatment device to add concentrate comprised in the concentrate supply device to the treated water to generate fresh dialysate fluid; tubing having a lumen for supplying the fresh dialysate fluid to a patient body via a flow path; and a tubing disinfectant supply device that contains and/or that is operable to receive disinfectant agents, wherein the tubing disinfectant supply device is in fluid connection with the tubing for disinfecting at least a portion of the tubing.

Abstract: The invention relates to a filtration unit for enabling the selective leucocytapheresis of a fluid containing blood platelets. The filtration unit includes an external pouch provided with an inlet orifice and an outlet orifice, the pouch enclosing a porous element interposed between the orifices. The porous element encloses a leucocytapheresis medium impregnated with a polymer, the polymer having the general formula -(A)m-(B)n- (I), wherein A is a unit originating from an alkoxyalkyl acrylate or alkoxyalkyl methacrylate monomer, B is a unit originating from a hydrophobic polymerisable monomer, and m and n are integers, the sum of which, m+n, is equal to 100, m being an integer greater than 80.

Abstract: A method includes flowing spent dialysate through a spent dialysate line of a dialysis system into a fluid receptacle fluidly coupled to the spent dialysate line, reacting the spent dialysate with a chemical reagent contained within the fluid receptacle to generate a reacted sample, emitting electromagnetic radiation through the reacted sample using an emitter; detecting a level of one or more waste products present in the spent dialysate using a spectroscopy sensor positioned proximate the fluid receptacle.

Abstract: The present disclosure provides apparatuses and systems for delivering a measureable absorbed-dose of a gaseous activating agent to a fluid including a biological liquid and/or cells. The apparatuses or systems include a gas-fluid contact device configured to controllably rotate or oscillate a control member having an interior surface in contact with the fluid and a control system configured to control rotation or oscillation of the contact member by the gas-fluid contact device. In some embodiments, the control system is further configured to control absorption of the gaseous activating agent by the fluid. The present disclosure also provides methods of treating a fluid including a biological liquid or cells with a gaseous activating agent to controllably activate the fluid.

Abstract: A dialysis system having motor driven pressure estimation of fluid within a patient line is disclosed. A peritoneal dialysis (“PD”) system includes a fluid pump and a patient line that fluidly couples the fluid pump to an indwelling catheter leading into a patient's peritoneal cavity. The PD system also includes a motor driver that controls a motor of the fluid pump and transmits an output signal that is indicative of a load on the motor. The PD system further includes a machine learning algorithm that associates data related to output signals from motor drivers with known fluid pressures within patient lines. A processor of the PD system transmits an input signal to activate the motor driver, receives the output signal from the motor driver, and estimates a fluid pressure within the patient line by applying the data from the received output signal to the machine learning algorithm.

Abstract: Systems and methods are disclosed for assessing the functionality of solenoid valve activation in peritoneal dialysis systems. In at least one embodiment, measurements of current values may be received from a solenoid valve at a predetermined sampling rate over a predetermine duration of time to generate a current profile for the solenoid valve. A fifth degree polynomial model may be fit to the current profile and optimized. The optimized polynomial model may be applied to a trained support vector machine to determine whether the current profile indicates that the corresponding solenoid valve has actually opened or closed.

Abstract: The safety device includes a tubular body extending along a longitudinal axis. The tubular body is configured to receive the medical container, a needle cover movable relative to said body between a retracted position, and an extended position in which the needle cover distally extends from the retracted position in order to shield the injection needle after activation of the safety device, a release element configured to move the needle cover from the retracted to the extended position after activation of the safety device, and a retainer for maintaining the release element in a compressed condition when the needle cover is in the retracted position. The retainer is configured to transmit a user's activation force to the needle cover once the injection operation is completed.

Abstract: A peritoneal dialysis fluid generation system including water purification equipment configured to provide purified water; a presterilized tubing set including a container for storing peritoneal dialysis fluid; at least one glucose or buffer concentrate; and a hemodialysis machine in fluid communication with the water purification equipment. The hemodialysis machine includes at least one mixing pump for mixing the at least one glucose or buffer concentrate with the purified water to form peritoneal dialysis fluid, a dialysis fluid pump for delivering the peritoneal dialysis fluid to the container, and a control unit configured to control the at least one mixing pump to form the peritoneal dialysis fluid and the dialysis fluid pump to deliver the peritoneal dialysis fluid to the container.