Patents Examined by John L. LeGuvader
  • Salmonella vaccines
    Patent number: 5843426
    Abstract: The invention features a Salmonella cell the virulence of which is attenuated by a deletion of a portion of the PhoQ gene and Salmonella cells having a deletion of the PhoQ gene and a deletion of the PhoP gene. The invention also features vaccines comprising such bacteria.
    Type: Grant
    Filed: December 1, 1995
    Date of Patent: December 1, 1998
    Assignees: The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: Samuel I. Miller, John J. Mekalanos