Abstract: Fibrous connective tissue for surgical implantation is made substantially antigen-free by contact with one or more extraction agents. Solutions or mixtures of molecules having bipolar regions act as antigen removing permeation enhancers. Cationic, anionic, non-ionic or amphoteric surfactants are suitable bipolar permeation enhancers. One or more extraction agents can be combined to form extraction mixtures.
Type:
Grant
Filed:
February 9, 1996
Date of Patent:
March 4, 1997
Assignee:
Osteotech, Inc.
Inventors:
Annamarie B. Prewett, Robert K. O'Leary
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