Patents Examined by John Pauls
  • Patent number: 12154683
    Abstract: Examples described herein any include a surgical module for use within the surgical system. The surgical module may include a first port connected to a surgical hub; a second port connected to an additional surgical module; and a controller. The controller may be configured to receive surgical data; determine if the surgical data is a first type of data or a second type of data; and instruct the surgical module to send the surgical data to the first port if the surgical data is the first type of data or to the second port if the surgical data is the second type of data.
    Type: Grant
    Filed: July 23, 2021
    Date of Patent: November 26, 2024
    Assignee: Cilag GmbH International
    Inventors: Frederick E. Shelton, IV, Shane R. Adams, Kevin Fiebig, Jeffrey D. Messerly
  • Patent number: 12146183
    Abstract: The present invention relates to a compound for use in detecting “reader” and “eraser” proteins of lysine lipoylation. The present invention provides an affinity-based probe, referred to herein as “KPlip”, capable of interrogating the lipoylated peptide/protein interactions under native cellular environments. The chemical probe allows for the identification of potential regulators of lysine lipoylation, thus uncovering new biology related to lipoylation. There is also provided a method of using the compound to identifying proteins that interact with lipoylated proteins.
    Type: Grant
    Filed: June 17, 2021
    Date of Patent: November 19, 2024
    Assignee: CITY UNIVERSITY OF HONG KONG
    Inventors: Yusheng Xie, Rui Wang, Liang Zhang, Hongyan Sun
  • Patent number: 12140600
    Abstract: Disclosed is a method for measuring activated partial thromboplastin time, the method comprising: mixing: a blood sample; a first reagent comprising an ellagic acid compound and a compound represented by Formula (I); and a second regent comprising a calcium ion; and measuring activated partial thromboplastin time using the mixture prepared in the mixing step, wherein the compound represented by Formula (I) is shown below wherein X is a hydrogen atom, —(C?O)—Y, or —(C?O)—OZ, Y is a hydroxyl group, a hydrogen atom, a linear or branched alkyl group having a carbon number of 1 or more and 6 or less, or a phenyl group, and Z is an alkali metal.
    Type: Grant
    Filed: September 23, 2020
    Date of Patent: November 12, 2024
    Assignee: SYSMEX CORPORATION
    Inventors: Takahiko Bando, Kohei Akatsuchi, Naoki Yamamoto, Masako Aki, Hiroshi Negoro, Masato Michishita
  • Patent number: 12134793
    Abstract: Disclosed are a recombinant microorganism for producing a hydrophobic material, which is subjected to cell-membrane engineering in order to be imparted with at least one characteristic among an increase in a cell-membrane area, an increase in formation and secretion of an outer membrane vesicle, and an increase in formation of an inner membrane vesicle, and a cell-membrane engineering method for preparation thereof, whereby an insoluble hydrophobic material can be produced with high efficiency, the recombinant microorganism for high-efficiency production of carotenoids or violacein analogues is useful for producing natural pigments, antioxidants, antibiotics, cosmetic additives, anticancer agents, food additives, or nutritional supplements, and the natural pigment production technology developed herein achieves a great increase in production ability.
    Type: Grant
    Filed: November 1, 2021
    Date of Patent: November 5, 2024
    Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Sang Yup Lee, Dongsoo Yang, Seon Young Park
  • Patent number: 12136099
    Abstract: The invention relates to methods, systems, and computer-readable media related to a system having a plurality of users, designed to display a user-customized subset of item and/or provider information to the user.
    Type: Grant
    Filed: November 16, 2023
    Date of Patent: November 5, 2024
    Assignee: Thermodynamic Design, LLC
    Inventors: Bradley Christiansen, Thomas Hampton, Michael Vock, Jacob N. Wohlstadter
  • Patent number: 12136479
    Abstract: Disclosed herein are methods for presenting therapy events on a continuous, time-based data feed. An algorithm for arranging data on the feed can position icons on the feed with information regarding therapy events at a time each event occurred without blocking or interfering with the data feed, including when the data feed is scrolled, zoomed, or otherwise repositioned. The algorithm can include clustering, buffering and affinity components. The clustering component can combine different events occurring at the same time into a single event and keep those events visually together on the data feed. The buffering component can provide a buffer around each event so there is no overlapping of depicted events. The affinity component provides an affinity for placing events as closed to a CGM trend line on the data feed as possible in view of the positioning of other events.
    Type: Grant
    Filed: November 3, 2021
    Date of Patent: November 5, 2024
    Assignee: TANDEM DIABETES CARE, INC.
    Inventor: Josh Juster
  • Patent number: 12131397
    Abstract: A computer system for identifying medical care providers outside a process-of-care standard for a field of health care is configured to perform steps that include retrieving claim line item information including procedure/service codes, and retrieving definitions for marker code groups associated with each of a set of medical conditions; deriving, for each marker-condition pair, an actual rate of utilization of the marker code group for episodes of the associated medical condition; and assigning a status to each marker-condition pair in response to the actual rate of utilization respectively exceeding or not exceeding a target rate. The steps also include aggregating the statuses across the marker-condition pairs to obtain an overall score, and causing an output to be displayed in a viewable format. The output includes the overall score, each marker-condition pair of the set of medical conditions, and the status for each marker-condition pair of the set of medical conditions.
    Type: Grant
    Filed: February 7, 2022
    Date of Patent: October 29, 2024
    Assignee: EFFINET, LLC
    Inventors: Douglas G. Cave, Yuri Alexandrian, John Calvin
  • Patent number: 12125585
    Abstract: A dialysis (e.g., hemodialysis or peritoneal dialysis) machine is instantiated with a blockchain application to help safeguard the machine from malicious attacks and provide a reviewable transaction log. The blockchain application may operate on a component level within a single dialysis machine or multiple dialysis machines that collectively operate within a blockchain community. Multiple rules and regulations may be utilized among the dialysis machines or dialysis machine components to ensure authorized instructions alter dialysis machine operations. The verification process can occur, for example, by discrete dialysis machine components verifying the instruction with a remote service or discrete dialysis machines verifying the instruction with the remote service. When a pre-set number of components or dialysis machines verify the instruction and develop a consensus, such as 50%, 75%, 90%, etc., the target component or machine executes the instruction.
    Type: Grant
    Filed: November 26, 2021
    Date of Patent: October 22, 2024
    Assignee: KATA Gardner Technologies
    Inventor: Thomas Tatonetti
  • Patent number: 12110521
    Abstract: The present invention provides engineered methionine gamma lyase polypeptides and compositions thereof. The engineered methionine gamma lyase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH<7) conditions. The present invention also relates to the use of the compositions comprising the engineered methionine gamma lyase polypeptides for therapeutic purposes.
    Type: Grant
    Filed: May 19, 2022
    Date of Patent: October 8, 2024
    Assignee: SYNTIS BIO, INC.
    Inventors: Kierra Aleece Franklin, Stephanie Sue Galanie, Gjalt W. Huisman, Nikki D. Kruse, Kerryn McCluskie, Vesna Mitchell, Leann Quertinmont Teadt, Kristen Jean Vallieu
  • Patent number: 12087428
    Abstract: System for generating a body degradation reduction program including a computing device configured to receive at least a degradation marker, retrieve a body degradation profile as a function of the at least a degradation marker, assign the body degradation profile to a degradation category, identify, using the degradation category and the body degradation profile, a plurality of lifestyle elements, wherein identifying the plurality of lifestyle elements includes calculating a plurality of lifestyle element amounts as a function of a respective effect of each of a plurality of lifestyle elements on the body degradation profile as a function of the degradation category, identifying the plurality of lifestyle elements as a function of the plurality of lifestyle element amounts, and generate a body degradation reduction program, using the plurality of lifestyle elements, wherein the body degradation reduction program includes a frequency and a magnitude of engagement of the plurality of lifestyle elements.
    Type: Grant
    Filed: July 28, 2021
    Date of Patent: September 10, 2024
    Assignee: KPN INNOVATIONS LLC
    Inventor: Kenneth Neumann
  • Patent number: 12080417
    Abstract: Methods and systems for managing patient compliance with a treatment are disclosed. An example method can comprise receiving data indicative of a time on active therapy. The method can comprise receiving data indicative of a pressure associated with the time on active therapy. The method can further comprise determining a patient compliance factor based on the data indicative of the time on active therapy and the data indicative of the pressure associated with the time on active therapy. The method can comprise determining a graphical object modifier based on the patient compliance factor and displaying a graphical object based on the graphical object modifier.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: September 3, 2024
    Assignee: Mölnlycke Health Care AB
    Inventor: Thomas Lawhorn
  • Patent number: 12064458
    Abstract: A use of a cell wall or a cell wall skeleton of Rhodococcus ruber in preparing a drug for treating a thermal injury. The thermal injury comprises a burn, a scald and a chemical burn. Applying the Rhodococcus ruber product to a subject has a good therapeutic effect on a thermal injury and has no side effects.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: August 20, 2024
    Assignee: Liaoning Greatest Bio-Pharmaceutical Co., Ltd.
    Inventors: Bo Gai, Chunyan Dou, Yi Zhang, Guoying Zhang
  • Patent number: 12068061
    Abstract: Systems, devices, user interfaces, and methods for managing patient conditions. A system for monitoring and/or managing a patient suffering from a brain condition may include a controller obtaining and/or storing data related to one or more monitored patient parameters contributing to the brain condition of the patient and displaying values of the one or more monitored patient parameters in trend lines over time on a user interface. The displayed trend lines may represent values of ventricular CSF volume, values of IVH volume, total ventricular volume in the brain, and/or values of other suitable parameters. The data related to the one or more monitored patient parameters may include images of the patient's brain and/or data derived from images of the patient's brain and/or suitable patient data.
    Type: Grant
    Filed: January 14, 2022
    Date of Patent: August 20, 2024
    Assignee: MINNETRONIX NEURO, INC.
    Inventors: Aaron Richard McCabe, Don William Eldon Evans, Laura Marie Zitella Verbick, William Raymond Bushnell, Abhi Vase, Owen Seymour
  • Patent number: 12057208
    Abstract: Medication security and healthcare privacy analytics systems are described that enable users to search for and process stored healthcare environment data. The medication security and healthcare privacy analytics systems receive and correlate data from a plurality of data sources, including medication dispensing systems, healthcare employee records, and patient records. The medication security and healthcare privacy analytics systems generate a plurality of feature vectors from processed healthcare environment data. The visualizations are created using datasets generated by clustering algorithms and can indicate those feature vectors from the plurality of feature vectors whose data indicate anomalous interactions with various systems (e.g., indicative of unexpected or non-customary events).
    Type: Grant
    Filed: September 1, 2022
    Date of Patent: August 6, 2024
    Assignee: Splunk Inc.
    Inventor: Gleb Esman
  • Patent number: 12040088
    Abstract: A system, device, and method for collecting user information. An image and metadata associated with the image are captured utilizing a wireless device. The image and the metadata are associated with a device incapable of communication. User information associated with the device is determined. The user information is characterized in context of historical data. The user information is distributed from the wireless device to one or more devices associated with the user information.
    Type: Grant
    Filed: August 22, 2022
    Date of Patent: July 16, 2024
    Assignee: DATA VAULT HOLDINGS, INC.
    Inventors: Nathaniel T. Bradley, David Bradley, Edward William Withrow, III
  • Patent number: 12027241
    Abstract: An example computer-implemented method of increasing veterinary health care compliance includes receiving information indicating that an animal patient concluded a visit at a veterinary practice, in response accessing diagnostic test results for the animal patient, based on the diagnostic test results creating a pet owner profile for an owner of the animal patient, matching the pet owner profile with a stored message and stored information relating to a product associated with recommended treatment for the animal patient, sending an electronic message to a second computing device associated with the owner of the animal patient that includes the stored message and the stored information relating to the product associated with recommended treatment for the animal patient, receiving a report indicating whether the owner of the animal patient obtained the product associated with recommended treatment for the animal patient, and updating the pet owner profile to be indicative of the report.
    Type: Grant
    Filed: November 12, 2020
    Date of Patent: July 2, 2024
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Elizabeth Peters, Jeffrey Lott, Matt Spradley, Matt Russell, Tanya Jarosz
  • Patent number: 12023175
    Abstract: A computer-implemented method improves efficacy of diabetes self-management to obtain a measurement message and/or contextual activity information used to determine a suitable insulin dosage to treat a patient. The method includes simulating a health coach in a natural conversation to obtain a measurement of the patient's blood-glucose level, processing the measured blood-glucose level with a personalized insulin titration algorithm to determine an insulin dosage recommendation, and generating an electronic signal configured to cause a corresponding action to be performed by a computing device.
    Type: Grant
    Filed: September 20, 2022
    Date of Patent: July 2, 2024
    Assignee: Verily Life Sciences LLC
    Inventors: Nikhil Roy, Miguel Angelo Drumond
  • Patent number: 12014821
    Abstract: Methods and apparatus, including computer program products, are provided for processing analyte data. In some example implementations, a method may include generating glucose sensor data indicative of a host's glucose concentration using a glucose sensor; calculating a glycemic variability index (GVI) value based on the glucose sensor data; and providing output to a user responsive to the calculated glycemic variability index value. The GVI may be a ratio of a length of a line representative of the sensor data and an ideal length of the line. Related systems, methods, and articles of manufacture are also disclosed.
    Type: Grant
    Filed: February 1, 2023
    Date of Patent: June 18, 2024
    Assignee: Dexcom, Inc.
    Inventors: Naresh C. Bhavaraju, Arturo Garcia, Phil Mayou, Thomas A. Peyser, Apurv Ullas Kamath, Aarthi Mahalingam, Kevin Sayer, Thomas Hall, Michael Robert Mensinger, Hari Hampapuram, David Price, Jorge Valdes, Murrad Kazalbash
  • Patent number: 12014384
    Abstract: The invention relates to methods, systems, and computer-readable media related to a system having a plurality of users, designed to display a user-customized subset of item and/or provider information to the user.
    Type: Grant
    Filed: December 7, 2022
    Date of Patent: June 18, 2024
    Assignee: Thermodynamic Design, LLC
    Inventors: Bradley Christiansen, Thomas Hampton, Michael Vock, Jacob N. Wohlstadter
  • Patent number: 12009095
    Abstract: Various systems and methods for tracking surgical procedure costs are disclosed. A computer system, such as surgical hub, is configured to be communicably coupled to a plurality of surgical devices. The computer system can be programmed to identify the surgical devices that are being utilized during a surgical procedure via perioperative data received from the surgical devices and then calculate the total cost associated with the surgical devices used in the surgical procedure. The total cost can include an aggregation of the maintenance costs of each of the reusable surgical devices and the replacement costs of the nonreusable surgical devices consumed during the surgical procedure.
    Type: Grant
    Filed: February 3, 2022
    Date of Patent: June 11, 2024
    Assignee: Cilag GmbH International
    Inventors: Frederick E. Shelton, IV, Jason L. Harris, Taylor W. Aronhalt