Patents Examined by John Peabody, III
  • Cis-4-(2,2,3,3-tetrafluoropropoxy)-cinnamonitrile and trans-4-(2,2,3,3-tetrafluoropropoxy)-cinnamonitrile and a process for their preparation
    Patent number: 5663410
    Abstract: The present invention relates to the compounds cis-4-(2,2,3,3-tetrafluoropropoxy)cinnamonitrile and trans-4-(2,2,3,3-tetrafluoropropoxy)cinnamonitrile and to a process for their preparation.
    Type: Grant
    Filed: November 6, 1995
    Date of Patent: September 2, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Matthias Beller, Ralf Pfirmann
  • Guanidinealkyl-1,1-bisphosphonic acid derivatives process for their preparation and their use
    Patent number: 5498617
    Abstract: Guanidinealkyl-1,1-bisphosphonic acid derivatives, process for their preparation and their useCompounds of the tautomeric formula Ia, Ib or Ic, ##STR1## where R is a radical of the formula ##STR2## are effective compounds for the treatment and prophylaxis of degenerative bone disorders. They are used as pharmaceuticals.
    Type: Grant
    Filed: November 23, 1994
    Date of Patent: March 12, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Christoph Naumann, Hans-Jochen Lang, Jurgen Sandow, Anne-Marie Moura
  • Inhibition of bone loss by 4-aryloxy-5-hydroxy-2(5H)-furanones
    Patent number: 5466830
    Abstract: This invention relates to 4-phenoxy (and 4-substituted phenoxy)5-hydroxy-2(5H)-furanones of the formula: ##STR1## where Z is ##STR2## where R is H, halogen, C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.8 cycloalkyl, trifluoromethyl, or ##STR3## and X is H, C.sub.1 -C.sub.8 alkyl, --O--C.sub.1 -C.sub.8 alkyl, or halogen;a process for their preparation, their use in the treatment of osteoporosis, and pharmaceutical compositions thereof.
    Type: Grant
    Filed: May 18, 1994
    Date of Patent: November 14, 1995
    Assignee: American Home Products Corporation
    Inventor: Joseph P. Sabatucci