Abstract: This disclosure relates generally to the facile and selective mono-perfluoro and poly-fluoroarylation of Meldrum's acid to generate a versatile synthon for highly fluorinated alpha-phenyl acetic acid derivatives which provide straightforward access to fluorinated building blocks. The reaction takes place quickly and all products were isolated without the need for chromatography. An embodiment provides an alternative strategy to access alpha-arylated Meldrum's acids which avoids the need for aryl-Pb(IV) salts or diaryliodonium salts and provides access to the tertiary product which was not previously synthetically accessible. The synthetic versatility and utility of the Meldrum's acid products is demonstrated by subjecting the products to several derivatizations of the Meldrum's acid products as well as photocatalytic hydrodefluorination which provide access to difficult but valuable synthetic targets such as multifluorinated aromatics.
Type:
Grant
Filed:
May 6, 2019
Date of Patent:
September 14, 2021
Assignee:
The Board of Regents for Oklahoma State University
Abstract: Stable Phytonadione compositions for parenteral administration are provided which comprise (E) isomer of phytonadione at or greater than 97% w/w as the active ingredient, and is substantially free of (Z) isomer. Said compositions are stable, sterile, and particulate-free. Further, said compositions reduce or avoid allergic reactions to benzyl alcohol and polysorbate. In some aspects, the compositions are free or substantially free of benzyl alcohol and/or reduced amounts of polysorbate. Methods of manufacture and methods of administration also provided.
Type:
Grant
Filed:
July 24, 2018
Date of Patent:
August 24, 2021
Assignee:
Exela Holdings, Inc.
Inventors:
Phanesh Koneru, Sreerarama Murthy Mallipeddi, Jonathan E. Sterling
Abstract: It is an aim of the present invention to provide inhibitors of human diphtheria toxin-like ADP-ribosyltransferases, such as ARTD10, for use as a medicine. It is another aim of the invention to provide compounds for use as human mono-ADP-ribosyltransferase (mARTD) inhibitors in vitro. In the present invention, it has been discovered that human ARTD10, which belongs to an enzyme family linked to cancer biology, can be specifically inhibited by the benzamide comprising compounds disclosed in the invention, such as 4,4?-oxydibenzamide.
Type:
Grant
Filed:
April 6, 2017
Date of Patent:
August 24, 2021
Assignee:
University of Oulu
Inventors:
Lari Lehtiö, Harikanth Venkannagari, Bernhard Lüscher, Patricia Verheugd
Abstract: Processes and reactor systems for biomass conversion are described. A continuous process for the conversion of carbo-hydrate-containing feed material into furanic compounds comprises a reaction step comprising subjecting said feed material to reaction conditions in a reaction medium comprising two immiscible liquid phases, including a reactive phase and an extractive phase, and a Brønsted acid as catalyst, wherein the reaction medium comprises a solid component comprising at least a part of a carbohydrate-containing fraction of said feed material.
Type:
Grant
Filed:
May 23, 2017
Date of Patent:
August 24, 2021
Assignee:
Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO
Abstract: The present invention is directed to methods of producing THC from CBD utilizing non-harsh methodology and resulting in substantially increased yields, as well as devices built upon these novel methods. The methods and devices are material efficient, and in certain embodiments, solvent-free. In particular, in certain embodiments, these methods and related devices are suitable for commercial production of THC from CBD. Furthermore, in certain embodiments, the present invention provides methods of producing THC from CBD in manner that affords tunability to select the ratio of THC-8 to THC-9.
Abstract: The invention relates to polymorphous crystal modifications of a DPP-IV inhibitor, the preparation thereof and the use thereof for preparing a medicament.
Type:
Grant
Filed:
October 24, 2019
Date of Patent:
August 10, 2021
Assignee:
Boehringer Ingelheim International GmbH
Inventors:
Peter Sieger, Dirk Kemmer, Peter Kohlbauer, Thomas Nicola, Martin Renz
Abstract: The present application relates to the use of roluperidone, i.e., Compound (I): and salts, solvates, pharmaceutical compositions, and dosage forms thereof, for use in methods of treating negative symptoms and disorders (e.g., autism disorders, amblyopia, personality disorders, traumatic brain injury), as well as increasing neuroplasticity and promoting neuroprotection in subjects in need thereof.
Abstract: Disclosed are methods of treating CGRP related disorders, e.g., migraine, by administering to a patient in need thereof rimegepant or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions comprising rimegepant and kits including the pharmaceutical compositions and instructions are also disclosed.
Abstract: Compounds of formula I: are disclosed, as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric diseases and disorders in a subject in need thereof are also disclosed.
Type:
Grant
Filed:
July 28, 2017
Date of Patent:
August 3, 2021
Assignees:
Sunovion Pharmaceuticals Inc., PGI Drug Discovery LLC
Inventors:
Vadim Alexandrov, Carrie A. Bowen, Taleen G. Hanania, Noel Aaron Powell
Abstract: The present invention discloses a composite phosphorus flame retardant comprising cyclic organophosphate with multiple DOPO moieties, and a manufacturing method thereof. The composite structure phosphorus flame retardant has a structural formula comprising at least one organophosphate and at least two DOPO cyclic organophosphates. The method comprises: mixing the DOPO with a polyhydroxy alkane or a hydrocarbon substituent, wherein the polyhydroxy alkane has at least three hydroxy groups, and the hydrocarbon substituent has a chain with at least three carbon atoms; heating the mixture to 195-210° C. and reacting for 14-17 hours in the presence of a protective gas, and then cooling to room temperature; adding a phosphorus oxohalide or an incompletely esterified phosphorus oxohalide; and heating to 55-65° C. and reacting for 1.5-3 hours, then cooling to room temperature to obtain the product.
Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.
Type:
Grant
Filed:
May 28, 2019
Date of Patent:
July 27, 2021
Assignee:
The Board of Trustees of lhe University of Illinois
Inventors:
Gregory R. Thatcher, Rui Xiong, Jiong Zhao, Debra A. Tonetti
Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
Type:
Grant
Filed:
February 14, 2019
Date of Patent:
July 20, 2021
Assignee:
Vertex Pharmaceuticals Incorporated
Inventors:
Jeremy J. Clemens, Alexander Russell Abela, Corey Don Anderson, Brett B. Busch, Weichao George Chen, Thomas Cleveland, Timothy Richard Coon, Bryan Frieman, Senait G. Ghirmai, Peter Grootenhuis, Anton V. Gulevich, Sara Sabina Hadida Ruah, Clara Kuang-Ju Hsia, Ping Kang, Haripada Khatuya, Jason McCartney, Mark Thomas Miller, Prasuna Paraselli, Fabrice Pierre, Sara E. Swift, Andreas Termin, Johnny Uy, Carl V. Vogel, Jinglan Zhou
Abstract: The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.
Type:
Grant
Filed:
September 10, 2019
Date of Patent:
July 20, 2021
Assignee:
Novartis AG
Inventors:
Mihai Azimioara, Bei Chen, Robert Epple, Ayako Honda, Philip Lam, Hasnain Ahmed Malik, Casey Jacob Nelson Mathison, True Ngoc Nguyen, Victor Ivanovich Nikulin, Sejal Patel, Dean Paul Phillips, Rodrigo A. Rodriguez, Baogen Wu, Xuefeng Zhu
Abstract: The present invention develops a series of methyl caffeate derivatives having biological activity in anti-angiogenesis. The present invention suggests that the compounds of the invention possess inhibiting angiogenesis through regulation of VEGF/VEGFR-2 and its downstream signaling cascades in the vascular endothelial cells (VECs).
Type:
Grant
Filed:
June 4, 2015
Date of Patent:
July 20, 2021
Assignees:
Taipei Medical University, China Medical University
Inventors:
Chieh-Hsi Wu, Yueh-Hsiung Kuo, Chun-Hsu Pan
Abstract: Described herein, inter alia, are compositions, formulations, methods, and systems for reducing regional fat deposits and treating fat-related conditions.
Abstract: The present invention relates to deuterated 1-piperazino-3-phenyl-indanes and salts thereof with activity at dopamine receptors D1 and D2 as well as the 5HT2 receptors in the central nervous system, to medicaments comprising such compounds as active ingredients, to the use of such compounds in the treatment of diseases in the central nervous system, and to methods of treatment comprising administration of such compounds.
Type:
Grant
Filed:
November 4, 2019
Date of Patent:
July 13, 2021
Assignee:
H. Lundbeck A/S
Inventors:
Morten Jorgensen, Peter Hongaard Andersen, Klaus Gjervig Jensen
Abstract: The present application relate to a process for preparation of 4-Methylene tetrahydrofuran compound of formula II, which is useful as an intermediate for the preparation of halichondrin B analogues such as Eribulin.
Type:
Grant
Filed:
May 25, 2017
Date of Patent:
July 13, 2021
Assignee:
DR. REDDY'S LABORATORIES LIMITED.
Inventors:
Sudhir Sai, Debjit Basu, Kumar Sarvesh, Uday Kumar Neelam, Amit Kumar Mandal, Rakeshwar Bandichhor, Vilas Hareshwar Dahanukar
Abstract: Disclosed is a fluorination method comprising providing a fluorinating reagent and a solvent to a reaction mixture; providing a compound having the formula Ar—X to the reaction mixture; wherein Ar is aryl, substituted aryl, heteroaryl or substituted heteroaryl, and X is Cl, Br, I or NO2, providing tetramethylammonium 2,6-dimethylphenolate to the reaction mixture; and reacting under conditions sufficient to provide a species having the formula Ar—F.
Type:
Grant
Filed:
July 13, 2017
Date of Patent:
July 13, 2021
Assignees:
Dow Global Technologies LLC, The Regents of the University of Michigan
Inventors:
Melanie S. Sanford, Megan A. Cismesia, Patrick S. Hanley, Douglas Bland
Abstract: Compounds of formula (I) and salts thereof: wherein R1, R2, R3, R4 are defined herein. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family of bromodomain proteins to, for example, acetylated lysine residues and thus may have use in therapy, for example in the treatment of autoimmune and inflammatory diseases, such as rheumatoid arthritis; and cancers.
Type:
Grant
Filed:
August 22, 2019
Date of Patent:
July 6, 2021
Assignee:
GlaxoSmithKline Intellectual Property Development Limited
Inventors:
Rino Antonio Bit, John Alexander Brown, Philip G. Humphreys, Katherine Louise Jones
Abstract: Crystalline forms of compound 6-(6,7-dimethoxyquinazolin-4-yloxy)-N,2-dimethylbenzofuran-3-carboxamide, pharmaceutical compositions and the methods of preparation and the use thereof.