Abstract: A composition and method for treatment of brittle, broken, cracked or otherwise damaged nail and hoof plates. The composition is an aqueous-organic medium containing a non-covalent complex of a diamine and an organic acid or an aqueous-organic medium with a diamine alone.
Abstract: Described herein is a perfluorinated aminoolefin compound of general formula (I): CFY?CXN(Rf)CF2Rf? where: (a) Rf and Rf? are (i) independently selected from a linear or branched perfluoroalkyl group having 1-8 carbon atoms, optionally comprising at least one catenated O or N atom, or (ii) bonded together to form a perfluorinated ring structure having 4-8 ring carbon atoms, optionally comprising at least one catenated O atom; and (b) X and Y are (i) independently selected from a perfluoroalkyl group having 1-4 carbon atoms, or (ii) bonded together to form a perfluorinated ring structure having 5-6 ring carbon atoms. Such compounds may be used in heat transfer, foam blowing or immersion cooling applications, or as a working fluid in a Rankine cycle, a coating or lubricant, or as a dielectric fluid. Also disclosed herein is a method for making such compounds.
Type:
Grant
Filed:
May 10, 2019
Date of Patent:
April 18, 2023
Assignee:
3M Innovative Properties Company
Inventors:
Sean M. Smith, Michael J. Bulinski, Michael G. Costello, Klaus Hintzer, Markus E. Hirscherg, William M. Lamanna
Abstract: Provided is a therapeutic product comprising at least one cannabinoid; at least one primary terpene; and at least 5% by weight of a non-cannabinoid, non-terpene carrier, wherein said non-cannabinoid, non-terpene carrier comprises cellulose and the terpenes to cannabinoids weight/weight ratio in said product is about 0.1 to about 1.0. Also provided is a method of treating certain conditions and/or symptoms in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of a product comprising at least one primary terpene. Further provided is a therapeutic product comprising a primary terpene blend, wherein said primary terpene blend comprises five or less terpenes, and wherein each one of those terpenes, where present, independently comprises at least 10% of the total terpene content.
Type:
Grant
Filed:
January 21, 2020
Date of Patent:
April 18, 2023
Assignee:
BUZZELET DEVELOPMENT AND TECHNOLOGIES LTD
Abstract: The present invention discloses a cannabinoid-based composition useful for treating or preventing dental pulp associated diseases. The composition comprises an effective amount of Cannabis extract or a derivative thereof or at least one synthetic cannabinoid for the treatment of dental pulp inflammation, pulp infection and/or dental bone defects. The present invention further discloses methods for treating or preventing dental pulp associated diseases.
Abstract: A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.
Type:
Grant
Filed:
December 19, 2020
Date of Patent:
March 7, 2023
Assignee:
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY
Inventors:
Chengyuan Liang, Cong Du, Qianqian Zhao, Liang Xin, Jingyi Li, Dan Yang, Nan Hui, Guaiping Qiao, Han Li, Yanjun Li, Liang Qi, Wenbo Yao, Gennian Mao
Abstract: A process for manufacturing chromenes which are intended for the preparation of thermosetting resins, includes transforming an aromatic propargyl ether of general formula (I) into a chromene by flash vacuum thermolysis, at a temperature of between 300 and 600° C., at a pressure of between 4 and 10,000 Pa. It also concerns a process for preparing a material made of thermoset resin, including successively: a) implementation of the above process; b) polymerization of the reaction product obtained in a) so as to obtain the material made of thermoset resin; c) recovery of the material made of thermoset resin obtained in b).
Type:
Grant
Filed:
July 23, 2020
Date of Patent:
February 28, 2023
Assignees:
ARIANEGROUP SAS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE
Inventors:
Robin Pouyet, Xavier Coqueret, Brigitte Defoort, Bastien Rivieres
Abstract: Disclosed herein is a novel process for preparing Compound A free base, 5-((2,4-diaminopyrimidin-5-yl)oxy)-4-iso-propyl-2-methoxybenzenesulfonamide, and a citrate salt of Compound A with simplified chemistry and a high overall yield: Compound A. In one embodiment, the overall yield from the starting material 2-isopropylphenol to Compound A citrate salt is greater than 50%. In another embodiment, the overall yield is greater than 60%. Also disclosed herein are novel salts and solvates of Compound A.
Abstract: A process includes the following steps: a) converting a solid material containing hemicellulose, cellulose and lignin, by: (i) hydrolyzing at least part of the hemicellulose of the solid material with a first aqueous hydrochloric acid solution, yielding a remaining solid material and a hydrochloric acid-containing, aqueous, first hydrolysate product solution; (ii) hydrolyzing at least part of the cellulose of the remaining solid material with a second aqueous hydrochloric acid solution, yielding a residue and a hydrochloric acid-containing, aqueous, second hydrolysate product solution; (b) forwarding to step (c) a, hydrochloric acid-containing, aqueous intermediate product solution comprising: a part of or the whole of the hydrochloric acid-containing, aqueous first and/or second hydrolysate product solution of step (a); and (c) heating at least part of the hydrochloric acid-containing, aqueous intermediate product solution to yield a product solution containing 5-(chloromethyl)furfural, and extracting the 5-
Type:
Grant
Filed:
January 31, 2019
Date of Patent:
February 14, 2023
Assignee:
Furanix Technologies B.V.
Inventors:
Robert-Jan van Putten, Benjamin McKay, Gerardus Johannes Maria Gruter, Jan Cornelis van der Waal
Abstract: Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
Type:
Grant
Filed:
September 15, 2020
Date of Patent:
January 31, 2023
Assignee:
Incyte Corporation
Inventors:
Liangxing Wu, Bo Shen, Meizhong Xu, Wenqing Yao
Abstract: The present invention relates to crystalline forms of (1aS,5aS)-2-(4-oxy-pyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid ((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-amide (Compound 1) and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor and are therefore useful in the treatment of CB2 receptor-mediated disorders, for example, osteoarthritis; pain; hyperalgesia; allodynia; inflammatory hyperalgesia; neuropathic hyperalgesia; acute nociception; osteoporosis; multiple sclerosis-associated spasticity; autoimmune disorders; allergic reactions; CNS inflammation for example; atherosclerosis; undesired immune cell activity, and inflammation associated with a disorder selected from: osteoarthritis, anaphylaxis, Behcet's disease, graft rejection, vasculitis, gout, spondylitis, viral disease, bacterial disease, lupus, inflammatory bowel disease, autoimmune hepatitis, and type 1 diabetes mellitus; age-related macular degeneration; cough;
Type:
Grant
Filed:
March 16, 2021
Date of Patent:
January 24, 2023
Assignee:
Arena Pharmaceuticals, Inc.
Inventors:
Anthony C. Blackburn, Sangdon Han, Robert M. Jones, Antonio Garrido Montalban, Biman B. Pal, Jaimie Karyn Rueter
Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts and esters thereof: pharmaceutical compositions comprising these compounds and methods of using these compounds to treat or prevent a disease or disorder mediated as FXR modulators. Specifically, the present invention relates to isoxazole derivatives useful as agonists for FXR, and methods for their preparation and use.
Type:
Grant
Filed:
May 11, 2020
Date of Patent:
January 17, 2023
Assignee:
Enanta Pharmaceuticals, Inc.
Inventors:
Guoqiang Wang, Jun Ma, Bin Wang, Ruichao Shen, Xuechao Xing, Yong He, Yat Sun Or
Abstract: The present invention relates to compounds of Formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, bonds a, b, c and d, X1, X2, X3, X4, R2, and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.
Type:
Grant
Filed:
February 2, 2021
Date of Patent:
January 10, 2023
Assignee:
Cancer Research Technology Limited
Inventors:
Allan Michael Jordan, Rebecca Newton, Bohdan Waszkowycz, Jonathan Mark Sutton, George Hynd, Silvia Paoletta, Euan Alexander Fraser Fordyce
Abstract: The present invention relates to the field of pesticides. Disclosed are a pyrazole amide compound and an application thereof, and a fungicide. The pyrazole amide compound has a structure as represented by Formula (1). The pyrazole amide compound provided by the present invention has significant control effects on soybean rust, corn rust, wheat powdery mildew, cucumber powdery mildew, and rice sheath blight even at low concentration.
Type:
Grant
Filed:
November 23, 2018
Date of Patent:
January 10, 2023
Assignee:
Shandong United Pesticide Industry Co. Ltd.
Abstract: An object of the present invention is to provide a drug which prevents progress of Alzheimer's disease and a method of preventing progress of Alzheimer's disease. Alzheimer's disease can be effectively prevented or treated by initiating administration of a pharmaceutical composition comprising 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof as an active ingredient to a patient within a certain period from clinical diagnosis of Alzheimer's disease.
Abstract: Methods for identification of new dosing strategies which optimize positive treatment outcomes and patient safety. Specifically, new dosing strategies for fosfomycin and pharmaceutically acceptable salt thereof which have improved treatment outcomes in mammals. For example, a method of treating mammals having a bacterial infection with fosfomycin or a pharmaceutically acceptable salt thereof using improved dosing regimens.
Abstract: Described herein are novel methods of synthesizing 2-amino-5-chloro-N,3-dimethylbenzamide. Compounds prepared by the methods disclosed herein are useful for preparation of certain anthranilamide compounds that are of interest as insecticides, such as, for example, the insecticides chlorantraniliprole and cyantraniliprole.
Abstract: The invention provides deuterium-enriched piperidinonyl-oxoisoindolinyl acetamide compounds, pharmaceutical compositions, and methods of using such compounds and pharmaceutical compositions to treat cancer, angiogenesis disorders, immune disorders, and other medical disorders.
Abstract: The disclosure relates to compounds of formula I, which are formyl peptide 2 (FPR2) receptor agonists and/or formyl peptide 1 (FPR1) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.
Type:
Grant
Filed:
June 11, 2020
Date of Patent:
December 20, 2022
Assignee:
Bristol-Myers Squibb Company
Inventors:
Nicholas R. Wurtz, Pravin Sudhakar Shirude
Abstract: A compound of formula (I) or a pharmaceutically acceptable salt, or N-oxide thereof and the use of the same in therapy: wherein Z, Y, R1, W, V, and R3 are as defined in claim 1.
Type:
Grant
Filed:
September 17, 2015
Date of Patent:
December 20, 2022
Assignee:
PROXIMAGEN, LLC
Inventors:
Lee Patient, Iain Simpson, Edward Savory