Abstract: The present invention introduces a system (S) and method for automatic detection of epileptogenic focus (EF) in pharmacoresistant epilepsy using an asymmetry index in FDG-PET images. The system (S) comprises of an acquisition unit for capturing FDG-PET scans and simultaneous whole-brain MRI images, a storage and communication unit for managing the acquired data, and a computation unit for processing and generating asymmetry index (AI) images. The method of the present invention comprises of a novel technique, PET asymmetry after anatomical symmetrization coregistered to MRI (PASCOM), to the AI images and is independent of healthy control PET data, facilitating implementation and multicenter translation. The method is effective in localizing the epileptogenic zone, especially in MRI-negative patient (Su), and can detect epileptogenic focus (EF) independently.

Abstract: A method for performing magnetic resonance imaging on a subject comprises: injecting a contrast agent into a region of interest of the subject; applying a pulse sequence to the region of interest; collecting auxiliary data for the region of interest, the auxiliary data being related to one or more time-varying parameters of the subject within the region of interest; determining a temporal factor ? from the auxiliary data; collecting imaging data for the region of interest, the imaging data being related to one or more spatially-varying parameters of the subject within the region of interest; determining a spatial factor Ur from the imaging data; modeling a multi-dimensional image sequence as I=Ur?; and deriving at least a first metric and a second metric from the multi-dimensional image sequence I, the first metric and the second metric being associated with distinct perfusion-based imaging techniques.

Abstract: Systems and methods include executing a labeling phase of a pulse sequence while respective first shim currents are applied to first-order shim coils, respective second shim currents are applied to second-order shim coils, and a center frequency of an RF system is set to a first center frequency, switching, during a post-labeling delay of the pulse sequence, the first shim currents to third shim currents and the center frequency of the RF system to a second center frequency, executing a readout phase of the pulse sequence to acquire first MR data from an imaging volume of a subject while the respective third shim currents are applied, the respective second shim currents are applied s, and the center frequency is set to the second center frequency, and generating an image based on the first MR data.

Abstract: Methods and systems for instrument tracking and navigation are described. In one embodiment, a non-transitory computer readable storage medium has stored thereon instructions that, when executed, cause a processor of a device to at least receive position sensor data from at least one position sensor tracking an instrument positioned within a luminal network, determine a first estimated state of the instrument derived from the position sensor data, determine a second estimated state of the instrument based on the position sensor data and at least one other type of position data, determine a location transform based on the second estimated state and the first estimated state, adjust the first estimated state based on the location transform to determine a third estimated state of the instrument, and output the third estimated state of the instrument.

Abstract: A needle direction estimation unit estimates a needle direction L based on needle information generated by a needle information generation unit, and outputs the position information of the needle direction L. A search region setting unit sets the needle direction L in a tissue image based on the position information of the needle direction L, and sets a search region F that extends to both sides with a predetermined width r. A needle tip search unit calculates the brightness distribution of the tissue image, determines a maximum brightness point B in the search region F to be the needle tip, and outputs the position information of the needle tip. A needle tip visualizing unit visualizes a needle tip N, which is a predetermined point image, in the tissue image from the position information of the needle tip.

Abstract: A computer-implemented method for producing compatibility of a patient table and of a medical imaging system. The patient table is designed to mount a patient during an examination with the medical imaging system. The method includes receiving a functional scope of the patient table, wherein the functional scope of the patient table (15) includes at least one function; receiving a functional scope of the medical imaging system, wherein the functional scope of the medical imaging system includes at least one function; comparing the functional scope of the patient table with the functional scope of the medical imaging system; and if at least one function is included only in the functional scope of the patient table and/or only in the functional scope of the medical imaging system, locking the at least one function.

Abstract: Noncontact sensing of subject motion using Doppler radar within a magnetic resonance imaging (MRI) apparatus transmits a band-pass filtered continuous wave radio signal at a microwave frequency and receives a band-pass filtered reflected radio signal. The subject motion is detected from the received band-pass filtered reflected radio signal using a quadrature radio receiver with a software defined radio implementing Doppler radar. A first antenna, used for transmission and reception, is connected to the quadrature radio using band-pass filters and an RF coupler. A second antenna, used for reception, is connected directly to the quadrature radio using band-pass filters. The antennas are positioned in a bore of the MRI apparatus.

Abstract: The invention relates to a medical system comprising a tool including: a body; a location measurement device adapted to emit an ultrasound location signal and receive a reflected location signal; a location processing device adapted to compare each of the echoes of the reflected location signal to a pre-determined location threshold, emit an information signal if no target location echo corresponding to the interface between first and second anatomical structures has been identified within an analysis time window, the target location echo having an amplitude that exceeds the location threshold.

Abstract: The present disclosure provides a biomagnetic field sensor system for diagnostic evaluation of a cardiac condition of an individual. The biomagnetic field sensor system may comprise an array of biomagnetic field sensors configured to sense an electromagnetic field associated with a heart of the individual and generate electromagnetic field data therefrom; a computer processor coupled to the array of biomagnetic field sensors; a memory configured to store the electromagnetic field data generated by the array of biomagnetic field sensors; and a non-transitory computer-readable medium encoded with a computer program including instructions that, when executed by the computer processor, cause the computer processor to receive the electromagnetic field data, and generate a diagnostic evaluation of a cardiac condition of the individual based at least in part on an analysis of the electromagnetic field data.

Abstract: A position detection apparatus including: an electromagnetic induction module configured to send to a mode triggering module an induced voltage signal generated due to a change in a magnetic field; a mode triggering module configured to output a preset trigger signal based on the induced voltage signal, the trigger signal corresponding to the induced voltage signal; and a signal generating module configured to generate an analog signal of a first mode corresponding to the induced voltage signal based on the received trigger signal, and send the analog signal of the first mode to an MR receiving module of an MRI system via an antenna module, so that: the MR receiving module judges whether the wireless squeeze ball has entered the interior of a body coil from outside a tubular body of the MRI system, based on the analog signal of the first mode.

Abstract: By repeatedly performing ultrasound transmission and reception with respect to a single scan plane designated within a target subject's body, a temporally sequential target set of time series data is obtained in a reception unit, an image generation unit, a tracking processing unit, an elastography processing unit, or a Doppler processing unit. A feature prediction unit inputs the target set of time series data into a learner, and predicts a feature indicated by the target set of time series data based on output data output from the learner in response to the target set of time series data, wherein the learner is trained to predict and output, based on an input set of time series data, a feature indicated by that set of time series data. A display control unit notifies a result of prediction by the feature prediction unit to a user.

Abstract: The invention relates to a system and method for performing a laser Doppler flowmetry, LDF, measurement. The system comprises a coherent light source, a photodetector and one or more processors. The photodetector generates an output signal. The processor(s) determines a selected frequency range for computing an LDF signal. A spectrum of the photodetector output signal is computed for a series of time intervals, thereby obtaining a series of spectra. A measure of the amount of physiological information in the spectra is computed for a number of different frequencies. The selected frequency range is determined as the range of frequencies for which the computed measure of amount of physiological information fulfills a predetermined criterion. The processor(s) compute an LDF signal using the selected frequency range, and output the LDF signal.

Abstract: A device, and methods for using said device, for inserting a marker into a patient's body. The device may comprise a retention mechanism to hold the device in an first, undeployed, state. The device may be inserted into a patient's body in the first state, transitioned by the user into a second state wherein the retention mechanism is overcome, and then transition the device into a third state to deliver a marker to a precise location. The device may then be removed from the patient's body.

Abstract: This invention relates generally to an ultrasound device configured to generate a frustum-shaped beam capable of fragmenting a plurality of biomineralizations located within a patient's body in combination with synthetic cavitation nuclei. The ultrasound device includes a transducer assembly comprising a plurality of ultrasound transducer elements, and a multi-channel amplifier circuit. Each channel of the multi-channel amplifier circuit is configured to actuate a distinct subset of the plurality of transducer elements. The multi-channel amplifier circuit is configured to operate in each of a plurality of states, each state of comprising a set of frequencies at which each channel of the multi-channel amplifier circuit is configured to actuate the distinct subset of transducer elements. The multi-channel amplifier circuit is further configured to switch between the plurality of states, thereby causing the plurality of ultrasound transducer elements to produce a frustum-shaped beam.

Abstract: Methods and systems are provided for determining diagnostic-scan parameters for a magnetic resonance (MR) diagnostic-scan, from MR calibration images, enabling acquisition of high-resolution diagnostic images of one or more anatomical regions of interest, while bypassing acquisition of localizer images, increasing a speed and efficiency of MR diagnostic-scanning. In one embodiment, a method for a magnetic resonance imaging (MRI) system comprises, acquiring a magnetic resonance (MR) calibration image of an imaging subject, mapping the MR calibration image to a landmark map using a trained deep neural network, determining one or more diagnostic-scan parameters based on the landmark map, acquiring an MR diagnostic image according to the diagnostic-scan parameters, and displaying the MR diagnostic image via a display device.

Abstract: Provided herein are methods of analyzing tissue using a magnetic resonance imaging (MRI) compatible tissue analysis device that includes radio-frequency (RF) tracking and imaging elements. Related kits, systems, and computer program products are also provided.

Abstract: A method is provided for determining a movement-corrected B1 field map on contrast medium injection, wherein before the injection, a B1 field map is determined. Following the contrast medium administration, a position change is determined at the position at which the B1 field map was determined. With the position change and the B1 field map, the movement-corrected B1 field map is determined.

Abstract: An association of a pre-operative plan and tracked position and orientation of a surgical instrument relative patient anatomy in a navigation system is generated. The pre-operative plan includes a virtual representation of the patient anatomy data. Position and orientation of the patient anatomy as well as position and orientation of the surgical instrument within the navigation system is obtained. A virtual representation of the surgical instrument relative the virtual representation of the patient anatomy data is generated in multiple orientations in separate parts of a split window. A system with a tracker comprising a tracker interface for attaching the tracker to the instrument includes a surgical navigation module for generating the virtual representation in a split window.

Abstract: In one embodiment, a biological information monitoring apparatus includes: an antenna assembly including at least one antenna, the antenna assembly being disposed close to an object; a signal generator configured to generate a radio-frequency (RF) signal; and a displacement detection circuit configured to detect a physical displacement of the object based on the RF signal, wherein the at least one antenna includes: a dipole antenna having a feeding point to be supplied with the RF signal, the feeding point being positioned in a center of the dipole antenna; a coaxial line configured to supply the RF signal to the feeding point; and a conductor element that has a ¼ wavelength and is short-circuited on one end to an outer conductor of the coaxial line.

Abstract: A method of determining a location of an optical fibre positioned at least partially inside a scattering medium, the method comprises transmitting pulsed light into the scattering medium, receiving, by a detector, photons of the pulsed light that have passed through the scattering medium, selecting signals corresponding to some of the received photons, wherein the selecting is based on a time of arrival of the received photons; and determining a location of the optical fibre based on the selected signals.