Patents Examined by Johnnie R. Brown
  • Ketophosphamide glycosides
    Patent number: 5132416
    Abstract: Compounds of the formula (I) ##STR1## wherein R.sup.1 represents a pyranosyl radical and R.sup.4, R.sup.2, and R.sup.3 are as specified herein, compositions containing the compounds, methods of using the compounds to selectively kill tumor cells, and a process for the preparation of the compounds.
    Type: Grant
    Filed: August 20, 1990
    Date of Patent: July 21, 1992
    Assignee: Bayer Aktiengesellschaft
    Inventors: Lutz F. Tietze, Roland Fischer, Matthias Beller
  • Dideoxynucleoside-5'-phosphonoformic acid compounds
    Patent number: 5132414
    Abstract: Compounds having the structure ##STR1## in which R is alkyl, aryl, or aralkyl, A is hydrogen or a water-soluble cation, B is hydrogen, fluorine, or azido, the bond is saturated when B is fluorine or azido and is saturated or unsaturated when B is hydrogen, and D is a purine or pyrimidine base are effective inhibitors of retrovirus replication.
    Type: Grant
    Filed: May 10, 1990
    Date of Patent: July 21, 1992
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Andre Rosowsky, Ruth M. Ruprecht
  • Antioxidative glycoside and antioxidative composition containing the same
    Patent number: 5132294
    Type: Grant
    Filed: July 2, 1991
    Date of Patent: July 21, 1992
    Assignee: Kabushiki Kaisha Kobe Seiko Sho
    Inventors: Akio Mimura, Keiichi Takebayashi, Yoshimasa Takahara, Toshihiko Osawa
  • Composition of antibiotic L 17054 and a method for the treatment of bacterial infections using the antibiotic
    Patent number: 5132286
    Abstract: The present invention is directed to the essentially pure preparation of an antibiotic substance arbitrarily designated antibiotic L 17054. This antibiotic substance is obtained from the known antibiotic substance named teicoplanin (formerly teichomycin) by chemical treatment. The new compound and the pharmaceutically acceptable salts possess antimicrobial activity.
    Type: Grant
    Filed: May 17, 1991
    Date of Patent: July 21, 1992
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Adriano Malabarba, Angelo Borghi, Paolo Strazzolini, Bruno Cavalleri, Carolina Coronelli
  • Composition and method for treating nicotine dependency
    Patent number: 5130132
    Abstract: An anti-smoking remedy with biochemical effect. The remedy consists of non-toxic plant components including Radix bupleuri, Radix peucedani and Rhizoma cimicifugae. Additional components to the preparation can include Rhizome phragmiles, or a mixture of Pinellia ternata and either Liguiritiae or Robinia pseudo acacia.
    Type: Grant
    Filed: July 13, 1989
    Date of Patent: July 14, 1992
    Inventor: Vladimir Badmajew
  • Process for the production of alkyl glycoside
    Patent number: 5130420
    Abstract: A process is described for the production of an alkyl glycoside which comprises distilling a higher alcohol in the presence of an alkaline substance, or washing a higher alcohol with an aqueous solution of an alkaline substance, and then reacting the higher alcohol with a sugar or a reaction product of a sugar and a lower alcohol. According to this process, an alkyl glycoside showing an excellent hue can be produced by repeatedly using unreacted alcohol recovered from the reaction mixture in the production of an alkyl glycoside.
    Type: Grant
    Filed: March 16, 1990
    Date of Patent: July 14, 1992
    Assignee: Kao Corporation
    Inventors: Akira Yamamuro, Toyomi Koike, Hiroki Sawada, Akio Kimura
  • Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same
    Patent number: 5130302
    Abstract: A novel class of pharmaceutically active boronated nucleosides are provided. The nucleosides are boronated at a ring nitrogen of the purine or pyrimidine or analogues thereof. Also provided are phosphate esters of these nucleosides and oligomers thereof. Methods of making and using the boronated nucleosides are also disclosed.
    Type: Grant
    Filed: December 20, 1989
    Date of Patent: July 14, 1992
    Assignee: Boron Bilogicals, Inc.
    Inventors: Bernard F. Spielvogel, Anup Sood, Iris H. Hall, Barbara Ramsay Shaw
  • Composition having anti-endotoxic activity
    Patent number: 5128323
    Abstract: The invention relates to pharmaceutical compositions having antiendotoxic activity, comprising as the active component a fraction which can be isolated from lactulase syrup by means of absorption at a sulphonated polystyrene cation resin in the Ca.sup.2+ - form and elution with a suitable solvent. The lactulose syrup can be obtained by basic isomerization of lactose at elevated temperature, optionally in the presence of sodiumsulphite.
    Type: Grant
    Filed: May 23, 1989
    Date of Patent: July 7, 1992
    Assignee: Duphar International Research B.V.
    Inventor: Maarten H. Pranger
  • 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents
    Patent number: 5128458
    Abstract: 2'3'-dideoxy-4'-thioribonucleosides useful as antiviral agents in the treatment and prevention of AIDS are disclosed. In accordance with one aspect of the invention there are provided compounds of the formula ##STR1## where X=H, N.sub.3 or F, and B is a member selected from the group consisting of pyrimidine, 5-azapyrimidine, 6-azapyrimidine, 3-deazapyrimidine, purine, 3-deazapurine, 7-deazapurine, 8-azapurine, and 2-azapurine bases.The intermediate 1-O-acetyl-5-O-t-butyldiphenylsilyl-4-thio-2,3-dideoxyribofuranose useful in the production of certain of the 2',3'-dideoxy-4'-thioribonucleosides is also disclosed.
    Type: Grant
    Filed: January 9, 1991
    Date of Patent: July 7, 1992
    Assignee: Southern Research Institute
    Inventors: John A. Montgomery, John A. Secrist, III
  • Eriodictyon compositions and methods for treating internal mucous membranes
    Patent number: 5128132
    Abstract: Methods and formulations are provided for alleviating the dryness of mucosal membranes in the upper and lower respiratory tract and gastrointestinal tract. The compositions are formulated into aerosol sprays and delayed release tablets which include eriodictyon fluid which is a Yerba Santa extract. The formulations may additionally contain other components such as preservatives, bronchodilators, choleretics, antibiotics, topical anesthetics, coloring agents, emulsifiers, and the like. The Yerba Santa-based compositions of the invention are administered to an affected patient to alleviate or prevent dryness on the mucosal membranes of the respiratory and gastrointestinal tracts.
    Type: Grant
    Filed: November 2, 1990
    Date of Patent: July 7, 1992
    Assignee: Parnell Pharmaceuticals, Inc.
    Inventor: Francis W. Parnell
  • Hydrophobically modified carboxyalkyl hydroxyalkyl ethers of polygalactomannans
    Patent number: 5128462
    Abstract: Alkyl and hydroxyalkyl ethers of polygalactomannans are further modified with long chain haloalkanoic acids. The resulting derivatized polygalactomannans are useful as thickening agents in aqueous systems, particularly in combination with surfactants at acidic pH.
    Type: Grant
    Filed: July 1, 1991
    Date of Patent: July 7, 1992
    Assignee: Rhone-Poulenc Inc.
    Inventor: George M. Zody
  • Increased protein production in animals
    Patent number: 5128127
    Abstract: The present invention provides a method of increasing the ratio of body protein to fat in a animal by maintaining the animal in a hyperimmune state. The invention also provides a method of increasing carcass protein levels in animals. The invention further provides a method for producing lean, low-fat meat for human or animal consumption.
    Type: Grant
    Filed: February 8, 1989
    Date of Patent: July 7, 1992
    Assignee: Stolle Research & Development Corp.
    Inventor: Lee R. Beck
  • Process for preparing a watersoluble composition containing ginkgo leaf extracts
    Patent number: 5128131
    Abstract: A composition containing an extract obtained by a water-containing organic solvent, comprising: (a) an extract containing active ingredients including flavone glycoside or biflavone almost insoluble in water, said extract being obtained for ginkgo plant tissues by extraction with a water-containing organic solvent, and at least one of (b) a water-soluble high-molecular substance and (c) a fatty acid ester of polyglycerol. This composition can be formulated into preparations not containing ethanol, i.e. solid preparations including tablets, granules, and powder preparations, or non-alcoholic liquid preparations such as drinkable preparations and syrups, in such a way that the extract contained is well absorbed through the digestive tract.
    Type: Grant
    Filed: November 2, 1989
    Date of Patent: July 7, 1992
    Assignee: Freund Industrial Co., Ltd.
    Inventors: Shimesu Motoyama, deceased, Seiichi Umeda, Yukihiro Saito
  • Oxazoline-carboxylic acid derivatives and method for the preparation thereof
    Patent number: 5128478
    Abstract: Optically active oxazoline-carboxylic acid derivatives of the formula: ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, an alkykl group which is substituted and has 1 to 20 carbon atoms, a cycloalkyl group, a cycloalkyl group which is substituted, a phenyl group, a phenyl group which is substituted, a vinyl group, a vinyl group which is substituted, an ethynyl group or an ethynyl group which is substituted;R.sup.2 represents a lower alkyl group having 1 to 4 carbon atoms or a benzyl group;R.sup.3 represents a hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms, a phenyl group or a benzyl group,and a method for preparing the above compounds and derivatives thereof involving a reaction between an aldehyde and an isocyano-carboxylate in the presence of a catalyst mixture.
    Type: Grant
    Filed: August 9, 1990
    Date of Patent: July 7, 1992
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yoshihiko Ito, Tamio Hayashi
  • 6,6'-dihalo-6,6'-dideoxy-1',2,3,3',4,4'-hexa-o-methylsucrose compounds
    Patent number: 5126438
    Abstract: 6,6'-dihalo-6,6'-dideoxy-1',2,3,3',4,4'-hexa-O-methylsucrose compounds are disclosed as useful intermediates for the synthesis of water-absorbent polyethers. These compounds may also be used as intermediates in the preparation of other difunctional monomers and metal complexing agents from sucrose.
    Type: Grant
    Filed: December 7, 1990
    Date of Patent: June 30, 1992
    Assignee: Hawaiian Sugar Planters' Association
    Inventor: Navzer D. Sachinvala
  • Aldophosphamide glycosides, a process for their preparation and their use as pharmaceutical active compounds
    Patent number: 5126437
    Abstract: Compounds of the formula ##STR1## in which R.sup.1 represents saturated, unsaturated or anhydro desoxypentosyl, desoxyhexosyl or didesoxyhexosyl, where the OH functions of the sugar are optionally protected, andR.sup.2 represents straight-chain or branched or heterosubstituted alkyl having up to ten carbon atoms andR.sup.3 represents straight-chain or branched or heterosubstituted alkyl having up to ten carbon atoms andX represents halogens andR.sup.4 represents straight-chain or branched or heterosubstituted alkyl having up to ten carbon atoms.Such compounds are useful as highly selective cytostatics in cancer therapy.
    Type: Grant
    Filed: June 7, 1989
    Date of Patent: June 30, 1992
    Assignee: Bayer Aktiengesellschaft
    Inventors: Lutz-F. Tietze, Manfred Neumann, Roland Fischer
  • Compositions for topical use containing depolymerized deoxyribonucleic acids in the skin and body cosmetic treatment
    Patent number: 5126331
    Abstract: Compositions for topical use containing as active ingredients depolymerized deoxyribonucleic acids can be used for the reduction of the unaesthetisms of the face skin, due to the couperose. Said compositions can be advantageously used also to locally reduce, in the lower limbs, the skin unaesthetisms (dilated capillaries, oedemas, tumefactions), resulting from a situation of an extended physical stress acting on the above-mentioned legs.
    Type: Grant
    Filed: August 16, 1990
    Date of Patent: June 30, 1992
    Assignee: Crinos Industria Farmacobiologica S.p.A.
    Inventor: Giovanni Gazzani
  • Glucosamine derivatives and compositions reagents and containing the same
    Patent number: 5126329
    Abstract: Novel phenylazonaphthol derivatives, e.g., 4-(4'-nitro-2'-sulfophenylazo)-1-naphthyl-N-acetyl-.beta.-D-glucosaminide sodium salt, are excellent substrates for determining N-acetyl-.beta.-D-glucosaminidase (NAG) activity in urine collected from the patient with renal disorders. The substrate has high water solubility, is not affected by interferences in urine and provides a simple method for determination of NAG activity which is suited for both rate and endpoint assays.
    Type: Grant
    Filed: December 27, 1989
    Date of Patent: June 30, 1992
    Assignee: Nitto Boseki Co., Ltd.
    Inventors: Kenji Tani, Yoshio Nakamura, Takeshi Nagasawa
  • Sialosyl cholesterol and neuropathy remedy comprising the same
    Patent number: 5126330
    Abstract: The present invention relates to a sodium salt of sialosyl cholesterol. The present compound has an excellent high water solubility, and therefore the compound is very useful as a medicine to be used for treating various diseases derived from lesions of peripheral or central nerves.
    Type: Grant
    Filed: February 1, 1991
    Date of Patent: June 30, 1992
    Assignee: Mect Corporation
    Inventors: Haruo Ogura, Kimio Furuhata, Shingo Sato, Masayoshi Ito, Yoshiyasu Shitori, Yoshitaka Nagai
  • Physiologically active SN-198C compounds
    Patent number: 5126436
    Abstract: Physiologically active material SN-198C producing bacteria are disclosed which belong to Streptomyces species and products which have the following structural formula: ##STR1##
    Type: Grant
    Filed: May 25, 1990
    Date of Patent: June 30, 1992
    Assignee: Snow Brand Milk Products Company Limited
    Inventors: Kenichi Kimura, Shoji Nakayama, Nobuo Miyata