Abstract: A method of predicting an adverse event in a patient having an implantable blood pump including correlating a pulsatility value to a flow trough value associated with the blood pump to determine a flow peak value; dividing the determined flow peak value by a pump current to determine a pulsatility peak value; tracking a first moving average of the pulsatility peak value, the first moving average defining a threshold range; tracking a second moving average of the pulsatility peak value, the second moving average being faster than the first moving average; and generating an alert when the second moving average deviates from the threshold range.

Abstract: The present invention provides an intravascular blood pump system with an external motor and comprising an impeller housing and/or impeller blade(s) that may be expandable and collapsible. The blade(s) and/or impeller housing may be biased to expand or may be expanded by centrifugal forces generated during rotation of the impeller and blades an operatively connected rotational external motor.

Abstract: The present disclosure relates generally to percutaneous heart pumps including a self-expandable and collapsible impeller housing fabricated from a mesh of a shape memory alloy, such as nitinol, and a base polymer coating and a top polymer coating. Specifically, the present disclosure relates to highly flexible and fluid-impermissible polymer coatings having improved adherence and performance properties on the metallic surfaces of the impeller housing mesh thus improving the overall performance of the percutaneous heart pumps.

Abstract: Methods and devices for reducing ventricle filling volume are disclosed. In some embodiments, an electrical stimulator may be used to stimulate a patient's heart to reduce ventricle filling volume or even blood pressure. When the heart is stimulated in a consistent way to reduce blood pressure, the cardiovascular system may over time adapt to the stimulation and revert back to the higher blood pressure. In some embodiments, the stimulation pattern may be configured to be inconsistent such that the adaptation response of the heart is reduced or even prevented. In some embodiments, an electrical stimulator may be used to stimulate a patient's heart to cause at least a portion of an atrial contraction to occur while the atrioventricular valve is closed. Such an atrial contraction may deposit less blood into the corresponding ventricle than when the atrioventricular valve is opened throughout an atrial contraction.

Abstract: An example of a system for programming a neurostimulator may include a storage device and a user interface. The storage device may be configured to store waveform building blocks. The user interface may include a display screen, a user input device, and an interface control circuit. The interface control circuit may include a waveform composer configured to allow for composition of one of more building blocks and composition of a pattern of neurostimulation pulses using selected one or more waveform building blocks. The waveform composer may include a library controller and waveform building block editors. The library controller may be configured to display a library management area on the screen. The displayed library management area allows a user to manage the stored waveform building blocks. The waveform building block editors may each be configured to allow the user to compose a type of the waveform building blocks.

Abstract: This disclosure relates to a communication amplification device for an implantable capsule, in particular for an autonomous cardiac stimulation capsule. The amplification device comprises a first holding element and a second element configured to hold the implantable capsule. The first holding element is configured to receive the distal end of the capsule and the second holding element is configured to receive the proximal end of the capsule. The first holding element comprises a communication amplification antenna configured to couple to a distal electrode of the capsule.

Abstract: An implantable cardiac monitor (ICM) and a computer implemented method are provided. The ICM includes electrodes that are configured to sense analog cardiac activity (CA) signals when engaged with tissue at a location remote from the heart. One or more of the electrodes transition between an engaged state and disengaged state with respect to the tissue. An analog to digital (A/D) converter communicates with the electrodes along a data signal path. The A/D converts the analog CA signals to digital CA signal. An electrode-tissue feedback (ETF) circuit is provided along the data signal path between the electrodes and the A/D converter. The ETF circuit generates a feedback signal component into the data signal path when one or more of the electrodes is in the disengaged state. The feedback signal component is superimposed onto the analog CA signals.