Abstract: Regulating cardiac activity may include pacing the patient's heart at a starting pacing rate and instigating an intrinsic heart beat search algorithm that includes pacing at a reduced rate for a period of time and capturing electrical signals representative of cardiac electrical activity while pacing at the reduced rate in order to determine a presence or absence of intrinsic heart beats. If intrinsic heart beats are not detected, the heart may be paced at a further reduced rate for a period of time. If intrinsic beats are detected, the heart may be paced again at the starting pacing rate. This may continue until intrinsic heart beats are detected or until a lower search rate limit is reached. Diagnostic data may be collected at each stage and transmitted to a display device for analysis by a physician or the like.

Abstract: Methods and devices for treating patients such as patients who suffer from migraine headaches including attaching electrodes of an electrical stimulation device to the patient bilaterally at a first location overlying a trigeminal nerve and at a second location overlying a second nerve, and then delivering electrical series of stimulation pulses to the patient, the stimulation pulses having a duration of between about 1 and about 20 microseconds, wherein the electrical stimulation device comprises a stimulation unit and a plurality of electrodes.

Abstract: Method and system for monitoring the autonomic nervous system (ANS) of a subject, comprising acquiring at least one physiological signal having W heartbeats, generating data which is a function of the variability of the heart rate on the W heartbeats, with the HRV having W?1 RR intervals separating two consecutive heartbeats detected respectively at the moments tk?1 and tk, each RR interval having a duration of value a?=t??t??1 with k=(X?W+2) . . . X; calculating at least one parameter taken from the parameter TAS(tx) representing the level of activity of the sympathetic system and/or the parameter TAP(tx) representing the level of activity of the parasympathetic system; and/or other parameters such as the parameter SL(tx) representing stress level of the subject at the moment tx and calculated using the equation such that SL(tx)=100+TAS(tx)?TAP(tx); and supplying data representative of at least one parameter.

Abstract: The present disclosure concerns a device for sensing at least one biological parameter (e.g., heart rate, heart rate variability) of a subject, the device comprising a contact surface configured for being brought into a contact with a skin surface of the subject. The device has at least one light source for illuminating the skin surface through the contact surface along an illumination source optical axis with illumination including at least one sensing wavelength, and at least one detector for detecting a response of said illumination at least at said wavelength, from the skin surface through the contact surface along a detector optical axis, and providing signals configured for determining said biological parameter based thereon, said illumination optical axis forming with said contact surface an acute included angle.

Abstract: A way of indicating a risk for coronary artery disease is disclosed. A first plurality of first sound recordings of heartbeats and second plurality of second sound recording of the ambient background are obtained. A filtering of each first sound recording is performed by using a simultaneously recorded second sound recording. The filtering of each first sound recording involves determining a diastolic period of the heartbeat of the first sound recording, and performing an adaptive filtering of the first sound recording based in the diastolic period of the first sound recording and the simultaneously recorded second sound recording. This is followed by determination of an indication of the risk for coronary artery disease based on the filtered first sound recordings.

Abstract: A biopsy tracking kit includes a trocar, a stylet, a biopsy needle, a biopsy tracking cassette, and a fiducial marker. The trocar has a cannula with a blunt first end and a second end with a cup. The stylet has a conical tip at a first end and a cap on a second end that engages the cup of the trocar and prevents the stylet from falling through the trocar. The biopsy needle is used to obtain biopsy specimens when inserted through the trocar. The biopsy tracking cassette comprises an internal surface with a plurality of coded zones in a single column, and is used to differentiate the biopsy specimen into smaller regions. The fiducial marker is oriented to mark the position where the biopsy specimen was taken. Other systems, devices, and methods of use are also described.

Abstract: Devices for controlling spinal cord modulation for inhibiting pain, and associated systems and methods, including controllers for modulation program recommendation are disclosed. A particular embodiment includes receiving, from multiple computing devices, ratings for modulation programs executed by implantable medical devices for a plurality of patients, ranking the modulation programs based on the received ratings and based on at least one characteristic of the patients and the symptoms described by the patients, receiving a recommendation request for a modulation program for a particular patient; and transmitting one or more of the highest ranking modulation programs in response to the request for a modulation program for the particular patient.

Abstract: An example of a system may include a processor and a memory device comprising instructions, which when executed by the processor, cause the processor to: access a patient metric of a subject; use the patient metric as an input to a machine learning algorithm, the machine learning algorithm to search a plurality of neuromodulation parameter sets and to identify a candidate neuromodulation parameter set of the plurality of neuromodulation parameter sets, the candidate neuromodulation parameter set designed to produce a non-regular waveform that varies over a time domain and a space domain; and program a neuromodulator using the candidate neuromodulation parameter set to stimulate the subject.

Abstract: A medical monitoring device for monitoring electrical signals from the body of a subject is described. The medical monitoring device monitors electrical signals originating from a cardiac cycle of the subject and associates each cardiac cycle with a time index. The medical monitoring device applies a forward computational procedure to generate a risk score indicative of hyperkalemia, hypokalemia or arrhythmia of the subject. The medical monitoring device can adjust the forward computational procedure based upon clinical data obtained from the subject.

Abstract: Methods and systems for reducing interference in a therapeutic energy delivery system by delivering an electrical therapeutic signal to a patient to provide a therapeutic benefit to the patient, and delivering an electrical counter signal to the patient that destructively interferes with an electrical interference signal resulting from delivering the electrical therapeutic signal.

Abstract: A neuromodulation system for treatment of physiological disorders. The system includes one or more stimulators for stimulating one or more cranial nerves; one or more detectors configured for detecting a predetermined physiological state; and a control unit that controls nerve stimulation by the one or more stimulators so that it is synchronized with the at least one predetermined physiological state detected by the one or more detectors. A method of neuromodulating a patient for treatment of physiological disorder. The method includes the steps of detecting a predetermined physiological state and applying stimulation to one of the cranial nerves during the predetermined physiological state by one or more stimulators of a neuromodulation system.

Abstract: An apparatus, including a flexible insertion tube having a distal end for insertion into a body cavity, and first and second conduits configured to deliver first and second fluids, respectively, to the distal end. The distal end includes a first balloon coupled to the first conduit so that the first fluid inflates the first balloon and is delivered, via one or more spray ports in the first balloon, to tissue in the body cavity, a second balloon contained within the first balloon and coupled to the second conduit so that the second fluid inflates the second balloon, and multiple splines including a flexible, resilient material and extending along a longitudinal axis of the distal end, and configured to constrain the second balloon so that inflation of the second balloon creates lobes that form, along the longitudinal axis between the lobes, channels that direct the first fluid to the spray ports.

Abstract: The spreading of cancer cells in a target region can be inhibited by imposing a first AC electric field in the target region for a first interval of time, with a frequency and amplitude selected to disrupt mitosis of the cancer cells; and imposing a second AC electric field in the target region for a second interval of time, with a frequency and the amplitude selected to reduce motility of the cancer cells. The amplitude of the second AC electric field is lower than the amplitude of the first AC electric field.

Abstract: An ablation procedure. The ablation procedure may be applied to tooth buds 120 and result in tooth agenesis. The ablation procedure may be applied to lesions or tumors. A tooth bud ablation system for use in a tooth bud ablation procedure that results in tooth agenesis. A method for volume scanning both hard tissues and soft tissues of a patient. A method for manufacturing or fabricating a custom surgical stent 110. A custom surgical stent 110 for use in a tooth bud ablation procedure that results in tooth agenesis, the custom surgical stent 110 for use with an ablation probe tip 108 having a center of ablation 130a.

Abstract: This disclosure provides a laser acupuncture apparatus and a laser acupuncture device. The laser acupuncture apparatus includes: a bracket; an acupuncture unit movably installed on the bracket, where the acupuncture includes at least one laser emitter; an image capturer installed on the bracket; and a control unit coupled to the acupuncture unit and the image capturer, where the control unit is configured to analyze an image acquired by the image capturer, and to control the acupuncture unit according to an image analysis result to move relative to the bracket.

Abstract: A method for tumor suppression is disclosed. The method includes preparing a chip by forming a layer of electrically conductive nanostructures on a substrate, placing the chip adjacent to a cancerous tumor, positively charging the layer of electrically conductive nanostructures by applying a positive electrostatic voltage on the chip, and reducing size of the cancerous tumor by electrostatically stimulating cancer cells of the cancerous tumor responsive to accumulating positive charges on the layer of electrically conductive nanostructures.

Abstract: This disclosure provides non-invasive methods to induce motor control in a mammal subject to spinal cord or other neurological injuries. In certain embodiments the method involves administering transcutaneous electrical spinal cord stimulation (tSCS) to the mammal at a frequency and intensity that induces the desired locomotor activity.

Abstract: A muscle electrostimulation device includes: a main body; a power source stored in the main body; an electrode unit that receives power from the power source; a controller that controls the supply of power to the electrode unit; and an operation unit that changes a control mode of the controller. The electrode unit includes a first and a second electrode group. The first group extends from the main body to be disposed on a right hand side of a person with respect to a center line of the main body. The second group extends from the main body to be disposed on a left hand side of the person with respect to the center line when the device is attached to the abdomen. The first and the second electrode group can be electronically connected via the person and include four or more electrodes in total.

Abstract: A medical device may receive sensor data from sensing sources, and determine confidence levels for sensor data received from each of the plurality of sensing sources. Each of the confidence levels of the sensor data from each of the sensing sources is a measure of accuracy of the sensor data received from respective sensing sources. The medical device may also determine one or more therapy parameter values based on the determined confidence levels, and cause delivery of therapy based on the determined one or more therapy parameter values.

Abstract: The invention relates to an energy application apparatus for applying energy to an object. A plurality of energy application elements (4) applies energy to the object at different locations and at least one ultrasound element (18) generates an ultrasound signal being indicative of a property of the object at the different locations, wherein at least one energy application element is individually controlled depending on an energy application influence, in particular, an ablation depth, determined for the location at which the at least one energy application element applies energy from the ultrasound signal. Thus, at least one local control point for applying energy to the object is provided, thereby improving the control of applying energy to the object.