Patents Examined by Jon P. Weber
  • Patent number: 9103826
    Abstract: The present invention provides methods for detecting, analyzing, and identifying biomolecules used to identifying patient with dengue-like symptom who are at risk of DHF. The inventive method comprises detecting in a sample from a subject dengue infected patient one or more biomarkers selected from the group consisting of IL-10, fibrinogen, C4A, immunoglobulin, tropomyosin, and three isoforms of albumin, and which are used in a predictive MARS model to detect patients with risk of developing DHF.
    Type: Grant
    Filed: June 6, 2012
    Date of Patent: August 11, 2015
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Tadeusz Kochel, Josefina Nores Garcia, Allan Brasier, Adrian Recinos, John E. Wiktorowicz, Heidi Spratt, Hyunsu Ju
  • Patent number: 9102953
    Abstract: Method of bioconversion of coal to methane, carbon dioxide, and other valuable gaseous and liquid products in a multi-step process that may include particle size reduction, separation of non-coal materials, addition of chemicals, and multi-stage anaerobic fermentation are disclosed.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: August 11, 2015
    Assignee: Ciris Energy, Inc.
    Inventors: Robert A. Downey, Song Jin, Paul H. Fallgren
  • Patent number: 9101693
    Abstract: This invention relates to cell-independent processes which mimic cellular bioremodelling and produce organized biomaterials which have mechanical properties and viable cell densities suitable for use as functional tissue implants. The biomaterials are produced by providing a gel comprising a matrix of scaffold fibers of and an interstitial fluid; and plastically compacting the gel to produce the biomaterial. The biomaterials may comprise 3D structures such as layering, alignment and meso-scale zonal heterogeneities of cells and matrix which mimic native tissue structure. Biomaterials with biomimetic structure as described herein may be useful in a range of therapeutic applications.
    Type: Grant
    Filed: July 5, 2005
    Date of Patent: August 11, 2015
    Assignee: UCL BUSINESS PLC
    Inventors: Robert Brown, Showan Nazhat, Vivek Mudera, Mike Wiseman
  • Patent number: 9102915
    Abstract: Compositions and methods for the growth and expansion of mammalian cells in culture are provided. In particular, methods for the growth and expansion of postpartum-derived cells in vitro are provided using surfaces such as microcarrier beads.
    Type: Grant
    Filed: November 13, 2007
    Date of Patent: August 11, 2015
    Assignee: Depuy Synthes Products, Inc.
    Inventors: Alexander M. Harmon, L. S. Klaudyne Hong, Anthony J. Kihm, Anna Gosiewska
  • Patent number: 9097702
    Abstract: A three-dimensional cell culture system is provided comprising one or more cell types of interest incorporated in a natural or synthetic hydrogel. An apparatus for high-throughput drug screening is also provided comprising a plurality of three-dimensional cell culture systems and a dispenser for placing at least one three-dimensional cell culture system into a pre-determined well of a multiwell plate. A method for high-throughput drug screening is also provided that comprises providing a test agent, providing a three-dimensional cell culture system, determining a first cellular response of the cell of interest before culturing in the presence of the agent, culturing the cell of interest in the cell culture system in the presence of the agent, determining a second cellular response of the cell of interest after culturing in the presence of the agent, and comparing the first and second cellular responses.
    Type: Grant
    Filed: July 28, 2009
    Date of Patent: August 4, 2015
    Assignee: Cornell University
    Inventor: Claudia Fischbach
  • Patent number: 9097618
    Abstract: The present invention relates to a method for preparing cell samples for histological examination and, more particularly, a method for preparing a cell sample as a standard, or control, for use in the fields of cytology and histology.
    Type: Grant
    Filed: July 17, 2009
    Date of Patent: August 4, 2015
    Inventors: Craig Barker, Victoria Reid
  • Patent number: 9090878
    Abstract: The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express a hepatic stellate phenotype and cells that express a hepatic sinusoidal endothelial phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other things, for treatment of liver deficiency, liver metabolism studies, and liver toxicity studies.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: July 28, 2015
    Assignee: Katholieke Universiteit Leuven
    Inventors: Pau Sancho-Bru, Catherine M. Verfaillie
  • Patent number: 9090925
    Abstract: A process for the large-scale chemoenzymatic production of (6S)-5-methyl-5,6,7,8-tetrahydrofolic acid, also known as (6S)-5-methylTHFA, the process comprising the steps of: (1) reducing folic acid (FA) so as to yield dihydrofolic acid (DHFA); (2) stereoselectively reducing DHFA with dihydrofolate reductase (DHFR) in the presence of NADP/NADPH, glucose and GluDH so as to yield (6S)-THFA; (3) converting (6S)-THFA to (6S)-5-methlTHFA; and (4) isolating (6S)-5-methylTHFA.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: July 28, 2015
    Assignee: Chemic Laboratories Inc.
    Inventors: Gerald S. Jones, Jr., Joseph P. St. Laurent, Scott A. Goodrich, George Maguire
  • Patent number: 9090932
    Abstract: Disclosed are a highly safe treatment method for hyperlipidemia and a therapeutic agent for hyperlipidemia. Specifically, the invention provides a novel method for screening an agent for treating hyperlipidemia, more specifically, a method for screening a substance that can inhibit the production or function of gangliosides, particularly GM3, or inhibit the activity or expression of GM3 synthase to reduce a blood lipid level. A pharmaceutical composition, which can specifically inhibit the production of gangliosides, particularly GM3, thereby effective for hyperlipidemia treatment, and others are also provided.
    Type: Grant
    Filed: November 25, 2010
    Date of Patent: July 28, 2015
    Assignee: Japan Science and Technology Agency
    Inventors: Jinichi Inokuchi, Masakazu Nagafuku, Hirotaka Hayamizu
  • Patent number: 9090885
    Abstract: This invention provides devices and methods that enable co-incubation of microorganisms. Also provided are methods of making such devices for co-incubation of microorganisms, and various applications of such devices.
    Type: Grant
    Filed: July 28, 2008
    Date of Patent: July 28, 2015
    Assignee: The University of Chicago
    Inventors: James Q. Boedicker, Rustem F. Ismagilov, Hyun Jung Kim
  • Patent number: 9090916
    Abstract: The present invention relates to a method of producing sweet juice from lignocellulosic substrate, wherein enzymatic hydrolysis is carried out by performing cellulase supplementation with supported ?-glucosidases used in a reactor separate from the lignocellulose enzymatic hydrolysis reactor.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: July 28, 2015
    Inventors: Dominique Casanave, Nicolas Lopes Ferreira
  • Patent number: 9085779
    Abstract: There is provided a process for producing H2S comprising: a) continuously providing an electron donor at a variable rate to a biosolution comprising sulphur-reducing bacteria; b) reacting elemental sulphur with HS? to from soluble polysulphide; c) providing said polysulphide to a bioreactor having the biosolution, thereby producing H2S gas in the bioreactor; and d) continuously removing H2S gas from the bioreactor, wherein an average rate of providing polysulphide to sulphur-reducing bacteria is equal to an average rate of polysulphide consumption by the sulphur-reducing bacteria.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: July 21, 2015
    Inventors: David Kratochvil, Maxmillian Nodwell, Michael Bratty
  • Patent number: 9074186
    Abstract: This disclosure provides methods of making a megakaryocyte-erythroid progenitor cell (MEP), comprising differentiating a stem cell into a MEP in culture in the presence of an aryl hydrocarbon receptor (AhR) agonist. In some embodiments the stem cell is a pluripotent stem cell. In some embodiments the MEP co-expresses CD41 and CD235. In some embodiments the number of MEPs produced in the culture increases exponentially. Methods of making a red blood cell (RBC) by culturing a MEP in the presence of an AhR agonist are also provided. Methods of making a megakaryocyte and/or a platelet, comprising culturing a MEP in the presence of an AhR modulator are also provided. In some embodiments the AhR modulator is an AhR antagonist. This disclosure also provides compositions comprising at least 1 million MEPs per ml and compositions in which at least 50% of the cells are MEPs.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: July 7, 2015
    Inventors: George J. Murphy, David H. Sherr, Sarah S. Rozelle, Brenden W. Smith
  • Patent number: 9075061
    Abstract: The present invention relates to a method for determining the estrogen receptor status of patients suffering from breast cancer. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed with breast cancer to specific medicaments. More specifically, the present invention provides methods which measure kinase activity by studying phosphorylation levels and profiles in samples obtained from patients diagnosed with breast cancer.
    Type: Grant
    Filed: April 12, 2010
    Date of Patent: July 7, 2015
    Assignee: PamGene B.V.
    Inventors: Robby Ruijtenbeek, Maria Helena Hilhorst, Arzu Umar, Johannes Albert Foekens, Johannes Wilhelmus Maria Martens
  • Patent number: 9068168
    Abstract: The present invention relates to the arrangement of one or more cells in a medium or on a substrate through the use of boundary conditions, which are changes in local environment compared to the medium or substrate alone or cause an alteration of cell response upon interaction of a cell with the boundary condition.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: June 30, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Adam W. Feinberg, Kevin Kit Parker, Po-Ling Kuo, Chin-Lin Guo
  • Patent number: 9068182
    Abstract: A cell culture polysaccharide microcarrier includes (1) a cross-linked polysaccharide microcarrier base having a neutral or negative charge at pH 7, and (ii) a polypeptide conjugated to the base. The polypeptide may contain a cell adhesive sequence, such as RGD. Cells cultured with such microcarriers exhibit peptide-specific binding to the microcarriers.
    Type: Grant
    Filed: July 28, 2010
    Date of Patent: June 30, 2015
    Assignee: Corning Incorporated
    Inventors: Sophie Deshayes, David Henry, Martial Hervy
  • Patent number: 9068998
    Abstract: A reference solution is provided, which comprises, in a liquid phase, at least one of a first compound and a second compound which are mutually convertible into each other, and at least one catalyst, which catalyzes the conversion between the first compound and the second compound.
    Type: Grant
    Filed: June 17, 2008
    Date of Patent: June 30, 2015
    Assignee: Radiometer Medical ApS
    Inventor: Gitte Lunding
  • Patent number: 9063132
    Abstract: An assay method and device can perform at least one (e.g., at least two) assays on a single aliquot of a sample liquid. The device can mix a sample liquid with assay reagents including magnetically susceptible particles. The device is configured to create a sample liquid-air interface with the sample liquid. The magnetically susceptible particles can be located (via an applied magnetic field) at the liquid-air interface when a second liquid contacts the interface to form a liquid-liquid interface. The magnetic particles travel across the liquid:liquid interface to the second liquid. The magnetically susceptible particles are configured to transport an analyte across the interface into the second liquid. An assay for the analyte is performed in the second liquid. An assay for another analyte can also be performed in the sample liquid.
    Type: Grant
    Filed: April 2, 2010
    Date of Patent: June 23, 2015
    Inventors: John William Dilleen, Phillip Lowe, Ruth Polwart, Jennifer Hay, Claus Marquordt, Steven Alexander Keatch, Steven Howell, Alan Thomson
  • Patent number: 9063127
    Abstract: The present invention generally relates to devices and methods for determining and/or isolating cells. One aspect is generally directed to methods and devices for detecting, identifying, counting, and/or potentially sorting cells of interest in blood or other biological sample. In some embodiments, blood samples (or other biological fluids) may be treated with signaling entities, such as pH-sensitive entities, that change color or otherwise produce a signal in suitable internal environments. For example, certain cells, such as cancer or fetal cells, may have differences in intracellular pH compared to other cells, which can be detected using pH-sensitive entities. In certain embodiments, the cells may be sorted based on such signaling entities; for example, illumination of cells in a suitable machine for sorting cells (e.g., using fluorescent light) may allow determination of the cells, which may also be recovered or isolated for further manipulation in some cases.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: June 23, 2015
    Assignee: Analiza, Inc.
    Inventors: Pavel Idelevich, Arnon Chait, Alan Bauer
  • Patent number: 9056154
    Abstract: Polymer surfaces coated with organometallic layers, wherein the organometallic layers and polymer surfaces have functional groups that react to bond the organometallic layer to the polymer surface with organometallic functional groups remaining unreacted for the subsequent covalent attachment of organic overlayers. Coating methods and coated articles are also disclosed.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: June 16, 2015
    Assignee: The Trustees of Princeton University
    Inventors: Jeffrey Schwartz, T. Joseph Dennes