Patents Examined by Jon P. Weber
  • Method of detecting articular cartilage degeneration or damage
    Patent number: 8557536
    Abstract: An object of the present invention is to provide a detection method capable of detecting articular cartilage degeneration or damage in which the abnormality cannot be detected in a radiograph in a simple method and with high accuracy, a method of evaluating the rate of progression of articular cartilage degeneration or damage, and the like. The present invention as a means for achieving the object provides a method of detecting articular cartilage degeneration or damage which cannot be detected in a radiograph, by using the concentration of keratan sulfate in a sample derived from blood as an index, and the like. Further, the present invention provides a method of evaluating the rate of progression of articular cartilage degeneration or damage by using the concentration of keratan sulfate in a sample derived from blood as an index, and the like.
    Type: Grant
    Filed: February 5, 2008
    Date of Patent: October 15, 2013
    Assignee: Seikagaku Corporation
    Inventors: Shigeyuki Wakitani, Masashi Nawata, Kyosuke Miyazaki, Hiroyuki Masuda, Hiroshi Fujita, Yasuhiro Kurahashi
  • Coral-derived collagen and methods of farming same
    Patent number: 8552153
    Abstract: An isolated collagen fiber is disclosed, wherein a length of the fiber prior to stretching by about 15%, is identical to a length of the fiber following said stretching by about 15%. The fiber comprises a Nuclear Magnetic Resonance (NMR) spectroscopic profile as shown in FIG. 1. Uses thereof and method of isolating are also disclosed.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: October 8, 2013
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Yehuda Benayahu, Dafna Benayahu, Yoel Kashman, Amira Rudi, Yoram Lanir, Ido Sella, Einat Raz
  • Device including bone cage and method for treatment of disease in a subject
    Patent number: 8551750
    Abstract: Devices, methods, and systems are described for controlling pathogenic condition or disease in a subject. Devices are described that include one or more bone cages. The device including one or more bone cages can be configured to include one or more immunogens and one or more adjuvants. The device including one or more bone cages can be configured to, and/or structured to at least partially or completely surround one or more cells or tissues that produce one or more immunogens and/or one or more adjuvants. The device is useful in a method for treating a pathogenic condition or disease in the subject.
    Type: Grant
    Filed: July 28, 2009
    Date of Patent: October 8, 2013
    Assignee: The Invention Science Fund I, LLC
    Inventors: Ed Harlow, Edward K. Y. Jung, Robert Langer, Eric C. Leuthardt, Elizabeth A. Sweeney, Lowell L. Wood, Jr.
  • Device including bone cage and method for treatment of disease in a subject
    Patent number: 8551749
    Abstract: Devices, methods, and systems are described for controlling pathogenic condition or disease in a subject. Devices are described that include one or more bone cages. The device including one or more bone cages can be configured to include one or more immunogens and one or more adjuvants. The device including one or more bone cages can be configured to, and/or structured to at least partially or completely surround one or more cells or tissues that produce one or more immunogens and/or one or more adjuvants. The device is useful in a method for treating a pathogenic condition or disease in the subject.
    Type: Grant
    Filed: April 23, 2009
    Date of Patent: October 8, 2013
    Assignee: The Invention Science Fund I, LLC
    Inventors: Ed Harlow, Edward K. Y. Jung, Robert Langer, Eric C. Leuthardt, Elizabeth A. Sweeney, Lowell L. Wood, Jr.
  • Method of making an anti-inflammatory composition
    Patent number: 8551532
    Abstract: In order to prepare an anti-inflammatory composition extracted from the skin of the Arabian Gulf catfish (Arius bilineatus (Valenciennes)), a gelatinous secretion is collected from the skin of the Arabian Gulf catfish. The gelatinous secretion is biologically active due to the presence of biologically active proteins and lipids. The lipids are extracted from the gelatinous secretion, and then are mixed into an inert dermatological cream. The inert dermatological cream serves as a carrier for the lipids. Preferably, the mixture includes approximately 0.2% to 0.8% of the lipids by weight. Either the total lipids may be used in the mixture, or the lipids, prior to mixing into the cream, may be fractionated into major lipid fractions.
    Type: Grant
    Filed: November 2, 2011
    Date of Patent: October 8, 2013
    Assignee: Kuwait University
    Inventor: Jassim M. Al-Hassan
  • Gold nanoparticle based protease imaging probes and use thereof
    Patent number: 8551727
    Abstract: Disclosed are a metal nanoparticle onto which a peptide substrate specifically degraded by protease and fluorophore are chemically modified for selectively imaging protease expressed in cell and in tissue in a human body, and the use thereof. Also, a quantitative analysis method of protease using the metal nanoparticle, a cell imaging method and a drug screening method of inhibiting a protease overexpression are provided. In detail, the present invention is directed to a metal nanoparticle having a peptide substrate and fluorophore coupled thereto, the peptide substrate and the fluorophore being specifically degraded by due to a protease activated in various ways in cell and in a human body to exhibit fluorescence. Hence, the metal nanoparticle can be used to rapidly screen activation and inhibition of the protease in the imaging manner.
    Type: Grant
    Filed: April 10, 2008
    Date of Patent: October 8, 2013
    Assignee: Korea Institute of Science and Technology
    Inventors: Ick-Chan Kwon, Kui-Won Choi, Kwang-Meyung Kim, Cheol-Hee Ahn, In-Chan Youn, Seul-Ki Lee, Kyeong-Soon Park
  • Method for fractionating lignocellulose-based biomass
    Patent number: 8546116
    Abstract: A method and apparatus for fractionating a lignocellulose-based biomass are provided. The method includes providing a lignocellulose-based biomass, extracting lignin from the biomass by adding a first solvent capable of dissolving the lignin, extracting xylose by adding a second solvent capable of dissolving hemicellulose to the biomass treated with the first solvent, and extracting the cellulose remaining in the biomass. In this method, a continuous process can be performed instead of a low efficiency batch-type process and components of the biomass can be obtained at high yield.
    Type: Grant
    Filed: August 10, 2009
    Date of Patent: October 1, 2013
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Jin Woo Kim, Jae Chan Park, Hwa Young Cho, Jun Seok Kim
  • Composite probes and use thereof in super resolution methods
    Patent number: 8547533
    Abstract: Composite probes for super resolution optical techniques using super resolution via transiently activated quenchers (STAQ) include a donor moiety and an acceptor moiety joined by a linker, wherein the acceptor moiety, when excited by incident radiation, is excited to a state which, for example, absorbs in the donor emission region, such that the acceptor moiety in its excited state quenches at least a portion of the donor moiety emission. Other transiently activated quenching mechanisms and moieties could accomplish the same task by reducing donor population. Also disclosed are methods for irradiating a selected region of a target material including the composite probe, wherein the composite probe enables improved resolution by point spread function modification and/or nanoscale chemical reactions.
    Type: Grant
    Filed: December 28, 2010
    Date of Patent: October 1, 2013
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Jay R. Knutson, Gary L. Griffiths
  • Pharmaceutical compositions and methods for treating oxalate-dependent conditions
    Patent number: 8545836
    Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans, animals and plants. For example, the invention provides methods and compositions for the delivery of one or more oxalate-reducing pharmaceutical compositions to the intestinal tracts of persons and animals. The methods and compositions can be used in treating and preventing oxalate-related conditions. A composition of the invention comprises an oral delivery vehicle comprising an oxalate degrading bacteria, one or more cryopreserving agents and one or more excipients. A composition of the invention is enteric coated and has a suitable shelf-life and acceptable properties to avoid negative impact from gastric fluid when it is orally administered.
    Type: Grant
    Filed: December 14, 2006
    Date of Patent: October 1, 2013
    Assignee: Oxthera, Inc.
    Inventors: Poonam Kaul, Harmeet Sidhu
  • Method and device for forming a three-dimensional arrangement of biological cells
    Patent number: 8546117
    Abstract: A method for forming a three-dimensional cell arrangement (1) of biological cells is disclosed, including the steps of preparation of the cell arrangement (1) on a flexible substrate (10) and deformation of the substrate (10), wherein the deformation of the substrate (10) is brought about by an attractive force exerted by the cells (2) on the substrate (10). A substrate (10), is also disclosed, made from a flexible material and including a substrate surface (11) for adhesion of a cell arrangement (1) of biological cells, wherein the substrate surface (11) has a number of force attachment points arranged to exert an attraction force which may be transmitted from the cells to the substrate (10) and the substrate (10) has a flexibility such that the substrate (10) is deformable with the action of the attraction force.
    Type: Grant
    Filed: June 6, 2008
    Date of Patent: October 1, 2013
    Assignee: Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V.
    Inventors: Charli Kruse, Philipp Ciba, Guenter Fuhr
  • Composition comprising a progenitor/precursor cell population
    Patent number: 8541232
    Abstract: A population of cultured cells is provided that comprises at least 10% of a sub-population of cells that: stain as CD31 Bright, demonstrate uptake of Ac-LDL+, and secrete both IL-8 and angiogenin.
    Type: Grant
    Filed: March 8, 2007
    Date of Patent: September 24, 2013
    Assignee: Kwalata Trading Limited
    Inventors: Yael Porat, Valentin Fulga, Svetlana Porozov, Adina Belleli
  • Detecting micro-organisms in an electrocoating process
    Patent number: 8541194
    Abstract: Use of a micro-organism detection device to rapidly evaluate the presence of microorganisms in an electrocoating process.
    Type: Grant
    Filed: March 4, 2004
    Date of Patent: September 24, 2013
    Assignee: Valspar Sourcing, Inc.
    Inventors: Lonnie L. Pillar, Michael J. Bourdeau, Michael A. Contos, Robert A. Sailer
  • Biological marker for inflammation
    Patent number: 8541182
    Abstract: Inflammatory state in a subject is assayed by determining the level of expression of A3 adenosine receptor (A3AR) in white blood cells (WBC), e.g. circulating WBCs, from the subject. A high level of expression of A3AR is indicative of an inflammatory state in the subject. This assay can be used for determining the severity of inflammation in a subject and monitoring the efficacy of anti-inflammatory treatment. Also, the level of expression may be used for selecting patients to receive an anti-inflammatory treatment that comprises an A3AR agonist.
    Type: Grant
    Filed: June 21, 2010
    Date of Patent: September 24, 2013
    Assignee: Can-Fite Biopharma Ltd.
    Inventors: Pnina Fishman, Sara Bar-Yehuda, Lea Madi
  • Lactic acid bacteria having action of lowering blood uric acid level
    Patent number: 8541223
    Abstract: Various types of lactic acid bacteria were cultured in the presence of a purine, the amount of the purine consumed and the amount of purine degradation products produced were measured, and several lactic acid bacteria showing remarkable purine-decomposing ability were selected. Lactic acid bacteria that were assessed to have high purine-decomposing ability according to the above-mentioned selection were orally administered to rats reared on purine-containing feed, the general status and serum uric acid level of the rats were measured, and the effect of lactic acid bacteria administration on serum uric acid levels was examined. As a result, lactic acid bacteria that significantly suppress the increase of serum uric acid levels, Lactobacillus gasseri OLL2959 and Lactobacillus oris OLL2779, were found.
    Type: Grant
    Filed: July 9, 2012
    Date of Patent: September 24, 2013
    Assignee: Meiji Co., Ltd.
    Inventors: Hiroshi Tsuboi, Noriko Kaneko, Akina Satou, Yoshinobu Tsuchiya
  • Non-photosynthetic micro-organisms enriched with organic selenium from seleno-hydroxyacid compounds and applications thereof in the field of nutrition, cosmetics and pharmacueuticals
    Patent number: 8535931
    Abstract: The invention relates to the enrichment of non-photosynthetic micro-organisms with organic selenium, and more particularly with selenomethionine, from a compound of the seleno-hydroxyacid type such as 2-hydroxy-4-methylseleno-butanoic acid in the (D, L) form or in the form of an enantiomer, salt, ester, or amide derivative of said compound, and to the use of micro-organisms, particularly bacteria thus enriched in the fields of animal or human nutrition, cosmetics, or pharmaceuticals.
    Type: Grant
    Filed: August 28, 2009
    Date of Patent: September 17, 2013
    Assignee: Tetrahedron
    Inventors: Jean-Claude Yadan, Marc Moutet
  • Protein concentrates and isolates, and processes for the production thereof from toasted oilseed meal
    Patent number: 8535907
    Abstract: Protein concentrates and protein isolates, in addition to processes for the production of protein concentrates and protein isolates, are disclosed. In particular, the disclosure relates to the removal of fiber from a toasted oilseed meal using low g-force centrifugation.
    Type: Grant
    Filed: November 10, 2010
    Date of Patent: September 17, 2013
    Assignee: Bioexx Specialty Proteins Ltd.
    Inventor: Qingnong Nelson Tang
  • Apyrase therapy for bleeding conditions
    Patent number: 8535662
    Abstract: This invention provides new methods of treating subjects experiencing or at risk of bleeding due to vascular injury, especially to the microvasculature and/or platelet desensitization. Examples of injury usefully treated by apyrase agents are pathophysiological conditions, ischemia reperfusion injury, injury from pharmacologic agents such as anticoagulants, antiplatelet agents, antithrombotics, thrombolytics, and/or immunosuppressants, and injury resulting from transplantation. Apyrase agents are also useful to maintain organ function when said organs are transplanted into an allogeneic recipient.
    Type: Grant
    Filed: January 13, 2011
    Date of Patent: September 17, 2013
    Assignee: Apt Therapeutics, Inc.
    Inventors: Ridong Chen, Soon Seog Jeong
  • Epithelium-improving agent
    Patent number: 8529879
    Abstract: It is intended to provide an epithelium improving agent which improves the epithelial functions of various organs and, therefore, is usable in growing melanin-pigmented hair, relieving inflammatory symptoms in gingivitis and paradentitis, treating and relieving cold syndrome and bronchial asthma and, moreover, restoring sexual sensibility. An epithelium improving agent which comprises coenzyme Q10, cysteine, vitamins A, C and E and a skin extract of a rabbit inoculated with a vaccinia virus as the main components. In the case of treating gingivitis, paradentitis, cold syndrome and bronchial asthma, loratadine is further added. To an epithelium improving agent which is to be used in stimulating hair growth or restoring sexual sensibility, liquid paraffin and a hydrophilic ointment is further added to give a cream. Thus, the above problem can be solved.
    Type: Grant
    Filed: April 9, 2012
    Date of Patent: September 10, 2013
    Inventor: Haruzo Kobayashi
  • Yeast strains and their uses in the production of lipids
    Patent number: 8529886
    Abstract: The invention is directed to isolated microorganisms, as well as biomasses, cultures, microbial oils, and compositions thereof. The invention also provides methods of producing the microbial oils and methods of using the isolated microorganisms, biomasses, and microbial oils.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: September 10, 2013
    Assignee: DSM IP Assets B.V.
    Inventors: Kirk E. Apt, William R. Barclay, Paul Warren Behrens
  • Method for producing probiotically derived compounds
    Patent number: 8530209
    Abstract: A method for producing naturally derived beneficial compounds including dispersing a microbiological culture media including at least one live probiotic organism, and at least one nutraceutical and/or at least one nutritive agent in distilled water to form a broth, incubating the broth at a predetermined temperature for a select period of time to induce probiotic activity; halting the probiotic activity, and separating the desired compound from the broth.
    Type: Grant
    Filed: January 3, 2005
    Date of Patent: September 10, 2013
    Assignee: Premier Research Labs, LP
    Inventor: Robert J. Marshall