Patents Examined by Jonathan Bortoli
  • Patent number: 11325119
    Abstract: A fluidic device includes a fluidic layer, a capture material, and an electronics layer, the fluidic layer includes a main channel and a pair of sample channels fluidly coupled to the main channel. The pair of sample channels is configured to receive and introduce a sample material into the device. The sample material includes an analyte. The capture material is positioned in a portion of the main channel that is spaced from the pair of sample channels. The capture material has a three-dimensional matrix of receptors therein configured to bond with the analyte. The capture material has a length that is associated with a dynamic range of the fluidic device and a cross-sectional area that is associated with a sensitivity of the fluidic device. The electronics layer includes electrodes configured to measure an electrical resistance through a portion of the capture material.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: May 10, 2022
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Carlos Francisco NG Pitti, Ulri Nicole Lee, Richard Novak, Olivier Yves Frederic Henry, Remco Van Erp, Donald E. Ingber
  • Patent number: 11311883
    Abstract: Aniosotropic Ratchet Conveyor (“ARC”)-based biomolecule processing devices and related methods are described. The ARC-based biomolecule processing devices include (i) a substrate having an ARC track defined on or within the substrate and including a biomolecule receiving area, which is designed to receive biomolecule, and a reconstituting area, which is designed to contain dry reagents and is designed to receive a transport solution such that at the reconstituting area, dry reagents are reconstituted with transport solution; and (ii) a microheater area disposed at or near the biomolecule receiving area, fitted with a microheater, which is designed to heat biomolecule that is received through the biomolecule receiving area and designed to process heated biomolecule and dry reagents reconstituted with transport solution.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: April 26, 2022
    Assignees: CONSERVATION X LABS, INC., NATIONAL SCIENCE FOUNDATION
    Inventors: David Baisch, Hallie Ray Holmes, Karl F. Bohringer
  • Patent number: 11311881
    Abstract: The purpose of the present invention is to provide a liquid handling method that makes it possible to simply isolate a droplet, a fluid handling device used in this method, and a fluid handling system. This fluid handling method serves to flow a fluid including a solvent and a droplet through a fluid handling device comprising an inlet, a first flow path having one end connected to the inlet, a chamber connected to the other end of the first flow path, a second flow path having one end connected to the chamber, and an outlet connected to the other end of the second flow path. This fluid handling method includes an introduction step for introducing the fluid through the inlet and accommodating the droplet in the chamber, a rotation step for rotating the fluid handling device after the introduction step, and a removal step for removing the droplet from the inside of the chamber after the rotation step.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: April 26, 2022
    Assignee: Enplas Corporation
    Inventor: Nobuya Sunaga
  • Patent number: 11304638
    Abstract: Methods and devices are provided for sample collection. In one example, a device is provided comprising at least one capillary tube or collection channel directed to a sample vessel, wherein in a one-step removal step of detaching the sample vessel from the collection channel, a vacuum force is created within the sample vessel, due in part of the pulling of the sealed vessel away from the device, wherein this vacuum force draw out residual sample that may still be resident in the collection channel.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: April 19, 2022
    Assignee: Labrador Diagnostics LLC
    Inventor: Zachary Morrison
  • Patent number: 11305279
    Abstract: Various embodiments of fluidic devices and methods of the present teaching can provide precision on-device loading of fluidic samples, and merging, mixing, and splitting of the fluidic samples, in illustrative embodiments as droplets, using pressures that can be provided by standard laboratory liquid handling equipment. Various embodiments of fluidic devices of the present teachings can provide on-device manipulation of accurate and precise fluidic volumes at the picoliter to nanoliter scale for each steps from fluidic sample loading to fluidic sample splitting. Various embodiments of fluidic elements of the present teachings, for example, but not limited by, various embodiments of fluidic traps of the present teachings, can have a constrained and measurable geometry, allowing for accurate and precise tuning of each fluidic sample volume throughout the on-device liquid handling process.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: April 19, 2022
    Inventor: Deepak Solomon
  • Patent number: 11291989
    Abstract: Methods and devices are provided for sample collection. In one example, a device is provided comprising at least one capillary tube or collection channel directed to a sample vessel, wherein in a one-step removal step of detaching the sample vessel from the collection channel, a vacuum force is created within the sample vessel, due in part of the pulling of the sealed vessel away from the device, wherein this vacuum force draw out residual sample that may still be resident in the collection channel.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: April 5, 2022
    Assignee: Labrador Diagnostics LLC
    Inventor: Zachary Morrison
  • Patent number: 11292001
    Abstract: A microfluidic system and method for the recovery of particles; the system comprises at least one standing chamber, at least one outlet, at least one inlet and a moving assembly, which is adapted to move the particles; a fluid is fed from the inlet to the outlet so as to generate a substantially continuous flow of the fluid; a given particle of a group of particles arranged in the collecting chamber is moved selectively with respect to the other particles of the assembly to a release area, in which a dragging force created by the fluid flow is such as to move the particle towards the outlet.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: April 5, 2022
    Assignee: Menarini Silicon Biosystems S.p.A.
    Inventors: Gianni Medoro, Alex Calanca
  • Patent number: 11273446
    Abstract: A threaded fluidic fitting may include a fluid passage, at least one fluid port, a threaded fitting portion, an engageable body portion, and an electro-fluidic leak detection element. The fluid passage extends from the fluid port of the threaded fluidic fitting. The threaded fitting portion comprises a helical thread, extends from a leak detection face of the engageable body portion, and is configured to rotate with the engageable body portion to enhance a fluidically sealed engagement of one of the fluid ports with a complementary fluidic component. The electro-fluidic leak detection element is positioned on the leak detection face of the engageable body portion or on a drip edge portion of a face extending from the leak detection face. A fluid handling system may include a plurality of threaded fluidic fittings and a leak detecting computing hub in communication with the plurality of threaded fluidic fittings.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: March 15, 2022
    Assignee: BIO-CHEM FLUIDICS, INC.
    Inventors: Henry X Huang, Ethan Matthew Gardner, Razvan Bulugioiu, Michael Swern, William A Easterbrook, Sharad Harihar Joshi, Sr.
  • Patent number: 11268957
    Abstract: A device including a light source, one or more actuators, and an image capturing device. The device is operable to receive a request to capture image data of a sample, determine at least one of an analyte being tested within the sample or a container holding the sample, position the image capturing device relative to the sample based on the analyte being tested or the container holding the sample, illuminate the light source based on the analyte being tested or the container holding the sample, capture the image data, and send the image data to one or more computing devices for image processing.
    Type: Grant
    Filed: June 5, 2019
    Date of Patent: March 8, 2022
    Assignee: GenPrime
    Inventors: Jason Buck Somes, Darby Dawn McLean, Michael Arthur Russell
  • Patent number: 11260388
    Abstract: A system that include an sample analyzer having a sensor array. The sensor array includes a housing having a base, a top spaced above the base, and an outer wall that extends from the base to the top. The sensor array includes an inlet that is sized to receive a sample of the fluid, and a plurality of partitions arranged around the fluid inlet. Each partition has a port at the fluid inlet for receiving a portion of the sample of fluid received by the fluid inlet. The sensor array includes at least one sensor in each partition. The sensor array is configured to selectively direct the sample of fluid received by the fluid inlet into one or more of the plurality of partitions into contact the at least one sensor.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: March 1, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Jennifer Samproni
  • Patent number: 11253855
    Abstract: There is provided an arrangement in a capillary driven microfluidic system for dissolving a reagent in a fluid. The arrangement (200) comprises a channel (102) for receiving a fluid at a first end, a valve (105) arranged at a second end of the channel so as to control a flow of the fluid to stop as it reaches the second end of the channel, and an actuator (108) for opening the valve (105) a predetermined time after receipt of the fluid by the channel (102). The arrangement further comprises one or more structures (106) for holding a dried reagent. The one or more structures (106) each has a width (W2) which is larger than a width (W1) of the channel (102), and the one or more structures are coupled to a side wall of the channel such that the fluid is allowed to enter the one or more structures from the channel, dissolve the dried reagent held therein, and diffuse back into the channel.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: February 22, 2022
    Assignee: miDiagnostics NV
    Inventor: Lei Zhang
  • Patent number: 11255867
    Abstract: A movable piece includes a front arm and a rear arm. In a first process, the front arm retreats from a conveying path to permit forward movement of an n-th holder, and in a second process advances into the conveying path to restrict forward movement of an n+1-th holder. In the first process, the rear arm advances into the conveying path to restrict forward movement of the n-th holder, and in the second process retreats from the conveying path 18 to permit forward movement of the n-th holder. Midway through the second process, the n-th holder 84 is positioned in a reference stopping position.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: February 22, 2022
    Assignee: Hitachi, Ltd.
    Inventors: Yutaka Miura, Yuichi Takanami
  • Patent number: 11253859
    Abstract: A microfluidic apparatus for separating a droplet of an emulsion in a microfluidic environment is described. The microfluidic apparatus includes a flow cell comprising a first microfluidic channel configured for flowing a first fluid through the flow cell and a second microfluidic channel configured for flowing a stream of a second fluid through the flow cell. The microfluidic apparatus further comprises a first electrode positioned at the first microfluidic channel and a second electrode positioned at the second microfluidic channel on an opposite side of the interface with respect to the first electrode. The first electrode, the second electrode, and the first and second microfluidic channels are configured to generate a non-uniform electric field gradient in the microfluidic apparatus.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: February 22, 2022
    Assignee: Agilent Technologies, Inc.
    Inventors: Curt A. Flory, Dustin Chang
  • Patent number: 11251791
    Abstract: Disclosed are a microfluid detection device, system and method, a processing device and a storage medium, in the field of biochemistry. The device includes a first substrate and a second substrate facing each other, and a microfluid chamber between the first substrate and the second substrate; wherein the first substrate has a plurality of photoelectric sensors and an output circuit, each of the photoelectric sensors is configured to convert an optical signal passing through the second substrate and the microfluid chamber to an electrical signal, and the output circuit is configured to output the electrical signal obtained by the photoelectric sensor.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: February 15, 2022
    Assignee: BOE Technology Group Co., Ltd.
    Inventors: Yuzhen Guo, Haisheng Wang, Yingming Liu, Xiaoliang Ding, Yanling Han, Xueyou Cao
  • Patent number: 11234682
    Abstract: The present invention discloses an apparatus for detecting analyte in a liquid sample, comprising a cup body; a first receiving area for receiving a liquid sample; a flow-guiding channel through which a sample can be added or collected; the flow-guiding channel is in communication with the first receiving area, the bottom surface of the flow-guiding channel is a slope; wherein, the first receiving area and the flow-guiding channel are disposed in the cup body; the apparatus further comprises a secondary sampling port; the flow-guiding channel is a groove, in which is provided with a second receiving area; and the second receiving area includes a corner area for collecting samples for secondary sampling. The present invention further provides a method of using the apparatus for detecting an analyte in a liquid sample. The apparatus of the present invention can be used for detecting the presence or amount of an analyte in a liquid sample.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: February 1, 2022
    Assignees: ZHEJIANG ORIENT GENE BIOTECH CO., LTD., HEALGEN SCIENTIFIC LIMITED
    Inventors: Siyu Lei, Jianqiu Fang, Lili Shen
  • Patent number: 11235324
    Abstract: The present disclosure is drawn to temperature-cycling microfluidic devices. In one example, a temperature-cycling microfluidic device can include a driver chip having a top surface and a heat exchange substrate having a top surface coplanar with the top surface of the driver chip. A fluid chamber can be located on the top surface of the driver chip. A first and second microfluidic loop can have fluid driving ends and fluid outlet ends connected to the fluid chamber and can include portions thereof located on the top surface of the heat exchange substrate. A first and second fluid actuator can be on the driver chip. The first and second fluid actuators can be associated with the fluid driving ends of the first and second microfluidic loops, respectively, to circulate fluid through the first and second microfluidic loops.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: February 1, 2022
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Adam Higgins, Alexander Govyadinov, Michael W. Cumbie
  • Patent number: 11224879
    Abstract: An inspection chip according to the present invention is an inspection chip for stirring liquid by a circular movement of a bottom surface end, including a well main body for accommodating the liquid and a side wall member arranged on a side surface of the well main body. The bottom surface end has a bottom surface structure in contact with a rotating member for allowing the bottom surface end to perform the circular movement in a position leaning from a center line of the well main body toward the side wall member.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: January 18, 2022
    Assignee: Konica Minolta, Inc.
    Inventors: Takatoshi Kaya, Tomonori Kaneko
  • Patent number: 11207682
    Abstract: A distributor is described for distributing a fluid flow from a smaller to a more broad fluid flow. It comprises a fluid input and a plurality of fluid outputs, and a channel structure in between the fluid input and the plurality of fluid outputs. The channel structure comprises alternatingly bifurcating channel substructures and common channel substructures wherein the substructures are arranged so that fluid exiting different channels from a bifurcating channel substructure mixes in a subsequent common channel substructure, and whereby fluid channels of the bifurcating channel substructure are arranged such that these do not contact the subsequent common channel substructure at the edges thereof.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: December 28, 2021
    Assignee: PHARMAFLUIDICS NV
    Inventors: Gert Desmet, Sander Jespers, Sander Deridder
  • Patent number: 11207689
    Abstract: There is provided a cartridge for nucleic acid extraction comprising: a first body having a plurality of chambers in which ports are formed at the bottom; a second body coupled to a lower region of the first body; and a piston disposed rotatably in the centers of the first body and the second body and having a port formed at the bottom thereof; and characterized in that the cartridge comprises a plurality of flow paths formed on the upper region of the second body, one end overlapping the port of the piston and the other end overlapping the port of the first body.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: December 28, 2021
    Assignee: SD BIOSENSOR, INC.
    Inventors: Young Shik Cho, Hyo Guen Lee, Hae Joon Park, Sun Young Lee, Kwan Hun Lim, In Ae Kim, Jae Young Kim, Hyo Lim Park, Dong Hun Kim
  • Patent number: 11204358
    Abstract: A specimen treating and measuring system according to the present invention comprises: a treatment part having a plurality of lanes for carrying out parallel processing of a plurality of specimens, and mounting cartridges in each of the plurality of lanes; a cartridge storing unit storing a plurality of types of cartridge to be used for different processes corresponding to the plurality of specimens; a sample storing unit storing and conveying sample tubes containing the plurality of specimens; a pickup unit transferring each of the plurality of types of cartridge to each lane, and transferring each of the plurality of specimens from the sample tubes to each of the plurality of lanes; and a control unit controlling the transfer of the plurality of types of cartridge and the transfer of the plurality of specimens, performed by the pickup unit.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: December 21, 2021
    Assignee: UNIVERSAL BIO RESEARCH CO., LTD.
    Inventor: Hideji Tajima