Abstract: Techniques for determining fetal situs during an ultrasound imaging procedure are disclosed. The techniques can include obtaining an ultrasound image of a fetus in utero. The fetus will include a torso and a spine and the ultrasound image can comprise a circumferential view of the torso of the fetus. The circumferential view can include at least: (i) an outer border of the torso, and (ii) the spine that includes three landmarks arranged in a triangular orientation. The techniques can further include superimposing a fetal overlay based on an alignment instruction corresponding to an alignment between the outer border of the torso and the three landmarks to obtain an augmented reality image of the fetus. The fetal overlay can include a graphical element indicating a left side and a right side of the fetus. The augmented reality image of the fetus can be output on a display of the ultrasound machine.

Abstract: An ultrasound diagnostic apparatus includes: an ultrasound probe; an image acquisition unit that continuously acquires an ultrasound image of a blood vessel using the ultrasound probe; a blood vessel detection unit that detects the blood vessel from the ultrasound image; a blood vessel information acquisition unit that acquires blood vessel information of the blood vessel detected by the blood vessel detection unit; a needle information acquisition unit that acquires needle information of a puncture needle; an estimated reaching position calculation unit that calculates an estimated reaching position of the puncture needle based on a designated insertion position of the puncture needle, the blood vessel information, the needle information, and a predetermined needle insertion angle range; a monitor; and a display controller that displays the estimated reaching position calculated by the estimated reaching position calculation unit on the monitor.

Abstract: A method for using metastable perfluorocarbon nanodroplets for ultrasonic lysis of blood clots includes administering metastable perfluorocarbon nanodroplets into a blood vessel that includes or that leads to a blood vessel that includes a blood clot, the metastable perfluorocarbon nanodroplets each have a liquid core comprising a perfluorocarbon material that has a boiling point below 25° C. at atmospheric pressure and that remains stable in liquid form at 25° C. at atmospheric pressure. The method further includes applying ultrasound energy to the perfluorocarbon nanodroplets within or surrounding the blood clot, causing the perfluorocarbon nanodroplets to vaporize and convert to bubbles, which cavitate and lyse the blood clot.

Abstract: A portable device for detecting a large vessel occlusion in a patient's brain by transmitting a signal into both sides of the brain and receiving the reflections of the transmitted signals to capture a single reflection data point of the characteristics of the blood vessels and brain tissue on both sides of the brain. Using the captured single reflection data point values to perform a comparative analysis between the right and left side of the brain, and based on this analysis, assessing whether the patient is experiencing a large vessel occlusion. If so, the device generates an alert.

Abstract: In exemplary examples, methods and systems for treating vascular disease by implanting a stent within the vasculature and using intravascular imaging to determine and ensure that the stent was property implanted and producing a desirable and effective results is disclosed herein. For example, a system may obtain optical shape sensing data and intravascular imaging data for a blood vessel. The system may process the optical shape sensing data and the intravascular imaging data to generate a three-dimensional model and image of the blood vessel immediately before and immediately after stent implantation into the blood vessel, and perform a precise comparison of the before and after images to ensure that the stent was properly implanted and will produce or is producing a desirable and effective result. The precise comparison may be based on a derived diameter associated with the location at which the stent is placed in the blood vessel based on the generated pre and post generated three-dimensional models.

Abstract: Ultrasound image devices, systems, and methods are provided. An ultrasound imaging system, comprising an intraluminal imaging device including an ultrasound transducer array configured to obtain first signal data and second signal data representative of a body lumen, the first signal data and the second signal data associating with different imaging modes of the ultrasound transducer array; and a processor in communication with the intraluminal imaging device and configured to generate motion data of a flow within the body lumen based on the first signal data; generate structural data of the body lumen based on the second signal data; combine the motion data and the structural data based on a first threshold; and output, to a display in communication with the processor, an intraluminal ultrasound image representing the combined motion data and structural data.

Abstract: The disclosure provides methods for diagnosis or prediction of the likelihood of a subject experiencing obstructive sleep apnea, determined at least in part by measuring the degree of tongue fat in a subject using, e.g., thermal imaging, THz imaging or other multispectral imaging.

Abstract: Embodiments disclosed herein are directed to a vessel assessment system configured to image a target vessel and determine which vascular access device (VAD) to use to access the target vessel while remaining within one or more insertion parameters of percentage vessel occupancy, and dwell length given a predetermined range of insertion angles. The system can superimpose a target vessel sizing ring to measure a diameter or cross-sectional area, or to measure a depth of the target vessel. Further, the system can provide a list of VAD's that can access the target vessel within one or more insertion parameters. The system can provide an icon representing the VAD superimposed over the target vessel to provide a visual representation of the vascular access device within the target vessel.

Abstract: A viscoelasticity measurement method and an ultrasonic imaging system. The method includes: generating a shear wave that propagates in a target area of a measured object (S210); emitting, to the target area, an ultrasonic wave that tracks the shear wave, and receiving an ultrasonic echo returned from the target area, so as to obtain ultrasonic echo data (S220); obtaining tissue motion information in a shear wave propagation process according to the ultrasonic echo data (S230); extracting, from the tissue motion information, parts of tissue motion information corresponding to shear waves of at least two different frequencies (S240); and outputting the parts of tissue motion information of the shear waves of the at least two different frequencies. The parts of tissue motion information are used for reflecting a viscosity feature of the target area (S250).

Abstract: The present invention proposes a radiomics-based biomarker for detecting the presence and the density of tumor infiltrating CD8 T-cells in a solid tumor without having to use any biopsy of said tumor. The invention also proposes to use this information to assess the immune phenotype of said solid tumor. In a particular embodiment, the invention proposes to prognose the survival and/or the treatment efficiency of cancer patients treated with immunotherapy such as anti-PD-1/PD-L1 monotherapy.

Abstract: A system for detecting a blood vessel rupture is disclosed. The system includes a sensor assembly including a plurality of sensors, each of which is configured to detect a pressure wave through CSF and to generate a pressure signal in response thereto. The system also includes a processing device coupled to the sensor assembly. The processing device configured to analyze the pressure signal to determine a blood vessel rupture.

Abstract: A method for performing a minimally invasive procedure includes activating a sealing device of a flexible catheter to seal anatomic passageways. The flexible catheter comprises a plurality of first lumens to receive a working catheter and an imaging probe. The method includes determining a position of a distal portion of the flexible catheter, the imaging probe, or the working catheter while the imaging probe is within a first of the plurality of first lumens, the working catheter is within a second of the plurality of first lumens, and the imaging probe and the working catheter extend through the sealing device. The method includes collapsing a portion of the passageways using a third of the plurality of first lumens, one or more second lumens in the working catheter, or one or more third lumens in the imaging probe and capturing an image in the collapsed portion.

Abstract: Systems for nerve and tissue modulation are disclosed. An example system may include a first elongate element having a distal end and a proximal end and having at least one nerve modulation element disposed adjacent the distal end. The nerve modulation element may be positioned or moveable to target a particular target region. The nerve modulation element may be an ultrasound transducer. The nerve modulation element may be configured to be operated at a low intensity to provide a thermal nerve block or a high intensity to effect tissue modulation.

Abstract: A system is provided that includes a processor circuit in communication with an intravascular imaging catheter. The processor circuit is operable to: receive an intravascular imaging signal; perform, tissue characterization to identify a plaque component of the blood vessel; generate an intravascular image; receive an extravascular image of a blood vessel; co-register the intravascular image and the extravascular image to associate the intravascular image with a location of the blood vessel in the extravascular image; determine, if a spatial distribution of the plaque component within the intravascular image satisfies a criterion associated with the spatial distribution; and when the spatial distribution satisfies the criterion, output a screen display comprising: the extravascular image; and a first indicator at the location of the blood vessel in extravascular image. The first indicator is representative of the spatial distribution of the plaque component. Associated methods and devices are also provided.

Abstract: Systems and methods are provided for suppressing the side-lobe artifacts in ultrasound imaging with plane wave compounding. The use of discrete angles in transmitting plane waves may be used to suppress side-lobes and the resulting side-lobe artifacts without increasing the number of firings required. A method is provided that utilizes nulls in Rx beam pattern to suppress side-lobes based on the beam pattern formula. An apodization technique that uses window functions according to Tx angles and/or Rx aperture may also be used. A method using aperiodic sampling angles may also be used to suppress artifacts. Application to arbitrary interval sampling angles may be found. Suppressing artifacts according to the present disclosure may provide for wider field of view imaging without resorting to increasing the number of firings required (NFR).

Abstract: A surgical system includes a first trackable marker configured to be coupled to a first bone of a joint, a second trackable marker configured to be coupled to a second bone of the joint, and a tracking system configured to track a position of the first trackable marker and a position of the second trackable marker. A controller is configured to receive an input from a user specifying a user-input native deformity of the joint and determine, based on the position of the first trackable marker and the position of the second trackable marker, a detected native deformity of the joint. The controller is further configured to compare the detected native deformity of the joint to the user-input native deformity of the joint and generate an alert in response to a disagreement between the detected native deformity of the joint and the user-input native deformity of the joint.

Abstract: Ultrasound imaging devices, systems, and methods are provided. In one embodiment, an ultrasound imaging system comprising a processor configured to receive ultrasound channel data representative of a subject's anatomy generated from an ultrasound transducer; apply a predictive network to the ultrasound channel data to generate an image of the subject's anatomy; and output, to a display in communication with the processor, the image of the subject's anatomy. In one embodiment, a system for generating an image, the system comprising a memory storing at least one machine learning network; and a processor in communication with the memory, the processor configured to receive raw channel data generated from an ultrasound transducer; apply the machine learning network to the raw channel data to replace one or more image processing steps, thereby generating modified data; and generate an image using the modified data.

Abstract: An ultrasound diagnostic apparatus includes a display that displays a B-mode image in which at least a blood vessel region is imaged; a processor configured to accept designation of a position of the blood vessel region on the B-mode image; detect a vascular wall by performing image analysis on the B-mode image on the basis of the designated position of the blood vessel region; calculate a cross-sectional area of a blood vessel on the basis of the detected vascular wall; set a Doppler gate within the blood vessel region on the B-mode image on the basis of the detected vascular wall; calculate a blood flow velocity on the basis of Doppler data in the Doppler gate; and measure a blood flow volume on the basis of the cross-sectional area of the blood vessel and the blood flow velocity, and display a measurement result on the display.

Abstract: A method for deriving one or more hemodynamic parameters based on blood-velocity and arterial diameter measures, each sampled recurrently or continuously over a time period to obtain for each a data series spanning a time window (i.e. a waveform). Additionally, a radial blood velocity profile is computed indicative of blood velocity as a function of radial position across a plane cut perpendicularly across the vessel lumen. This gives an indication of how blood velocity varies for the individual patient across the vessel diameter. This information supplements the standard blood-velocity and arterial diameter measures as inputs to a transfer function which maps the inputs to hemodynamic parameters.

Abstract: A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.