Abstract: Glucose prediction using machine learning (ML) and time series glucose measurements is described. Given the number of people that wear glucose monitoring devices and because some wearable glucose monitoring devices can produce measurements continuously, a platform providing such devices may have an enormous amount of data. This amount of data is practically, if not actually, impossible for humans to process and covers a robust number of state spaces unlikely to be covered without the enormous amount of data. In implementations, a glucose monitoring platform includes an ML model trained using historical time series glucose measurements of a user population. The ML model predicts upcoming glucose measurements for a particular user by receiving a time series of glucose measurements up to a time and determining the upcoming glucose measurements of the particular user for an interval subsequent to the time based on patterns learned from the historical time series glucose measurements.

Abstract: A method for the measurement of oxygenation level of blood in a tissue. The method includes emitting on a tissue light having a wavelength range in which oxygenated hemoglobin has a first extinction coefficient and de-oxygenated hemoglobin has a second extinction coefficient, and wherein one of the first and second extinction coefficients changes monotonically as a function of wavelength while the other one of the first and second extinction coefficients is substantially constant with respect to the one of the first and second extinction coefficients. The method further includes detecting a transmitted spectrum of light transmitted through the tissue, measuring a differentiating parameter expressing a change in at least one parameter of the emitted spectrum with respect to same parameter in the transmitted spectrum, and determining an oxygenation level of blood in the tissue, wherein the oxygenation level corresponds to a value of the measured differentiating parameter.

Abstract: A body-worn patch to be worn by a patient, wherein the body-worn patch comprises a plurality of sensors and a controller. The plurality of sensors comprises a biopotential sensor capable of measuring an electrocardiogram (ECG) signal, an inertial measurement unit capable of measuring a seismocardiogram (SCG) signal, and an optical sensor capable of measuring a photoplethysmography (PPG) signal. The controller is in signal communication with the plurality of sensors and the controller is capable of receiving the ECG signal, the SCG signal, and the PPG signal. The controller is capable of determining a physiological property of the patient based on the ECG signal, the SCG signal, and the PPG signal.

Abstract: A sample collection container for a biopsy apparatus includes a sample capture body defining an interior space. The sample capture body is made of a fabric and has an interior sample capture surface that at least partially surrounds the interior space. The fabric has at least one fold.

Abstract: A flexible sensor configured for use in a bladder is flexible and moveable from a first position in which it is configured to not be discharged from the bladder to a second position in which it is configured to be inserted into the bladder. A sensor insertion tool includes an over sheath, a push rod configured to be inserted into a first lumen of the over sheath. The flexible sensor is positioned in the first lumen of the over sheath, the push rod is then inserted partially into the over sheath behind the flexible sensor. The sensor insertion tool is then positioned at a location, such as the opening to the bladder, in which the sensor is to be deployed.

Abstract: A system and method for automatic determination of type of pneumatic cuff is disclosed. A system can include a pneumatic cuff with an integrated valve, and a console connectable to the pneumatic cuff. The console can be a pneumatic control system that can include a processor and memory including instructions, which when executed by the processor causes the processor to: inflate the pneumatic cuff through the integrated valve past a threshold pressure such that the integrated valve opens, receive sensor data indicative of a pressure curve during inflation of the pneumatic cuff, compare the pressure curve to stored pressure curves, determine a recommendation, based on the comparison, including information verifying the type of pneumatic cuff attached, and output the recommendation to a user.

Abstract: A flexible sensor configured for use in a bladder is flexible and moveable from a first position in which it is configured to not be discharged from the bladder to a second position in which it is configured to be inserted into the bladder. A sensor insertion tool includes an over sheath, a push rod configured to be inserted into a first lumen of the over sheath. The flexible sensor is positioned in the first lumen of the over sheath, the push rod is then inserted partially into the over sheath behind the flexible sensor. The sensor insertion tool is then positioned at a location, such as the opening to the bladder, in which the sensor is to be deployed.

Abstract: A wearable sensor decal may include a flexible wrapper layer, an intermediate layer, and a porous film layer. A first plurality of electrodes may be deposited on the wrapper layer. A heating element may be conductivity coupled to the first plurality of electrodes. A second plurality of electrodes may be deposited on the intermediate layer. A biosensor may be conductively coupled to the second plurality of electrodes. The flexible film may be hydrophilic to allow biofluids pass to the biosensor and the wrapper layer may be hydrophobic to provide waterproofing to the biosensor and heating element. The heating element may be powered to reduce thermal variance in biosensor measurements.

Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).

Abstract: The disclosure relates to a guide wire friction feedback device and method for interventional surgical robot. The friction feedback device includes two sets of driving end parts, driven end parts and clamping parts symmetrically arranged along the guide wire. The structure of the friction feedback device is relatively simple, compact and stable. When the clamping part is subjected to the force in the clamping direction of the guide wire, the force is transmitted to the right-angle connecting plate through the U-shaped slot connector, the first slider and the first micro linear guide. The high precision load cell only measures the axial force of the guide wire, that is, the push-pull force felt by the high precision load cell (that is, the friction on the guide wire), so as to judge the force change of the axial friction of the guide wire.

Abstract: Systems, devices and methods for draining and analyzing bodily fluids and assessing health are described and generally comprise a drainage tube in fluid communication with at least one opening near or at a distal end of a catheter, a pump in fluid communication with the drainage tube and configured to apply a negative pressure to the drainage tube, and a valve configured for unidirectional flow and in fluid communication with the drainage tube. A controller is configured to actuate the pump to apply the negative pressure for clearing an airlock and to monitor a urine output from the patient over a first predetermined period of time above a urine output threshold and over a second predetermined period of time below the urine output threshold. The controller may determine a risk of acute kidney injury if the urine output below the urine output threshold exceeds the second predetermined period of time.

Abstract: Some systems, devices and methods detailed herein provide a system for use in determining metrics of a subject. The system can provide, as an output, a function-metric value determined based on a defined relationship between physiological measures and a chronological age.

Abstract: A method, a system and a program product for evaluating an intestinal function using bowel sounds are disclosed. The method comprises the following steps: A. continuously monitoring an abdominal cavity of an examinee within a specific time by using an audio collection apparatus, collecting a bowel sound signal of an intestinal tract inside the abdominal cavity, and converting the bowel sound signal into a digital signal; B. using higher-order statistics (HOS), by a processing unit, to remove noise from the digital signal; C. using a fractal dimension algorithm, by the processing unit, to capture a high-complexity feature from the digital signal, and defining the high-complexity feature as an intestinal motility signal, and D. evaluating the intestinal function of the examinee, by the processing unit, according to the intestinal motility signal.

Abstract: Methods, devices, systems and kits for obtaining blood samples are provided. Devices include a cuff, a pressure source, and a timing mechanism. The methods include placing a cuff on a digit of a subject, inflating the cuff, and obtaining a small volume blood sample. The methods further include warming a digit lancing a digit pulsing the cuff; and providing a signal indicating the end of the sample collection time period.

Abstract: A flexible sensor configured for use in a bladder is flexible and moveable from a first position in which it is configured to not be discharged from the bladder to a second position in which it is configured to be inserted into the bladder. A sensor insertion tool includes an over sheath, a push rod configured to be inserted into a first lumen of the over sheath. The flexible sensor is positioned in the first lumen of the over sheath, the push rod is then inserted partially into the over sheath behind the flexible sensor. The sensor insertion tool is then positioned at a location, such as the opening to the bladder, in which the sensor is to be deployed.

Abstract: The invention relates to a transponder system having at least one passive transponder, which has a resonant circuit having a variable resonant frequency, and having a readout device, wherein the readout device is designed to modify a frequency of the readout signal to the variable resonant frequency of the resonant circuit. The invention additionally relates to a method for readout of a passive transponder, which has a resonant circuit having a variable resonant frequency.

Abstract: A biological liquid collection device designed to draw blood using an “atmospheric-balanced vacuum” to ensure the blood is exposed to the sample atmospheric partial pressure oxygen and partial pressure carbon dioxide levels as found in standard arterial blood gas syringes, resulting in blood gas sample stabilization during collection and a superior vacuum shelf-life by reducing the gas permeation rate through the plastic tube. The biological liquid collection device comprises a collection module for receiving a biological liquid sample, an evacuated container having an open end and a closed end wherein the evacuated container contains the collection module therein, and a closure for closing the open end of the evacuated container. The evacuated container comprises a gas composition that is substantially equal to the gas composition of the atmosphere outside of the evacuated container. A method for forming the atmospherically balanced vacuum collection device is also provided.

Abstract: A wearable sensor for measuring a parameter of human skin is described and includes a flexible body comprising sensor components formed on, adjacent or within the flexible body and configured to generate a first signal indicative of the parameter of human skin; microfabricated processing circuitry formed within the flexible body, coupled to the sensor components and configured to process the first signal to produce a second signal; and an antenna, formed on, adjacent or within the flexible body, the antenna being coupled to the processing circuitry and configured to transmit the second signal to an external device.

Abstract: Computer-implemented method for determining a tension value of a limb of a person, the tension value of the limb being used along with a skin value of the limb for production of a custom-tailored compression garment for the limb, the skin value describing the circumference of the limb without any applied compression and the tension value describing the circumference of the limb with the compression garment applying a desired compression, wherein the skin value of the limb is received and the tension value of the limb is calculated from the skin value according to a calculation instruction parametrized by at least one parameter, the parameter being derived from a dataset comprising multiple associated tuples of skin values and tension values.

Abstract: Provided are an electronic device for selectively storing blood pressure information and updating calibration data on the basis of the stored blood pressure information, and a control method. The electronic device comprises, a memory operably connected with the processor, wherein the memory can include instructions, during the execution thereof, for allowing the processor to, display a user interface on a display, allow the user interface to provide guidelines for measuring the blood pressure, receive first data from the motion sensor, receive second data from a PPG sensor, receive third data from the PPG sensor, determine the validity of the third data at least partially on basis of the first data and the second data, and display an indication on the user interface at least partially basis of the determined validity.