Patents Examined by Jonathan E Lepage
  • Patent number: 12628818
    Abstract: A transport container and methods for preserving a heart at a hypothermic temperature. The transport container can maintain the heart at a temperature of 6-8° C. for improved results after transplantation. The preservation of the heart within this range can improve transplantation outcomes.
    Type: Grant
    Filed: April 7, 2025
    Date of Patent: May 19, 2026
    Assignee: Paragonix Technologies, Inc.
    Inventors: William Lucas Churchill, Michael Tajima, Ben Bulka, Pratik Patel
  • Patent number: 12610944
    Abstract: A cryopreservation cartridge has a frame and multiple cryopreservation trays. The frame has multiple mounting walls. Any two of the mounting walls have multiple tray shelf segments formed therebetween. The cryopreservation trays are respectively and detachably mounted on the tray shelf segments. Each of the cryopreservation trays has multiple cryovial mounting holes. Each of the cryovial mounting holes is adapted to load a cryovial. The cryopreservation cartridge is assembled by a frame and multiple cryopreservation trays so that one cryopreservation tray can be detached from the frame and held by a picker and then a mechanical arm can easily access any single cryovial loaded in the cryopreservation tray, thereby facilitating process of placing in or taking out the cryovial for automatic operation of cell cryopreservation and thawing.
    Type: Grant
    Filed: December 21, 2022
    Date of Patent: April 28, 2026
    Assignee: DRSignal BioTechnology Co., Ltd.
    Inventors: Hsin-Wu Mi, Chih-Huang Lin, Hsin-Fei Huang, Chia-I Hsu
  • Patent number: 12590277
    Abstract: Disclosed is an apparatus, such as an acoustofluidic device, for high-throughput fabrication of multicellular spheroids. The device has a chamber substrate having at least one cell assembly channel; an acoustic transducer; and, a coupling layer disposed between the chamber substrate and the acoustic transducer.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: March 31, 2026
    Assignee: The Trustees of Indiana University
    Inventor: Feng Guo
  • Patent number: 12584122
    Abstract: A medical device that includes: a base part that has an opening part; and a holder that holds the base part on a culture plate. The base part also has a channel that is in fluid communication with the opening part. Biological samples are cultured and embedded in an embedding material at the opening part.
    Type: Grant
    Filed: September 16, 2021
    Date of Patent: March 24, 2026
    Assignee: TOHOKU UNIVERSITY
    Inventor: Yuji Tanaka
  • Patent number: 12575558
    Abstract: A packaging system includes a holder and an inner container. The holder includes a top portion and a bottom portion that cooperate to form a cavity configured to receive one or more medical products therein and to retain the one or more medical products therein. The inner container defines an interior region configured to receive the holder therein. The holder includes sidewalls that form the cavity, and the sidewalls include channels configured to fluidly connect the cavity to the interior region of the inner container.
    Type: Grant
    Filed: October 19, 2021
    Date of Patent: March 17, 2026
    Assignee: Axogen Corporation
    Inventors: Brian Romot, Justin Deuerling, Cristina Slade, Shashank Kabra, Jane Severin
  • Patent number: 12540301
    Abstract: A cell culture device includes: a base; a rotary table attached to the base; a container holding member attached to the rotary table and configured to hold a cell culture container; and a drive mechanism configured to rotatably drive the rotary table around a first axis and the container holding member around a second axis, wherein a liquid port to which a liquid tube is connected is arranged on an outer peripheral surface of the cell culture container, wherein a first predetermined portion of the liquid tube is positioned on the container holding member by a first positioning member, wherein a second predetermined portion of the liquid tube is positioned on the rotary table by a second positioning member, and wherein the first positioning member is rotatably attached to the container holding member.
    Type: Grant
    Filed: January 27, 2022
    Date of Patent: February 3, 2026
    Assignee: Sinfonia Technology Co., Ltd.
    Inventors: Daichi Horii, Yasumichi Mieno, Haruki Takeuchi
  • Patent number: 12507692
    Abstract: An organ container includes a bag-shaped or tube-shaped insulating sheet. The insulating sheet has an opening and is capable of containing an organ inserted in an inner space through the opening. The insulating sheet is formed of an extra flexible material. The insulating sheet has a hardness less than or equal to F45 according to a durometer hardness test compliant with JIS K 6253-3:2012. Accordingly, in the transplantation of an organ with a variety of sizes and shapes into a recipient, the organ container is capable of covering the surface of the organ along the surface of the organ while holding the organ. The organ container suppresses a further outward spread of the organ, thereby ensuring the field of operation and reducing the possibility of interfering with the work of a surgeon.
    Type: Grant
    Filed: September 8, 2021
    Date of Patent: December 30, 2025
    Assignee: SCREEN Holdings Co., Ltd.
    Inventors: Shinji Torai, Syuhei Yoshimoto
  • Patent number: 12502672
    Abstract: Described herein is a microfluidic assay device that mimics in vitro the in vivo biological environment, supporting endothelization, allowing for perfusive flow similar to in vivo blood flow conditions, and providing for realistic interactions between T-cells and solid tumor cells, such as glioblastoma multiforme tumor cells. Also described herein are methods of using this microfluidic assay device for the study of interactions of immune cells with tumor cells, such as glioblastoma multiforme tumor cells, and the development of improved immunotherapeutic approaches against cancers, such as glioblastoma multiforme.
    Type: Grant
    Filed: April 8, 2020
    Date of Patent: December 23, 2025
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Lohitash Karumbaiah, Meghan T. Logun, Leidong Mao, Wujun Zhao, Yang Liu, Chaitanya Tondepu
  • Patent number: 12421483
    Abstract: A system with reusable components and methods are disclosed for culturing, forming, perfusing, and maintaining a perfusible-tissue construct. The system uses a production container comprising a floor, a wall extending from the floor, wherein the floor and wall define a production reservoir, a formation section defined in the floor, wherein the formation section comprises at least one well, and a grip extending outwardly from the formation section; wherein the production container is made of a biocompatible material that remains stable when autoclaved.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: September 23, 2025
    Assignee: THE TRUSTEES OF INDIANA UNIVERSITY
    Inventor: Lester J. Smith
  • Patent number: 12389903
    Abstract: A portable housing for holding an organ or tissue for at least one of perfusion, storage, diagnosis, and transport of the organ or tissue includes a main chamber within which the organ or tissue and a liquid perfusate for the organ or tissue may be located, and it also includes a secondary chamber that is within the main chamber and that is for holding the liquid perfusate. A volume of the secondary chamber is less than a volume of the main chamber, and a top of the secondary chamber is below a top of the main chamber.
    Type: Grant
    Filed: September 23, 2021
    Date of Patent: August 19, 2025
    Assignee: LIFELINE SCIENTIFIC, INC.
    Inventors: David Pettinato, Jeffrey Allen Doruff, Christopher Paul Steinman
  • Patent number: 12390546
    Abstract: Aspects of the present disclosure relate to a reading apparatus that a well formed from a portion of a housing. The well dimensioned to receive at least a portion of a sterilization indicator having spores. The reading apparatus can also have a heating element thermally coupled to a portion of the well and an excitation source to excite the substance in the sterilization indicator. The reading apparatus can have a sterilization indicator activation circuit for detecting activation of the sterilization indicator. The excitation source is positioned such that light from the excitation source is directed into the well. A color sensor can be positioned adjacent the well to receive reflected light from the sterilization indicator.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: August 19, 2025
    Assignee: Solventum Intellectual Properties Company
    Inventors: Peter D. Ludowise, Anthony J. Jennen, Barry W. Robole, Leroy J. Longworth
  • Patent number: 12338421
    Abstract: A biohydrogen production device of corn stalks based on synchronous saccharification and fermentation and a hydrogen production method thereof are provided. The biohydrogen production device has a vertical fermenter, an irradiation pretreatment unit, an enzymolysis saccharification unit, a dark fermentation unit, a photofermentation unit, a power supply box and a hydrogen storage tank. The method and device utilize the high specificity of different microorganisms to the substrate to combine the dark fermentation and the process of photofermentation hydrogen production. The method and device can be used for the preparation of hydrogen.
    Type: Grant
    Filed: August 20, 2024
    Date of Patent: June 24, 2025
    Assignee: Harbin Institute of Technology
    Inventors: Jie Ding, Nanqi Ren, Bingfeng Liu, Shanshan Yang
  • Patent number: 12329492
    Abstract: The present invention relates to a test device for body fluid analysis. The device according to the present invention comprises: a first assembly having a magnifying lens for magnifying and observing a target body fluid; a second assembly configured to be assembled to the first assembly and having a lens transmission hole for condensing light; and an observation sheet for receiving the target body fluid between the first assembly and the second assembly, wherein the observation sheet includes a body portion disposed inside the first assembly and the second assembly, and a handle portion extending from the body portion. According to the present invention, by providing a test device for body fluid analysis that can be easily carried and conveniently used by a user, the user can directly perform a body fluid test at a desired place and time, and immediately confirm an analysis result of the body fluid through a user terminal.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: June 17, 2025
    Inventor: Ji Hoon Kim
  • Patent number: 12325845
    Abstract: There is provided an incubator including an accommodation space that is shielded from an external environment, an environmental control unit that controls an environment of the inside of the accommodation space, a power supply unit that is provided in the accommodation space and transmits electric power to a power supply target in a noncontact state, and a partition wall that is provided in the accommodation space and shields electromagnetic waves radiated from the power supply unit.
    Type: Grant
    Filed: August 31, 2021
    Date of Patent: June 10, 2025
    Assignee: FUJIFILM CORPORATION
    Inventors: Hidetoshi Takayama, Koju Ito, Takahiro Oba, Keisuke Oku
  • Patent number: 12180445
    Abstract: A device for monitoring a biological process in a liquid medium includes a wall portion, a silanization layer and a sensor arrangement. The device attaches to a container of a bioreactor and can be used with disposable bioreactors. The wall portion is adapted to retain the liquid medium during operation of the bioreactor. A through-hole is disposed in the wall portion. A silanization layer covers the surface encircling the through-hole and the wall portion between the liquid medium and the wall portion. The sensor arrangement includes a glass layer, a substrate and an electrode. The glass layer is bonded by an adhesive to the silanization layer so as to cover the through-hole. The electrode is mounted on the substrate and measures electrical conductivity through the liquid medium. The sensor arrangement also includes an optical sensor that detects electromagnetic radiation that passes from the liquid medium through the glass layer.
    Type: Grant
    Filed: January 16, 2021
    Date of Patent: December 31, 2024
    Assignee: Hamilton Bonaduz AG
    Inventors: Dirk Schoenfuss, Frederic Juillerat
  • Patent number: 12163114
    Abstract: A cell culture vessel according to the present invention is characterized by comprising a first vessel having a stirring member disposed therein, and a second vessel configured to be inserted in the interior of the first vessel and having a hole for allowing a solvent accommodated in the first vessel to pass through the interior thereof, wherein the stirring member is arranged in a recess portion formed in the first vessel.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: December 10, 2024
    Assignee: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    Inventors: Sun Woong Kang, Sang Soo Han, Cho Rok Jung, Kyung Sook Chung
  • Patent number: 12104992
    Abstract: The present invention relates to a technology related to an exfoliative cell processing device which obtains exfoliative cells out of a vial which has contained specimen of exfoliative cells (e.g., exfoliative cells and liquid medium) of a human body and then thinly smears the exfoliative cells on a cell smear slide. More specifically, the present invention relates to a technology for vertically entering the upper entrance of a vial which containing a specimen so as to extract a part of the specimen from the vial and then for thinly smearing the part of specimen on a cell smear slide which being disposed adjacent to the vial. The present invention has an advantage in that exfoliative cells may be attached in a thinly spread state on the lower surface of the specimen collector since the process of suctioning specimen from the vial.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: October 1, 2024
    Assignee: BIODYNE CO., LTD.
    Inventors: Wook Bin Im, Jae Joon Lee, Moo Seong Shin
  • Patent number: 12091647
    Abstract: A moving bed biofilm reactor system for growing microorganisms comprising a reservoir containing a fluid that contains nutrients conducive to growth of microorganisms and a plurality of inert biomass carriers having a surface area configured to support growth of microorganisms is provided. The microorganisms may be used to remove a pollutant from a fluid. Furthermore, the microorganisms may be harvested and used as a foodstuff fertilizer, biofuels, and bioplastics.
    Type: Grant
    Filed: March 8, 2021
    Date of Patent: September 17, 2024
    Assignee: KIMLE AQUACULTURE, LLC
    Inventors: Jackson Kimle, Matthew Ellis
  • Patent number: 12077738
    Abstract: The present disclosure relates to algae cultivation including the integration of liners for large-scale open algal biomass to facilitate algae facility commercial scale-up operations. Liners include those having a first portion having a first thickness and a second portion comprising a second thickness, wherein the first thickness and the second thickness are different. Liners also include those having a first portion having a first thickness, a second portion comprising a second thickness, and a third portion comprising a third thickness, wherein the first thickness, the second thickness, and the third thickness are different.
    Type: Grant
    Filed: March 11, 2021
    Date of Patent: September 3, 2024
    Assignee: EXXONMOBIL TECHNOLOGY AND ENGINEERING COMPANY
    Inventors: Patrick L. Hanks, Louis R. Brown, Everett J. O'Neal
  • Patent number: 12012583
    Abstract: A bioreactor configured for stimulation of a plurality of samples includes a well plate containing a plurality of chambers and a cover placed over the well plate. A plurality of fixed arms are located in the cover, each chamber of the plurality of chambers having a fixed arm located therein. A plurality of moving arms are located in the cover, each chamber of the plurality of chambers having a moving arm located therein. The moving arm and fixed arm of each chamber hold a sample therebetween. A moving arm shaft is located in the cover, and is operably connected to the plurality of moving arms. An electrical motor is located outside of the cover and is operably connected to the moving arm shaft. The electrical motor is configured to drive movement of the plurality of moving arms relative to the plurality of fixed arms via the moving arm shaft.
    Type: Grant
    Filed: February 16, 2021
    Date of Patent: June 18, 2024
    Assignee: WESTERN NEW ENGLAND UNIVERSITY
    Inventors: Devina Jaiswal, Brennen Zolnoski, Emily Fernschild