Abstract: Systems and methods to estimate, on a breath-by-breath basis, the fraction of inhaled oxygen during ventilation of a subject. The fraction of inhaled oxygen may be based on exhaled tidal volume, a volume of dead space within the subject interface, leaked exhalation volume, and subsequently inhaled tidal volume and leaked inhalation volume.

Abstract: An airway device includes an airway tube having a first end surrounded by a laryngeal cuff which includes a back dorsal portion, a front face portion and a tip portion. The front face portion is shaped to form an anatomical fit over the laryngeal inlet of a patient, and to form a seal with the laryngeal inlet of the patient. The tip portion includes an annular sealing bulge which is adapted to wedge into an upper esophagus region of the patient. The annular sealing bulge improves sealing of the tip of the laryngeal cuff in the upper esophageal region of the patient. The annular sealing bulge is preferably formed from a soft polymeric or other plastics material with a Shore hardness of between 40 and 000 on the A scale, and allows for better sealing with a more variable range of upper esophageal anatomical features.

Abstract: A filtration device including a fluid-impermeable housing having a gas inlet and outlet, and containing within the housing first filter media particles of an extended surface area substrate and containing at least one metal impregnant, and second filter media particles of an extended surface area zirconium hydroxide substrate and zinc (hydr)oxide. The device may be used in atmospheres containing various harmful gases, and may provide particularly useful improvements in NOx breakthrough times compared to a device containing only the first filter media particles or only the second filter media particles.

Abstract: Various embodiments of the present disclosure provide systems, methods and devices for respiratory support. As one example, a method for respiratory support is described that includes measuring a pressure, providing a measured pressure, measuring an inlet flow and an outlet flow, and providing a measured net flow. A relationship between a first value related to the measured pressure, a second value related to the measured net flow and a third value related to patient effort is used to provide a prediction of patient effort. An interim value is updated based at least in part on the prediction of the patient effort.

Abstract: Systems and methods for compensating long term sensitivity drift of catalytic type electrochemical gas sensors used in systems for delivering therapeutic nitric oxide (NO) gas to a patient by compensating for drift that may be specific to the sensors. In at least some instances, the long term sensitivity drift of catalytic type electrochemical gas sensors can be addressed using calibration schedules, which can factor in the absolute change in set dose of NO being delivered to the patient that can drive one or more baseline calibrations. The calibration schedules can reduce the amount of times the sensor goes offline. Systems and methods may factor in actions occurring at the delivery system and/or aspects of the surrounding environment, prior to performing a baseline calibration, and may postpone the calibration and/or rejected using the sensor's output for the calibration.

Abstract: This invention relates to an inhaler with a respiration indicator, whereby the inhaler has a chamber wall forming a chamber and a dispensing device for fluidic connection of the chamber to a bodily opening, preferably a nostril, whereby the respiration indicator has a wall section of the chamber wall or is formed in this way, whereby the wall section is designed to indicate a respiratory activity by deformation and/or movement.

Abstract: A filtration device including a fluid-impermeable housing having a gas inlet and outlet, and containing within the housing first filter media particles of an extended surface area substrate and containing at least one metal impregnant, and second filter media particles of an extended surface area zirconium hydroxide substrate. The device may be used in atmospheres containing various harmful gases, and may provide particularly useful improvements in NOx breakthrough times compared to a device containing only the first filter media particles or only the second filter media particles.

Abstract: A medicine accommodating structure includes a medicine accommodating unit and a movable unit. The medicine accommodating unit is disposed in a receiving space, and the medicine accommodating unit includes a medicine accommodating space and a first opening communicated between the receiving space and the medicine accommodating space. The movable unit is movably disposed between the receiving space and the medicine accommodating space through the first opening. At least one pharmaceutical capsule having a medicinal liquid received therein is placed inside the medicine accommodating space. Whereby, when the movable unit is moved from the receiving space into the medicine accommodating space, the movable unit can pierce into the at least one pharmaceutical capsule, such that the medicinal liquid can flow from the at least one pharmaceutical capsule into the receiving space.

Abstract: A CPAP system includes a PAP device (5) structured to generate a supply of pressurized air, a patient interface (15) adapted to engage with the patient's face to provide a seal, an air delivery conduit (102,104) provided between the PAP device and the patient interface to deliver the supply of pressurized air along a gas delivery path from the PAP device to the patient interface, and a muffler (100) provided along the gas delivery path downstream of the PAP device.

Abstract: The present invention relates to an inhalation device used for inhalation of the medicament in dry powder form from capsules.

Abstract: A breathing airbag device includes a filter airbag, an inner holding stand, a nose holder, a mouth holder, and two elastic straps, wherein the filter airbag is adapted for interacting with and filtering the outside air, the inner holding stand is adapted for supporting and fixing the nose holder and mouth holder, the nose holder is adapted for fittingly supporting the human nose, the mouth holder is adapted for fittingly supporting the human mouth, the inner holding stand is located on the filter airbag, the nose holder and the mouth holder are located on the inner holding stand, and two ends of each of the elastic straps are fixed to an edge position of the nose holder. The present invention has some advantages of good tightness, simple structure and low manufacturing cost.

Abstract: A nasal breathing apparatus with multifunction has two nasal inserts and one tubular chamber. In one embodiment, the first nasal insert forms an airtight barrier inside one nostril for delivering gases. The second nasal insert does not block the other nostril and is for sampling gases. The tubular chamber is in fluid communication with the first nasal insert but not the second nasal insert and has an outlet for discharging and delivering gases and for providing continuous positive airway pressure and ventilation. In another embodiment, both nasal inserts form an airtight barrier in the corresponding nostrils. The first nasal insert is dedicated for delivering gases and the second nasal insert for sampling gases. The tubular chamber is in fluid communication with both nasal inserts and has an outlet for discharging and delivering gases and for providing continuous positive airway pressure and ventilation.

Abstract: A respiratory assistance device 10 includes: a mask 13 having an expiratory hole 13a; an expiratory valve 15 provided in the mask 13, for opening and closing the expiratory hole 13a; and a control unit 17 for performing overall control on the entire device. The mask 13 and the expiratory valve 15 together form an opening and closing device. The expiratory valve 15 is deformable by deformation of a piezo element 15a. The expiratory valve 15 is disposed on an inner surface 13f so that a deformation direction thereof, i.e., a thickness direction thereof, extends along the inner surface 13f of the mask 13 and a side surface 15m slides along the inner surface 13f by the deformation thereof.

Abstract: An inhaler, preferably for insertion into a nostril, in particular a horse's nostril, with an inhalation valve, which has a movable valve element, whereby the valve element is designed in an annular manner and has an outer edge and an inner edge, whereby the valve element is fastened at the outer edge, the inner edge forms the boundary of an indentation of the valve element, and the inhalation valve has a valve body seat that corresponds to the inner edge.