Patents Examined by José Dees
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Patent number: 6752997Abstract: The invention is directed to non-hygroscopic oral pharmaceutical compositions of a salt of valproic acid, and processes for preparing the compositions. The non-hygroscopic pharmaceutical compositions are prepared by blending a hygroscopic salt of valproic acid, carbomer, and a non-hygroscopic additive.Type: GrantFiled: January 24, 2002Date of Patent: June 22, 2004Assignee: Taro Pharmaceuticals U.S.A., Inc.Inventors: Mohammed S. Safadi, Maya Barder, Yechiel Golander, Avraham Yacobi, Daniel A. Moros, Barrie Levitt, Michael Friedman
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Patent number: 6410048Abstract: The invention provides a prolamine-plant polar lipid association, wherein the prolamine and plant polar lipid components are present in such proportions so that stable films can be obtained with this association, which is preferably in the form of a hydro-alcoholic gel comprising: 20-40% w/w of prolamines, preferably gliadin; 0.1-5% w/w of ceramides, preferably wheat ceramides; hydro-ethanolic solution (35 to 80°) ad 100%. This association may be used for preparing films, patches, aerosols for use in the delivery of active substances such as therapeutic and cosmetic agents.Type: GrantFiled: July 18, 2000Date of Patent: June 25, 2002Assignee: Laboratories Lavipharm S.A.Inventor: Spiros Fotinos
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Patent number: 6406714Abstract: Pharmaceutical compositions of bisphosphonic acids, and salts thereof, are prepared by direct compression/dry mix tablet formulation. These pharmaceutical compositions are useful in the treatment of disturbances involving calcium or phosphate metabolism, in particular, the treatment and prevention of diseases involving bone resorption, especially osteoporosis, Paget's disease, malignant hypercalcemia, and metastatic bone disease.Type: GrantFiled: October 17, 2000Date of Patent: June 18, 2002Assignee: Merck & Co., Inc.Inventors: Simon R. Bechard, Kenneth A. Kramer, Ashok V. Katdare
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Patent number: 6071494Abstract: A method for providing an image of an internal region of a patient has been developed. The method reduces imaging artifacts by providing enhanced contrast between tissue and blood during imaging. The method comprises administering to a patient a contrast agent in combination with a renal vasodilator and performing ultrasound imaging of the region. Renal disease, including renal arterial stenosis, may be diagnosed using the method.Type: GrantFiled: August 28, 1998Date of Patent: June 6, 2000Assignee: Imarx Pharmaceutical Corp.Inventor: Evan C. Unger
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Patent number: 5512591Abstract: Identified are particular class of imidazoles that inhibit anglogenesis. These imidazoles can be used to beneficially treat a variety of angiogenic conditions.Type: GrantFiled: February 18, 1993Date of Patent: April 30, 1996Assignee: President and Fellows of Harvard CollegeInventors: Jose Halperin, Carlo Brugnara
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Patent number: 5470960Abstract: A phenylalanine-glycine derivative of the general formula (I): ##STR1## wherein R represents a residue of an antitumor substance, or a salt or ester thereof, a process for preparation thereof, and a pharmaceutical composition containing the same are described.The novel conjugate of the phenylalanine-glycine derivative and the antitumor substance exhibits superior antitumor activity in comparison with the case wherein an antitumor substance is administered singly or as a mixture with phenylalanine.Type: GrantFiled: January 11, 1995Date of Patent: November 28, 1995Assignee: Kureha Chemical Industry Co., Ltd.Inventors: Koichi Niimura, Takako Kawabe, Takao Ando, Kenichi Saito
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Patent number: 5464809Abstract: Fungicidal new 2-methoximinocarboxylic esters of the general formula (I) ##STR1## in which Ar represents one of the radicals ##STR2## and A represents one of the radicals --CH.sub.2 --; ##STR3## where Y represents one of the radicals ##STR4## --O--CH.sub.2 --; --CH.sub.2 --O--; --S--CH.sub.2 --; ##STR5## --SO.sub.2 --CH.sub.2 --; --O--; --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --,n represents the number 0 or 1,R represents alkyl, halogenoalkyl, alkenyl, halogenoalkenyl, or represents optionally substituted cycloalkyl, or represents optionally substituted aryl or represents optionally substituted heteroaryl, and, moreover, in the event that n is 0, also represents halogen, andX.sup.1, X.sup.2, X.sup.3 and X.sup.4 independently of one another in each case represent hydrogen, halogen, hydroxyl or methoxy, but where, in the event that X.sup.2 represents bromine, X.sup.3 does not simultaneously represent hydroxyl or methoxy.Type: GrantFiled: September 12, 1994Date of Patent: November 7, 1995Assignee: Bayer AktiengesellschaftInventors: Wolfgang Kramer, Dieter Berg, Heinz-Wilhelm Dehne, Stefan Dutzmann
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Patent number: 5441830Abstract: Disclosed are methods for enhancing the adhesion of composite electrodes onto conductive plastic foils (e.g., current collectors). Also disclosed are electrochemical cells produced from these foils.Type: GrantFiled: September 13, 1994Date of Patent: August 15, 1995Inventors: Russell D. Moulton, Milton N. Golovin
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Liquid or flowable derivatives of natural fats and oils a process for their production and their use
Patent number: 5391784Abstract: The present invention relates to derivatives of natural fats and oils that are liquid or flowable, respectively, and to a process for the production of said derivatives, in which oxalkylation is carried out at elevated temperatures in the presence of basic catalysts with at least one compound containing an epoxide group, and sulfation is carried out in a manner known per se, in which a starting material containingA) at least one C.sub.8 -C.sub.24 -fatty acid ester of an aliphatic C.sub.1 -C.sub.5 -monoalcoholThe present invention furthermore relates to the use of said derivatives, optionally in combination with other greasing substances and anionic and/or non-ionic emulsifiers, for the fatliquoring and greasing of leather.Type: GrantFiled: December 6, 1993Date of Patent: February 21, 1995Assignee: Chemische Fabrik Stockhausen GmbHInventors: Helmut Brehn, Helmut Klimmek, Leonhard Strijbos -
Patent number: 5371101Abstract: An azole compound represented by the formula (I): ##STR1## wherein Ar is a substituted phenyl group;R.sup.1 and R.sup.2 independently are a hydrogen atom or a lower alkyl group, or R.sup.1 and R.sup.2 may combine together to form a lower alkylene group;R.sup.3 is a group bonded through a carbon atom;R.sup.4 is a hydrogen atom or an acyl group;X is a nitrogen atom or a methine group; and nY and Z independently are a nitrogen atom or a methine group which may optionally be substituted with a lower alkyl group, or a salt thereof, which is useful for prevention and therapy of fungal infections of mammals as antifungal agent.Type: GrantFiled: April 28, 1993Date of Patent: December 6, 1994Assignee: Takeda Chemical Industries, Ltd.Inventors: Katsumi Itoh, Kenji Okonogi, Norikazu Tamura
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Patent number: 5344969Abstract: A process for purifying a crude naphthalenedicarboxylic acid containing impurities and coloring substances obtained by the oxidation of a di-substituted naphthalene, dispense with the use of a large amount of alkali or acid, and producing a naphthalenedicarboxylic acid having a high purity and good color effectively and in a high recovery is disclosed, which comprises dissolving the crude naphthalenedicarboxylic acid in a mixed solvent comprising an amine compound and an alcohol and conducting crystallization.Type: GrantFiled: November 30, 1992Date of Patent: September 6, 1994Assignee: Mitsubishi Petrochemical Co., Ltd.Inventors: Hiroshi Iwane, Takahiro Sugawara, Miwa Shirasaki
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Patent number: 5326892Abstract: Bimetallic alkoxide compounds useful as source reagents for chemical vapor deposition of ferroelectric ceramics such as lead titanate and lead zirconate, and lead zirconate titanate (PZT). The novel bimetallic alkoxide compounds of the present invention have the formula R.sup.1.sub.x PbM(OR.sup.2).sub.y (OR.sup.3).sub.z (1) or R.sup.1.sub.x PbOM(OR.sup.2).sub.y (OR.sup.3).sub.z (2), wherein M is a Group IVB metal, especially titanium or zirconium, and R.sup.1, R.sup.2, and R.sup.3 are independently selected hydrocarbyls, especially C1-C6 alkyls. In these compounds, lead may be present in the +2 or +4 oxidation states. For compound 1, when lead is in the +2 oxidation state, x may be 0, 1 or 2, y and z range from 0 to 4, and x+y+z=6. When lead is present in the +4 oxidation state, x may range from 0 to 3, y and z range from 0 to 6, and x+y+z=8. For compound 2, when lead is in the +2 oxidation state, x may be 0, 1 or 2, y and z range from 0 to 4, and x+y+z=4.Type: GrantFiled: November 24, 1992Date of Patent: July 5, 1994Assignee: Advanced Technology Materials, Inc.Inventor: Brian A. Vaartstra
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Patent number: 5292444Abstract: This invention relates to novel compositions of matter that are lube oils comprising an oil/hydrocarbon soluble fullerene grafted amine-containing polymers and a suitable base oil and, optionally other suitable additives for use as a lubricating oil. This invention also relates to the method of using the fullerene grafted amine-containing polymer itself as additives to base oils. The graft is made by reacting a fullerene with a primary or secondary amine-containing polymer, preferably hydrocarbon containing polymers. Suitable starting polymers are those containing primary or secondary amino groups, e.g., EPDM amine, PIB-amine, PIBSA-PAM, and Mannich based polymers. The lube oil compositions are made by adding an effective amount of the polymer, and optionally, other suitable additives to a base oil typically on an active ingredient basis of from about 0.01 to about 20 wt. %.Type: GrantFiled: October 2, 1992Date of Patent: March 8, 1994Assignee: Exxon Research and Engineering CompanyInventors: Abhimanyu O. Patil, George W. Schriver, Robert D. Lundberg
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Patent number: 5281578Abstract: Gallium(III) complexes of general formula I, ##STR1## in which X=O.sub.2 CR.sup.2, halogen, NO.sub.3 or -OA, R.sup.1 =H, alkyl, alkoxy, halogen, NO.sub.2 or amino, R.sup.2 =alkyl, alkoxy or aryl, each of R.sup.3, R.sup.4, R.sup.5 and R.sup.6 =H or alkyl and n=0, 1 or 2, or when n=0 and R.sup.3 and R.sup.6 both=H, then R.sup.4 and R.sup.5 together may form tetramethylene, and A=an identical gallium complex moiety to that to which the oxygen atom is linked, are well absorbed orally, and are indicated as medicaments for hypercalcemia and for cancer chemotherapy.Type: GrantFiled: May 19, 1992Date of Patent: January 25, 1994Assignee: Johnson Matthey Public Limited CompanyInventors: Fontaine C. Bradley, Danielle T. Frost, Christen M. Giandomenico
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Patent number: 5268494Abstract: Compounds corresponding to the formula: ##STR1## wherein A represents --CH.sub.2).sub.2 or --C.tbd.C--;n is equal to 0, 1 or 2;R represents hydroxyl, alkoxy having the formula --OR.sub.1, or amino having the formula ##STR2## R.sub.1 represents alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl or aralkyl;R.sub.2 and R.sub.3 represent hydrogen, alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl or benzyl;R.sub.2 and R.sub.3 form, with the nitrogen atom, a heterocyclic ring.Application of these compounds in pharmacy and cosmetics.Type: GrantFiled: June 4, 1992Date of Patent: December 7, 1993Assignee: Centre International de Recherches Dermatologiques C.I.R.D.Inventors: Braham Shroot, Christopher Hensby, Jean Maignan, Gerard Lang, Michel Colin
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Patent number: 5210247Abstract: The present invention relates to compounds of the formula ##STR1## in which Y represents an organosilicon radical;R" represents a divalent radical which connects the radical Y to the benzene ring via a chain of at least three atoms;X represents a radical of the formula --COOH, --CN, --CHO, --NH.sub.2 or --OH, in which it is possible to block the hydroxyl group with a protecting group;Z represents the same or different substituents in the 2-, 3-, 5- or 6-position to the radical X, preferably hydrogen or halogen atoms; andp represents a value of 0 to 4;and the use of these and related compounds in the preparation of compounds having liquid-crystalline properties.Type: GrantFiled: October 22, 1990Date of Patent: May 11, 1993Assignee: Consortium fur elektrochemische Industrie GmbHInventors: Norman Haberle, Wolfgang Haas, Leonhard Brader, Franz-Heinrich Kreuzer
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Patent number: 5210324Abstract: A new process for producing allyl ethers, usually C.sub.8-30 alkyl (CH.sub.2 CH.sub.2 O).sub.5-100 allyl ether, by forming a solution of an alcohol, usually a surfactant alcohol, in a solvent capable of forming an azeotrope with water, azeotroping the mixture to remove substantially all the water, adding an alkalimetal alkoxide, usually sodium methoxide, removing the alkanol formed, usually by azeotroping with the solvent, adding a halide, usually allyl chloride, and recovering the allyl ether. The ethers are useful as monomers, for example to produce polymers by copolymerising with copolymerisable ethylenically unsaturated comonomers for a wide range of applications.Type: GrantFiled: October 11, 1989Date of Patent: May 11, 1993Assignee: Allied Colloids LimitedInventors: David Farrar, Malcolm Hawe
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Patent number: 5200541Abstract: The products having general formula (I) ##STR1## in which R represents a C.sub.1 -C.sub.18 alkoxyl, C.sub.1 -C.sub.18 alkylthio, C.sub.1 -C.sub.18 monoalkylamino or C.sub.2 -C.sub.36 dialkylamino group, R.sub.1 represents a hydrogen atom or a C.sub.1 -C.sub.18 alkyl group, R.sub.2 and R.sub.3, identical or different, represent a hydrogen atom or a C.sub.1 -C.sub.18 alkoxyl group and M represents a cobalt, nickel or copper atom, process of preparation, intermediates and use of the intermediates in order to obtain a product having general formula (I).Type: GrantFiled: January 10, 1992Date of Patent: April 6, 1993Assignee: Societe Francaise HoechstInventor: Thierry Thami
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Patent number: 5185452Abstract: The invention concerns novel, pharmaceutically useful, benzheterocyclyl sulphones of the formula I: ##STR1## in which ring A may bear optional halogeno, (1-4C)alkyl or fluoro(1-4C)alkyl substituents; X is oxygen, or a group of the formula --S(O).sub.n -- or --NR.sup.1 -- in which n is zero, 1 or 2 and R.sup.1 is hydrogen, (1-4C)alkyl, (1-6C)alkanoyl, benzoyl or phenyl(1-4C)alkyl, the last two optionally substituted; Y is various linking groups defined hereinafter, such as ethylene or trimethylene; and in which the group --SO.sub.2 CH.sub.2 NO.sub.2 is located at position a, b or c in ring A; together with the non-toxic thereof. Other aspects of the invention include the production of the novel compounds by analogy processes and pharmaceutical compositions of the novel compounds for use in the treatment of diabetic complications.Type: GrantFiled: February 5, 1990Date of Patent: February 9, 1993Assignee: Imperial Chemical Industries PLCInventors: David R. Brittain, Michael T. Cox
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Patent number: 5177259Abstract: The present invention is novel diarylalkanoids having activity as lipoxygenase inhibitors, novel pharmaceutical compositions therefor, and novel methods of use in treating asthma, allergies, cardiovascular diseases, migraines, psoriasis and immunoinflammatory diseases for diarylalkanoids. The compounds of this invention are also useful as cytoprotective agents.Type: GrantFiled: August 27, 1991Date of Patent: January 5, 1993Assignee: Warner-Lambert CompanyInventors: David T. Connor, Daniel L. Flynn