Abstract: Disclosed herein are methods of in silico generation of polypeptide structures using time-based data generated from molecular dynamics simulations. Also disclosed herein are methods of predicting an epitope or binding surface of a polypeptide using in silico methods. Also disclosed herein are compositions containing polypeptide therapeutics designed to bind to a predicted epitope structure of a polypeptide, as well as methods of treating a subject by administering to the subject compositions containing the same.
Type:
Grant
Filed:
March 7, 2024
Date of Patent:
April 21, 2026
Assignee:
Peptone, LTD.
Inventors:
Oliver Dutton, Carlo Fisicaro, Matthew Michael Heberling, Louie Derek Henderson, Istvan Redl, Kamil Tamiola
Abstract: Embodiments relate to methods and systems for analyzing genomic data, such as genetic variants. Some embodiments relate to the efficient analysis and presentation of certain genetic variants of an individual.