Abstract: Compounds having analgesic activity which have the formula ##STR1## wherein R.sub.1 -R.sub.6 represent hydrogen or a substituent and X and Y together represent inter alia as epoxyethylene, ethylene halohydrin, haloethylene or a --CH.dbd.CH-group.

Abstract: Estriol and estradiol glycidyl ethers, immunogenic conjugates thereof and processes for their preparation are provided. The immunogenic conjugates are useful for eliciting and purifying antibodies and in performing immunoassays for estriol and estradiol.

Abstract: A synergistic wood preservative composition is provided comprising a quaternary ammonium compound and 3-iodo-2-propynyl butyl carbamate having the properties of providing stain resistance to wood. The quaternary ammonium compound is preferably selected from the group consisting of didecyldimethyl ammonium chloride, tri-methyl-coco-ammonium chloride and dimethyl-di-coco-ammonium chloride.

Abstract: Vitamin D.sub.3 derivatives of formula (I): ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, each represent a hydrogen atom or a hydroxyl group; R.sub.4 is hydrogen or a C.sub.4-6 alkyl group that is optionally substituted by a hydroxyl group; preferably 22-oxa-1,25-(OJ).sub.2 D.sub.3, or OCT, are administered to treat hyperparathyroidism, particularly secondary hyperparathyroidism, without inducing hypercalcemia. The derivatives may be administered orally or parenterally. They are preferably administered intravenously in the course of renal dialysis.

Abstract: Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5.alpha.-reductase. Also invented are intermediates used in preparing these compounds.

Abstract: The present disclosure relates to a buck lure comprising a deer tarsal gland and a fluid in which the predominant ingredient is deer urine. Other ingredients include essence of deer interdigital gland, essence of deer femoral gland and a preservative.

Abstract: Insecticidal wettable powders containing an insecticide which is liquid at room temperature and a calcined synthetic hydrated silicon dioxide, which can retain its insecticidal effect for a long time without separating oil drops when used by diluting with water.

Abstract: A compound selected from the group consisting of compounds of the formula ##STR1## wherein R.sub.1 is an organo of 1 to 18 carbon atoms optionally containing at least one heteroatom connected to the C ring by a carbon atom, R.sub.2 is methyl or ethyl, the A and B rings being selected from the group consisting of ##STR2## Re is selected from the group consisting of hydrogen, optionally substituted alkyl of 1 to 6 carbon atoms and acyl and the D ring is selected from the group consisting of ##STR3## one of R.sub.3 and R.sub.4 is selected from the group consisting of hydroxy, protected hydroxy, acyl and alkoxy and the other is an optionally substituted aryl, R.sub.5 is an optionally substituted aryl and their non-toxic, pharmaceutically acceptable salts with acids and bases with the proviso that when the A and B rings are ##STR4## R.sub.1 is ##STR5## R.sub.2 is methyl, R.sub.3 is --OH, R.sub.4 is phenyl having anti proliferative properties.

Abstract: The invention relates to pesticidal composition against bacterial plant diseases comprising as active ingredient a nitrofurane derivative of the general Formula I ##STR1## wherein X represents a group of the Formula a/ ##STR2## and optionally one or more known fungicidal active ingredient/s/ in a total amount of 1-99% by weight, whereby the ratio of the active ingredient of the general Formula I to the known fungicidal active ingredient/s/ amounts to 1:99-99:1, preferably 1:9-9:1 if the composition comprises two active ingredients and 1:9:0.5-1:1:5, preferably 1:4:1-1:1:4 if the composition comprises three active ingredients, respectively, in admixture with suitable inert solid or liquid carrier/s/ or diluent/s/ and usual auxiliary agents such as wetting agents, dispersing agents, adhesives, antifoaming agents and/or antifreezers.

Abstract: A unique combination of isopropyl and isobutyl alcohols synergistically increases the permeability of the skin to steroid drugs.

Abstract: The invention provides new seco-sterol compounds which are effective in inducing the differentiation of malignant cells and are therefore useful for the treatment of malignancies such as leukemia.

Abstract: This invention relates to cholesterol synthesis and to the accumulation and regulation of cholesterol levels in body tissue. More specifically, the invention provides that the compound 26-aminocholesterol, ##STR1## and analogs and derivatives thereof, exhibit biological activity as a potent inhibitor of cholesterol synthesis and/or cholesterol accumulation in body tissue. The compounds strongly inhibit of the enzyme HMGCoA reductase and low density lipoprotein accumulation by non-hepatic cells. Surprisingly, it has been discovered that 26-aminocholesterol is selective for fibroblast (plasma) cells, and has little or no effect on hepato (liver) cells. Therapeutic compounds according to the invention include substituted or unsubstituted sterols of the formula: ##STR2## wherein the carbon atoms at positions 5 and 6 of the sterol are one of saturated and unsaturated, R.sub.1 is one of a 3-hydroxyl group and a 3-keto group, R.sub.2 is one of a hydroxyl group and a keto group, and wherein at least one of R.sub.

Abstract: To reduce the risk of breast cancer, a drug is periodically administered to young mammals before pregnancy in doses of about 1 microgram to 50 micrograms per kilogram of body weight. The drug: (1) competes with and displaces estradiol 17 beta from the mammary gland cells in an effective manner to prevent the possible formation of DNA-damaging epoxide estradiol metabolites; (2) binds to breast tissue to a greater extent than estradiol 17 beta; (3) induces terminal nonlactation differentiation of the mammary gland; (4) is nontoxic and noncarcinogenic; and (5) preferably does not cause anti-ovulatory activity. The drug is selected from a group of drugs including: (1) 4-OH estradiol; (2) d-equilenin; and (3) 17 alpha ethynyl estriol.

Abstract: Invented are phosphinic acid substituted analogues of steroidal synthetic compounds, pharamaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase, including using these compounds to reduce or maintain prostate size.

Abstract: This present invention relates to fungicidal compositions comprising an aqueous solution of an aluminum salt of alkyl phosphonates stabilized with the salt of a weak acid and a strong base. The stabilized aqueous solution can be used to prevent or treat fungal diseases in plants by spraying, soaking the roots or injecting into the trunks of shrubs or trees.

Abstract: The present invention relates to a method to set free sterols from organic materials containing esters of such sterols, generally enriched distillation residues, or desodorisates by treating said organic material with ammonia and/or an amine and/or compound releases ammonia and/or amines while heated, the treament being carried out preferably at an elevated temperature, and under an elevated pressure.

Abstract: 11-Desoxy-17.alpha.-hydroxycorticosterone derivatives of the general formula: ##STR1## wherein R is --OC(CH.sub.2).sub.n C.sub.6 H.sub.4 N(CH.sub.2 CH.sub.2 Cl).sub.2, n=1,3.

Abstract: 3,20-dione-11.beta.-hydroxypregn-4-ene-21-thioacetate-17-butyrate and 3,20-dione-11.beta.-hydroxypregn-4-ene-21-thiopropionate-17-butyrate, are anti-inflammatory agents.

Abstract: A unique crystalline polymorphic form of flunisolide is disclosed which is stable in aerosols such as Freon.RTM. mixtures and is valuable in the treatment of respiratory diseases, particularly bronchial asthma and allergic rhinitis.

Abstract: Compounds of the formula ##STR1## wherein R" is hydrogen or hydroxy, epimers at the 24-position of compounds of formula I, diastereomeric mixtures of compounds of formula I which are epimeric at the 24-position, and mixtures thereof, which are useful as agents for the treatment of psoriasis, and osteoporosis, are described.