Patents Examined by Joseph A. Lipovsky
  • Patent number: 4952586
    Abstract: A composition is provided which includes a balanced combination of an edrophonium component and an atropine component. A preferred embodiment has 0.5 mg of edrophonium chloride and 8 micrograms of atropine sulfate, with respect to patient weight. The inventive composition is useful to antagonize nondepolarizing blockade during medical treatment when muscle relaxation is no longer necessary, provides extremely rapid onset of action and results in minimal heart rate changes.
    Type: Grant
    Filed: October 18, 1988
    Date of Patent: August 28, 1990
    Assignee: The Regents of the University of California
    Inventors: Robert B. Morris, Roy Cronnelly, Ronald Dean Miller
  • Patent number: 4952569
    Abstract: Estriol and estradiol glycidyl ethers, immunogenic conjugates thereof and processes for their preparation are provided. The immunogenic conjugates are useful for eliciting and purifying antibodies and in performing immunoassays for estriol and estradiol.
    Type: Grant
    Filed: December 2, 1985
    Date of Patent: August 28, 1990
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Donald M. Simons
  • Patent number: 4950685
    Abstract: A synergistic wood preservative composition is provided comprising a quaternary ammonium compound and 3-iodo-2-propynyl butyl carbamate having the properties of providing stain resistance to wood. The quaternary ammonium compound is preferably selected from the group consisting of didecyldimethyl ammonium chloride, tri-methyl-coco-ammonium chloride and dimethyl-di-coco-ammonium chloride.
    Type: Grant
    Filed: August 23, 1989
    Date of Patent: August 21, 1990
    Assignee: Kop-Coat, Inc.
    Inventor: Hans A. Ward
  • Patent number: 4948789
    Abstract: Vitamin D.sub.3 derivatives of formula (I): ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, each represent a hydrogen atom or a hydroxyl group; R.sub.4 is hydrogen or a C.sub.4-6 alkyl group that is optionally substituted by a hydroxyl group; preferably 22-oxa-1,25-(OJ).sub.2 D.sub.3, or OCT, are administered to treat hyperparathyroidism, particularly secondary hyperparathyroidism, without inducing hypercalcemia. The derivatives may be administered orally or parenterally. They are preferably administered intravenously in the course of renal dialysis.
    Type: Grant
    Filed: March 28, 1989
    Date of Patent: August 14, 1990
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventor: Eduardo Slatopolsky
  • Patent number: 4946834
    Abstract: Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5.alpha.-reductase. Also invented are intermediates used in preparing these compounds.
    Type: Grant
    Filed: December 23, 1988
    Date of Patent: August 7, 1990
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • Patent number: 4945088
    Abstract: Insecticidal wettable powders containing an insecticide which is liquid at room temperature and a calcined synthetic hydrated silicon dioxide, which can retain its insecticidal effect for a long time without separating oil drops when used by diluting with water.
    Type: Grant
    Filed: February 14, 1985
    Date of Patent: July 31, 1990
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Yukikazu Okamoto, Manabu Tagami, Goro Shinjo, Kozo Tsuji
  • Patent number: 4944940
    Abstract: The present disclosure relates to a buck lure comprising a deer tarsal gland and a fluid in which the predominant ingredient is deer urine. Other ingredients include essence of deer interdigital gland, essence of deer femoral gland and a preservative.
    Type: Grant
    Filed: October 13, 1988
    Date of Patent: July 31, 1990
    Inventor: Leland G. Christenson, II
  • Patent number: 4943566
    Abstract: A compound selected from the group consisting of compounds of the formula ##STR1## wherein R.sub.1 is an organo of 1 to 18 carbon atoms optionally containing at least one heteroatom connected to the C ring by a carbon atom, R.sub.2 is methyl or ethyl, the A and B rings being selected from the group consisting of ##STR2## Re is selected from the group consisting of hydrogen, optionally substituted alkyl of 1 to 6 carbon atoms and acyl and the D ring is selected from the group consisting of ##STR3## one of R.sub.3 and R.sub.4 is selected from the group consisting of hydroxy, protected hydroxy, acyl and alkoxy and the other is an optionally substituted aryl, R.sub.5 is an optionally substituted aryl and their non-toxic, pharmaceutically acceptable salts with acids and bases with the proviso that when the A and B rings are ##STR4## R.sub.1 is ##STR5## R.sub.2 is methyl, R.sub.3 is --OH, R.sub.4 is phenyl having anti proliferative properties.
    Type: Grant
    Filed: July 28, 1988
    Date of Patent: July 24, 1990
    Assignee: Roussel Uclafi
    Inventors: Lucien Nedelec, Francois Nique, Daniel Philibert, Martine Moguilewsky, Marie-Madeleine Bouton
  • Patent number: 4943678
    Abstract: The invention relates to pesticidal composition against bacterial plant diseases comprising as active ingredient a nitrofurane derivative of the general Formula I ##STR1## wherein X represents a group of the Formula a/ ##STR2## and optionally one or more known fungicidal active ingredient/s/ in a total amount of 1-99% by weight, whereby the ratio of the active ingredient of the general Formula I to the known fungicidal active ingredient/s/ amounts to 1:99-99:1, preferably 1:9-9:1 if the composition comprises two active ingredients and 1:9:0.5-1:1:5, preferably 1:4:1-1:1:4 if the composition comprises three active ingredients, respectively, in admixture with suitable inert solid or liquid carrier/s/ or diluent/s/ and usual auxiliary agents such as wetting agents, dispersing agents, adhesives, antifoaming agents and/or antifreezers.
    Type: Grant
    Filed: June 25, 1985
    Date of Patent: July 24, 1990
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt
    Inventors: Sandor Angyan, Gyula Oros, Istvan Racz, Tamas Detre
  • Patent number: 4942158
    Abstract: A unique combination of isopropyl and isobutyl alcohols synergistically increases the permeability of the skin to steroid drugs.
    Type: Grant
    Filed: October 13, 1988
    Date of Patent: July 17, 1990
    Assignee: Eastman Kodak
    Inventors: Pramod P. Sarpotdar, Tammy B. Strassburg
  • Patent number: 4940700
    Abstract: The invention provides new seco-sterol compounds which are effective in inducing the differentiation of malignant cells and are therefore useful for the treatment of malignancies such as leukemia.
    Type: Grant
    Filed: April 30, 1987
    Date of Patent: July 10, 1990
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Wan F. Lau
  • Patent number: 4939134
    Abstract: This invention relates to cholesterol synthesis and to the accumulation and regulation of cholesterol levels in body tissue. More specifically, the invention provides that the compound 26-aminocholesterol, ##STR1## and analogs and derivatives thereof, exhibit biological activity as a potent inhibitor of cholesterol synthesis and/or cholesterol accumulation in body tissue. The compounds strongly inhibit of the enzyme HMGCoA reductase and low density lipoprotein accumulation by non-hepatic cells. Surprisingly, it has been discovered that 26-aminocholesterol is selective for fibroblast (plasma) cells, and has little or no effect on hepato (liver) cells. Therapeutic compounds according to the invention include substituted or unsubstituted sterols of the formula: ##STR2## wherein the carbon atoms at positions 5 and 6 of the sterol are one of saturated and unsaturated, R.sub.1 is one of a 3-hydroxyl group and a 3-keto group, R.sub.2 is one of a hydroxyl group and a keto group, and wherein at least one of R.sub.
    Type: Grant
    Filed: September 19, 1988
    Date of Patent: July 3, 1990
    Assignee: New York University
    Inventors: Norman B. Javitt, Stephen R. Wilson
  • Patent number: 4937237
    Abstract: Invented are phosphinic acid substituted analogues of steroidal synthetic compounds, pharamaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase, including using these compounds to reduce or maintain prostate size.
    Type: Grant
    Filed: December 23, 1988
    Date of Patent: June 26, 1990
    Assignee: SmithKline Beckman Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • Patent number: 4937238
    Abstract: To reduce the risk of breast cancer, a drug is periodically administered to young mammals before pregnancy in doses of about 1 microgram to 50 micrograms per kilogram of body weight. The drug: (1) competes with and displaces estradiol 17 beta from the mammary gland cells in an effective manner to prevent the possible formation of DNA-damaging epoxide estradiol metabolites; (2) binds to breast tissue to a greater extent than estradiol 17 beta; (3) induces terminal nonlactation differentiation of the mammary gland; (4) is nontoxic and noncarcinogenic; and (5) preferably does not cause anti-ovulatory activity. The drug is selected from a group of drugs including: (1) 4-OH estradiol; (2) d-equilenin; and (3) 17 alpha ethynyl estriol.
    Type: Grant
    Filed: September 30, 1988
    Date of Patent: June 26, 1990
    Assignee: The Board of Regents of the University of Nebraska
    Inventor: Henry M. Lemon
  • Patent number: 4935168
    Abstract: The present invention relates to a method to set free sterols from organic materials containing esters of such sterols, generally enriched distillation residues, or desodorisates by treating said organic material with ammonia and/or an amine and/or compound releases ammonia and/or amines while heated, the treament being carried out preferably at an elevated temperature, and under an elevated pressure.
    Type: Grant
    Filed: May 22, 1989
    Date of Patent: June 19, 1990
    Assignee: Triple Crown Aktiebolag
    Inventors: Kjell Sjoberg, Bjorn kermark
  • Patent number: 4935410
    Abstract: This present invention relates to fungicidal compositions comprising an aqueous solution of an aluminum salt of alkyl phosphonates stabilized with the salt of a weak acid and a strong base. The stabilized aqueous solution can be used to prevent or treat fungal diseases in plants by spraying, soaking the roots or injecting into the trunks of shrubs or trees.
    Type: Grant
    Filed: July 29, 1986
    Date of Patent: June 19, 1990
    Assignee: Rhone-Poulenc Agrochimie S.A.
    Inventor: Denis Barlet
  • Patent number: 4933332
    Abstract: 11-Desoxy-17.alpha.-hydroxycorticosterone derivatives of the general formula: ##STR1## wherein R is --OC(CH.sub.2).sub.n C.sub.6 H.sub.4 N(CH.sub.2 CH.sub.2 Cl).sub.2, n=1,3.
    Type: Grant
    Filed: September 30, 1988
    Date of Patent: June 12, 1990
    Inventors: Kira N. Kurdjumova, Elizaveta N. Shkodinskaya, Ljudmila P. Sushinina, Valentina P. Yaguzhinskaya, Nina D. Lagova, Zoya P. Sofiina, Irina M. Valueva, Petr V. Lopatin, Margarita A. Krasnova, Anatoly B. Syrkin, Ljudmila M. Mikhailova
  • Patent number: 4933331
    Abstract: 3,20-dione-11.beta.-hydroxypregn-4-ene-21-thioacetate-17-butyrate and 3,20-dione-11.beta.-hydroxypregn-4-ene-21-thiopropionate-17-butyrate, are anti-inflammatory agents.
    Type: Grant
    Filed: November 4, 1985
    Date of Patent: June 12, 1990
    Assignee: Jouveinal, S.A.
    Inventors: Gilbert G. Aubard, Agnes G. Grouhel, Jean-Louis Junien, Claude P. Roux, Dieran R. Torossian
  • Patent number: 4933168
    Abstract: A unique crystalline polymorphic form of flunisolide is disclosed which is stable in aerosols such as Freon.RTM. mixtures and is valuable in the treatment of respiratory diseases, particularly bronchial asthma and allergic rhinitis.
    Type: Grant
    Filed: September 14, 1981
    Date of Patent: June 12, 1990
    Assignee: Syntex Pharmaceuticals International Limited
    Inventors: Richard E. Jones, Gisela T. Haringer
  • Patent number: 4929609
    Abstract: Compounds of the formula ##STR1## wherein R" is hydrogen or hydroxy, epimers at the 24-position of compounds of formula I, diastereomeric mixtures of compounds of formula I which are epimeric at the 24-position, and mixtures thereof, which are useful as agents for the treatment of psoriasis, and osteoporosis, are described.
    Type: Grant
    Filed: November 14, 1988
    Date of Patent: May 29, 1990
    Assignees: Hoffmann-La Roche Inc., The United States of America as represented by the Department of Agriculture
    Inventors: Andrew D. Batcho, Ronald L. Horst, Milan R. Uskokovic, Joseph L. Napoli