Abstract: Stabilisers of formula I ##STR1## wherein R.sub.1 and R.sub.2 may be C.sub.1 -C.sub.5 alkyl, the substituents R.sub.3 to R.sub.8 may be hydrogen, the variable n may be 1 or 2, and, when n is 1, A may be an alkoxy radical, and, when n is 2, A may be a diamine radical.

Abstract: A novel crystalline modification of 2-dimethylaminoethyl-n-butylaminobenzoate hydrochloride and a method for production of said compound residing in that a solution of 2-dimethylaminoethyl-n-butylaminobenzoate hydrochloride of polymorphic form in water or organic solvent, or in their mixture, is cooled by a cooling agent at a rate of no less than 8.degree. C./min till complete crystallization of the solution with subsequent drying of obtained crystals.Compound of the invention has a local anaesthetic activity and is an active principle of a pharmaceutical preparation for anaesthesia of eyes (content of active principle is from 0.05 to 0.5% by mass).

Abstract: This invention relates to a process for preparing perfluoroalkoxysulphonic compounds having formula: ##STR1## wherein R.sub.f represents a perfluoroalkyl or perfluoroethereal group, X represents F, OH or OM, in which M is an alkaline cation, an alkaline-earth cation, or X represents NR.sub.1 R.sub.2, in which R.sub.1 and R.sub.2, independently of each other, represent H or an alkyl group containing from 1 to 5 carbon atoms and p is a number selected from 1 to 2, characterized in that the perfluoro vinyl sulphonyl fluoride of formula (II) CF.sub.2 =CF--SO.sub.2 F is reacted with a hypofluorite of formula (III):R.sub.f (OF).sub.r (III)wherein R.sub.f is the same as defined above, and r represents 1 or 2, optionally in an inert solvent, at a temperature approximately ranging from -140.degree. C. to +40.degree. C.

Abstract: Near-quantitative conversion of maleate to D,L-malate is rapidly secured by heating an aqueous alkaline mixture of maleate and excess of the divalent cations calcium, magnesium or mixtures thereof in a reactor at autogenous pressures and at temperatures above reflux. The simplest raw materials for the process are maleic anhydride and calcium hydroxide. The product is secured as an unusual, typically granular solid form of the divalent metal malate salt which is very useful in processes for preparing other malate salts, malic acid, or 2,2'-oxodisuccinate laundry detergent builders.

Abstract: Process for preparing haloketo acid derivatives [I]: ##STR1## wherein R is H or C.sub.1-6 alkyl, and X is chlorine or bromine, which comprises reacting .beta.-oxo-acid ester [II]: ##STR2## wherein R.sup.1 is H or C.sub.1-6 alkyl, R.sup.2 is C.sub.1-5 alkyl or OR.sup.3 (R.sup.3 is C.sub.1-6 alkyl), and X is the same as above, with nitrosating agent [IV]:ONOR.sup.4 [IV]wherein R.sup.4 is H, alkyl, halogen or SO.sub.3 H to give 7-halo-2-hydroxyminoheptanoic acid ester [III]: ##STR3## wherein R.sup.1 and X are the same as above, following by reacting the product with aldehyde or ketone; and intermediates therefor, and process for preparing said intermediates. Said haloketo acid derivatives are useful as intermediate for synthesis of cilastatin, which is useful as medicament, especially as dehydropeptidase inhibitor.

Abstract: Development of medicament having anti-virus activity, particularly anti-HIV (anti-human immunodeficiency virus) activity. An anti-virus agent comprising bis-naphthalenedisulfonic acids having aliphatic spacer represented by the formula (1) and their physically usable salts.

Abstract: In the production of methacrylic acid by the vapor phase catalytic oxidation of isobutylene, t-butanol, methacrolein isobutyl aldehyde or isobutyric acid, or mixture thereof, the reaction product gas is condensed by contact with an aqueous phase containing methacrylic acid and acetic acid thereby forming an aqueous solution of methacrylic acid and a gas phase containing methacrolein and methacrylic acid. The aqueous solution of methacrylic acid is extracted with a saturated hydrocarbon solvent containing from 6-9 carbon atoms. The methacrylic acid is extracted into the solvent phase and an aqueous phase containing acetic acid is also formed. Methacrolein is recovered from the gas containing methacrolein and methacrylic acid by contacting the gas with an aqueous phase containing methacrylic acid and acetic acid. An aqueous phase containing methacrylic acid, acetic acid and methacrolein is formed in the methacrolein recovery step.

Abstract: The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and method for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

Abstract: Acetylenic derivatives of general formula ##STR1## in which R.sub.1 denotes a hydrogen atom or a phenyl radical or a radical of general formula ##STR2## in which R.sub.2 and R.sub.3, which may be identical or different, denote a hydrogen atom or a saturated or unsaturated aliphatic radical, substituted if appropriate, or form together a cycloaliphatic radical, R.sub.4 denotes a hydrogen atom or a saturated or unsaturated aliphatic radical, a hydroxy, alkyloxy, methanesulphonyloxy, benzenesulpnonyloxy or p-toluenesulphonyloxy radical, R.sub.5 denotes a hydrogen atom or a saturated aliphatic radical, R.sub.6 denotes a hydrogen atom or a saturated or unsaturated aliphatic radical are made by reaction of an acetylenic derivative of general formulaR.sub.1 --C.tbd.C--H (III)with an allyl derivative of general formula ##STR3## in the presence of a cuprous salt and an anhydrous organic base. The compounds of formula (I) are useful in organic synthesis, in particular in the preparation of the vitamins A and E.

Abstract: The present invention pertains to a method of forming a salt of 4-hydroxystyrene by reacting 4-acetoxystyrene with a suitable base in a suitable solvent system. Subsequently, or simultaneously, the salt of 4-hydroxystyrene can be reacted, preferably in situ, with di-tertiary-butyl-dicarbonate to form 4-tertiary-butoxycarbonyloxystyrene.

Abstract: Adsorbents comprising amorphous silicas with effective average pore diameters of up to about 5000 Angstroms are useful in processes for the removal of soaps and phospholipids (along with associated metal ions) from caustic treated, primary centrifuged, water-wash centrifuged or caustic refined glyceride oils.

Abstract: The known liming sulfuric acid process for the recovery of crystalline citric acid from a fermentation broth is modified by subjecting the mother liquor from the crystallization to extraction with a water-immiscible organic extraction that contains an amine. The resulting extract is neutralized with a recycled brine with alkali citrate and alkali citrate is crystallized from the concentrated brine obtained this way.

Abstract: A benzamide derivative of the formula: ##STR1## wherein R.sub.1 is hydrogen or methyl, and R is hydroxyl, C.sub.1 -C.sub.6 alkoxy, alkenylalkoxy, alkoxyalkoxy, amino, C.sub.1 -C.sub.4 monoalkylamino, monoalkenylamino, dialkylamino or O-cat wherein cat is a metal, ammonium or an organic cation.

Abstract: Phenylacetaldehydes of the structure (I) ##STR1## where the substituents X are 2,4-dichloro, difluoro, trifluoro, tetrafluoro, p-trifluoromethyl, 2-methyl-4-fluoro, haloalkoxy or haloalkylthio radicals or are adjacent Cl, F, CF.sub.3, alkyl, alkoxy, haloalkoxy and/or haloalkylthio radicals.

Abstract: Inositol compounds grouped into an aminocyclitol family are disclosed which have stereospecific structure and optical activity and find application to the manufacture of medicinal products and agricultural chemicals. The compound is produced with use of optically active L-quebrachitol as a starting material and by way of specific steps of reaction.

Abstract: Polymerizable carbonate compounds of the formula: ##STR1## wherein A is an aromatic polycycle, R.sup.1 and R.sup.2 are independently hydrogen atom or alkyl, and n is 1, 2 or 3, are disclosed. They are useful as a component of nonemanating, self-curing and heat resistant resin compositions.

Abstract: Production of stable ozonized oils from unsaturated vegetable oils by introducing an ozone-oxygen mixture into the oil until it reaches saturation, and following the ozonization, an extraction process in acid medium is carried out in the presence of a redox reaction system, which is capable of moderately reacting the radicals in the presence of a synthetic or natural anti-oxidation medium or reducing medium.

Abstract: A process and a catalyst for the homogeneous liquid phase reaction of aromatic haloformates with aromatic hydroxy compounds for the production of diaryl carbonates with the elimination of anhydrous hydrogen halide. The catalysts of the present invention comprise at least one aromatic heterocyclic nitrogen compound. These catalysts permit the production of the products in very high yield, and the reaction proceeds at high rates.

Abstract: Quinone derivatives of the general formula: ##STR1## (wherein R.sup.1 and R.sup.2 are the same or different, and independently are a hydrogen atom or a methyl or methoxy group, or R.sup.1 and R.sup.2 combine with each other to represent --CH.dbd.CH--CH.dbd.CH--R.sup.3 is a hydrogen atom or a methyl group; R.sup.4 is an aliphatic, aromatic or heterocyclic group which may be substituted; R.sup.5 is a methyl or methoxy group, a hydroxymethyl group which may be substituted or a carboxyl group which may be esterified or amidated; Z is a group represented by --C.dbd.C--, --CH.dbd.CH--, ##STR2## n is an integer of 0 to 10; m is an integer of 0 to 3; k is an integer of 0 to 5, provided, however, that in the case of m being 2 or 3, Z and k can vary arbitrarily within the bracketed repeating units) are novel compounds, possess metabolism ameliorating action for polyunsaturated fatty acids, particularly production inhibitory activity of lipid peroxides (antioxidant activity), thromboxane A.sub.

Abstract: The invention makes available an improved process for the crystallization and purification of a water-insoluble aromatic dicarboxylic acid, such as 2,6-naphthalenedicarboxylic acid. The process involves steps of contacting the insoluble acid with aqueous base to make a water-soluble di salt of the acid, removal of insoluble impurities to obtain a clear solution of the di salt, partial acidification of the solution by adding a water-soluble acid, holding the thus-obtained slurry of the insoluble acid and its salt for a time sufficient to allow dissolution of the initially-formed small particles of the insoluble acid and the formation of large well-formed crystals, then acidifying the slurry further to convert remaining salts to the insoluble acid, and recovering this acid. The crystallization can be accelerated by recycling product and by adding surfactants, and can be operated in a continuous mode. 2,6-Naphthalenedicarboxylic acid thus crystallized is readily dried, non-sticky, non-dusty, and of high purity.