Patents Examined by Joseph K. McKane
  • Process for producing tertiary phosphine
    Patent number: 7250535
    Abstract: A production process by which tertiary phosphine with an attached sterically bulky hydrocarbon group is produced in a high yield and with high purity on an industrial scale through simple and safe operations by allowing a dialkylphosphinous halide to react with a Grignard reagent in the presence of a copper compound in an amount corresponding to 0.1 to 5% by mol based on the dialkylphosphinous halide to produce tertiary phosphine represented by the following formula (3): wherein R1 and R2 are each a tertiary hydrocarbon group of 4 to 13 carbon atoms, and R3 is an alkyl group, an alkenyl group, an aryl group or the like.
    Type: Grant
    Filed: February 3, 2003
    Date of Patent: July 31, 2007
    Assignee: Hokko Chemical Industry Co., Ltd.
    Inventors: Shinya Maehara, Hideyuki Iwazaki
  • Mercaptophenyl naphthyl methane compounds and synthesis thereof
    Patent number: 7250446
    Abstract: Novel mercaptophenyl naphthyl methane compounds, their pharmaceutically acceptable salts and compositions comprised thereof are useful for the prevention or treatment of various medical indications associated with estrogen dependent diseases or syndromes related to osteoporosis, bone loss, bone formation, cardiovascular disorders, neurodegenerative disorders, menopausal disorders, physiological disorders, diabetes disorders, prostatic carcinoma, cancer of breast, cancer of uterus, cancer of the cervix and cancer of the colon, threatened or habitual abortion, obesity, ovarian development or function, post-partum lactation and depression.
    Type: Grant
    Filed: March 26, 2004
    Date of Patent: July 31, 2007
    Assignee: Council of Scientific and Industrial Research
    Inventors: Sangita, Atul Kumar, Man Mohan Singh, Girish Kumar Jain, Puvvada Sri Ramanchandra Murthy, Suprabhat Ray
  • Tetrazole and oxadiazolone substituted ?-amino acid derivatives
    Patent number: 7250433
    Abstract: This invention relates to novel tetrazole and oxadiazalone ?-amino acids derivatives of the formula wherein G is wherein R1 through R4 are defined as in the specification, pharmaceutical compositions containing them and their use for the treatment of various central nervous system and other disorders. The cyclopropyl ?-amino acids derivatives of this invention exhibit activity as alpha2delta ligands (?2? ligands). Such compounds have affinity for the ?2? subunit of a calcium channel.
    Type: Grant
    Filed: March 8, 2004
    Date of Patent: July 31, 2007
    Assignee: Warner Lambert Company LLC
    Inventors: Nancy Sue Barta, Norman Lloyd Colbry, Raymond Hudack, Jr., Kristin Knapp Lin, Jacob Bradley Schwarz, Andrew John Thorpe, David Juergen Wustrow, Zhijian Zhu
  • Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators
    Patent number: 7250442
    Abstract: The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation, particularly congestive heart failure, comprising administering to a patient in need thereof an effective amount of a compound of the formula: I or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 11, 2003
    Date of Patent: July 31, 2007
    Assignee: Eli Lilly and Company
    Inventors: Matthew Lee Brown, Timothy Alan Grese, Prabhakar Kondaji Jadhav, David Andrew Neel, Mitchell Irvin Steinberg, Peter Ambrose Lander
  • Histone deacetylase inhibitors
    Patent number: 7250514
    Abstract: Histone deacetylase inhibitors and uses thereof are provided that have the general formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, M and L have the definitions as described herein.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: July 31, 2007
    Assignee: Takeda San Diego, Inc.
    Inventor: Xiao-Yi Xiao
  • Gamma-aminoamide modulators of chemokine receptor activity
    Patent number: 7247725
    Abstract: The present invention is directed to compounds of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R11, R12, W, X, and n are defined herein, which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
    Type: Grant
    Filed: October 24, 2003
    Date of Patent: July 24, 2007
    Assignee: Merck & Co., Inc.
    Inventors: Gabor Butora, Alexander Pasternak, Lihu Yang, Changyou Zhou
  • ?-benzyloxyaspartate derivatives with amino group on benzene ring
    Patent number: 7247652
    Abstract: L-threo-?-benzyloxyaspartate derivatives having a substituent on the benzene ring, represented by the following formula (1): wherein R is hydrogen, a linear or branched lower aliphatic acyl group with the acyl portion optionally substituted, an alicyclic acyl group, an aromatic acyl group with a substituent on the aromatic ring, an amino acid-derived group or a biotin derivative-derived group, having an amino substituent on the benzene ring, and salts thereof, which can easily bind to affinity column chromatography carriers as ligands of glutamate transporter proteins.
    Type: Grant
    Filed: June 24, 2002
    Date of Patent: July 24, 2007
    Assignee: Suntory Limited
    Inventor: Keiko Shimamoto
  • Process for preparing 1,5-diaryl-3-substituted pyrazoles
    Patent number: 7247745
    Abstract: A process for making a compound of formula I wherein the substituents are as described in the specification comprising reacting a ketone of formula II with succinic anhydride and an alkoxide base to form a compound of formula III which is reacted with a compound of formula IV to form a compound of V and reacting with an alcohol to form the corresponding ester of formula VI and reacting the ester with N-methylhydroxylamine.
    Type: Grant
    Filed: August 30, 2005
    Date of Patent: July 24, 2007
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Ahmed F. Abdel-Magid, Bruce D. Harris, Cynthia A. Maryanoff
  • Imidazole derivatives, processes for preparing them and their uses
    Patent number: 7244747
    Abstract: The present invention relates to imidazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
    Type: Grant
    Filed: November 30, 2004
    Date of Patent: July 17, 2007
    Assignee: UCB, S.A.
    Inventors: Benoit Kenda, Philippe Michel, Yannick Quesnel
  • 2-methylthiazolidine-2,4-dicarboxylic acid and salts thereof for treatment of neurodegenerative diseases
    Patent number: 7244754
    Abstract: The invention relates to the compounds (2R,4R), (2S,4R)-2-methylthiazolidine-2,4-dicarboxylic acid and (2RS,4R)-2-methylthiazolidine-2,4-dicarboxylic acid and salts of said compounds, the use thereof for the prophylaxis and/or treatment of neurodegenerative diseases, methods for the prophylaxis and/or treatment of neurodegenerative diseases, and pharmaceutical compositions containing said compounds together with physiologically compatible carriers, auxiliary agents, and/or solvents.
    Type: Grant
    Filed: April 21, 2006
    Date of Patent: July 17, 2007
    Inventor: Rudy Susilo
  • 6-Methylpyridine derivatives, method for preparing thereof and antiviral pharmaceutical composition comprising the same
    Patent number: 7244731
    Abstract: The present invention relates to 6-methylpyridine derivatives useful as an antiviral agent. More particularly, the present invention relates to novel 6-methylpyridine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV), or pharmaceutically acceptable salts thereof, to a method for preparing thereof, and to an antiviral pharmaceutical composition comprising the compound as an active ingredient.
    Type: Grant
    Filed: October 2, 2003
    Date of Patent: July 17, 2007
    Assignee: B & C Biopharm
    Inventors: Jong-Woo Kim, Sang-Wook Lee, Geun-Hyung Lee, Jae-Jin Han, Sang-Jin Park, Eul-Yong Park, Joong-Chul Shin
  • Compounds active in spinigosine 1-phosphate signaling
    Patent number: 7241790
    Abstract: The present invention relates to S1P analogs that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: July 10, 2007
    Assignee: University of Virginia Patent Foundation
    Inventors: Kevin R. Lynch, Timothy L. Macdonald
  • Fused pyrazole derivatives and methods of treatment of metabolic-related disorders thereof
    Patent number: 7241792
    Abstract: The present invention relates to certain fused pyrazole derivatives of Formula (Ia), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: July 10, 2007
    Assignee: Arena Pharmaceuticals, Inc.
    Inventors: P. Douglas Boatman, Thomas O. Schrader, Graeme Semple, Philip J. Skinner, Jae-Kyu Jung
  • Process for preparing thiazole derivative and the intermediate compounds for preparing the same
    Patent number: 7241901
    Abstract: The present invention provides a process for preparing thiazole derivatives of formula (XI), that activate the delta subtype of the human Peroxisome Proliferator Activated Receptor (hPPAR?), and also provides processes for compounds of formula (VI), (VII), (VIII) and (IX), intermediate compounds for preparation of the above compounds of formula (XI).
    Type: Grant
    Filed: May 1, 2003
    Date of Patent: July 10, 2007
    Inventors: Heonjoong Kang, Jungyeob Ham
  • 1-calcium phosphate-uracil and method for preparing thereof
    Patent number: 7241917
    Abstract: The present invention provides a compound of 1-calcium phosphate-uracil of the following structure. The compound can be a flavourless, white crystal or crystalline powder with a molecular weight of 216.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: July 10, 2007
    Inventor: Qizhi Ning
  • Fused pyrrolocarbazoles
    Patent number: 7241779
    Abstract: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: July 10, 2007
    Assignee: Cephalon, Inc.
    Inventors: Robert L. Hudkins, Allison L. Zulli, Dandu R. Reddy, Ming Tao, Theodore L. Underiner
  • NK1 antagonists
    Patent number: 7241798
    Abstract: The invention is to compounds exhibiting neurokinin inhibitory properties, pharmaceutical compositions comprising same and methods of treatment for neurokinin-mediated conditions.
    Type: Grant
    Filed: June 7, 2005
    Date of Patent: July 10, 2007
    Assignee: Pfizer Inc.
    Inventors: Barbara E. Segelstein, Travis T. Wager, Willard M. Welch
  • Polymorph V of torasemide
    Patent number: 7241782
    Abstract: The invention relates to a novel polymorph V of torasemide, to a process for its preparation, to its use as a raw material for the preparation of crystalline modifications I and III of torasemide, to amorphous torasemide modifications and to pharmaceutically acceptable salts of torasemide, to pharmaceutical forms containing the said novel polymorph V of torasemide as the active ingredient as well as to its use.
    Type: Grant
    Filed: September 25, 2000
    Date of Patent: July 10, 2007
    Assignee: PLIVA, farmaceutska industrija, dionicko drustvo
    Inventors: Darko Filić, Miljenko Dumić, Bo{hacek over (z)}ena Klepić, Aleksandar Danilovski, Marijan Tudja
  • Metathesis catalysts
    Patent number: 7241898
    Abstract: The present invention relates to new compounds of formula 1, the preparation thereof, intermediate products for preparing them and the use of the compounds of formula 1 as catalysts in various metathesis reactions The new metathesis catalysts, which are obtained from readily accessible preliminary products, have a high activity and can be used for all kinds of metathesis reactions.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: July 10, 2007
    Assignee: Boehringer Ingelheim International GmbH
    Inventor: Dieter Arlt
  • Boronate esters
    Patent number: 7238826
    Abstract: The present invention relates to optically active boronate derivatives which are useful as intermediates for the synthesis of HMG-CoA enzyme inhibitors such as atorvastatin, cerivastatin, rosuvastatin, pitavastatin, and fluvastatin.
    Type: Grant
    Filed: August 23, 2004
    Date of Patent: July 3, 2007
    Assignee: Biocon Limited
    Inventors: Tom Thomas Puthiaparampil, Sumithra Srinath, Madhavan Sridharan, Sambasivam Ganesh