Patents Examined by Joseph Kosack
  • Cycloalkyl-diamines
    Patent number: 9126891
    Abstract: The invention is directed to a compound of formula I, as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a method of treatment of a disorder or condition that may be treated by administration of the compound, the method comprising administering to a mammal, especially a human, in need of such treatment a compound of formula I as described above, and a method of treatment of a disorder or condition selected from the group consisting Human African Trypanosomiasis (HAT), Chagas Disease, Malaria, Leishmaniasis, and other infectious diseases transmitted to humans and animals by exposure to parasites, the method comprising administering to a human or mammal in need of such treatment a compound of formula I as described above.
    Type: Grant
    Filed: January 29, 2014
    Date of Patent: September 8, 2015
    Assignee: MediSynergics, LLC
    Inventors: Dennis Michael Godek, Harry Ralph Howard
  • Substrates for chromogenic detection and methods of use in detection assays and kits
    Patent number: 9127028
    Abstract: Embodiments of substrates and processes for chromogenic detection, and in particular pyrazolyl dihydrogen phosphate compounds, are disclosed.
    Type: Grant
    Filed: August 12, 2011
    Date of Patent: September 8, 2015
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Brian Daniel Kelly, Christopher Bieniarz, Hiro Nitta, Fabien Gaire
  • Amido compounds and their use as pharmaceuticals
    Patent number: 9126927
    Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: September 8, 2015
    Assignees: Incyte Holdings Corporation, Incyte Corporation
    Inventors: Wenqing Yao, Jincong Zhuo, Meizhong Xu, Brian W. Metcalf, Chunhong He, Ding-Quan Qian, Colin Zhang
  • Hepatitis C virus inhibitors
    Patent number: 9127021
    Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: September 8, 2015
    Assignee: Enanta Pharmaceuticals, Inc.
    Inventors: Yao-Ling Qiu, Ce Wang, Xiaowen Peng, Yat Sun Or
  • Phosphoric acid ester derivatives
    Patent number: 9120835
    Abstract: To provide a novel compound that has S1P lyase inhibitory ability and induces a reduction in the number of lymphocytes, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the compound or pharmaceutically acceptable salt thereof as an active ingredient. A compound represented by the general formula (I): or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 27, 2012
    Date of Patent: September 1, 2015
    Assignee: Daiichi Sankyo Company Limited
    Inventors: Nobuo Machinaga, Jun Chiba, Ryuji Hashimoto, Mamoru Otoyo, Ryotaku Inoue
  • Ruthenium-based metathesis catalysts and precursors for their preparation
    Patent number: 9108996
    Abstract: The invention is directed to ruthenium-based metathesis catalysts of the Hoveyda-Grubbs type. The new N-chelating diarylamino-based ruthenium catalysts described herein are stable in solid state and in solution and reveal rapid initiation behavior. Further, the corresponding N-substituted styrene precursor compounds are disclosed. The catalysts are prepared in a cross-metathesis reaction starting from N-substituted styrene precursors. The new Hoveyda-Grubbs type catalysts are suitable to catalyze ring-closing metathesis (RCM), cross metathesis (CM) and ring-opening metathesis polymerization (ROMP). Low catalyst loadings are sufficient to convert a wide range of substrates via metathesis reactions.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: August 18, 2015
    Assignee: UMICORE AG & CO. KG
    Inventors: Herbert Plenio, Lars Peeck
  • Crystal of 5-hydroxy-1H-imidazole-4-carboxamide 3/4 hydrate, method for producing the same and crystal of 5-hydroxy-1H-imidazole-4-carboxamide hydrate
    Patent number: 9108928
    Abstract: Provided is a method for producing 5-hydroxy-1H-imidazole-4-carboxamide.3/4 hydrate, including: reacting 2-aminomalonamide with a compound represented by the following formula [1] in the presence of a carboxylic acid to obtain 5-hydroxy-1H-imidazole-4-carboxamide: wherein, in formula [1], each R independently represents a C1-3 alkyl group; reacting the resulting 5-hydroxy-1H-imidazole-4-carboxamide with an acidic compound to obtain a 5-hydroxy-1H-imidazole-4-carboxamide acid salt or a hydrate thereof; and reacting the resulting 5-hydroxy-1H-imidazole-4-carboxamide acid salt or hydrate thereof with a salt in the presence of an acidic solvent to obtain the 5-hydroxy-1H-imidazole-4-carboxamide.3/4 hydrate.
    Type: Grant
    Filed: March 26, 2014
    Date of Patent: August 18, 2015
    Assignee: FUJIFILM Corporation
    Inventors: Taisuke Fujimoto, Tomohiro Hashimoto, Katsuyuki Hayashi, Tomoyuki Tanaka
  • Process for preparing a porous metal-organic framework composed of zinc methylimidazolate
    Patent number: 9096616
    Abstract: Described is a process for preparing a porous metal-organic framework comprising at least one at least bidentate organic compound coordinated to at least one metal ion, where the at least one metal ion is a zinc ion and the at least one at least bidentate organic compound is based on 2-methylimidazole, which comprises the steps (a) addition of a first water-based solution comprising zinc ions to a second water-based solution comprising 2-methylimidazole, with a suspension being formed after addition of the second solution; (b) addition of a third solution comprising a strong base to the suspension formed in step (a).
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: August 4, 2015
    Assignee: BASF SE
    Inventors: Natalia Trukhan, Ulrich Müller
  • 2-IODO imidazole-derivatives
    Patent number: 9095136
    Abstract: The present invention relates to novel 2-iodoimidazole derivatives, to processes for preparing these compounds, to compositions comprising these compounds and to their use as biologically active compounds, in particular for controlling harmful microorganisms in crop protection and in the protection of materials and as plant growth regulators.
    Type: Grant
    Filed: November 23, 2012
    Date of Patent: August 4, 2015
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Hendrik Helmke, Sebastian Hoffmann, Carl Friedrich Nising, Alexander Sudau, Tomoki Tsuchiya, Jürgen Benting, Peter Dahmen, Ulrike Wachendorff-Neumann, David Bernier, Stephane Brunet, Marie-Claire Grosjean-Cournoyer, Hélène Lachaise, Philippe Rinolfi
  • Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds for use in the treatment of chemokine-mediated pathologies
    Patent number: 9090596
    Abstract: Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds are disclosed that are represented by general formula (I). Also disclosed, are pharmaceutical compositions including these compounds and methods of using these compounds and compositions for the treatment of chemokine-mediated pathologies.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: July 28, 2015
    Assignee: GALDERMA RESEARCH & DEVELOPMENT
    Inventors: Branislav Musicki, Jerôme Aubert, Jean-Guy Boiteaux, Laurence Clary, Patricia Rossio, Marlène Schuppli-Nollet
  • Compounds and methods for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds
    Patent number: 9090539
    Abstract: Compounds and methods for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds from an isomerically pure starting material are described. In particular, methods of preparing a 3-(1-(dimethylamino)-2-methylpentane-3-yl)phenol as a substantially optically pure (R,R) stereoisomer are described. Using a method of the present invention, only the (R,R) and (S,S) stereoisomers of the target compound are produced, increasing the yield and stereoselectivity of the desired (R,R) stereoisomer.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: July 28, 2015
    Assignee: AMPAC Fine Chemicals LLC
    Inventors: Brian Morgan, Olivier Dapremont, Patrick Berget, Ali Suleman, William Dubay, Jeffrey D. Butler
  • Precursors and methods for the selective deposition of cobalt and manganese on metal surfaces
    Patent number: 9090641
    Abstract: Provided are metal coordination complexes comprising a pyrrole or imidazole-based ligands and cobalt or manganese. Also provided are methods for the selective deposition of cobalt and/or manganese films on metal surfaces using these metal coordination complexes comprising a pyrrole or imidazole-based ligand.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: July 28, 2015
    Assignee: Applied Materials, Inc.
    Inventor: Jeffrey W. Anthis
  • Conjugates of nitroimidazoles and their use as chemotherapeutic agents
    Patent number: 9084779
    Abstract: Novel compounds which are derivatives of tetra-O-methyl nordihydroguaiaretic acid (NDGA), as well as pharmaceutically acceptable salts, solvates, and stereoisomers thereof are provided. These NDGA derivatives have a nitroimidazole moiety and these derivatives show preferential toxicity to hypoxic cells as hypoxic cytotoxins. Their cytotoxicity toward hypoxic cells is a result of abstraction of hydrogen from target molecules by free radicals formed in the reduction of the nitro group. This makes the disclosed compounds an effective anti cancer drug because hypoxic cells are generally considered to be more resistant to anti cancer drugs than normal cells. Pharmaceutical compositions comprising such compounds, as well as methods of use, and treatment for cancers, including hepatocellular carcinoma, breast cancer and prostate cancer, are also provided.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: July 21, 2015
    Assignee: The Johns Hopkins University
    Inventors: Ru Chih C. Huang, David Edward Mold, Jih Ru Hwu, Ming Hua Hsu, Szu Chun Wu
  • 2,3-diphenyl-valeronitrile derivatives, method for the production thereof and use thereof as herbicides and plant growth regulators
    Patent number: 9084425
    Abstract: The invention describes compounds of formula (I), processes for preparing the compounds and methods of using the compounds as herbicides for the control of harmful plants or as plant growth regulators.
    Type: Grant
    Filed: July 11, 2012
    Date of Patent: July 21, 2015
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Marc Mosrin, Harald Jakobi, Alfred Angermann, Elmar Gatzweiler, Isolde Häuser-Hahn, Ines Heinemann, Christopher Hugh Rosinger, Stefan Lehr, Stefan Schnatterer
  • Silicone containing citrate co-polyesters
    Patent number: 9085662
    Abstract: The present invention is directed to a series of citrate ester emulsifiers that are effective in making water in oil (regular emulsions) and oil in water (invert emulsions) and contain a silicone portion that provides better spreadability and skin aesthetics. In addition to being outstanding emulsifiers, these emulsifiers provide unique solubility, liquidity and outstanding feel when applied to the skin, making them highly desirable in cosmetic emulsions.
    Type: Grant
    Filed: May 27, 2014
    Date of Patent: July 21, 2015
    Assignee: SurfaTech Corporation
    Inventor: Thomas George O'Lenick
  • Platinum (II) di (2-pyrazolyl) benzene chloride analogs and uses
    Patent number: 9082989
    Abstract: Synthesis of platinum(II) di(2-pyrazolyl)benzene chloride and analogs includes forming a 1,3-di-substituted benzene including two aromatic five-membered heterocycles, and reacting the 1,3-di-substituted benzene with an acidic platinum-containing solution to form a luminescent platinum(II) complex. The luminescent platinum(II) complex is capable of emitting blue and white light and can be used as an emitter in a light emitting device.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: July 14, 2015
    Assignee: Arizona Board of Regents for and on behalf of Arizona State Univesity
    Inventors: Jian Li, Zixing Wang
  • Ethyl acetate production
    Patent number: 9079851
    Abstract: A reactive distillation method comprises introducing an feed stream comprising ethanol to a reactive distillation column, contacting the feed stream with a catalyst in the reactive distillation column during a distillation, where the feed stream reacts in the presence of the catalyst to produce a reaction product comprising ethyl acetate and hydrogen, removing ethyl acetate during the distillation from the reactive distillation column as a bottoms stream, and removing hydrogen during the distillation from the reactive distillation column as an overhead stream.
    Type: Grant
    Filed: February 1, 2012
    Date of Patent: July 14, 2015
    Assignee: Greenyug, LLC
    Inventors: Sagar B. Gadewar, Brian Christopher Vicente, Robert Elliot Norton, Michael Francis Doherty
  • (4-phenylimidazol-2-yl) ethylamine derivatives useful as sodium channel modulators
    Patent number: 9079878
    Abstract: The present invention is directed to imidazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new imidazole NaV1.8 modulators of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4 and R5 are as defined in the description. NaV1.8 modulators are useful in the treatment of a wide range of disorders, particularly pain.
    Type: Grant
    Filed: October 15, 2012
    Date of Patent: July 14, 2015
    Assignee: Pfizer Limited
    Inventors: Sharanjeet Kaur Bagal, Mark Ian Kemp, Duncan Charles Miller, Yoshihisa Murata
  • Process for making dimethyl carbonate
    Patent number: 9073849
    Abstract: An eco-friendly process for making dimethyl carbonate comprising contacting methanol with carbon dioxide in the presence of a solid, calcined catalyst derived from zirconium phosphonate catalyst having molecular formula: Zr(X)2-nYn.mH2O where X refers to phosphonate, Y refers to HPO42? or HPO32?, n varies from 0.2 to 1.8 and m varies from 0 to 5, is disclosed.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: July 7, 2015
    Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Darbha Srinivas, Unnikrishnan Pulikkeel
  • 5-aryl isoxazolines for controlling invertebrate pests
    Patent number: 9073910
    Abstract: Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein A1, A2 and A3 are independently selected from the group consisting of CR3 and N; B1 B2 and B3 are independently selected from the group consisting of CR2 and N; Q is a phenyl ring or a 5- or 6-membered saturated or unsaturated heterocyclic ring, each ring optionally substituted with one or more substituents independently selected from halogen, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 haloalkylthio, C1-C6 alkylsulfinyl, C1-C6 haloalkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkylsulfonyl, —CN, —NO2, —N(R4)R5, —C(W)N(R4)R5, —C(O)OR5 and R8; or —S(O)2N(R21)R22, —S(O)pR25 or —S(O)(?NR28)R29; and R1, R2, R3, R4, R5, R8, R21, R22, R25, R28, R29; p and n are as defined in the disclosure.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: July 7, 2015
    Assignee: E.I. du Pont de Nemours and Company
    Inventors: George Philip Lahm, Kanu Maganbhai Patel, Thomas Francis Pahutski, Jr., Benjamin Kenneth Smith, Jeffrey Keith Long