Abstract: Polyanhydrides with uniform distribution of alkyl and aromatic residues are prepared by melt polycondensation or solution polymerization of p-carboxyphenoxyalkanoic acids or p-carboxyphenylalkanoic acids. These polymers are soluble in common organic solvents and have low melting points, generally in the range of 40.degree.-100.degree. C.The polyanhydrides are especially well suited for forming bioerodible matrices in controlled bioactive compound delivery devices. A polymeric matrix formed according to the method described here degrades uniformly during drug release, preventing the wholescale channeling of the bioactive compound into the environment, and eliminating the problem of the presence of the polymer matrix at the site long after drug release. The polymer displays zero-order kinetic degradation profiles over various periods of time (days to months), at a rate useful for controlled drug delivery.
Abstract: A process for polymerizing or copolymerizing a member of the group consisting of an alpha olefin or mixtures thereof, consisting of the steps of:polymerizing an alpha olefin in a polymerization reactor using a polymerization catalyst, a cocatalyst, and an amount of hydrogen adjusted for molecular weight control as measured by melt flow;rapidly changing the melt flow of the polymerized alpha olefin from high to low melt flow by reacting a portion of the unreacted hydrogen in the reactor with a quantity of the alpha olefin present therein by interaction with a hydrogenation catalyst; andremoving the hydrogenation catalyst from the reactor through continuous exchange of the reactor contents.
Abstract: Polymerization of acetylenic monomers is achieved by using a catalyst which is the reaction product of a tungsten compound and a reducing agent effective to reduce W(VI) to W(III) and/or IV), e.g., WCl.sub.6.(organo-Li, organo-Mg or polysilane). The resultant silylated polymers are of heretofore unachievable high molecular weight and can be used as precursors to a wide variety of new acetylenic polymers by application of substitution reactions.
Type:
Grant
Filed:
November 9, 1987
Date of Patent:
March 14, 1989
Assignee:
The Unites States of America as represented by the United States Department of Energy
Abstract: Coupling agents of general formula ##STR1## and their use in a method for the termination of living polymers obtained by the anionic polymerization of dienic and/or vinylaromatic monomers.
Abstract: Described is a process for the preparation of ethylene/vinyl alcohol copolymers with low residual acetate content and low ash levels, and in a form that is easily pelletized. Such polymers have good thermal stability and excellent barrier properties.
Abstract: A microporous powder form polylactide which can take up a multiple of its own weight of active material and which can be used for the controlled release of that active material. The aforesaid microporous polylactide powder can be prepared by dissolving polylactide under warming in phthalicacid diethylester, preferably at a temperature over 150.degree. C. and then slowly cooling the clear solution. The resulting suspension is then subjected to filtering and any remain phthalicacid diethylester preferably removed by extraction. The microporous powder recovered is especially suitable for applying thereto therapeutically active substances for controlled release therefrom and is particularly suitable for utilization in veterinary and human medicine. The microporous powder in this form can be introduced into the body subcutaneously, intramuscularly and intraperitoneally.
Abstract: Continuous dyeing and printing of cellulose fibre material by impregnating the material with a 2-hydroxy-naphthalene-3-carboxylic acid phenyl amide, alkali and nitrite, by crosspadding or over-printing with a dispersion or emulsion of a 4-amino-diphenyl amine as well as acid or acidic salt, and bringing about the development of the dyestuff by drying the fiber material and/or exposing it to sodium carbonate.