Patents Examined by Joseph L. Schoffer
  • Patent number: 4857311
    Abstract: Polyanhydrides with uniform distribution of alkyl and aromatic residues are prepared by melt polycondensation or solution polymerization of p-carboxyphenoxyalkanoic acids or p-carboxyphenylalkanoic acids. These polymers are soluble in common organic solvents and have low melting points, generally in the range of 40.degree.-100.degree. C.The polyanhydrides are especially well suited for forming bioerodible matrices in controlled bioactive compound delivery devices. A polymeric matrix formed according to the method described here degrades uniformly during drug release, preventing the wholescale channeling of the bioactive compound into the environment, and eliminating the problem of the presence of the polymer matrix at the site long after drug release. The polymer displays zero-order kinetic degradation profiles over various periods of time (days to months), at a rate useful for controlled drug delivery.
    Type: Grant
    Filed: July 31, 1987
    Date of Patent: August 15, 1989
    Assignee: Massachusetts Institute of Technology
    Inventors: Abraham J. Domb, Robert S. Langer
  • Patent number: 4851488
    Abstract: A process for polymerizing or copolymerizing a member of the group consisting of an alpha olefin or mixtures thereof, consisting of the steps of:polymerizing an alpha olefin in a polymerization reactor using a polymerization catalyst, a cocatalyst, and an amount of hydrogen adjusted for molecular weight control as measured by melt flow;rapidly changing the melt flow of the polymerized alpha olefin from high to low melt flow by reacting a portion of the unreacted hydrogen in the reactor with a quantity of the alpha olefin present therein by interaction with a hydrogenation catalyst; andremoving the hydrogenation catalyst from the reactor through continuous exchange of the reactor contents.
    Type: Grant
    Filed: April 23, 1987
    Date of Patent: July 25, 1989
    Assignee: Shell Oil Company
    Inventor: Israel G. Burstain
  • Patent number: 4812520
    Abstract: Polymerization of acetylenic monomers is achieved by using a catalyst which is the reaction product of a tungsten compound and a reducing agent effective to reduce W(VI) to W(III) and/or IV), e.g., WCl.sub.6.(organo-Li, organo-Mg or polysilane). The resultant silylated polymers are of heretofore unachievable high molecular weight and can be used as precursors to a wide variety of new acetylenic polymers by application of substitution reactions.
    Type: Grant
    Filed: November 9, 1987
    Date of Patent: March 14, 1989
    Assignee: The Unites States of America as represented by the United States Department of Energy
    Inventor: John M. Zeigler
  • Patent number: 4758630
    Abstract: Zinc and strontium unmixed partial salts of lower alkyl vinyl ether-maleic acid copolymers useful as denture adhesives.
    Type: Grant
    Filed: October 27, 1986
    Date of Patent: July 19, 1988
    Assignee: Richardson-Vicks Inc.
    Inventors: Nutan B. Shah, Michael C. Gounaris, Kenneth T. Holeva
  • Patent number: 4754005
    Abstract: Coupling agents of general formula ##STR1## and their use in a method for the termination of living polymers obtained by the anionic polymerization of dienic and/or vinylaromatic monomers.
    Type: Grant
    Filed: June 20, 1986
    Date of Patent: June 28, 1988
    Assignee: Eniricerche S.p.A.
    Inventors: Arnaldo Roggero, Alberto Gandini
  • Patent number: 4719259
    Abstract: Described is a process for the preparation of ethylene/vinyl alcohol copolymers with low residual acetate content and low ash levels, and in a form that is easily pelletized. Such polymers have good thermal stability and excellent barrier properties.
    Type: Grant
    Filed: April 29, 1985
    Date of Patent: January 12, 1988
    Assignee: Eastman Kodak Company
    Inventor: Waylon L. Jenkins
  • Patent number: 4645664
    Abstract: A microporous powder form polylactide which can take up a multiple of its own weight of active material and which can be used for the controlled release of that active material. The aforesaid microporous polylactide powder can be prepared by dissolving polylactide under warming in phthalicacid diethylester, preferably at a temperature over 150.degree. C. and then slowly cooling the clear solution. The resulting suspension is then subjected to filtering and any remain phthalicacid diethylester preferably removed by extraction. The microporous powder recovered is especially suitable for applying thereto therapeutically active substances for controlled release therefrom and is particularly suitable for utilization in veterinary and human medicine. The microporous powder in this form can be introduced into the body subcutaneously, intramuscularly and intraperitoneally.
    Type: Grant
    Filed: July 31, 1985
    Date of Patent: February 24, 1987
    Assignee: AKZO, NV
    Inventor: Wolfgang Lange
  • Patent number: 3961886
    Abstract: Continuous dyeing and printing of cellulose fibre material by impregnating the material with a 2-hydroxy-naphthalene-3-carboxylic acid phenyl amide, alkali and nitrite, by crosspadding or over-printing with a dispersion or emulsion of a 4-amino-diphenyl amine as well as acid or acidic salt, and bringing about the development of the dyestuff by drying the fiber material and/or exposing it to sodium carbonate.
    Type: Grant
    Filed: September 12, 1974
    Date of Patent: June 8, 1976
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hasso Hertel, Willy Gronen