Abstract: A process for sulfonating internal olefins wherein a dilute solution of the internal olefins in an inert hydrocarbon solvent is sulfonated to produce a reaction mixture containing intermediate sulfonated compounds, the intermediate sulfonated compounds in the reaction mixture being neutralized under conditions to form neutralized sulfonated compounds, the neutralized sulfonated compounds in the reaction mixture being hydrolyzed to form a product mixture containing hydroxy alkane sulfonates and alkene sulfonates that are then recovered.

Abstract: The present invention provides a convenient, simple, safe and efficient one-pot method for the synthesis of a number of diarlyiodonium triflate salts which does not involve sulfuric acid and which eliminates the need for any counter-ion exchange processes.

Abstract: Using in vitro adhesion of recombinant rat L-selectin-Ig or rat neutrophils, it has been demonstrated that these materials bind to sulfatide that has been present in solid phase on a plastic surface. The binding activity appears to have structural requirements, with the sulfate group being critically present in position 3 on the pyranose ring of galactose. When used in vivo, it has been demonstrated that sulfated glycolipids such as brain sulfatide and ganglioside, have significantly protective effects in two models of lung inflammation, the first systemic activation of complement and the second occurring after intrapulmonary deposition of immune complexes. Both inflammatory reactions are complement, neutrophil and selectin-dependent. The protective effects of these compounds are linked to their ability to prevent the recruitment of neutrophils into lung tissue. On the basis of these findings, it is demonstrated by sulfatides and related compounds have significant in vivo anti-inflammatory activities.

Abstract: Compound of formula (I): ##STR1## in which: R.sub.1 represents a hydroxyl, alkoxy or amino (unsubstituted or substituted) group,R.sup.2 represents an unsubstituted or substituted alkyl group,X.sub.1 represents --NH--,X.sub.2 represents --0--,R.sub.3 represents a hydrogen atom or an alkyl or phenyl group,R.sub.4 represents an alkyl group which is always substituted with one or more hydroxyl, benzyloxy, benzyloxycarbonylamino, amino, mono- or dialkylamino, acetoxy or 2,2-dimethyl-1,3-dioxolan-4-yl groups, such groups being identical or different,R.sub.5 represents a 3-indolylmethyl, naphthylmethyl, alkyl, phenyl or benzyl group, its isomers as well as its addition salts with a pharmaceutically acceptable acid or base,and medicinal products containing the same are useful as endothelin convertase inhibitor.

Abstract: Compounds of Formula 1 bind opioid receptors: which binds to the opioid receptor: ##STR1##

Abstract: The invention relates to a catalyst comprising a rare metal of Group VIII of the Periodic Table of Elements which has been deposited on an inert support and which has been used to dehalogenate .alpha.-halogenated carboxylic acids in the presence of hydrogen, and a rare metal of Group VIII of the Periodic Table of Elements which has been deposited on an inert support and which is such that the granulometry of b) is very much lower than that of a) to form a homogeneous mixture as a result of the action of currents of .alpha.-halogenated carboxylic acid and hydrogen wherein said invention is particularly useful for regenerating palladium catalyst used in the purification of crude monochloroacetic acid.

Abstract: The invention is a hard surface abrasive scouring cleanser having no significant syneresis, undue viscosity or yield stress increase, stably suspends abrasives, and has excellent rinsing characteristics. Furthermore, the present invention provides a stably suspended abrasive scouring cleanser which uses relatively small amounts of surfactants, thus lowering the total cost of producing these cleansers. The lesser amount of surfactant also affords the cleanser a milder feel and lower unaesthetic surfactant odor, while also requiring lower levels of fragrance. The absence of solvents results in a less irritating product as well.In one aspect the invention comprises, in aqueous solution:(a) a cross-linked polyacrylate;(b) at least one nonionic surfactant;(c) a pH adjusting agent; and(d) a calcium carbonate abrasive.

Abstract: This invention relates to the novel pharmaceutical compositions of Formulas (I) and (II) each of which comprises a compound of Formula (I) or (II) and a pharmaceutically acceptable diluent or carrier.This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound or composition of Formula (I) or (II).

Abstract: A phenylalanine-glycine derivative of the general formula (I): ##STR1## wherein R represents a residue of an antitumor substance, or a salt or ester thereof, a process for preparation thereof, and a pharmaceutical composition containing the same are described.The novel conjugate of the phenylalanine-glycine derivative and the antitumor substance exhibits superior antitumor activity in comparison with the case wherein an antitumor substance is administered singly or as a mixture with phenylalanine.

Abstract: A composition comprising a mixture of dialkylbenzene monosulfonic acids or salts thereof containing greater than about 60 weight percent of the para dialkylbenzene isomer and greater than about 80 weight percent of the combined di(2-alkyl)benzene and di(3-alkyl)benzene isomers. The composition exhibits improved properties as a mineral collector in ore flotation.

Abstract: The present invention relates to environmentally safe aqueous cleaning compositions comprising alkaline salts, organic adjuvants and a hydrotrope comprised of alkali metal salts of carboxylic acids having a chain length of 7-13 carbon atoms so as to maintain the organic adjuvant in solution.

Abstract: An originally viscous, non-flowable and non-pumpable cleaning composition made less viscous, flowable and pumpable by the addition of psyllium husks to the composition. The cleaning composition includes an oil phase including at least one of a hydrocarbon oil and a hydrocarbon solvent and mixtures thereof, and at least one of a fatty acid and a non-fatty acid soap surfactant; and the water phase including water and a base. The addition of psyllium husks in various amounts relative to the amount of water in the composition makes the composition flowable. In particular, the addition of from about 2 to about 38 percent by weight of psyllium husks has been found to be suitable to provide a flowable composition containing between about 30 and 55 percent water. A method for the preparation of flowable cleaning compositions is also provided. The cleaning composition (13) forms a novel combination with a container (10) as a replacement element for dispensing apparatus.

Abstract: The invention relates to a process for the oxidative preparation of C.sub.5 -C.sub.8 aliphatic dibasic acids by(1) reacting(a) at least one saturated cycloaliphatic hydrocarbon having from 5 to 8 ring carbon atoms in the liquid phase and(b) an excess of an oxygen-containing gas in the presence of(c) a solvent comprising an organic acid containing only primary and/or secondary hydrogen atoms and(d) at least about 0.002 mole per 1000 grams of reaction mixture of a polyvalent heavy metal catalyst;(2) removing the aliphatic dibasic acid; and(3) recycling intermediates, post-oxidation components, and derivatives thereof remaining after removal of the aliphatic dibasic acid into the oxidation reaction.

Abstract: Triterpene derivatives of the formula (I): ##STR1## wherein R.sup.1 is hydrogen or metabolic ester residue; and R.sup.2 is hydrogen or --R.sup.3 --R.sup.4 wherein R.sup.3 is --SO.sub.3 --, --CH.sub.2 COO--, --COCOO--, or --COR.sup.5 COO-- (R.sup.5 is lower alkylene or lower alkenylene), and R.sup.4 is hydrogen or metabolic ester residue or a pharmaceutically acceptable salt thereof, which have anti-endothelin activities and are useful in prophylaxis and treatment of diseases caused by excessive secretion of endothelin.

Abstract: Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

Abstract: Process for producing 10-deacetylbaccatin III from the various parts of the yew (Taxus sp.) by extraction and selective crystallization from a methanolic extract of the plant mass.

Abstract: A novel crystalline modification of 2-dimethylaminoethyl-n-butylaminobenzoate hydrochloride is characterized by a melting point of 148.6.degree..+-.0.3.degree. C. and has an interplanar spacing d and relative intensities defined herein, and a method for making said crystal. The compound of the invention is has local anaesthetic activity and is an active principle of a pharmaceutical preparation for the eyes.

Abstract: A formaldehyde scavenger composition consisting of a water-soluble compound of the formula, wherein ##STR1## --R and R' are the identical or different and are methyl or ##STR2## where m=1-3 and n=1-19, --Y is CH2 or --CH2--CO--CH2 and M and N are hydrogen or lower alkyl.

Abstract: A process for preparing a carboxylic acid having (n+1) carbon atoms (e.g. acetic acid) from an alcohol having n carbon atoms (e.g. methanol) by liquid phase, rhodium catalyses carbonylation is provided. The process is characterized by using a catalyst stabilizer selected from certain classes of imidazolium iodides, alkyl substituted pyridinium iodides and hydroxypyridinium iodides. Most preferred are those derived from the amines 2-ethyl-4-methyl imidazole, 4-ethylpyridine, 4-t-butylpyridine and 3,4-lutidine by quarternisation with a methyl group.

Abstract: Certain new 1,2-dihydroellipticine compounds having activity against CNS specific cancer cell lines because of their ease of passage across the blood-brain barrier are disclosed along with formulations and methods for treating CNS cancers employing these compounds.