Abstract: A method and external device for providing sub-perception stimulation to a patient via an implantable stimulator device is disclosed. Stimulation parameters for the patient are determined that provide sub-perception stimulation to address a symptom of the patient. A schedule is determined to provide scheduled boluses of stimulation, where each bolus comprises a duration during which stimulation is applied to the patient in accordance with the stimulation parameters, and where the scheduled boluses are separated by off times when no stimulation is provided to the patient. Preferably, the duration of each of the scheduled boluses is 3 minutes or longer, and the duration of each of the off times is 30 minutes or greater. Additional boluses can be provided on demand in addition to the scheduled boluses by selecting an option on the external device, although the provision of such additional boluses may be constrained by a lockout period.

Abstract: An example of a system may include a processor subsystem; and a memory device comprising instructions, which when executed by the processor subsystem, cause the processor subsystem to: receive at an application executing on a user device, a request to modify the application; transmit the request to an administrative user device for approval; receive a response to the request from the administrative user device; and modify a functionality of the application in response to receiving the response.

Abstract: For the purpose of efficiently converting a beam profile of laser light with a simple configuration, provided is a beam profile converter including: a first optical fiber that outputs guided light from a first end surface; and a second optical fiber being a multi-mode optical fiber to which the light is input to a second end surface and configured to guide the light, in which a core diameter of the second optical fiber is larger than a core diameter of the first optical fiber at the first end surface, and the light output from the first end surface is input to a core portion of the second end surface at a position separated from an optical axis of the second optical fiber in a direction inclined with respect to the second end surface.

Abstract: A method for tumor suppression. The method includes inserting an active part of a wire into a cancerous tumor, electrostatically stimulating cancer cells of the cancerous tumor by injecting positive electrostatic charges to the cancer cells, and reducing size of the cancerous tumor responsive to the electrostatically stimulating cancer cells of the cancerous tumor. The active part of the wire is located at a first end of the wire. Injecting the positive electrostatic charges to the cancer cells includes accumulating the positive electrostatic charges on the inserted active part of the wire, and generating a positive electrostatic charge flow through the cancerous tumor responsive to accumulating the positive electrostatic charges on the inserted active part of the wire.

Abstract: The present invention generally relates to heart treatment systems. In some aspects, methods and systems are provided for facilitating communication between implanted devices. For example, an implantable cardiac rhythm management device may be configured to communicate with an implantable blood pump. The implantable cardiac rhythm management device may deliver heart stimulation rate information in addition to information associated with any detected abnormalities in heart function. In response, the pump may be configured to adjust pumping by the pump to better accommodate a patient's particular needs.

Abstract: An architecture is disclosed for an Implantable Pulse Generator having improved compliance voltage monitoring and adjustment software and hardware. Software specifies which stimulation pulses are to be measured as relevant to monitoring and adjusting the compliance voltage. Preferably, specifying such pulses occurs by setting a compliance monitoring instruction (e.g., a bit) in the program that defines the pulse, and the compliance monitor bit instruction may be set at a memory location defining a particular pulse phase during which the compliance voltage should be monitored. When a compliance monitor instruction issues, the active electrode node voltages are monitored and compared to desired ranges to determine whether they are high or low. Compliance logic operates on these high/low signals and processes them to decide whether to issue a compliance voltage interrupt to the microcontroller, which can then command the compliance voltage generator to increase or decrease the compliance voltage.

Abstract: An implantable lead system may include an adjustable lead assembly. The lead assembly may include a fixation member and an implantable lead slidably coupled to and rotatable relative to the fixation member. The implantable lead system may include a telescoping delivery system. The delivery system may include an outer catheter and an inner catheter slidably coupled to and rotatable relative to the outer catheter. The lead assembly may be implanted in a cardiac septal wall through the delivery assembly.

Abstract: Implantable medical devices include an enclosure that is constructed by machining of a material rather than by forming or stamping. The machining produces one or more internal features within the enclosure. These internal features may include shelves that may act as a stiffener and create separate compartments within the enclosure. These internal features may include contoured edges along the shelves to accommodate conductors and other structures that extend from one compartment to another. These features may include slots that are present in one or more locations, such as on a surface of one of the shelves. These internal features may also include standoffs that establish a gap between an internal component and the external wall of the enclosure. These internal features may also include different thicknesses in different areas of the enclosure, such as one wall thickness in one compartment and a different wall thickness in another compartment.

Abstract: In certain embodiments, a system for sensing occlusions in an optical system includes a first laser source configured to generate optical signals and a set of optical elements arranged to receive the optical signals from the first laser source and to direct the optical signals along a beam path. The system also includes a detector arranged to receive reflections of the optical signals traveling along at least a portion of the beam path and a control system communicably coupled to the detector. The control system is configured to detect, based on signals generated by the detector, reflection signals associated with the reflections of the optical signals, and disable a second laser source based on detection of the reflection signals.

Abstract: A multicatheter subsystem is provided for a steerable catheter robotic system. The subsystem includes a flexible output sheath, a plurality of flexible multi-lumen assemblies and a plurality of robotic instruments for performing a surgical procedure. The plurality of flexible multi-lumen assemblies extends through the outer sheath. Each of the multi-lumen assemblies has a proximal end and a distal end. Each of the robotic instruments is operatively and removably attachable to the distal end of one of the multi-lumen assemblies such that each instrument is teleoperable independently of every other robotic instrument. At least a first of the robotic instruments includes a plurality of interconnected articulating segments. Each of the articulating segments is operatively and removably attachable to a different one of the multi-lumen assemblies.

Abstract: An optically stimulating module to be integrated into a probe is implantable into a living being with a view to locally illuminating a region of said living being. The module includes a casing that is at least partially transparent, and a hermetic electronic unit placed in the casing. The hermetic electronic unit includes an internal volume housing two light sources, a control and processing unit, and a first photodetector. The module also includes a connecting device for connecting the module to a central control and power unit.

Abstract: The present disclosure facilitates the evaluation of wide-band phase gradient information of the heart tissue to assess, e.g., the presence of heart ischemic heart disease. Notably, the present disclosure provides an improved and efficient method to identify and risk stratify coronary stenosis of the heart using a high resolution and wide-band cardiac gradient obtained from the patient. The patient data are derived from the cardiac gradient waveforms across one or more leads, in some embodiments, resulting in high-dimensional data and long cardiac gradient records that exhibit complex nonlinear variability. Space-time analysis, via numeric wavelet operators, is used to study the morphology of the cardiac gradient data as a phase space dataset by extracting dynamical and geometrical properties from the phase space dataset.

Abstract: A method including causing current to flow from a first electrode of an intra-cochlea electrode array to a second electrode of the intra-cochlea electrode array at a plurality of temporal locations, measuring, at a third electrode and a fourth electrode of the intra-cochlea electrode array, a voltage induced by the flowing current at the plurality of temporal locations and determining that a change between the voltage measurements at the third electrode and the fourth electrode has occurred from the first temporal location to the second temporal location.

Abstract: A remote controller updating system for an implantable blood pump including an implantable blood pump, an implantable controller coupled to the implantable blood pump, and a pump driveline including a data network connection in communication with the implantable controller. The system may also include a pump connector coupled to the pump driveline, a remote controller couplable to the implantable blood pump, and a system update assembly including a system update connector couplable to the pump connector and a power source coupled to the system update connector.

Abstract: In laser-assisted corneal lenticule extraction procedures, the lenticule incision profile includes anterior and posterior lenticule incisions, with one or more of the following features: plano transition zone outside the optical zone, to improve mating of anterior and posterior incision surfaces after lenticule extraction; shallow arcuate incisions above the anterior incision and near the lenticule edge, to improve surface mating; separate ring cut intersecting the anterior and posterior incisions in the transition zone, to reduce tissue bridges and minimize tear at the lenticule edges and facilitate easy lenticule extraction; larger posterior incision, which includes a pocket zone outside the lenticule edge, for better surface mating and bubble management during cutting; and a separate ring shaped pocket cut intersecting the pocket zone of the posterior incision, for bubble management.

Abstract: A system and method for providing diagnostic analysis of a physical condition of a human body. A signal generator, an emitter, a receiver, and processor(s) generate a baseline signal. In some implementations, the emitter may emit the baseline signal through cells of the human body over scanning points for a predetermined amount of time, and a receiver detects reflected signals that have propagated through the cells of the human body. Some implementations include determining, by the one or more processors, a power spectrum density (PSD) of the reflected baseline signal and a spectral variance in the PSD of the reflected baseline signal relative to the baseline signal. Some implementations may compare the spectral variance to one or more predetermined spectral variances corresponding to one or more conditions of the human body and determine the condition of the human body, based on the comparison.

Abstract: An instrument drive unit for use in a robotic surgical system includes a carriage configured to be coupled to a robotic arm, a hub rotationally coupled to the carriage and configured to be non-rotatably coupled to an electromechanical surgical instrument, a plurality of electric motors disposed within the carriage, a plurality of drive shafts rotationally supported in the hub, and a plurality of drive gears. Each electric motor includes a stator and a rotor disposed within the stator. Each drive gear is fixed to a corresponding drive shaft and is configured for interfacing with a corresponding driven member of the electromechanical surgical instrument. Each rotor is configured to rotate a corresponding drive gear in response to an activation of a respective electric motor to actuate a function of the electromechanical surgical instrument.

Abstract: A teleoperational medical system includes a teleoperational control system, a teleoperational manipulator configured for operating a medical instrument in a medical environment, and an operator controller. The teleoperational control system includes a processing unit including one or more processors. The processing unit is configured to determine whether a head portion of an operator of the operator controller is directed toward or away from a display region of a display device based on at least one marker on the operator that is configured to remain substantially fixed relative to the head portion of the operator during a movement of the head portion. The processing unit is further configured to, based on a determination that the head portion is directed away from the display region for at least a threshold time period, enter a standby mode such that movement of the operator controller does not provide corresponding movement to the teleoperational manipulator.

Abstract: A user interface of a computing device for programming a medical device configured to review historical user session data while disconnected from the medical device. During a programming session, the user interface on the computing device may include features to control the functionality of the medical device as well as view and manipulate available data stored at the medical device. The user interface may interactively view screens and features and manipulate data using the programming user interface, e.g., as if the external programming device were in a live programming session with the medical device, but while disconnected from the medical device and not in a live programming session. As one example, the user interface of the external programming device may permit flexible, extensive manipulation and viewing of sensed signals, patient events, and operational information, such as patient adjustments made over time or coincident with particular signals or events.

Abstract: The invention relates to a fluid pump or rotary cutter having at least one first element (9??, 10??) which can be brought from a transport state into an operating state by changing at least one mechanical property. Such a pump can, for example, be a blood pump for the medical, microinvasive area. The object of achieving a transition between the transport state and the operating state which is as comfortable as possible and in so doing leaving a freedom in the design of the corresponding apparatus, in particular of a pump, which is as large as possible, is achieved using the means of the invention in that the first element at least partly comprises a material (24, 25, 26, 27) or can be filled with a material or material mixture which passes through a chemical reaction, in particular cross-linking, or a crystallization for transition into the operating state.