Patents Examined by Joseph M McKane
  • Nitric oxide releasing phosphodiesterase type 5 inhibitor
    Patent number: 11980618
    Abstract: The invention relates to nitric oxide releasing phosphodiesterase type 5 (PDE5) inhibitors of formula or a stereoisomer or a pharmaceutically acceptable salt thereof: useful for the treatment of ocular condition associated with elevated intraocular pressure such as ocular hypertension, glaucoma or retinopathies.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: May 14, 2024
    Assignee: NICOX S.A.
    Inventors: Nicoletta Almirante, Stefania Brambilla, Laura Storoni, Francesco Impagnatiello, Elena Bastia
  • Pyrazole pyrimidine derivative and uses thereof
    Patent number: 11925641
    Abstract: The present invention provides pyrazole pyrimidine derivatives which inhibit Casein kinase I (CKI) and/or Interleukin-1 receptor-associated kinase 1 (IRAKI) and methods of their manufacture, compositions comprising them and uses thereof in methods of treating malignant disease and disorders and methods for treating inflammatory diseases and disorders.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: March 12, 2024
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd
    Inventors: Yinon Ben-Neriah, Guy Brachya, Ido Burstain, Waleed Minzel, Irit Snir-Alkalay, Joseph P. Vacca, Dansu Li
  • Preparation of cyanoacetic esters
    Patent number: 6130347
    Abstract: Cyanoacetic esters are prepared by reacting a corresponding monochloroacetic ester with hydrogen cyanide in the presence of a base, where the base is a compound selected from the group consisting of tertiary amines, salts of carbonic acid, salts of carbonic acid monoesters, salts of carboxylic acids, amidines, guanidines and aromatic N-heterocyclic compounds.
    Type: Grant
    Filed: November 2, 1999
    Date of Patent: October 10, 2000
    Assignee: BASF Aktiengesellschaft
    Inventors: Manfred Julius, Rolf Schneider, Klaus Mundinger, Jakob Fischer