Patents Examined by Joseph Murray
  • Patent number: 6891045
    Abstract: In a process for preparing carbonyldiimidazole from imidazole and phosgene in an inert solvent, the imidazole hydrochloride which results as coupled product is removed as melt from the resulting reaction mixture by phase separation.
    Type: Grant
    Filed: June 14, 1999
    Date of Patent: May 10, 2005
    Assignee: BASF Aktiengesellschaft
    Inventors: Armin Stamm, Jochem Henkelmann
  • Patent number: 6573396
    Abstract: A process for the production of a dialkyl carbonate and a diol from a cyclic carbonate and an aliphatic monohydric alcohol wherein the cyclic carbonate and aliphatic monohydric alcohol are reacted in the presence of a transesterification catalyst to form a crude product stream which contains a dialkyl carbonate, a diol, a hydroxy alkyl carbonate, which is formed as an intermediate of the two step transesterification reaction, unreacted aliphatic monohydric alcohol and unreacted cyclic carbonate. The dialkyl carbonate and unreacted aliphatic monohydric alcohol are separated from the crude product stream and then the hydroxy alkyl carbonate is diminished, reduced or eliminated from the crude product stream, prior to the separation and purification steps needed to recover the diol, resulting in improved yields and product purity.
    Type: Grant
    Filed: October 12, 2001
    Date of Patent: June 3, 2003
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: J. Scott Buchanan, Jose G. Santiesteban, Zhaozhong Jiang
  • Patent number: 6545173
    Abstract: A process for the preparation of arylcyclobutylnitrile derivatives which involves reaction of a solution of a 1,3-dihalopropane and a cyanobenzyl derivative in a substantialy dimethyl sulphoxide-free solvent with a suspension of a base in a substantially dimethyl sulphoxide-free solvent at a temperature of at least 35° C.
    Type: Grant
    Filed: May 28, 1998
    Date of Patent: April 8, 2003
    Assignee: Abbott Laboratories
    Inventors: Stephen John Barker, Sharon Michelle Clark
  • Patent number: 6500978
    Abstract: A process for producing cyclopropanecarbonitrile involves reacting cyclopropanecarbaldoxime with acetic anhydride to obtain a mixture containing acetic acid and cyclopropanecarbonitrile. The acetic acid can be removed from the mixture through azeotropic distillation of acetic acid with a solvent that forms with acetic acid an azeotropic mixture having an azeotropic point lower than the boiling point of the cyclopropanecarbonitrile.
    Type: Grant
    Filed: February 25, 2002
    Date of Patent: December 31, 2002
    Assignee: Kuraray Co., Ltd.
    Inventors: Tatsuhiko Hayashibara, Junko Sato, Eriko Matsuda, Masahiro Torihara, Yoshin Tamai
  • Patent number: 6495533
    Abstract: The present invention relates to phosphoric acid derivatives represented by general formula (I), wherein each symbol is as defined in the description and nontoxic salts thereof. Because of having a TNF&agr; production inhibitory effect, the compounds represented by general formula (I) are useful as preventives and/or remedies for rheumatoid arthritis, ulcerative colitis, Crohn's disease, hepatitis, sepsis, hemorrhagic shock, multiple sclerosis, cerebral infarction, diabetes, interstitial pneumonia, uveitis, pain, glomerulonephritis, HIV-associated diseases, cachexia, myocardial infarction, chronic heart failure, oral aphtha, Hansen's disease, infection, etc.
    Type: Grant
    Filed: August 22, 2001
    Date of Patent: December 17, 2002
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Toshiaki Matsui, Nagashige Omawari
  • Patent number: 6486098
    Abstract: The present invention relates to novel herbicidal phenoxypropionic acid N-alkyl-N-2-fluorophenyl amides represented in formula (1), a method for preparing thereof, their use to control barnyard grass produced from rice and composition as suitable herbicides. In said formula, R is methyl or ethyl group; X is hydrogen, halogen, cyano, C1˜C6 alkyl, C1˜C6 alkoxy, C1˜C3 haloalkyl substituted with 1 to 3 of halogen atom(s), C1˜C3 haloalkoxy substituted with 1 to 3 of halogen atom(s), C2˜C4 alkoxyalkoxy, phenoxy, benzyloxy, C2˜C6 alkenyl, C2˜C6 alkinyl, C2˜C6 alkkenyloxy, C2˜C6 alkinyloxy, or phenyl group; Y is hydrogen or fluoro; n is an integer of 1 or 2 and when n is 2, X can be in a combination of other substituents.
    Type: Grant
    Filed: February 20, 2001
    Date of Patent: November 26, 2002
    Assignee: Dongbu Hannong Chemical Co. Ltd.
    Inventors: Dae Whang Kim, Hae Sung Chang, Young Kwan Ko, Jae Wook Ryu, Jae Chun Woo, Dong Wan Koo, Jin Seog Kim
  • Patent number: 6486340
    Abstract: A method for producing an &agr;-aminonitrile, is disclosed, which method includes the step of oxidizing a tertiary amine with oxygen by using a transition metal catalyst in the presence of a cyanide. The &agr;-aminonitrile thus obtained can be easily converted to amino acids as well as various nitrogen-containing physiologically active materials.
    Type: Grant
    Filed: July 18, 2001
    Date of Patent: November 26, 2002
    Assignee: Osaka University
    Inventors: Shun-ichi Murahashi, Naruyoshi Komiya
  • Patent number: 6482971
    Abstract: The present invention provides a process, which includes: preparing 3-alkoxyacrylonitrile from 3,3-dialkoxypropionitrile by catalytically eliminating alcohol from 3,3-dialkoxypropionitrile in the presence of at least one aromatic sulfonic acid catalyst and at least one high-boiling solvent. Another embodiment of the invention provides a method of producing a pharmaceutical compound, which includes the above-described process. Another embodiment of the invention provides a method of producing a cosmetic product, which includes the above-described process.
    Type: Grant
    Filed: August 6, 2001
    Date of Patent: November 19, 2002
    Assignee: Degussa AG
    Inventors: Renate Paulczynski, Manfred Kaufhold, Artur Hunds
  • Patent number: 6479669
    Abstract: Disclosed are novel compounds, and methods of making the same, represented by Structural Formula II, IX or XXVII: The compounds can be used to prepare combinatorial libraries based on a multicomponent Ugi reaction.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: November 12, 2002
    Assignee: Pharm-Eco Laboratories, Inc.
    Inventors: Richard L. Gabriel, Jurjus Jurayj
  • Patent number: 6479490
    Abstract: This invention relates to inhibitors of glycogen synthase kinase-3&bgr;, methods of treating diseases characterized by an excess of Th2 cytokines, and to 3-indolyl-4-phenyl-1H-pyrrole-2,5-dione derivatives of Formula (I): that are inhibitors of glycogen synthase kinase -3&bgr;, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: July 27, 2001
    Date of Patent: November 12, 2002
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Leyi Gong, Andrew Grupe, Gary Allen Peltz
  • Patent number: 6479689
    Abstract: A method for continuously producing a dialkyl carbonate and a diol, comprising: (1) continuously feeding a cyclic carbonate and an aliphatic monohydric alcohol to a continuous multi-stage distillation column, and continuously effecting a transesterification between the cyclic carbonate and the aliphatic monohydric alcohol in the presence of a transesterification catalyst in the distillation column, while continuously withdrawing a low boiling point mixture in a gaseous form containing the produced dialkyl carbonate and the unreacted aliphatic monohydric alcohol from an upper portion of the distillation column and continuously withdrawing a high boiling point mixture in a liquid form containing the produced diol and the unreacted cyclic carbonate from a lower portion of the distillation column, and (2) continuously feeding the high boiling point mixture withdrawn from the lower portion of the distillation column to a continuous etherification reactor, to thereby effect a continuous etherification reaction betw
    Type: Grant
    Filed: June 11, 2001
    Date of Patent: November 12, 2002
    Assignee: Asahi Kasei Kabushiki Kaisha
    Inventors: Masahiro Tojo, Kazuhiro Oonishi
  • Patent number: 6479688
    Abstract: A process for the formation of a di(hydroxyalkylaryl) aryl phosphate is disclosed which comprises the reaction of an o-alkyl substituted aromatic diol, e.g., an o-alkyl substituted hydroquinone such as o-t-butylhydro-quinone, and monoaryl dihalophosphate, such as monophenyl dichlorophosphate. This process can, in particular, be used to make certain di(hydroxy-o-alkylphenyl) phenyl phosphate compounds, preferably those that are p-hydroxy, such as di(p-hydroxy-o-t-butylphenyl) phenyl phosphate.
    Type: Grant
    Filed: April 15, 2002
    Date of Patent: November 12, 2002
    Assignee: Akzo Nobel NV
    Inventors: Danielle A. Bright, Jeffrey E. Telschow
  • Patent number: 6479698
    Abstract: The invention concerns a method for preparing sulphonate salts, alkaline or alkaline-earth, corresponding to anion of general formula (I):(R—CF2—SO3−)n, through alkaline hydrolysis of sulphonyl chlorides corresponding to formula (II). The invention is characterized in that it comprises at least a step which consists in alkaline hydrolysis of sulphonyl chloride carried out in the presence of a phase-transfer agent.
    Type: Grant
    Filed: March 20, 2002
    Date of Patent: November 12, 2002
    Assignee: Rhodia Chimie
    Inventors: Virginie Pevere, Pierre Danerol
  • Patent number: 6475948
    Abstract: An object of the present invention is to provide an ammoxidation reaction catalyst composed of an Sb—Re compound oxide with which ammoxidation into an unsaturated nitrile such as methacrylonitrile or the like can be performed in the presence of a molecular oxygen-containing gas and ammonia, and a method for manufacturing an unsaturated nitrile such as methacrylonitrile or the like from an aliphatic hydrocarbon such as isobutylene, isobutane or the like using this ammoxidation reaction catalyst. An unsaturated nitrile such as methacrylonitrile or the like is manufactured by subjecting an aliphatic hydrocarbon such as isobutylene, isobutane or the like to vapor phase contact ammoxidation with ammonia and a molecular oxygen-containing gas in the presence of an ammoxidation reaction catalyst composed of an Sb—Re compound oxide such as SbRe2O6 or the like.
    Type: Grant
    Filed: September 7, 2001
    Date of Patent: November 5, 2002
    Assignee: Japan Science and Technology Corporation
    Inventors: Yasuhiro Iwasawa, Takafumi Shido, Haichao Liu
  • Patent number: 6472551
    Abstract: A process for catalytic production of diaryl carbonates by oxidative carbonylation of aromatic hydroxy compounds with carbon monoxide and oxygen achieves water removal during reaction by a process comprising the steps of: removing a liquid stream from an oxidative carbonylation reaction mixture in a reaction vessel, subjecting the liquid stream to reduced pressure, and returning at least a portion of dried liquid stream to the reaction vessel. Typical catalyst systems for oxidative carbonylation contain (A) at least one Group 8, 9, or 10 metal having an atomic number of at least 44 or a compound thereof; (B) at least one alkali metal salt; (C) at least one metal co-catalyst; (D) at least one activating organic solvent; and (E) optionally, at least one base.
    Type: Grant
    Filed: April 11, 2002
    Date of Patent: October 29, 2002
    Assignee: General Electric Company
    Inventors: John Yaw Ofori, Eric James Pressman, Kirill Vladimirovich Shalyaev, Eric Douglas Williams, Richard Anthony Battista
  • Patent number: 6469178
    Abstract: A new process for the catalytic conversion of hydroxymethyl imidazoles to formylimidazoles is described. The reaction takes place in the presence of a peroxide. Formylimidazoles are important intermediate products for pharmaceutical substances.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: October 22, 2002
    Assignee: Lonza AG
    Inventors: Yves Bessard, Josef Heveling
  • Patent number: 6469194
    Abstract: Ethylenically unsaturated organic compounds, for example diolefins, olefinic nitriles and monoolefins, are noncontaminatingly hydrocyanated into corresponding nitriles by (a) reacting such ethylenically unsaturated organic compounds with hydrogen cyanide in the presence of an aqueous solution containing a catalytically effective amount of a catalyst which comprises at least one nickel compound and at least one water-soluble phosphine, (b) thereafter separating the organic phase from the aqueous phase which result, the separated aqueous phase comprising a solid phase formed during hydrocyanation, and (c) thence treating the separated aqueous phase, or a solid phase removed therefrom, with hydrogen cyanide to thus at least partially dissolve said solid phase contained therein or removed therefrom.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: October 22, 2002
    Assignee: Rhodia Fiber & Resin Intermediates
    Inventors: Paolo Burattin, Pierre Coqueret, Marc Huser
  • Patent number: 6469192
    Abstract: High yields of ester-substituted diary carbonates such as bis-methyl salicyl carbonate were obtained by the condensation of ester-substituted phenols with phosgene in the presence of a phase transfer catalyst (PTC) and optionally a tertiary amine catalyst in a solvent free reaction system comprising an aqueous phase held at a pH of 8.3 or higher. The optimized conditions of the present invention use an excess of ester-substituted phenol relative to phosgene and high conversion of phosgene to ester-substituted diaryl carbonate is observed. The product ester-substituted diaryl carbonate may be conveniently isolated as a solid by filtration or as a liquid in which the excess ester-substituted phenols serves as solvent. The method represents an attractive route for the manufacture of bis methyl salicyl carbonate and ester-substituted diaryl carbonates generally.
    Type: Grant
    Filed: July 24, 2001
    Date of Patent: October 22, 2002
    Assignee: General Electric Company
    Inventors: Timothy Brydon Burnell, Patrick Joseph McCloskey, Ganesh Kailasam, James Anthony Cella
  • Patent number: 6469177
    Abstract: N-halamine biocidal materials and coatings are provided. Monomeric oxazolidinones or hydantoins are homopolymerized or copolymerized with other monomers so as to produce materials or coatings, which upon exposure to solutions of chlorine or bromine become biocidal. The biocidal materials and coatings are effective at inactivating microorganisms upon surface contact and are regenerable following loss of efficacy upon further exposure to solutions of chlorine or bromine. Surfaces which could be treated with the materials and coatings include, but are not limited to: glass, plastic, metals, fibers, and wood for use in pool and tank liners, food wrappers, catheters, paints, tiles, shower walls, fabrics, sterile bandages, pipes, medical and dental coatings, preservatives, and the like.
    Type: Grant
    Filed: November 10, 2000
    Date of Patent: October 22, 2002
    Assignee: Auburn University
    Inventors: Shelby D. Worley, Michael W. Eknoian, Yanjun Li
  • Patent number: 6465656
    Abstract: A novel process for making 1,3,5-trisubstituted pyrazoles of the type shown below from appropriate phenyl hydrazines is described. These compounds are useful as factor Xa inhibitors.
    Type: Grant
    Filed: December 3, 2001
    Date of Patent: October 15, 2002
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Jiacheng Zhou, Lynette May Oh, Pasquale N. Confalone, Hui-Yin Li, Philip Ma