Patents Examined by Joseph R. Kosack
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Patent number: 10925968Abstract: Provided herein are cell penetrating compounds having the Formula I: where, generally, each T is a thiol reactive group (e.g., a phosphorothioate), each L is a linker (e.g., a linear alkyl), and Y is a biologic (e.g., an antibody). Also provided are pharmaceutical compositions including the cell penetrating compounds, and methods of delivering the compound into a cell.Type: GrantFiled: June 27, 2019Date of Patent: February 23, 2021Assignee: Sorrento Therapeutics, Inc.Inventors: Yanwen Fu, Gunnar F. Kaufmann, Heehyoung Lee, Tong Zhu, Henry Hongjun Ji
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Patent number: 10927128Abstract: The present invention relates to compounds having pharmacological activity towards the sigma (?) receptor, and more particularly to oxadiazaspiro compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular against drug abuse and addiction.Type: GrantFiled: November 15, 2016Date of Patent: February 23, 2021Assignee: ESTEVE PHARMACEUTICALS. S.A.Inventors: Marina Virgili-Bernado, Carmen Almansa-Rosales, Carlos Alegret-Molina
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Patent number: 10919855Abstract: An alternative and improved process for the preparation of Apremilast (Formula I) and Apremilast form B or a pharmaceutically acceptable salt thereof is provided. The novel process includes hydrogenation in acetone, Cyclization and acetylation followed by condensation in methyl isobutyl ketone (MIBK) and acetic acid mixture in specific volume ratios.Type: GrantFiled: April 27, 2018Date of Patent: February 16, 2021Assignee: UNICHEM LABORATORIES LTDInventors: Dhananjay G. Sathe, Arijit Das, Bhavesh B. Patel, Dipak Subhash Patil, Ashok Govind Matale, Eknath Kamalakar Kshirsagar
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Patent number: 10919868Abstract: Provided are benzotriazole derivative compounds of the general formula that are novel compounds capable of strongly absorbing light in the ultraviolet range, particularly 300-330 nm, while strongly absorbing light in the visible light short-wavelength range up to around 450 nm and being used suitably as a light absorber having high light fastness with a light-blocking function over an extended period of time. Preferably, R1 is a hydrogen atom or alkyl group, R2 is a C1-8 alkyl group, R3 is a hydrogen atom, alkyl group, acryloyloxyalkyl group, or methacryloyloxyalkyl group.Type: GrantFiled: June 3, 2020Date of Patent: February 16, 2021Assignee: SHIPRO KASEI KAISHA, LTD.Inventors: Tomoyuki Ishitani, Toshiyuki Uesaka, Takuya Iwamoto
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Patent number: 10913740Abstract: The invention provides compounds of formula (I): wherein X is and the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.Type: GrantFiled: November 20, 2019Date of Patent: February 9, 2021Assignee: Theravance Biopharma R&D IP, LLCInventors: Paul R. Fatheree, John R. Jacobsen, Gary E. L. Brandt, Noah Benjamin, Marta Dabros, Venkat R. Thalladi
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Patent number: 10907046Abstract: Provided herein are compounds that are able to bind metal ions (e.g., free metal ions or metal ions bound to low affinity ligands) in a sample or subject. Also provided herein are methods of using the compounds for chelating metal ions and for the treatment of diseases associated with abnormal levels of metal ions. Methods of preparing the compounds and pharmaceutical compositions are also provided.Type: GrantFiled: June 29, 2017Date of Patent: February 2, 2021Assignees: The General Hospital Corporation, Northeastern UniversityInventors: Hak Soo Choi, Jonghan Kim, Georges El Fakhri
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Patent number: 10906881Abstract: The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its proteases arginine gingipain A/B (Rgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.Type: GrantFiled: May 9, 2018Date of Patent: February 2, 2021Assignee: CORTEXYME, INC.Inventors: Andrei Konradi, Stephen S. Dominy, Casey C. Lynch, Craig Coburn, Joseph Vacca
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Patent number: 10905668Abstract: The present invention relates to compounds of formula (I) and to pharmaceutical compositions containing them: wherein meanings of the substituents are indicated in the description. Such compounds for use in the treatment of cancer and other diseases related to altered angiogenesis, such as arthritic pathology, diabetic retinopathy, psoriasis and chronic inflammatory disease, are also within the scope of the present invention.Type: GrantFiled: September 28, 2017Date of Patent: February 2, 2021Assignee: BIOGEM S.C. A R.L.Inventors: Claudio Pisano, Sabrina Dallavalle, Raffaella Cincinelli, Lucio Merlini
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Patent number: 10907047Abstract: The present application relates to novel whitening agents for cellulosic substrates. The whitening agents are comprised of at least two constituents: at least one chromophore constituent and at least one polymeric constituent. Suitable chromophore components generally fluoresce blue, red, violet, or purple color when exposed to light, or they may absorb light to reflect these same shades. The whitening agents are further characterized by the polymeric component comprising at least two repeating glycerol units. This disclosure also relates to laundry care compositions including but not limited to liquid and/or powder laundry detergent formulations and rinse added fabric softening (RAFS) compositions that comprise such whitening agents.Type: GrantFiled: March 19, 2020Date of Patent: February 2, 2021Assignee: Milliken & CompanyInventors: Eduardo Torres, Gregory Scot Miracle
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Patent number: 10894247Abstract: A fluidized-bed catalyst suitable for the production of halogenated aromatic nitriles includes an active component and a support. The active component is a complex having the following composition expressed in atomic ratio: VPaCrbAcMdOx, wherein A represents at least one metal selected from the group consisting of alkali metals and alkaline earth metals; M represents at least one element selected from the group consisting of Ti, Zr, Hf, La, Ce, Nb, Mo, W, Co, Zn, Fe, Ni, B, Sb, Bi, As, Ga, Ge, Sn, and In; in the XRD spectrum of the catalyst, diffraction peaks are present at 2?=27.8±0.5° and 2?=13.8±0.5°, and the ratio of the height (I1) of the diffraction peak at 2?=27.8±0.5° to the height (I2) of the diffraction peak at 2?=13.8±0.5° is 3.5-6, i.e. I1:I2=3.5-6.Type: GrantFiled: June 27, 2018Date of Patent: January 19, 2021Assignees: CHINA PETROLEUM & CHEMICAL CORPORATION, SHANGHAI RESEARCH INSTITUTE OF PETROCHEMICAL TECHNOLOGY, SINOPECInventors: Weimin Yang, Longqin Gu, Wei Zeng, Liang Chen, Junfeng Xu
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Patent number: 10894776Abstract: Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.Type: GrantFiled: September 27, 2017Date of Patent: January 19, 2021Assignee: Blade Therapeutics, Inc.Inventors: Brad Owen Buckman, John Beamond Nicholas, Shendong Yuan, Marc Adler, Kumaraswamy Emayan, Jingyuan Ma
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Patent number: 10889580Abstract: Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and methods of use in treating non-alcoholic steatohepatitis are provided. The substituted fused imidazole derivatives may control the activity or the amount or both the activity and the amount of heme-oxygenase.Type: GrantFiled: January 10, 2020Date of Patent: January 12, 2021Assignee: vTv Therapeutics LLCInventors: Adnan M. M. Mjalli, Dharma Rao Polisetti, Jareer Nabeel Kassis, Matthew J. Kostura, Mustafa Guzel, Otis Clinton Attucks, Robert Carl Andrews, Samuel Victory, Suparna Gupta
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Patent number: 10889554Abstract: The present application is directed to excimer forming compounds of Formula I: W—V—[Y]n wherein W is an excimer forming fluorophore, V is a linker moiety, Y is a metal ion coordinating moiety and n is 1, 2 or 3. In particular, the application is directed to excimer forming compounds for the detection of proximally phosphorylated sites including those found on polypeptides, proteins, pyrophosphate and RNA, for example in aqueous solution, polyacrylamide gels blotting membranes, solid-support assays and in cell culture samples.Type: GrantFiled: December 19, 2014Date of Patent: January 12, 2021Assignee: The Governing Council of the University of TorontoInventors: Patrick Thomas Gunning, Dziyana Kraskouskaya
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Patent number: 10882870Abstract: The present invention relates to a crystalline metal organic framework which comprises repeating units of formula (RR)-(IA) or (SS)-(IA) or (RS)-(IA) or (SR)-(IA); or alternatively of formula (RR)-(IB) or (SS)-(IB) or (RS)-(IB) or (SR)-(IB) and a composition containing it. It also relates to processes for their preparation and their uses as a separation agent and as a catalyst.Type: GrantFiled: October 20, 2017Date of Patent: January 5, 2021Assignees: FUNDACIÓ INSTITUT CATALÀ D'INVESTIGACIÓ QUÍMICA (ICIQ), INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATSInventors: Mᵃ de las Nieves Corella Ochoa, Vanesa Lillo García, Jose Ramón Galán Mascaros
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Patent number: 10886479Abstract: The present invention provides a photoelectric conversion element exhibiting excellent responsiveness, and excellent photoelectric conversion efficiency in a case where the photoelectric conversion film is a thin film, an optical sensor, an imaging element which include the photoelectric conversion element, and a compound. The photoelectric conversion element of the present invention includes a conductive film, a photoelectric conversion film, and a transparent conductive film, in this order, in which the photoelectric conversion film contains a compound represented by Formula (1) and having a structure represented by Formula (2).Type: GrantFiled: October 4, 2019Date of Patent: January 5, 2021Assignee: FUJIFILM CorporationInventors: Tomoaki Yoshioka, Kimiatsu Nomura, Eiji Fukuzaki
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Patent number: 10875865Abstract: Disclosed are a class of URAT1 inhibitor compounds and the use of such compounds. These compounds are compounds represented by the structure of formula (I) or pharmaceutically acceptable salts thereof. Experiments show that the compounds provided by the present invention have a very good inhibitory effect on hURAT1-transported uric acid in HEK293 transfected cells, and show that such compounds have a good potential for application in the treatment of hyperuricemia or gout.Type: GrantFiled: November 15, 2017Date of Patent: December 29, 2020Assignee: JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO., LTD.Inventors: Dongfang Shi, Changjin Fu, Xi Cheng, Jianghua Zhu, Jie Gu
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Patent number: 10865336Abstract: A polymer consisting of small functional molecules can be integrated into solar thermal fuels in the solid-state for solar energy harvesting and storage. In certain embodiments, a solar energy storage device can include one or more layers of photoswitchable moieties associated with a polymer. Such solar thermal fuel polymers can be used to enable deposition from low concentration solutions, resulting in uniform and large-area thin-films. This approach enables conformal deposition on a variety of conducting substrates that can be either flat or structured and control over film growth via electrodeposition conditions and results in highly uniform and large-area thin films.Type: GrantFiled: December 11, 2016Date of Patent: December 15, 2020Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Jeffrey C. Grossman, David Zhitomirsky
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Patent number: 10857170Abstract: A SIRT6 activating molecule as shown in Tables 1-3 or a compound according to a pharmacophore as described herein.Type: GrantFiled: December 30, 2016Date of Patent: December 8, 2020Assignee: SirTLab CorporationInventors: Haim Yosef Cohen, Yariv Kanfi
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Patent number: 10858315Abstract: Disclosed in the present specification is a method capable of preparing N-[4-[(1R)-1-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]ethyl]-2,6-difluorophenyl]-methanesulfonamide (INT028-2) with high optical purity, through the selection of Ellman-chiral auxiliaries and the recrystallization and separation of optical isomers. According to the above method, high-purity N-[4-[(1R)-1-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]ethyl]-2,6-difluorophenyl]-methanesulfonamide with excellent quality can be produced at room temperature by improving cryogenic process conditions necessary for realizing high optical purity, and thus the trimming due to the process failure rate can be remarkably reduced.Type: GrantFiled: September 26, 2017Date of Patent: December 8, 2020Assignee: AMOREPACIFIC CORPORATIONInventors: Byoung Young Woo, Ki-Wha Lee, Jihae Lee, Chang Soon Choi, Miyoung Park, Young-Ho Park, Sarva Jayaprakash, Sridhar Regati, Mamidi Srinivas, Krushnakant Patel, M. Ramamohan
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Patent number: 10858306Abstract: The present invention concerns a method of synthesizing a iodo- or astatoarene comprising the reaction of a diaryliodonium compound with a iodide or astatide salt, respectively. The invention also relates to said iodo- or astatoarene and diaryliodonium compound as such. The invention also concerns a method of synthesizing a iodo- or astatolabelled biomolecule and/or vector using said iodo- or astatoarene.Type: GrantFiled: April 9, 2020Date of Patent: December 8, 2020Assignees: INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE NANTES, UNIVERSITE D'ANGERS, THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICESInventors: François Guerard, Jean-François Gestin, Martin W. Brechbiel, Yong-Sok Lee