Abstract: A novel association between IBD and a polymorphism at amino acid residue 241 of ICAM-1 has been discovered. In accordance with the present invention there is provided methods of screening for IBD, methods for treating IBD, antibodies specifically reactive with ICAM-1 encoded by, R241 allele and kits which exploit the inventive methods.
Type:
Grant
Filed:
October 15, 1999
Date of Patent:
April 26, 2005
Assignee:
Cedars-Sinai Medical Center
Inventors:
Jerome I. Rotter, Stephan R. Targan, Huiying Yang, Arthur L. Beaudet, Devendra Vora