Patents Examined by Josephine Young
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Patent number: 6753322Abstract: The present invention relates to compounds of the formula: and pharmaceutically acceptable salts and solvates thereof, and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such compounds.Type: GrantFiled: June 5, 2001Date of Patent: June 22, 2004Assignee: Pfizer IncInventors: Simon John Mantell, Peter Thomas Stephenson
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Patent number: 6663886Abstract: This invention relates generally to the field of therapeutic compounds designed to interfere between the binding of ligands and their receptors on cell surface. More specifically, it provides products and methods for inhibiting cell migration and activation using lipid assemblies with surface recognition elements that are specific for the receptors involved in cell migration and activation.Type: GrantFiled: April 27, 2001Date of Patent: December 16, 2003Assignee: Regents of the University of CaliforniaInventors: Jon O. Nagy, Robert F. Bargatze
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Patent number: 6653289Abstract: The present invention refers to compounds of general formula (I), the pharmaceutically acceptable salts thereof, the processes for their preparation, and the pharmaceutical compositions containing them.Type: GrantFiled: December 18, 2001Date of Patent: November 25, 2003Assignee: Menarini Ricerche S.p.A.Inventors: Fabio Animati, Marco Berettoni, Mario Bigioni, Amalia Cipollone, Carlo Alberto Maggi
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Patent number: 6649753Abstract: This invention relates to the production of new & stable salts of S-adenosyl-L-methionine SAMe). The source of SAMe used in the salt formation is from chemical process wherein stereoselective methylation of S-adenosyl-L-homocysteine is achieved. The process for the salt preparation is simple, efficient & reproducible on large scale. The new salts were found to be stable at accelerated temperature for minimum 3 months.Type: GrantFiled: June 7, 2001Date of Patent: November 18, 2003Assignee: Orchid Chemicals & Pharmaceuticals Ltd.Inventors: Pandurang Balwant Deshpande, Udayampalam Palanisamy Senthilkumar, Subramaniam Ganesan
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Patent number: 6646118Abstract: The present invention relates to a support system for solid phase synthesis of oligomers, such as oligonucleotides, wherein the starting compound is bound to the support via a disiloxyl linkage. Furthermore, the invention relates to a method for synthesis of oligonucleotides on a solid support. The support system comprises a stable disiloxyl linkage providing high nucleoside loadings to the support and the method allows convenient non-laborious oligomer synthesis.Type: GrantFiled: March 25, 2002Date of Patent: November 11, 2003Assignee: Quiatech ABInventors: Marek Kwiatkowski, Mats Nilsson, Ulf Landegren
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Patent number: 6642373Abstract: The present invention relates to improved methods for the preparation of nucleoside phosphoramidites and oligonucleotides. In one aspect, the methods of the invention are used to prepare phosphitylating reagents using pyridinium salts as activators. In a further aspect, the methods of the invention are used to prepare internucleoside linkages using activators which include at least one pyridinium salt and at least one substituted imidazole. In a further aspect, methods are provided preparation of internucleoside linkages between nucleosides having 2′-substituents using imidazolium or benzimidazolium salts as an activator. In a further aspect, methods are provided preparation of internucleoside linkages between nucleosides having bioreversible protecting group that confers enhanced chemical and biophysical properties, without exocyclic amine protection, using imidazolium or benzimidazolium salts as an activator.Type: GrantFiled: December 12, 2002Date of Patent: November 4, 2003Assignee: ISIS Pharmaceuticals, Inc.Inventors: Muthia Manoharan, Vasulinga T. Ravikumar
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Patent number: 6632941Abstract: Chitin is extracted from the shells of exoskeletal animals such as crab, shrimp, crayfish, and lobster, by a primarily physical process comprising the step of cutting the shells in a wet state to approximately uniform particles. The resultant mass is then diluted and mixed to form a pumpable slurry. The slurry is separated to remove most unwanted materials, after which the particle size of the concentrated chitinous residue is further reduced. The once-washed, finely-cut chitinous slurry is again separated, resulting in a chitin end product.Type: GrantFiled: September 14, 2001Date of Patent: October 14, 2003Inventors: James Wooten, Norman S. Singer
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Patent number: 6610843Abstract: The present invention describes transgenic plant cells and plants which due to a reduced activity of a disproportionating enzyme (D enzyme) synthesize a modified starch. Furthermore, the starch synthesized in these plant cells and plants is described.Type: GrantFiled: October 19, 2000Date of Patent: August 26, 2003Assignee: Bayer CropScience GmbHInventors: Jens Kossmann, Franziska Springer, Volker Büttcher
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Patent number: 6596856Abstract: Nucleic acid labeling compounds containing heterocyclic derivatives are disclosed. The heterocyclic derivative containing compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds are suitable for enzymatic attachment to a nucleic acid, either terminally or internally, to provide a mechanism of nucleic acid detection.Type: GrantFiled: February 9, 2001Date of Patent: July 22, 2003Assignee: Affymetrix, Inc.Inventors: Glenn McGall, Anthony D. Barone
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Patent number: 6570008Abstract: The instant invention discloses utilization of a cDNA clone to construct sense and antisense genes for inhibition of starch synthase enzymatic activity in corn.Type: GrantFiled: January 15, 2001Date of Patent: May 27, 2003Assignee: E. I. du Pont de Nemours and CompanyInventors: Karen E. Broglie, Jonathan Edward Lightner
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Patent number: 6548659Abstract: Process for enriching the organic nitrogen content of commercial scale quantities of cellulosic materials which includes the steps of: a) placing substantially dry or unwetted cellulosic material in a pressurizable reactor; b) injecting an ammonia or ammonia-forming nitrogen solution into the reactor until the cellulosic material is approximately submerged; c) setting the temperature in the reactor to maintain a liquid temperature between about 80 and 200° C.; d) pressurizing the reactor to at least 750 psi; e) maintaining the temperature and pressure in the reactor for a period of time sufficient for the organically bound nitrogen content of the cellulosic material to exceed about 1.5%; and f) drying the cellulosic material to a moisture content sufficiently low to arrest microbial activity.Type: GrantFiled: March 30, 2001Date of Patent: April 15, 2003Assignee: The Board of Supervisors of Louisiana State University & Agricultural & Mechanical CollegeInventors: Gary Breitenbeck, Keith Kember