Patents Examined by Joshua A Atkinson
  • Patent number: 12370201
    Abstract: The present disclosure provides ophthalmic compositions comprising a steroid, such as prednisolone encapsulated in a liposomal carrier and methods of use thereof.
    Type: Grant
    Filed: July 10, 2024
    Date of Patent: July 29, 2025
    Assignee: EDEN Ophthalmic PTE Ltd.
    Inventors: Subramanian Venkatraman, Chee Wai Wong, Tina Howden
  • Patent number: 12357618
    Abstract: A rapamycin (RAPA) self-microemulsifying injection includes a drug stock solution and a diluent. The drug stock solution includes a drug solvent, an antioxidant, and RAPA, and the diluent includes a surfactant and water. RAPA is dissolved in the drug solvent. After the stock solution is diluted with the diluent, the solution is self-assembled into a microemulsion under the action of a surfactant, and RAPA is encapsulated in the microemulsion, which improves the solubility and stability of RAPA.
    Type: Grant
    Filed: January 18, 2023
    Date of Patent: July 15, 2025
    Inventor: Pengke Yan
  • Patent number: 12285526
    Abstract: A method for the production of the present disclosure comprises: a) a step of agitating a mixture containing a material to be ground, beads and a dispersion medium in a bead mill; and b) a step of adjusting the pH of the mixture. This method reduces a contamination caused by grinding process using a bead mill.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: April 29, 2025
    Assignees: SHIONOGI & CO., LTD., HIROSHIMA METAL & MACHINERY CO., LTD.
    Inventors: Hironori Tanaka, Yuya Ochii, Tetsuharu Ibaraki
  • Patent number: 12280067
    Abstract: Formulations of creatine, preferably phosphocreatine and most preferably disodium phosphocreatine, combined with cyclodextrin exhibit improved uptake across digestive mucosa, including intestinal, esophageal, and stomach mucosa. In particular, the formulations of the present invention are designed for protection of the cyclodextrin as it comes in contact with gastric juices so as to allow thereafter for unexpectedly improved site-specific intestinal release.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: April 22, 2025
    Assignee: Phenolics, LLC
    Inventors: Michael S Tempesta, F. Joseph Daugherty
  • Patent number: 12280149
    Abstract: Embodiments of the present disclosure relates to a new and improved large scale commercial manufacturing process of making bupivacaine multivesicular liposomes (MVLs). Batches of bupivacaine MVLs prepared by the new process have high yields, improved stabilities, and desired particle size distributions.
    Type: Grant
    Filed: July 2, 2024
    Date of Patent: April 22, 2025
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Eran Levy, Jeffrey S. Hall, John J. Grigsby, Jr.
  • Patent number: 12263238
    Abstract: Compositions and methods for styling the hair are provided. The compositions improve the curl definition, softness, smoothness, sensory feel, and/or frizz control to the hair. Also provided are methods of using the compositions.
    Type: Grant
    Filed: September 30, 2022
    Date of Patent: April 1, 2025
    Assignee: L'OREAL
    Inventors: Stephanie Laga, Allison Perner
  • Patent number: 12257262
    Abstract: Methods of reconstituting lyophilized Annamycin and methods of treating patients are described.
    Type: Grant
    Filed: December 17, 2021
    Date of Patent: March 25, 2025
    Assignees: Board of Regents, The University of Texas System, Moleculin Biotech, Inc.
    Inventors: Donald Picker, Waldemar Priebe
  • Patent number: 12251471
    Abstract: Disclosed herein are embodiments of a nanoparticle composition suitable for delivering a therapeutic agent to a subject by nebulization. The nanoparticle comprises an ionizable lipid, cholesterol or a derivative thereof, a structural lipid, and a PEG lipid. The nanoparticle may partially or completely encapsulate a therapeutic agent, and may be nebulized for administration, such as by inhalation. In some embodiments, the therapeutic agent is mRNA.
    Type: Grant
    Filed: July 25, 2022
    Date of Patent: March 18, 2025
    Assignee: Oregon State University
    Inventors: Jeonghwan Kim, Gaurav Sahay
  • Patent number: 12251470
    Abstract: The invention provides certain specific lipid nanoparticles comprising: (a) one or more nucleic acid molecules; (b) cholesterol; (c) DSPC; (d) PEG-C-DMA; and (e) a cationic lipid; and pharmaceutical compositions comprising the lipid nanoparticles. The lipid nanoparticles and pharmaceutical compositions are particularly useful for delivering a nucleic acid such as siRNA or mRNA to a patient (e.g. a human) or to a cell.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: March 18, 2025
    Assignee: ARBUTUS BIOPHARMA CORPORATION
    Inventors: James Heyes, Adam Judge, Kieu Mong Lam, Lorne Ralph Palmer, Petra Schreiner
  • Patent number: 12239708
    Abstract: A dry powder inhalation formulation includes at least one active pharmaceutical ingredient (API) and a lipid matrix having at least one triglyceride chosen in the group consisting of monohydroxystearin, dihydroxystearin, trihydroxystearin and their mixture and its manufacturing method.
    Type: Grant
    Filed: December 27, 2019
    Date of Patent: March 4, 2025
    Assignee: UNIVERSITÉ LIBRE DE BRUXELLES
    Inventors: Karim Amighi, Nathalie Wauthoz, Rémi Rosière
  • Patent number: 12226533
    Abstract: Silica modified vaterite Janus nanoparticles are provided, together with methods for the synthesis of such particles. The disclosed methods make use of a Pickering emulsion, in a scalable aqueous process. The silica-modified surface is amenable to chemical modification, for example with physiologically acceptable labels.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: February 18, 2025
    Assignee: UTI LIMITED PARTNERSHIP
    Inventors: Giovanniantonio Natale, Harsovin Kaur
  • Patent number: 12201710
    Abstract: A hydrophilic silica/polymer blend is provided comprising (a) a hydrophilic silica powder; and (b) a thickening polymer powder, comprising (i) structural units of C4-8 alkyl (meth)acrylate monomer; (ii) structural units of (meth)acrylic acid monomer; (iii) structural units of (methoxy) poly(ethylene glycol) (meth)acrylate monomer; and (iv) structural units of multiethylenically unsaturated monomer; wherein the weight ratio of hydrophilic silica powder to thickening polymer powder in the hydrophilic silica/polymer blend is 1:9 to 9:1. Also provided are personal care compositions containing same and methods of using same.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: January 21, 2025
    Assignees: Dow Global Technologies LLC, Rohm and Haas Company
    Inventors: Luqing Qi, Liang Chen, Lu Bai, Lyndsay M. Leal, David M. Meunier, Yunshen Chen, Fanwen Zeng
  • Patent number: 12203122
    Abstract: Processes for transesterifying wax esters. Implementations may include: providing a feedstock including wax esters, contacting the feedstock with a lipase, and catalytically transesterifying the wax esters in the feedstock with the lipase to form a transesterified product. An oxidative stability index (OSI) of the transesterified product may be greater than an OSI of the feedstock.
    Type: Grant
    Filed: January 26, 2023
    Date of Patent: January 21, 2025
    Assignee: CARGILL, INCORPORATED
    Inventors: Jeff Addy, James H. Brown, Clay Daly
  • Patent number: 12194017
    Abstract: Methods, compositions of matter, and devices for delivering a therapeutic composition to a heart of a subject using a biopolymer scaffold material are described. In some embodiments, the biopolymer scaffold material including the therapeutic composition may be attached to a first cardiac tissue of a subject. The therapeutic composition is delivered from the biopolymer scaffold material to the heart of the subject.
    Type: Grant
    Filed: August 24, 2022
    Date of Patent: January 14, 2025
    Assignee: Helios Cardio Inc.
    Inventors: Kevin Cornwell, Yiannis Monovoukas, Peter Jackson, Clayton Kaiser
  • Patent number: 12167730
    Abstract: The present invention is directed to agricultural compositions comprising at least one agriculturally active ingredient and gellan gum. The present invention is further directed to tank mixes comprising a high electrolyte composition comprising at least one agriculturally active ingredient and a second composition comprising at least one agriculturally active ingredient, wherein gellan gum is present in the high electrolyte composition or the second composition or is added to the tank mix.
    Type: Grant
    Filed: November 30, 2022
    Date of Patent: December 17, 2024
    Assignee: VALENT U.S.A., LLC
    Inventors: Tak Wai Cheung, Ke Zhou
  • Patent number: 12161115
    Abstract: The present invention relates to compounds of Formula (I), 5 wherein R1, R2, R3, R4 and G are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I), to their use for controlling weeds, in particular in crops of useful plants.
    Type: Grant
    Filed: February 19, 2020
    Date of Patent: December 10, 2024
    Assignee: SYNGENTA CROP PROTECTION AG
    Inventors: Alan Joseph Hennessy, Elizabeth Pearl Jones, Suzanna Jane Dale, Alexander William Gregory, Ian Thomas Tinmouth Houlsby, Yunas Bhonoah, Julia Comas-Barcelo
  • Patent number: 12156924
    Abstract: Provided is an inorganic powder composite used for a water-in-oil type fine dispersion system which is excellent in emulsification and emulsification stability. The inorganic powder composite includes: an inorganic powder; and a first hydrophobic treatment agent, a second hydrophobic treatment agent, and a hydrophilic treatment agent, which cover at least one part of a surface of the inorganic powder, the first hydrophobic treatment agent is a silicon compound, the second hydrophobic treatment agent is a fatty acid, and the hydrophilic treatment agent is hydrous silica.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: December 3, 2024
    Assignee: TAYCA CORPORATION
    Inventors: Shunsuke Mito, Kenji Kayahara, Naoki Kanda
  • Patent number: 12151074
    Abstract: A method of providing therapeutic treatment by delivering therapeutic aptamers locally to a target site using microneedles includes providing complementary sequence modified microneedles by reacting a complementary sequence (CS) with a polymer thereby forming a covalent bond between the polymer and the CS, forming microneedle patches using an initial casting solution consisting of the polymer, the therapeutic aptamer, and a covalent bond between a complementary sequence (CS) and the polymer, thereby loading the therapeutic aptamer into the microneedles, each microneedle having a base, shaft and tip, physically binding the therapeutic aptamer to the CS, inserting the microneedles into the tissue such that the tips and shafts are embedded into the target site and the bases are on a surface of the target site, and sustained release of the aptamer to the target site due to dissociation of the aptamer from the CS over time.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: November 26, 2024
    Assignee: The Penn State Research Foundation
    Inventors: Yong Wang, James Coyne, David Kauffman, Brandon Davis
  • Patent number: 12138366
    Abstract: The present disclosure is concerned with magneto-patterned cell-laden hydrogel materials and methods of making and using those materials. The disclosed materials are useful for, among other things, repair of tissue defects, e.g., tissue at a tissue interface such as a bone-cartilage interface.
    Type: Grant
    Filed: April 13, 2021
    Date of Patent: November 12, 2024
    Assignees: The United States Government as Represented by the Department of Veterans Affairs, The Trustees of the University of Pennsylvania
    Inventors: Hannah M. Zlotnick, Andrew Todd Clark, Robert L. Mauck, Xuemei Cheng
  • Patent number: 12109293
    Abstract: The instant disclosure relates to a cosmetic composition containing high amounts of lactone polyols and to methods for treating skin with the compositions. The cosmetic compositions include: (a) poly C10-30 alkyl acrylate; (b) at least 5 wt. % of one or more lactone polyols; (c) one or more nonionic emulsifiers; (d) one or more fatty compounds; and (e) water. In addition, the amount of the one or more lactone polyols in the composition is typically at least 10-fold higher than the amount of the poly C10-30 alkyl acrylate in the composition.
    Type: Grant
    Filed: December 30, 2022
    Date of Patent: October 8, 2024
    Assignee: L'OREAL
    Inventors: Jonathan James Faig, Yon Jae Yoon, Rukil Patel