Patents Examined by Joshua A Atkinson
-
Patent number: 12370201Abstract: The present disclosure provides ophthalmic compositions comprising a steroid, such as prednisolone encapsulated in a liposomal carrier and methods of use thereof.Type: GrantFiled: July 10, 2024Date of Patent: July 29, 2025Assignee: EDEN Ophthalmic PTE Ltd.Inventors: Subramanian Venkatraman, Chee Wai Wong, Tina Howden
-
Patent number: 12357618Abstract: A rapamycin (RAPA) self-microemulsifying injection includes a drug stock solution and a diluent. The drug stock solution includes a drug solvent, an antioxidant, and RAPA, and the diluent includes a surfactant and water. RAPA is dissolved in the drug solvent. After the stock solution is diluted with the diluent, the solution is self-assembled into a microemulsion under the action of a surfactant, and RAPA is encapsulated in the microemulsion, which improves the solubility and stability of RAPA.Type: GrantFiled: January 18, 2023Date of Patent: July 15, 2025Inventor: Pengke Yan
-
Patent number: 12285526Abstract: A method for the production of the present disclosure comprises: a) a step of agitating a mixture containing a material to be ground, beads and a dispersion medium in a bead mill; and b) a step of adjusting the pH of the mixture. This method reduces a contamination caused by grinding process using a bead mill.Type: GrantFiled: February 28, 2020Date of Patent: April 29, 2025Assignees: SHIONOGI & CO., LTD., HIROSHIMA METAL & MACHINERY CO., LTD.Inventors: Hironori Tanaka, Yuya Ochii, Tetsuharu Ibaraki
-
Patent number: 12280067Abstract: Formulations of creatine, preferably phosphocreatine and most preferably disodium phosphocreatine, combined with cyclodextrin exhibit improved uptake across digestive mucosa, including intestinal, esophageal, and stomach mucosa. In particular, the formulations of the present invention are designed for protection of the cyclodextrin as it comes in contact with gastric juices so as to allow thereafter for unexpectedly improved site-specific intestinal release.Type: GrantFiled: April 23, 2019Date of Patent: April 22, 2025Assignee: Phenolics, LLCInventors: Michael S Tempesta, F. Joseph Daugherty
-
Patent number: 12280149Abstract: Embodiments of the present disclosure relates to a new and improved large scale commercial manufacturing process of making bupivacaine multivesicular liposomes (MVLs). Batches of bupivacaine MVLs prepared by the new process have high yields, improved stabilities, and desired particle size distributions.Type: GrantFiled: July 2, 2024Date of Patent: April 22, 2025Assignee: Pacira Pharmaceuticals, Inc.Inventors: Eran Levy, Jeffrey S. Hall, John J. Grigsby, Jr.
-
Patent number: 12263238Abstract: Compositions and methods for styling the hair are provided. The compositions improve the curl definition, softness, smoothness, sensory feel, and/or frizz control to the hair. Also provided are methods of using the compositions.Type: GrantFiled: September 30, 2022Date of Patent: April 1, 2025Assignee: L'OREALInventors: Stephanie Laga, Allison Perner
-
Patent number: 12257262Abstract: Methods of reconstituting lyophilized Annamycin and methods of treating patients are described.Type: GrantFiled: December 17, 2021Date of Patent: March 25, 2025Assignees: Board of Regents, The University of Texas System, Moleculin Biotech, Inc.Inventors: Donald Picker, Waldemar Priebe
-
Patent number: 12251471Abstract: Disclosed herein are embodiments of a nanoparticle composition suitable for delivering a therapeutic agent to a subject by nebulization. The nanoparticle comprises an ionizable lipid, cholesterol or a derivative thereof, a structural lipid, and a PEG lipid. The nanoparticle may partially or completely encapsulate a therapeutic agent, and may be nebulized for administration, such as by inhalation. In some embodiments, the therapeutic agent is mRNA.Type: GrantFiled: July 25, 2022Date of Patent: March 18, 2025Assignee: Oregon State UniversityInventors: Jeonghwan Kim, Gaurav Sahay
-
Patent number: 12251470Abstract: The invention provides certain specific lipid nanoparticles comprising: (a) one or more nucleic acid molecules; (b) cholesterol; (c) DSPC; (d) PEG-C-DMA; and (e) a cationic lipid; and pharmaceutical compositions comprising the lipid nanoparticles. The lipid nanoparticles and pharmaceutical compositions are particularly useful for delivering a nucleic acid such as siRNA or mRNA to a patient (e.g. a human) or to a cell.Type: GrantFiled: November 8, 2019Date of Patent: March 18, 2025Assignee: ARBUTUS BIOPHARMA CORPORATIONInventors: James Heyes, Adam Judge, Kieu Mong Lam, Lorne Ralph Palmer, Petra Schreiner
-
Patent number: 12239708Abstract: A dry powder inhalation formulation includes at least one active pharmaceutical ingredient (API) and a lipid matrix having at least one triglyceride chosen in the group consisting of monohydroxystearin, dihydroxystearin, trihydroxystearin and their mixture and its manufacturing method.Type: GrantFiled: December 27, 2019Date of Patent: March 4, 2025Assignee: UNIVERSITÉ LIBRE DE BRUXELLESInventors: Karim Amighi, Nathalie Wauthoz, Rémi Rosière
-
Patent number: 12226533Abstract: Silica modified vaterite Janus nanoparticles are provided, together with methods for the synthesis of such particles. The disclosed methods make use of a Pickering emulsion, in a scalable aqueous process. The silica-modified surface is amenable to chemical modification, for example with physiologically acceptable labels.Type: GrantFiled: December 2, 2019Date of Patent: February 18, 2025Assignee: UTI LIMITED PARTNERSHIPInventors: Giovanniantonio Natale, Harsovin Kaur
-
Patent number: 12201710Abstract: A hydrophilic silica/polymer blend is provided comprising (a) a hydrophilic silica powder; and (b) a thickening polymer powder, comprising (i) structural units of C4-8 alkyl (meth)acrylate monomer; (ii) structural units of (meth)acrylic acid monomer; (iii) structural units of (methoxy) poly(ethylene glycol) (meth)acrylate monomer; and (iv) structural units of multiethylenically unsaturated monomer; wherein the weight ratio of hydrophilic silica powder to thickening polymer powder in the hydrophilic silica/polymer blend is 1:9 to 9:1. Also provided are personal care compositions containing same and methods of using same.Type: GrantFiled: April 16, 2020Date of Patent: January 21, 2025Assignees: Dow Global Technologies LLC, Rohm and Haas CompanyInventors: Luqing Qi, Liang Chen, Lu Bai, Lyndsay M. Leal, David M. Meunier, Yunshen Chen, Fanwen Zeng
-
Patent number: 12203122Abstract: Processes for transesterifying wax esters. Implementations may include: providing a feedstock including wax esters, contacting the feedstock with a lipase, and catalytically transesterifying the wax esters in the feedstock with the lipase to form a transesterified product. An oxidative stability index (OSI) of the transesterified product may be greater than an OSI of the feedstock.Type: GrantFiled: January 26, 2023Date of Patent: January 21, 2025Assignee: CARGILL, INCORPORATEDInventors: Jeff Addy, James H. Brown, Clay Daly
-
Patent number: 12194017Abstract: Methods, compositions of matter, and devices for delivering a therapeutic composition to a heart of a subject using a biopolymer scaffold material are described. In some embodiments, the biopolymer scaffold material including the therapeutic composition may be attached to a first cardiac tissue of a subject. The therapeutic composition is delivered from the biopolymer scaffold material to the heart of the subject.Type: GrantFiled: August 24, 2022Date of Patent: January 14, 2025Assignee: Helios Cardio Inc.Inventors: Kevin Cornwell, Yiannis Monovoukas, Peter Jackson, Clayton Kaiser
-
Patent number: 12167730Abstract: The present invention is directed to agricultural compositions comprising at least one agriculturally active ingredient and gellan gum. The present invention is further directed to tank mixes comprising a high electrolyte composition comprising at least one agriculturally active ingredient and a second composition comprising at least one agriculturally active ingredient, wherein gellan gum is present in the high electrolyte composition or the second composition or is added to the tank mix.Type: GrantFiled: November 30, 2022Date of Patent: December 17, 2024Assignee: VALENT U.S.A., LLCInventors: Tak Wai Cheung, Ke Zhou
-
Patent number: 12161115Abstract: The present invention relates to compounds of Formula (I), 5 wherein R1, R2, R3, R4 and G are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I), to their use for controlling weeds, in particular in crops of useful plants.Type: GrantFiled: February 19, 2020Date of Patent: December 10, 2024Assignee: SYNGENTA CROP PROTECTION AGInventors: Alan Joseph Hennessy, Elizabeth Pearl Jones, Suzanna Jane Dale, Alexander William Gregory, Ian Thomas Tinmouth Houlsby, Yunas Bhonoah, Julia Comas-Barcelo
-
Patent number: 12156924Abstract: Provided is an inorganic powder composite used for a water-in-oil type fine dispersion system which is excellent in emulsification and emulsification stability. The inorganic powder composite includes: an inorganic powder; and a first hydrophobic treatment agent, a second hydrophobic treatment agent, and a hydrophilic treatment agent, which cover at least one part of a surface of the inorganic powder, the first hydrophobic treatment agent is a silicon compound, the second hydrophobic treatment agent is a fatty acid, and the hydrophilic treatment agent is hydrous silica.Type: GrantFiled: October 18, 2019Date of Patent: December 3, 2024Assignee: TAYCA CORPORATIONInventors: Shunsuke Mito, Kenji Kayahara, Naoki Kanda
-
Patent number: 12151074Abstract: A method of providing therapeutic treatment by delivering therapeutic aptamers locally to a target site using microneedles includes providing complementary sequence modified microneedles by reacting a complementary sequence (CS) with a polymer thereby forming a covalent bond between the polymer and the CS, forming microneedle patches using an initial casting solution consisting of the polymer, the therapeutic aptamer, and a covalent bond between a complementary sequence (CS) and the polymer, thereby loading the therapeutic aptamer into the microneedles, each microneedle having a base, shaft and tip, physically binding the therapeutic aptamer to the CS, inserting the microneedles into the tissue such that the tips and shafts are embedded into the target site and the bases are on a surface of the target site, and sustained release of the aptamer to the target site due to dissociation of the aptamer from the CS over time.Type: GrantFiled: August 27, 2019Date of Patent: November 26, 2024Assignee: The Penn State Research FoundationInventors: Yong Wang, James Coyne, David Kauffman, Brandon Davis
-
Patent number: 12138366Abstract: The present disclosure is concerned with magneto-patterned cell-laden hydrogel materials and methods of making and using those materials. The disclosed materials are useful for, among other things, repair of tissue defects, e.g., tissue at a tissue interface such as a bone-cartilage interface.Type: GrantFiled: April 13, 2021Date of Patent: November 12, 2024Assignees: The United States Government as Represented by the Department of Veterans Affairs, The Trustees of the University of PennsylvaniaInventors: Hannah M. Zlotnick, Andrew Todd Clark, Robert L. Mauck, Xuemei Cheng
-
Patent number: 12109293Abstract: The instant disclosure relates to a cosmetic composition containing high amounts of lactone polyols and to methods for treating skin with the compositions. The cosmetic compositions include: (a) poly C10-30 alkyl acrylate; (b) at least 5 wt. % of one or more lactone polyols; (c) one or more nonionic emulsifiers; (d) one or more fatty compounds; and (e) water. In addition, the amount of the one or more lactone polyols in the composition is typically at least 10-fold higher than the amount of the poly C10-30 alkyl acrylate in the composition.Type: GrantFiled: December 30, 2022Date of Patent: October 8, 2024Assignee: L'OREALInventors: Jonathan James Faig, Yon Jae Yoon, Rukil Patel