Patents Examined by Julia Ha
  • Protease-activated receptor-2 modulators
    Patent number: 11091533
    Abstract: Provided herein are peptides comprising a mutated fragment of a wild-type protease-activated receptor-2 (PAR2). The peptides comprising a hydrophobic moiety can penetrate the cell membrane and act as an antagonist of PAR2. Also provided herein are compositions and cells comprising the peptides and methods of using the peptides.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: August 17, 2021
    Assignee: Oasis Pharmaceuticals, LLC
    Inventor: Richard Looby
  • Anti-HIV peptides
    Patent number: 10538556
    Abstract: Simple ?-hairpin peptides in linear and cyclic form that specifically bind to HIV-1 Trans-Activation Response element (HIV-1 TAR), as well as compositions and use thereof are described.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: January 21, 2020
    Assignees: Colorado State University Research Foundation, University of Rochester
    Inventors: Brian R. McNaughton, David W. Crawford, Joseph E. Wedekind, Ivan A. Belashov
  • Toll-like receptor 4 (TLR4) antagonist
    Patent number: 10435443
    Abstract: Provided is a peptide that binds to a toll-like receptor 4 (TLR4)/myeloid differentiation factor 2 (MD2) composite and inhibit secretion of interleukin-6 (IL-6), nitrogen monoxide (NO) and reactive oxygen species (ROS), and activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF?B) and mitogen-activated protein kinases (MAPKs) via inhibiting a TLR4 signaling pathway induced by a liphopolysaccharide (LPS); a TLR4 antagonist including the peptide; and a composition thereof for preventing or treating autoimmune diseases and inflammatory diseases.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: October 8, 2019
    Assignee: Genesen Co., Ltd.
    Inventors: Sangdun Choi, Tae Hyeon Yoo, Seol Hee Park
  • Method and drug composition for treating septic shock hypotension
    Patent number: 8846606
    Abstract: Provided herein are methods and compositions for treating septic hypotension. More specifically, the methods may comprise, administering one alpha-2 agonist or other sympatholytic and at least one vasopressor.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: September 30, 2014
    Inventor: Luc Quintin
  • Treatment of endometriosis
    Patent number: 7615210
    Abstract: A method of combating menorrhagia, dysmenorrhoea or endometriosis in a female individual that includes administering to the individual at least one agent that reduces the effect of prokineticin 1 on a prokineticin receptor.
    Type: Grant
    Filed: August 24, 2004
    Date of Patent: November 10, 2009
    Assignee: Medical Research Council
    Inventors: Henry Nicolas Jabbour, Robert Peter Millar
  • Peptides and medicinal compositions containing the same
    Patent number: 7332473
    Abstract: This invention provides a pharmaceutical composition comprising, as an active ingredient, a peptide derived from a PACAP or VIP peptide or a pharmaceutically acceptable salt thereof. This invention provides a PACAP/VIP derivative that can inhibit tautomerization in a solution and that can be applied to clinical applications over a long period of time. Such peptides are useful for ameliorating symptoms of diseases, such as regressive neurodegenerative diseases, erectile dysfunction, and bronchial asthma.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: February 19, 2008
    Assignee: Itoham Foods Inc.
    Inventors: Satomi Onoue, Kousuke Endo, Asami Matsumoto