Patents Examined by Jyothsna Denkat
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Patent number: 5474783Abstract: The method of adjusting the saturation concentration of a drug in a transdermal composition for application to the dermis, which comprises mixing polymers having differing solubility parameters, so as to modulate the delivery of the drug. This results in the ability to achieve a predetermined permeation rate of the drug into and through the dermis. In one embodiment, a dermal composition of the present invention comprises a drug, an acrylate polymer, and a polysiloxane. The dermal compositions can be produced by a variety of methods known in the preparation of drug-containing adhesive preparations, including the mixing of the polymers, drug, and additional ingredients in solution, followed by removal of the processing solvents. The method and composition of this invention permit selectable loading of the drug into the dermal formulation and adjustment of the delivery rate of the drug from the composition through the dermis, while maintaining acceptable shear, tack, and peel adhesive properties.Type: GrantFiled: June 27, 1991Date of Patent: December 12, 1995Assignee: Noven Pharmaceuticals, Inc.Inventors: Jesus Miranda, Steven Sablotsky
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Patent number: 5441740Abstract: Compositions containing at least one alpha hydroxyacid, salicylic acid, and at least one digestive enzyme derived from fruit are disclosed for cosmetic uses in the treatment of various skin conditions such as lack of adequate skin firmness, wrinkles, and dry skin. Various formulations of the compositions including gels, creams, lotions and ointments are disclosed for topical use. The alpha hydroxyacids include glycolic acid, lactic acid and citric acid. The digestive enzymes include bromelain and papain.Type: GrantFiled: May 6, 1994Date of Patent: August 15, 1995Assignee: Longevity Network. Ltd.Inventor: Susan N. Ozlen
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Patent number: 5286862Abstract: The present invention relates to a process for the preparation of compounds of the formula I ##STR1## where X is CH.dbd.CH, N.dbd.CH, CH.dbd.N or S,R.sup.1 and R.sup.2 independently of one another are H, halogen, alkyl, alkoxy, alkylthio, haloalkyl, haloalkoxy, haloalkylthio or the bivalent methylenedioxy group,R.sup.3 is a radical of the formulae (A), (B) or (C) ##STR2## where R.sup.4 and R.sup.5 independently of one another are H, halogen, alkyl, alkoxy or a radical of the formula (D) ##STR3## in which R.sup.6 is H or halogen andY is CH.sub.2, O or S, andm, n, o, p and q are 0, 1, or 2, which comprises reacting a compound of the formula IIH.sub.2 C.dbd.CH--CH.sub.2 --R.sup.3 (II)where R.sup.3 is as defined in formula I, with dichloromethylsilane in the presence of a catalyst suitable for hydrosilylation reactions, and reacting the resulting intermediate of the formula III ##STR4## where R.sup.Type: GrantFiled: August 24, 1989Date of Patent: February 15, 1994Assignee: Hoechst AktiengesellschaftInventor: Hans H. Schubert
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Patent number: 5218119Abstract: The present invention relates to racemic or optically active cis octahydro-indolo [2,3-a] quinolizine diester derivatives.Type: GrantFiled: January 13, 1992Date of Patent: June 8, 1993Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Janos Kreidl, Maria Farkas nee Kirjak, Katalin Nogradi, Ida Deutsch nee Juhasz, Judit Meszaros nee Brill, deceased, Bela Stefko, Gyorgy Visky, Zsuzsanna Aracs nee Tischler, Bela Benke, Maria Stiller, Ferenc Drexler
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Patent number: 5155220Abstract: The invention concerns intermediates having the formula ##STR1## wherein R is 2-propylpentyl optionally with one, two or three internal unsaturated bonds, or 2-substituted-2-propylpentyl optionally with one or two internal unsaturated bonds wherein the 2-substituent is a leaving group.Type: GrantFiled: February 19, 1991Date of Patent: October 13, 1992Assignee: Kabi Pharmacia AktiebolagInventors: Sven Hernestam, Bernt Thelin, Elisabeth Seifert, Arne Nilsson
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Patent number: 5153334Abstract: Partially fluorinated tetracarboxylic acid and the dianhydride thereof, a process for their preparation and their useA compound of the formula ##STR1## and the dianhydride thereof are prepared by air oxidation in the presence of a catalyst mixture composed of at least 2 heavy metal salts and also bromine in an acid organic medium. The compounds can be employed for the preparation of partially fluorinated polycondensates, such as polyimides, polycarboxamides, esters of polyamidecarboxylic acids, polyamides and imide-oligomers.Type: GrantFiled: June 20, 1991Date of Patent: October 6, 1992Assignee: Hoechst AktiengesellschaftInventors: Freimund Rohrscheid, Wolfgang Appel, Gunter Siegemund
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Quinoline substituted naphthalenepropionic acid derivatives as anti-inflammatory/antiallergic agents
Patent number: 5084575Abstract: There are disclosed compounds of the formula ##STR1## wherein a is alkyl 3-19 carbon atoms, diloweralkyl allyl, diahaloallyl, diphenylallyl, lower alkynyl, ##STR2## W is --CR.sub.2 O--, --CH.dbd.CH-- or --CH.dbd.CHCH.sub.2 O-- X is N or CR;Z is ##STR3## R is hydrogen or lower alkyl; Y is ##STR4## R.sup.1 is hydrogen, lower alkyl or phenyl; R.sup.2 is hydrogen or lower alkyl; orR.sup.1 and R.sup.2 taken together form a benzene ring, optionally substituted by halo;R.sup.3 is --OR, ##STR5## -- NHSO.sub.2 R.sup.4 ; R.sup.4 is phenyl or loweralkyl substituted phenyl;R.sup.5 is halo;and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as alelrgic rhinitis, allergic bronchial asthma and the like, in psoriasis, ulcerative colitis, rheumatoid arthritis as well as in other immediate hypersensitivity reactions.Type: GrantFiled: September 6, 1990Date of Patent: January 28, 1992Assignee: American Home Products CorporationInventors: Anthony F. Kreft, III., John H. Musser, James J. Bicksler, John W. Giberson, Dennis M. Kubrak, Annette L. Banker -
Patent number: 5068426Abstract: Crude organic solutions of N,N-dialkylcarbamoylmethylphosphine oxide compounds can be purified by treatment with a first row transition metal salt to form a complex which can be treated to regenerate a purified solution of the compound. The first row transition metal can be selected from the monobasic acid salts of zinc, for example.Type: GrantFiled: January 19, 1990Date of Patent: November 26, 1991Assignee: Akzo N.V.Inventor: Jeffrey E. Telschow
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Patent number: 5049691Abstract: Phosphorus compounds having at least one chlorine, bromine or iodine bonded directly to phosphorus are transhalogenated with fluorine by reaction with anhydrous hydrogen fluoride in an inert solvent, e.g., xylene, methylene chloride, in a manner such that said anhydrous hydrogen fluoride is added to said phosphorus compound at a rate such that said anhydrous hydrogen fluoride reacts with said phosphorus compound without the accumulation of an amount of unreacted anhydrous hydrogen fluoride which is sufficient to cause substantial decomposition of the desired fluorophosphorus product.Type: GrantFiled: March 5, 1990Date of Patent: September 17, 1991Assignee: Ethyl CorporationInventors: Edward A. Burt, Lester P. J. Burton, Meng-Sheng Ao, Barbara C. Stahly
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Patent number: 5041567Type: GrantFiled: November 28, 1988Date of Patent: August 20, 1991Assignee: Beecham Group plcInventors: Norman H. Rogers, Peter J. O'Hanlon, Graham Walker, Michael J. Crimmin
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Patent number: 5015636Abstract: Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof, R.sup.1 is hydrogen, alkyl or aryl unsubstituted or substituted by one or two halo moieties, R.sup.3 is hydrogen or alkyl, A is N, W is O or NR.sup.3 wherein R.sup.3 is hydrogen, alkyl, acyl, haloacyl, 2alkoxycarbonyl or (5-methyl-2-oxo-1,3-dioxolen-4-yl) methyl are useful for treating bacterial infections in humans and animals.Type: GrantFiled: August 3, 1989Date of Patent: May 14, 1991Assignee: Nippon Shinyaku Co., Ltd.Inventors: Masahiro Kise, Masakuni Ozaki, Kenji Kazuno, Yoshifumi Tomii, Jun Segawa, Shoji Yasufuki