Abstract: The present disclosure is directed to methods of treating a steatosis-associated disorder and methods of treating a cytoplasmic glycogen storage disorder, including glycogen storage disease I, glycogen storage disease III, glycogen storage disease IV, and/or conditions associated with a PRKAG2 mutation, by administering a therapeutic agent selected from a lysosomal enzyme, an autophagy-inducing agent, or a combination thereof. Steatosis-associated disorders discussed herein include GSD Ia, GSD Ib, GSD Ic, NAFLD, and NASH. Other embodiments are directed to methods of reversing steatosis, modulating autophagy, inducing autophagy, and reversing glycogen storage. Methods of treating a cytoplasmic glycogen storage disorder by administering a lysosomal enzyme and a second therapeutic agent are also described. Other embodiments are directed to methods of treating a cytoplasmic glycogen storage disorder by administering a therapeutic agent as an adjunctive therapy to lysosomal enzyme replacement therapy.
Type:
Grant
Filed:
August 21, 2021
Date of Patent:
July 16, 2024
Assignee:
Duke University
Inventors:
Priya Kishnani, Baodong Sun, Dwight D. Koeberl
Abstract: Disclosed are pharmaceutical compositions comprising a combination of five or more phages and a pharmaceutically acceptable carrier, as well as methods of treating, reducing, or preventing a disease caused by Mycobacterium tuberculosis in a mammal, methods of treating an antibiotic resistant infection in a mammal, and methods of treating, reducing, or preventing activation of a latent disease caused by M. tuberculosis.
Type:
Grant
Filed:
April 8, 2022
Date of Patent:
June 25, 2024
Assignee:
University of Pittsburgh the Commonwealth System of Higher Education
Abstract: An improved bacterial oil treatment composition or pool for handling a decommissioned oil cable, which may be laid in particular as part of a power grid in the ground. The invention further relates to a bacteria growth culture medium containing the bacterial oil treatment composition for refurbishing an oil cable and a corresponding use.
Type:
Grant
Filed:
July 29, 2020
Date of Patent:
June 18, 2024
Assignee:
TIBIO SAGL
Inventors:
Davide Staedler, Thibaud Spinetti, Marco Torriani
Abstract: The present invention provides methods for the cultivation of the Methylobacterium genus of bacteria. In particular the method provides methods for the efficient and inexpensive cultivation of these bacteria. Additionally, the invention provides methods for the utilization of these bacterial cultures to improve plant agriculture.
Abstract: Microbial starter cultures. More specifically, a method for preparing a microbial culture such as a lactic acid bacteria (LAB) starter culture wherein at least one microbial strain such as a lactic acid bacteria and at least one inactivated yeast strain is inoculated in a culture medium.
Type:
Grant
Filed:
December 10, 2020
Date of Patent:
May 14, 2024
Assignee:
Chr. Hansen A/S
Inventors:
Neda Faraghiparapari, Marie Penderup Jensen, Jakub Kovacs, Anisha Goel
Abstract: Soil plant productivity is improved by manipulation of soil microflora. The soil microflora is manipulated by addition of a bacterium belonging to Rhizobium (Rhizobiales) to the soil.
Abstract: The invention relates to systems and methods for effective production and use of microorganisms and/or the fermentation broth in which they are produced. Advantageously, the system is cost-effective, scalable, quick, versatile, efficacious, and helpful in reducing resistance to chemical compounds and residue that concerns consumers.
Type:
Grant
Filed:
August 10, 2023
Date of Patent:
April 16, 2024
Assignee:
LOCUS SOLUTIONS IPCO, LLC
Inventors:
Sean Farmer, Paul S. Zorner, Ken Alibek, Kent Adams, Tyler Dixon
Abstract: Methods, compositions, and kits are provided for rapidly analyzing microbial growth and/or number in a plurality of water-in-oil emulsion droplets.
Type:
Grant
Filed:
March 4, 2022
Date of Patent:
April 9, 2024
Assignee:
BIO-RAD EUROPE GMBH
Inventors:
Christophe Quiring, Christine Favier, Patrice Sarfati, Jean Francois Mouscadet, Ronald Lebofsky, Rebecca Dievart
Abstract: This invention provides, in part, various compositions and methods for protecting the gastrointestinal microbiome from antibiotic disruption.
Type:
Grant
Filed:
February 2, 2023
Date of Patent:
April 2, 2024
Assignee:
Theriva Biologics, Inc.
Inventors:
Michael Kaleko, Sheila Connelly, Vincent John Wacher
Abstract: An enhanced caffeinated beverage composition includes a caffeinated drink combined with an effective blend of methylliberine and theacrine providing increased mood, energy, alertness, focus, motivation, and/or decreased fatigue without adversely affecting heart rate or blood pressure.
Type:
Grant
Filed:
February 21, 2023
Date of Patent:
March 12, 2024
Assignee:
ORTHO-NUTRA, LLC
Inventors:
Hector L. Lopez, Tim N. Ziegenfuss, Matthew Titlow
Abstract: In one aspect, nutraceutical compositions, methods of preparation and methods of use comprise a nutraceutical composition comprising an antimicrobial hevamine A-related protein from Momordica balsamina alone or in combination with one or more nutraceutical ingredients. In another aspect, a method of preventing or treating a microbial infection in a plant comprises applying an effective amount of a composition containing the hevamine A-related protein to a whole plant, plant part, or media in which the plant is growing. In a further aspect, the present application provides a transgenic plant stably transformed with a polynucleotide encoding the hevamine A-related protein.
Type:
Grant
Filed:
June 7, 2022
Date of Patent:
March 12, 2024
Assignee:
Morehouse School of Medicine
Inventors:
Michael Powell, Erick Vidjin' Agnih Gbodossou
Abstract: The process of making a biocomposite material utilize a bacterial species and a fungal species in an agricultural feedstock composed of a substrate of non-nutrient discrete particles and a nutrient material wherein the bacterial species imparts mechanical properties to the biocomposite material and the fungal species binds the biocomposite material. Both bacterium and fungus can be genetically engineered to produce desired properties within the microbial communities.
Abstract: A method for reducing hemolysis and microparticle formation during storage of pathogen reduced blood. Oxygen reduced blood compositions comprising SAGM and riboflavin having reduced hemolysis. Oxygen reduced blood compositions comprising SAGM and riboflavin having reduced microparticles. Oxygen and pathogen reduced blood compositions comprising CPAD and riboflavin having reduced hemolysis. Oxygen and pathogen reduced blood compositions comprising SAGM and riboflavin having reduced microparticles.
Type:
Grant
Filed:
September 23, 2021
Date of Patent:
February 27, 2024
Assignee:
Hemanext Inc.
Inventors:
Samuel O. Sowemimo-Coker, Jeffrey Sutton, Tatsuro Yoshida
Abstract: Stabilized use solutions of low phosphorus, alkali metal carbonate detergents employing enzymes for cleaning compositions are disclosed. In particular, the present invention is a composition for, and method of, removing soils, preventing redeposition of protein soils and reducing foam, using stabilized enzyme cleaning compositions, namely use solutions of the same.
Type:
Grant
Filed:
March 30, 2021
Date of Patent:
February 20, 2024
Assignee:
ECOLAB USA INC.
Inventors:
Wendy Chan, Jennifer Stokes, Lyndal Jensen, Carter M. Silvernail, Terrence P. Everson, Graig Legatt, Nathan Richard Ortmann, Devon Beau Hammel
Abstract: A method for preparing a protein-containing sample for analysis by mass spectrometry includes introducing the sample into a reaction vessel. The reaction vessel contains a reagent mixture including pre-measured quantities of an immobilized proteolytic enzyme, a reducing agent and an alkylating agent. The contents of the reaction vessel are activated by heating or by sonication.
Type:
Grant
Filed:
August 5, 2021
Date of Patent:
February 20, 2024
Assignee:
Thermo Finnigan LLC
Inventors:
Daniel Lopez Ferrer, Aaron M. Robitaille, Michael O. Krawitzky, Greg A. Foster
Abstract: This invention provides, in part, various compositions and methods for protecting the gastrointestinal microbiome from antibiotic disruption from orally administered antibiotics.
Abstract: The disclosure relates to methods for the screening, identification, and/or application of one or more microorganisms of use in imparting one or more beneficial properties to one or more plants.
Type:
Grant
Filed:
July 11, 2022
Date of Patent:
January 9, 2024
Assignee:
BioConsortia, Inc.
Inventors:
Peter Wigley, Caroline George, Susan Turner
Abstract: Provided is a fermentation fungal substance of Astragalus membranaceus/Paecilomyces cicadae and its use. The fermentation fungal substance is obtained by solid fermentation with Astragalus membranaceus powder as a fermentation substrate and Paecilomyces cicadae as a fermentation strain. The fermentation fungal substance of Astragalus membranaceus/Paecilomyces cicadae in the present disclosure plays a significant role in treating hyperuricemia and/or hypertriglyceridemia.
Type:
Grant
Filed:
September 2, 2020
Date of Patent:
January 9, 2024
Inventors:
Jiayu Zhang, Long Dai, Shaoping Wang, Zikai Geng, Yuqi Wang
Abstract: The disclosure is directed to cleaning compositions, methods of making the cleaning compositions, and methods of using the cleaning compositions. The cleaning compositions comprise an enzyme composition and a nonionic surfactant having an HLB between 10 and 22. Preferably, the enzyme compositions included in the cleaning compositions comprise a cellulase, an AA9 polypeptide having cellulolytic enhancing activity, a hemicellulase, an esterase, an expansin, a laccase, a ligninolytic enzyme, a pectinase, a peroxidase, a protease, a swollenin, or a combination or mixture thereof. The compositions are useful for degradation of bacterial cellulose.