Abstract: A pharmaceutical composition comprising a compound of formula 1 wherein: n is 1 or 2; R1 is hydrogen, C1–C4-alkyl, halogen, OH, or —O—C1–C4-alkyl; R2 is hydrogen, C1–C4-alkyl, halogen, OH, or —O—C1–C4-alkyl; R3 is hydrogen, C1–C4-alkyl, OH, halogen, —O—C1–C4-alkyl, —O—C1–C4-alkylene-COOH, or —O—C1–C4-alkylene-CO—O—C1–C4-alkyl, or an acid addition salt thereof with a pharmacologically acceptable acid, or a solvate or hydrate thereof; and a pharmaceutically acceptable excipient or carrier, and methods for using the pharmaceutical formulation in the treatment of chronic obstructive pulmonary disease (COPD).
Type:
Grant
Filed:
November 10, 2003
Date of Patent:
June 6, 2006
Assignee:
Boehringer Ingelheim Pharma GmbH & Co. KG
Inventors:
Ingo Konetzki, Kurt Schromm, Hermann Schollenberger, Sabine Pestel, Andreas Schnapp, Thierry Bouyssou, Frank Buettner, Claudia Heine, Philipp Lustenberger, Christoph Hoenke, Klaus Rudolf
Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S are described.
Type:
Grant
Filed:
August 10, 2001
Date of Patent:
October 21, 2003
Assignee:
Ortho-Pharmaceutical, Inc.
Inventors:
Hui Cai, James P. Edwards, Steven P. Meduna, Barbara A. Pio, Jianmei Wei