Patents Examined by Kahsay T. Habte
  • Therapeutic agents useful for treating pain
    Patent number: 7964606
    Abstract: The present invention discloses compounds of formula: where Ar1, Ar2, X, R3, and m are as disclosed herein or a pharmaceutically acceptable salt thereof (a “Phenylene Compound”); compositions comprising an effective amount of a Phenylene Compound; and methods for treating or preventing pain and other conditions in an animal comprising administering to an animal in need thereof an effective amount of a Phenylene Compound.
    Type: Grant
    Filed: July 29, 2010
    Date of Patent: June 21, 2011
    Assignee: Purdue Pharma L.P.
    Inventor: Qun Sun
  • Pyridazine derivatives and their use as therapeutic agents
    Patent number: 7964591
    Abstract: Methods of treating an SCD-mediated skin disorder or condition in a mammal, preferably a human include administering to a mammal in need thereof a compound of formula (I): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: June 21, 2011
    Assignees: Novartis Pharma AG, Xenon Pharmaceuticals Inc.
    Inventors: Andreas Billich, Michael D. Winther, Yigal Paul Goldberg
  • And practical process for exclusively producing (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3,de][1,4]benzoxazine-6-carboxylic acid hemihydrate
    Patent number: 7964723
    Abstract: A novel and practical process for selectively producing a pyridobenzoxazine carboxylic acid hemihydrate (e.g., (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3-de] [1,4]benzoxazine-6-carboxylic acid hemihydrate) in high yield via crystallization from an organic solvent or a mixed organic solvent system containing a calculated amount of water released from sodium sulfate decahydrate under gradually heating.
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: June 21, 2011
    Assignee: Apeloa-Kangyu
    Inventors: Zheqing Wang, Lijan Shu, Weifeng Guo, HangChang Zhu, Pingai Yang, Xiaofeng Shen, Chenming Jin
  • Substituted pyridoxazines
    Patent number: 7960377
    Abstract: The invention provides compounds having the structure of formula I, and prodrugs, stereoisomers, racemates, salts, hydrates, solvates, acid salt hydrates and isomorphic crystalline forms thereof, wherein A, Y and the groups R1, R2, R3 and R4 are defined in the specification. These compounds can be administered in pharmaceutical formulations to modulate cannabinoid receptor activity for the prevention and treatment of a variety of diseases and conditions, including pain, inflammation and pruritis.
    Type: Grant
    Filed: March 24, 2009
    Date of Patent: June 14, 2011
    Assignee: Cara Therapeutics, Inc.
    Inventors: Jason S. Newcom, Stephen J. O'Connor, Gary R. Gustafson
  • Benzo-fused heterocycles
    Patent number: 7960376
    Abstract: The present invention provides benzo-fused heterocyclic compounds having the structure of formula I, as well as prodrugs, stereoisomers, racemates, salts, hydrates, solvates, acid salt hydrates and isomorphic crystalline forms thereof. The compounds directly or indirectly modulate the activity of one or more cannabinoid receptors and can be incorporated into pharmaceutical preparations that are useful for the prevention and treatment of a variety of diseases and conditions, including pain, inflammation and pruritis.
    Type: Grant
    Filed: September 10, 2008
    Date of Patent: June 14, 2011
    Assignee: Cara Therapeutics, Inc.
    Inventors: Jason S. Newcom, Carla M. Gauss, Gary R. Gustafson
  • Methods of synthesis and/or purification of diaminophenothiazinium compounds
    Patent number: 7956183
    Abstract: A method for the synthesis of a diaminophenothiazinium compound of the following formula: comprising (a) purifying a corresponding reduced compound which is N-acylated at the heterocyclic nitrogen; (b) deacylating the purified compound to provide the corresponding reduced compound; and (c) oxidizing the reduced compound to provide the diaminophenothiazinium compound. Optional purification may performed, for example, after deacylating and after oxidizing. The method provides high purity diaminophenothiazinium compounds which are suitable for pharmaceutical and related therapeutic uses. Such uses include inactivating pathogens, the treatment of the infectious diseases, and for the treatment of diseases of protein aggregation, such as tauopathies, including Alzheimer's disease.
    Type: Grant
    Filed: July 10, 2007
    Date of Patent: June 7, 2011
    Assignee: WisTa Laboratories Ltd.
    Inventors: Claude Michel Wischik, John Mervyn David Storey, Colin Marshall, James Peter Sinclair, Thomas Craven Baddeley
  • Intramolecular C-H amination with sulfonyl azides
    Patent number: 7956193
    Abstract: Cobalt (II) complexes of porphyrins are effective catalysts for intramolecular nitrene insertion of C—H bonds with arylsulfonyl azides. The cobalt-catalyzed process can proceed efficiently under mild and neutral conditions in low catalyst loading without the need of other reagents or additives, generating nitrogen gas as the only byproduct.
    Type: Grant
    Filed: May 5, 2008
    Date of Patent: June 7, 2011
    Assignee: University of South Florida
    Inventors: X. Peter Zhang, Joshua V. Ruppel
  • Inhibitors of human immunodeficiency virus replication
    Patent number: 7956068
    Abstract: The present invention relates to compounds of formula (I) wherein c, X, Y, R2, R3, R4 and R6 are as defined herein, compositions and uses thereof for treating human immunodeficiency virus (HIV) infection. In particular, the present invention provides novel inhibitors of HIV integrase, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HIV infection.
    Type: Grant
    Filed: November 3, 2008
    Date of Patent: June 7, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Rebekah J. Carson, Lee Fader, Stephen Kawai, Serge R. Landry, Youla S. Tsantrizos, Christian Brochu, Sebastien Morin, Mathieu Parisien, Bruno Simoneau
  • Anti-infective agents
    Patent number: 7951800
    Abstract: The present invention provides HCV polymerase inhibiting compounds having the formula (I): where R1 is cyclobutyl-N(Ra)—, n is 1, 2, 3 or 4, and at least one R5 is RaSO2N(Rj)alkyl-. In a non-limiting example, a compound of the present invention is N-[(3-{1-[(cyclobutyl)amino]-4-hydroxy-2-oxo-1,2-dihydro-quinolin-3-yl}-1,1-dioxo-1,4-dihydro-1?6-thieno[2,3-e][1,2,4]thiadiazin-7-yl)methyl]methanesulfonamide. The present invention also features compositions comprising the compounds of the present invention or pharmaceutically acceptable salts, stereoisomers or tautomers thereof, and methods of using the same to treat or prevent HCV infection.
    Type: Grant
    Filed: November 6, 2009
    Date of Patent: May 31, 2011
    Assignee: Abbott Laboratories, Inc.
    Inventors: Rolf Wagner, Pamela L. Donner, Dale J. Kempf, Clarence J. Maring, Vincent S. Stoll
  • 2,4,6-phenyl-substituted cyclic ketoenols
    Patent number: 7947704
    Abstract: The invention relates to novel 2,4,6-phenyl-substituted cyclic ketoenols of the formula (I), in which CKE, W, X and Y are as defined above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides, and also to selective herbicidal compositions comprising firstly the 2,4,6-phenyl-substituted cyclic ketoenols and secondly at least one compound which improves crop plant tolerance.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: May 24, 2011
    Assignee: Bayer CropScience AG
    Inventors: Thomas Bretschneider, Reiner Fischer, Oliver Gaertzen, Klaus Kunz, Stefan Lehr, Dieter Feucht, Peter Lösel, Olga Malsam, Guido Bojack, Christian Arnold, Thomas Auler, Martin Jeffrey Hills, Heinz Kehne, Chris Rosinger
  • Bicyclic-substituted amines as histamine-3 receptor ligands
    Patent number: 7947711
    Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
    Type: Grant
    Filed: August 21, 2008
    Date of Patent: May 24, 2011
    Assignee: Abbott Laboratories
    Inventors: Marlon D. Cowart, Yu-ming Pu, Yi-Yin Ku
  • Chiral fused [1,2]imidazo[4,5-C] ring compounds
    Patent number: 7943609
    Abstract: Fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a —CH(—X1—R1)-group in the fused ring at the 1-position of the imidazo ring, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
    Type: Grant
    Filed: December 29, 2005
    Date of Patent: May 17, 2011
    Assignee: 3M Innovative Proprerties Company
    Inventors: George W. Griesgraber, Tushar A. Kshirsagar, Azim A. Celebi, Sarah J. Slania, Michael E. Danielson, Michael J. Rice, Joshua R. Wurst
  • Benzamidine derivative, process for the preparation thereof and pharmaceutical composition comprising same
    Patent number: 7943646
    Abstract: The present invention relates to a novel benzamidine derivative, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The benzamidine derivative of the present invention effectively inhibits osteoclast differentiation at an extremely low concentration, and greatly increases the trabecular bone volume, and thus it can be advantageously used for the prevention and treatment of osteoporosis.
    Type: Grant
    Filed: January 31, 2007
    Date of Patent: May 17, 2011
    Assignee: Dong Wha Pharmaceutical Co., Ltd.
    Inventors: Jei Man Ryu, Jin Soo Lee, Young Goo Jin, Ki Young Lee, Jae Hoon Park, Yun Ha Hwang, Sae Kwang Ku
  • 5,6-dihydro-1H-pyridin-2-one compounds
    Patent number: 7939524
    Abstract: The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I wherein X is N, and A is and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Grant
    Filed: April 2, 2008
    Date of Patent: May 10, 2011
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Chinh V. Tran, Frank Ruebsam, Douglas E. Murphy, Peter Dragovich, Yuefen Zhou, Lijian Chen, David Kucera
  • Enantiomeric pure beta agonists, manufacturing and use as a medicaments thereof
    Patent number: 7939658
    Abstract: The present invention relates to enantiomerically pure compounds of formula 1 wherein the groups m, n, B, X, R1, m and Ym? may have the meanings given in the claims and specification, methods for preparing them and their use as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints.
    Type: Grant
    Filed: April 7, 2009
    Date of Patent: May 10, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Uwe Ries, Peter Sieger
  • Hydroxylation of ?-dicarbonyls with zirconium catalysts
    Patent number: 7939685
    Abstract: The present invention pertains to a process for preparing a compound of Formula I that is achiral, racemic or enantiomerically enriched at the hydroxylation center indicated by * comprising contacting a compound of Formula II with an oxidant selected from oxygen, hydrogen peroxide, peracids or alkyl hydroperoxides in the presence of a zirconium complex, wherein R1, R2 and R3 are as defined in the disclosure. This invention also pertains to zirconium complexes useful in this procedure comprising zirconium and a ligand of Formula III or its enantiomer wherein J, R6 and n are as defined in the disclosure. This invention further pertains to a compound of Formula III or its enantiomer.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: May 10, 2011
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Albert Loren Casalnuovo
  • Oxabispidine compounds for the treatment of cardiac arrhythmias
    Patent number: 7928225
    Abstract: There is provided compounds of formula I, wherein R1, R2, R3, R41 to R46, X, Y and Z have meanings given in the description, which compounds are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
    Type: Grant
    Filed: June 12, 2006
    Date of Patent: April 19, 2011
    Assignee: AstraZeneca AB
    Inventors: Annika Björe, David Cladingboel, Gareth Ensor, Adam Herring, Johan Kajanus, Robert Lundqvist, Christina Olsson, Carl-Gustav Sigfridsson, Gert Strandlund
  • Cyclopentaphenanthrene-based compound and organic electroluminescent device using the same
    Patent number: 7919654
    Abstract: Provided are a cyclopentaphenanthrene-based compound and an organic EL device using the same. The cyclopentaphenanthrene-based compound is easy to prepare and excellent in solubility, color purity, and color stability. The cyclopentaphenanthrene-based compound is useful as a material for forming an organic layer, in particular, a light-emitting layer in an organic EL device, and as an organic dye or an electronic material such as a nonlinear optical material.
    Type: Grant
    Filed: August 4, 2010
    Date of Patent: April 5, 2011
    Assignee: Samsung Mobile Display Co., Ltd.
    Inventors: Sang-Hoon Park, Che-Un Yang, Jong-Jin Park, Jhun-Mo Son, O-Hyun Kwon, Yu-Jin Kim
  • Pyridine derivatives and their use in the treatment of psychotic disorders
    Patent number: 7919491
    Abstract: A pyridine derivative novel compounds of formula (I) or a pharmaceutically acceptable salt thereof where all variables are defined herein. The compounds are useful in the treatment of psychotic disorders.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: April 5, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Giuseppe Alvaro, Sandro Belvedere
  • C-phenyl-substituted cyclic keto-enols used as pesticides and herbicides
    Patent number: 7915282
    Abstract: The present invention relates to novel C2-phenyl-substituted cyclic ketoenols of the formula (I) in which W, X, Y, Z and CKE are as defined in the description, to processes for their preparation and to their use as pesticides and herbicides.
    Type: Grant
    Filed: March 21, 2001
    Date of Patent: March 29, 2011
    Assignee: Bayer Aktiengesellschaft
    Inventors: Michael Ruther, Hermann Hagemann, Udo Schneider, Markus Dollinger, Peter Dahmen, Ulrike Wachendorff-Neumann, Reiner Fischer, Alan Graff, Thomas Bretschneider, Christoph Erdelen, Mark Wilhelm Drewes, Dieter Feucht, Folker Lieb