Abstract: An optical fiber multi-parameter sensing system and method are provided. The optical fiber multi-parameter sensing system comprises a light source, an optical circulator, a fiber-tip probe sensor and an optical spectrum analyzer, wherein the fiber-tip probe sensor can be placed into an analyte without changing the characteristics of the analyte. The variation of a bulk parameter that is a bulk refractive index of bulk environment around the fiber-tip probe sensor and a surface parameter which is a thickness of surface dielectric layer of the fiber-tip probe sensor can be determined simultaneously by monitoring the changing of resonance intensity and resonance wavelength of a single fiber-tip leaky mode resonance. The sensing system optionally configured such that multiple parameters in the analyte around the fiber-tip probe sensor can be obtained by detecting a single resonance peak.