Abstract: Disclosed herein are cold slurry formulations, devices, and methods for alleviating symptoms of ocular surface discomfort. Cold slurry formulations comprising ice, a freezing temperature depressant, and, optionally, a lipid are disclosed. Devices and methods for protecting a target ocular surface from contacting a cold slurry formulation that is used to maintain the target ocular surface at a temperature desired for alleviating symptoms of ocular surface discomfort are disclosed. Self-contained devices configured to receive a cold slurry formulation for maintaining the target ocular surface at a temperature desired for alleviating symptoms of ocular surface discomfort are disclosed. Devices and methods are disclosed for protecting a cornea and/or eyelid of a subject from the freezing cold slurry formulation that is directly or indirectly applied or injected into the target ocular surface.

Abstract: A system is provided for use with a subject suffering from cancer that includes one or more primary or metastatic solid tumors. The system includes nanoparticles including a magnetic metallic core and a phase-change material (PCM) that surrounds the magnetic metallic core and is configured to absorb latent heat of fusion by undergoing a phase change that occurs at a phase-change temperature of 42-80 degrees C. A radiofrequency (RF) transmitter is configured to transmit energy, in a pulse train alternating between high power and low power at a pulse frequency of 1 Hz-5 Hz, to at least a portion of the subject's body, such so that the nanoparticles are heated to the phase-change temperature of the PCM, and store energy from the pulse train in the PCM as latent heat of fusion. Other embodiments are also described.

Abstract: A system for laparoscopic thermal treatment of visceral fat includes an elongate cooling probe configured for placement through a trocar, the probe including an elongate shaft having a proximal end and a distal end and having a maximum transverse dimension, and an expandable endpiece having a proximal end and a distal end, and including a collapsed state configured for placement through a channel of the trocar and an expanded state, the expanded state having a maximum outer diameter, the maximum outer diameter at least about twice the maximum transverse dimension of the shaft, wherein the proximal end of the endpiece is sealingly coupled to the distal end of the shaft, and a heat exchanger coupled to the cooling probe and configured to remove heat from the endpiece such that adipose tissue placed in contact with the endpiece can be cooled to a temperature of between about 2° C. and about +1° C.

Abstract: A catheter has at least two irrigated ablation electrodes and a coaxial irrigation tubing to transport fluid to the electrodes by separate and dedicated flow paths. A valve is used to control flow of fluid into the coaxial irrigation tubing by means of a plunger assembly that allows fluid to flow through one lumen of the coaxial irrigation tubing while regulating the flow into the other lumen of the coaxial irrigation tubing in response to the fluid flow rate and pressure applied to the plunger assembly.

Abstract: Systems and methods directed to a renal sheath, one or more electrode pairs in the renal sheath, and a wiring system configured to connect the one or more electrode pairs to an electric current. The renal sheath can include a distal end portion, a proximal end portion, and a medial portion between the distal and proximal end portions. The medial portion can include the one or more electrode pairs. The one or more electrode pairs can be configured to produce heat sufficient to induce hemostasis in bleeding tissue surrounding the renal sheath. The wiring system can be configured to connect the one or more electrode pairs to the electric current to produce the heat sufficient to effect the hemostasis. In some embodiments, an electrosurgical generator can be configured to provide an alternating current to the one or more electrode pairs to produce the heat sufficient to effect the hemostasis.

Abstract: A portable hand warmer charging case includes a case body. A placement chamber configured to place a hand warmer unit for charging is provided on the case body. The case body is provided with a first circuit board, a first charging unit, and a first battery. The first battery and the first charging unit are electrically connected to the first circuit board. When the hand warmer unit is placed in the placement chamber, the first circuit board is configured to output electrical energy, which is output by the first battery, from the first charging unit; and the first charging unit is configured to be adapted to a second charging unit on the hand warmer unit for use and transmit the electrical energy output by the first circuit board to the second charging unit on the hand warmer unit.

Abstract: A radiation-free heating pad and a processing technology thereof is provided. The radiation-free heating pad includes heating wires, a fiber layer, a flexible shielding layer, and a reinforcement layer. The heating wires are uniformly arranged on the fiber layer in a serpentine pattern, a layer of aluminum foil is arranged on each of an upper side and a lower side of the fiber layer, and the aluminum foil tightly wraps the heating wire. The flexible shielding layer is arranged outside the aluminum foil, and the reinforcement layer is arranged outside the flexible shielding layer. The radiation-free heating pad is based on the Faraday cage effect, and an electromagnetic field generated when an electric current passes through the heating wire can be effectively counteracted by a double shielding structure composed of the aluminum foil and the flexible shielding layer.

Abstract: The present invention relates to a pulsed radio frequency therapy system adapted to project the beam onto the skin surface of a living body overlying a problem region, the beam serving to relieve pain and to obtain other health related beneficial effects. The system includes an energy-generating unit in which a radio-frequency carrier is over-modulated by a sonic signal to produce periodic bursts of radio-frequency energy whose repetition rate corresponds to the frequency of the signal. The output of the unit is fed to a tank circuit tuned to the carrier frequency and housed within the barrel of a portable applicator gun. Supported within the barrel and coupled to the tank circuit is a discharge electrode whose tip is adjacent to the mouth of the barrel whereby a pulsed radio frequency is projected from the tip. The portable applicator gun includes automated applicator coil tuning, automated coil protection, and a phase-up conditioning system.

Abstract: A therapeutic apparatus is disclosed, comprising a signal generator configured for generating a therapeutic signal, a treatment head, multiple sets of electrodes arranged on the treatment head, a switch circuit connected between the signal generator and multiple sets of electrodes, and a control unit connected with the switch circuit, and by the control unit controlling on-off of the switch circuit, the signal generator is controlled to be connected with at least one set of electrodes to output the therapeutic signal. Through the therapeutic apparatus, energy can be controlled to be output only to the local area, so as it can be attached to the surface of the skin in the narrow space and treat the skin in the narrow space. When only part of the electrodes are connected with the signal generator, the output power of the signal generator can be concentrated on outputting the therapeutic signal.

Abstract: Muscles held under tension undergo a chemical reaction that generates heat within the muscle, and subsequently that heat contributes to muscle fatigue. Research in the field of physiology and sports medicine has demonstrated that actively cooling an athlete's core body temperature can rapidly rejuvenate a fatigued muscle thereby allowing the athlete to extend the muscle's potential. Mammalians have several areas of glabrous tissue wherein a dense network of veins near the surface of the skin act as heat exchangers for cooling and regulating their core temperature. The process for effective cooling via glabrous tissue is optimized within a narrow range of temperatures. Presented herein is a handheld cooling device which is optimized for the efficient transfer of heat away from the fatigued muscles via direct contact with glabrous tissue.

Abstract: An in vivo temperature control system includes a catheter insertable into a biological lumen; two or more temperature sensors placed such that they can measure a temperature distribution in a longitudinal direction of the biological lumen; a liquid storage section that stores a liquid; and a control section that estimates a spatial change in the biological lumen based on a temperature change before and after the liquid in the liquid storage section is released outwardly through the catheter, wherein the temperature change is measured by each of two or more temperature sensors.

Abstract: Methods, devices, and systems employ cryolysis of oropharyngeal adipose tissues to selectively remove fat cells from the tissues causing obstructive sleep apnea. In various embodiments, a chilled liquid—e.g., a liquid or air—is applied to the target tissue at a temperature and for a duration sufficient to cause cryolysis.

Abstract: A means for controlling the temperature of a warming material includes an air-permeable film or the like. The warming material includes the temperature control means and a heating composition. The temperature control means for controlling the heating temperature of the warming material includes one or more aliphatic compounds that have a melting point of 35-65° C. and a solubility in water (g/100 mL) at 20° C. of 5 or less.

Abstract: Provided in the present disclosure are materials, devices, systems, and methods for performing cryo-surgery in a mammalian subject. More particularly, presented are a slurry, devices, systems, and methods for subcutaneously injecting the slurry into a patient in need of bodyfat reduction intervention. The slurry, devices, systems, and methods permit highly efficacious subcutaneous ice phase-change lipolysis while not requiring that the patient be placed under general anesthesia, nor requiring significant new surgical training among practitioners.

Abstract: A method of treating a patient includes providing an applicator to the patient to provide a treatment. The applicator includes an electrode to provide an electromagnetic field and a cavity to provide flow of air to provide pressure treatment. The electromagnetic field is applied with a frequency in a range of 0.1 MHz to 300 MHz to provide heating to the patient. The pressure treatment provides a massage to the patient.

Abstract: A hand warming device for warming a hand of a user gripping the device may comprise a housing having an exterior surface, a heating element to heating the exterior surface, a power source, and a power switch. The exterior surface may be contoured to facilitate contact between the exterior surface and the hand of the user when the housing is held by a clenched fist of the user. The housing may be elongated along a first axis between opposite first and second ends. The exterior surface of the housing has a shape having a longitudinal profile taken in a longitudinal plane extending along the first axis. The longitudinal profile may have an inner boundary and an outer boundary extending between the ends, and the longitudinal profile may be generally comma-shaped.

Abstract: Methods, devices, and systems employ cryolysis of oropharyngeal adipose tissues to selectively remove fat cells from the tissues causing obstructive sleep apnea. In various embodiments, a chilled liquid—e.g., a liquid or air—is applied to the target tissue at a temperature and for a duration sufficient to cause cryolysis.

Abstract: A reconfigurable, foldable, and manually transportable infant radiant warmer. In a collapsed configuration, the warmer consumes a minimal amount of space and can be manually transported easily. In a deployed configuration, the warmer provides open access to an infant lying on a bed platform for receiving resuscitative therapy and warmth from a radiant heater disposed upon an adjacent mast. The reconfigurable infant radiant warmer includes mutually reconfigurable bed, mast, and suspension modules. The mast module and the suspension module may be selectively moved relative to the bed module to achieve the collapsed configuration.

Abstract: A quantum graphene generator contains: a far-infrared quantum implantation device which includes: a body, a lid, a crystal quartz, a plasma sheet, an intermediate-frequency current device, a magnet assembly, and an energy medium. The body includes an accommodation chamber. The lid is covered on the body and includes a receiving space. The crystal quartz is received in the accommodation chamber and includes the energy medium. The plasma sheet is comprised of multiple multi-stranded coil layers, multiple copper adhering layers, and a copper sheet. The intermediate-frequency current device includes multiple magnetic elements. A top of the magnet assembly is arranged on a middle copper adhering layer below the top copper adhering layer, and a bottom of the magnet assembly is located on the energy medium to increase the magnetic field.

Abstract: A heating pad assembly includes a flexible heating pad having a flexible substrate forming a plurality of deflectable tabs and one or more electrically conductive heating traces routed through the plurality of deflectable tabs and configured to radiate heat therefrom in response to electrical current flowing through the one or more heating traces.