Abstract: A resin composition quality controlling method includes a step of measuring a Raman spectrum of a resin composition composed of TiO2 particles dispersed in a base material mainly composed of a silicone rubber by irradiating the resin composition with laser, and a step of determining a concentration of the TiO2 particles in the resin composition based on an intensity of a fluorescence spectrum in the Raman spectrum.

Abstract: An inspection system (1600), a lithography apparatus, and an inspection method are provided. The inspection system (1600) includes an illumination system (1602), a detection system (1606), and processing circuitry (1622). The illumination system generates a first illumination beam (1610) at a first wavelength and a second illumination beam (1618) at a second wavelength. The first wavelength is different from the second wavelength. The illumination system irradiates an object (1612) simultaneously with the first illumination beam and the second illumination beam. The detection system receives radiation (1620) scattered by a particle (1624) present at a surface (1626) of the object at the first wavelength. The detection system generates a detection signal. The processing circuitry determines a characteristic of the particle based on the detection signal.

Abstract: Systems and methods for generating volumetric data are disclosed. Such systems and methods may include scanning a sample at a plurality of focal planes located along a depth direction of the sample. Such systems and methods may include generating, via a detector of a metrology sub-system, a plurality of images of a volumetric field of view of the sample at the plurality of focal planes. Such systems and methods may include aggregating the plurality of images to generate volumetric data of the volumetric field of view of the sample. The metrology sub-system may include a Linnik interferometer.

Abstract: Example embodiments add an optical amplifier to a multi-channel, continuously swept OFDR measurement system, adjust amplified swept laser output power between rising and falling laser sweeps, and/or utilize portions of a laser sweep in which OFDR measurements are not typically performed to enhance the integrity of the OFDR measurement system, improve the performance and quality of OFDR measurements, and perform additional measurements and tests.

Abstract: An optical system includes a multispectral sensor; an optical filter including a plurality of optical channels that is disposed over the multispectral sensor; and a lens that is disposed over the optical filter. The lens is configured to direct first light that originates from a scene to the optical filter. The optical filter is configured to pass one or more portions of the first light to the multispectral sensor. The multispectral sensor is configured to generate, based on the one or more portions of the first light, spectral data associated with the scene.

Abstract: Methods of deep ultraviolet fluorescence (DUVF) and multi spectral imaging (MSI) detection are disclosed herein for the detection and identification of pathogens on plants. DUV light and visible or near-infrared light are used to illuminate plants or plant leaves such that the light intensity reflected or emitted by the plant or plant leaves can be used to identify the type of pathogen and measure the amount of pathogen on the plant or plant leaves and, additionally, be used to measure the plant's stress response to such pathogen. Also provided herein is a biophotonic analyzer device that uses both DUVF and MSI detection for the monitoring and surveillance of plant health and for the identification and enumeration of pathogens on plants or plant leaves.

Abstract: A new spectral measurement technique is provided which enables measurement even if the light to be measured exists for a very short period. In one embodiment, a broadband pulsed light wave whose wavelength shifts temporally and continuously in a pulse interferes with a light wave to be measured. The intensity at each wavelength of the light wave to be measured is obtained using a Fourier transform of the output signal from a detector that has detected the intensity of the wave resulting from the interference. A laser beam from a laser source is converted to a supercontinuum wave by a nonlinear optical element, and a pulse extension element extends pulses of the supercontinuum wave, thus generating the broadband pulsed light wave.

Abstract: The monitoring and control of bioprocesses is provided. The present disclosure provides the ability to generate generic calibration models, independent of cell line, using inline Raman probes to monitor changes in glucose, lactate, glutamate, ammonium, viable cell concentration (VCC), total cell concentration (TCC) and product concentration. Calibration models were developed from cell culture using two different CHOK1SV GS-KO™ cell lines producing different monoclonal antibodies (mAbs). Developed predictive models, qualified using an independent CHOK1SV GS-KO™ cell line not used in calibration, measured changes in glucose, lactate, ammonium, VCC, and TCC with minor prediction errors over the course of cell culture with minimal cell line dependence. The development of these generic models allows the application of spectroscopic PAT techniques in a clinical manufacturing environment, where processes are typically run once or twice in GMP manufacturing based on a common platform process.

Abstract: An optical system includes a first optical path configured to supply a first light with a first range of wavelengths; a second optical path configured to supply a second light with a second range of wavelengths shorter than the first range of wavelengths; a third optical path configured to supply a third light with a third range of wavelengths shorter than the second range of wavelengths; an optical I/O unit configured to emit the first light, the second light and the third light to a target and acquire a light from the target; a reference unit configured to split off a reference light from the third light; and a detector that includes a range of detection wavelengths shared with a CARS light and an interference light.

Abstract: A laser analysis device includes a laser analysis unit that a sample is irradiated with laser light, a cover that covers a periphery of the laser analysis unit, so as to prevent the laser light from being emitted to outside, and has a slit in at least a part of the cover, a fastener configured to open and close the slit, and an interlock mechanism including a key provided on the fastener and a detector that detects a state in which the fastener is fully closed, in which in a state where the detector has detected that the fastener is fully closed, laser light having a predetermined intensity or more is introduced into the laser analysis unit.

Abstract: Provided are a flow path device capable of rapidly performing a drug sensitivity test, and a testing device and a testing method using the same. A flow path device adjusted for observing a test solution existing in a well plate having a well includes: a plate-shaped main body having a main surface; and an insertion body provided in the main body, the insertion body extending along a direction perpendicular to the main surface of the main body, the insertion body configured to be inserted into the well. The insertion body includes a pore having a dimension capable of sucking up the test solution in the well, and the main body includes an observation flow path which communicates with the pore and extends along a direction in plane with the main surface of the main body.

Abstract: A method for investigating an electrolyte solution for processing a component, particularly a component or a component material of an aircraft engine, by near infrared spectroscopy.

Abstract: The disclosure provides systems and methods to monitor the degradation of polymer layers in polymer based photovoltaic modules using an optical sensor. The optical sensor is embedded in a polymer layer of the polymer based photovoltaic module.

Abstract: An object of the present invention is to realize an optical analysis system that enables long-term analysis by reducing the amount of liquid used for analysis. The optical analysis system includes: a first flow channel for transporting a liquid in a container; a branching medium for alternately outputting the liquid and the gas in the first flow channel; a third flow channel for transporting the liquid and the gas flowing out from the branching medium; an analysis cell into which the liquid and the gas in the third flow channel flow; a fourth flow channel that is connected to the analysis cell to discharge the liquid and the gas after passing through the analysis cell; a pump for transporting the liquid and the gas; and a control device. Then, the control device sets a reference liquid amount that is a reference required for analysis, and controls the branching medium and the pump to make the liquid and the gas alternately flow into the third flow channel.

Abstract: Disclosed is a method and apparatus for determining information about an alignment of one or more optical components of a multi-component assembly involving: detecting an optical interference pattern produced from a combination of at least three optical wave fronts including at least two optical wave fronts caused by reflections from at least two surfaces of the one or more optical components; and computationally processing information derived from the detected optical interference pattern with at least one simulated optical wave front derived from a model of at least one selected optical surface of the at least two surfaces to computationally isolate information corresponding to an alignment of the selected optical surface.

Abstract: An optical fiber including a plurality of embedded optical reflectors distributed periodically along the length of the fiber and a method of quantifying loss associated with an optical connector that is connected to optical fiber comprising a plurality of embedded optical reflectors distributed periodically along the length of the fiber. The method includes inserting an optical signal into the fiber through the optical connector; measuring a component of the optical signal reflected by at least one of the plurality of embedded optical reflectors, in which the component is received through the optical connector; calculating the difference in power level between the inserted and reflected signals; and quantifying, based on the calculated power level difference and the reflectivity of the embedded optical reflector, the loss associated with the optical connector.

Abstract: The invention provides differential refractive index detectors and methods for the use of differential refractive index detectors. In an exemplary embodiment, a differential refractive index detector includes a flow cell body having a proximal end, a distal end, and a flow axis extending between the proximal and the distal end. The flow cell body includes a first chamber and a second chamber and the fluid conduits coupled to the flow cell body can be tapered to reduce dispersion.

Abstract: A multi-wavelength laser diode based optical sensor system capable of monitoring the dynamics and physiological changes of a microorganism culture in real-time. The microorganism culture from a microorganism production chamber is pumped to a flow chamber. Laser diodes emit light at certain wavelengths through the flow chamber, which is sensed by photodiodes. A laser control circuitry is operatively connected to the laser diodes and a signal conditioning circuitry is operatively connected to the photodiodes. A microprocessor reads and records voltage signals corresponding to the wavelengths. A data acquisition system converts said voltage signals into measurements of biological parameters, which are displayed on a graphical user interface and allow a user to monitor the measurements in real time.

Abstract: An electro-optical assembly, in particular a sensor assembly for detecting ambient light, includes a reflection surface, a lens body and an electro-optical component, in particular a light receiver. The component includes a depression having a main lens section, in particular a diverging lens section with a concave interior wall, and a converging lens section with a convex interior wall. The interior wall of the converging lens section is formed in such a way that the rays of the ray path which travel through the converging lens section to the electro-optical component hit the reflection surface in such way that the angle of incidence at the reflection surface is larger or the same as the critical angle of the total internal reflection at the reflection surface. In another aspect a method for detecting ambient light is described.

Abstract: A test pattern (170) comprising a set of dots (174) which define a first ellipse (176) of best fit in which the major and minor axes R1, R2 are equal (i.e. a circle) is displayed on a plane surface and a digital image of the (usually distorted) test pattern seen through a lens is captured. A second ellipse of best fit joining the dots in the set is derived from the distorted test pattern in the image. Characteristics of the first and second ellipses are compared to determine the degree and nature of distortion to the test pattern, from which the power of the lens is calculated. The major and minor axes of the first and second ellipses may be compared. The test pattern can include a number of said sets of dots distributed over an area of the surface with each set being analysed to determine the optical parameters of the lens at multiple locations.