Abstract: A chromatographic column that includes a distributor plate secured to a backing plate of the chromatography column without the need for releasable fixing means such as screws or bolts, by employing a negative pressure or vacuum to affix the distributor to the backing plate.

Abstract: A flash chromatography apparatus which provides an improved apparatus for large and medium commercial scale flash chromatography columns. More particularly, the invention relates to a flash chromatography column and cartridge system for positioning and ease of loading and unloading of stationary phase agent in the flash chromatography column. The flash chromatography column further provides flow distributors to support the stationary phase and permit plug flow through the column. The apparatus of the present invention is a modular and can be disposed in any configuration to reduce maintenance cost and downtime in a commercial installation. Flash chromatography is widely used for purification of low molecular weight organic compounds and products of organic synthetic reactions.

Abstract: A filtration apparatus which has a filtration chamber, and the filtration chamber has a fluid inlet, a filtered fluid outlet, a residue outlet, and a filtering element. The filtering element is situated between the fluid inlet and the filtered fluid outlet. The apparatus also includes a wiping member which is situated within, or about, the filtering element and which is adapted to wipe the surface of the filtering element. The wiping member also wipes any residue toward the residue outlet when the apparatus is in use. The filtration apparatus includes a first pumping configured to create a flow toward the filtering chamber, and a second pumping situated within the filtering chamber and configured to induce a counter-flow back toward the first pumping.

Abstract: A chromatography column design and a packing device, as well as a method for obtaining a column with a very compact and uniform bed are provided. The bed remains compact and uniform during operation of the column and during sanitization, storage and transportation of the column. The amount of hardware, particularly the hardware parts in contact with product, is minimized, especially with the implementation of an internal liner. With this internal liner, the packed bed can be separated from the column in intact form, or even prepared separately from, and outside of, the column.

Abstract: A multifunctional device for chromatographic separation, in particular for affinity chromatographic separation of a substance mixture, provides for a uniform fluid distribution on a separation medium and a uniform flow through a stationary phase. The fluid to be separated is passed through a radial inlet line in an upper partial region of the device, to the center of the upper partial region. The radial inlet line is enlarged in the form of a cupola at the center of the upper partial region.

Abstract: Proteins are purified by a mixed-mode chromatography system formed by attaching a ligand with cation exchange and hydrophobic functionalities to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of no more than three atoms between the hydrophobic group and the support matrix.

Abstract: A connector is used to connect a conduit to a threaded orifice of a fluidic component, such as a component of an apparatus for chromatography. The connector includes a flexible fitting, a deformable fitting, and a compression fitting. The flexible fitting fixes the position of the conduit with respect to the threaded orifice. The deformable fitting provides a fluid-tight seal between the fluidic conduit and the threaded orifice. The compression fitting includes an external-thread portion for attachment to the orifice, to urge the flexible fitting toward an outer surface of the fluidic conduit, and to urge the deformable fitting toward both the outer surface and the orifice, a cam portion in mechanical communication with the flexible fitting via a through-hole in the external thread portion, and a graspable portion in rotatable communication with the cam portion.

Abstract: A filtration device is disclosed. The device includes a filter inlet, a filter outlet, and a filter flow path from the filter inlet to the filter outlet. A filter in the filter flow path filters contaminants from lubricant flowing from a lubricant supply to a lubricant destination. A bypass flow path bypasses the filter in the event the filter becomes clogged. The bypass flow path has a bypass inlet in fluid communication with the filter flow path at a location upstream from the filter and a bypass outlet separate from the filter outlet and not in fluid communication with the filter outlet. The bypass outlet is normally closed to permit flow along the filter flow path and opens if the filter becomes clogged so that lubricant is directed along the bypass flow path and through the bypass outlet for disposal without going to the lubricant destination.

Abstract: The one step process of removal of chromophore/dye/organic pollutant from a solution comprising a polymer free titanium oxide gel i.e. high zeta potential is disclosed. The concentration of the chromophores is removed up to 95-100%.

Abstract: A fluid filter assembly with sight glass provides an upper housing carrying a transparent sight glass for visualizing the interior of the filter assembly and fluids passing therethrough. A sight glass retainer secures the sight glass within the upper housing. A screen filter is carried between the upper housing and a mating lower housing. A fluid inlet port is defined in the upper housing above the screen filter and a fluid output port is defined in the lower housing below the screen filter. The sight glass retainer carries plural fluid deflectors and plural sight glass supports for fluid dispersion and fluid cooling. A pressurized air input communicating with fluid inlet port allows pressurized air to be injected into the assembly to force fluids through the screen filter and out of the filter assembly. A low pressure drain valve and a bypass valve are carried in the lower housing.

Abstract: A fractionating and refining device includes a solution sending flow path for supplying a solution, including a fractionated target component, a gas supply flow path, a collecting vessel, a warming mechanism for warming the collecting vessel, and a probe formed by integrating tip end portions of the solution sending flow path and the gas supply flow path with each other. A lid of the vessel includes a solution inlet to which the tip end portion of the solution sending flow path is connected, gas inlets to which the tip end portion of the gas supply flow path is connected, and gas discharge ports connecting an inside and an outside of a vessel main body of the vessel.

Abstract: A scraper device discharges a filter cake on a filter plate of a pressure filter, which includes fixed bracket and movable carriage parts, and hoist rack and scraper parts. The fixed bracket part has transverse and vertical bracket beams. The movable carriage part has a movable carriage base, bottom and upper transverse beams, and an upright column. The hoist rack part, mounted in the movable carriage, includes upper and bottom transverse beams of the hoist rack, which are connected by an upright column of the hoist rack. A hoist slide plate connects with a connection plate of the hoist rack, and the hoist slide plate is movably connected to a chain. Scrapers are placed at both sides of the filter plate, and position limiters are placed in the movable carriage part and the hoist rack part. The position limiters are connected to clamping and unclamping proximity switches.