Patents Examined by Karen Cochrane Carlson
  • Patent number: 9914945
    Abstract: Continuous processes for the anaerobic bioconversion of syngas to oxygenated hydrocarbonaceous products, in particular lower alkanols, are disclosed in which nutrients, including micronutrients, and lower carboxylate anion are recovered from at least a portion of an aqueous distillation fraction from a distillation unit operation to recover lower alkanols by using a “tight” ultrafiltration membrane. At least about 75 percent of the water permeates the ultrafiltration membrane. The tight ultrafiltration membrane rejects sufficient components that are adverse to the microorganisms used in the bioconversion that continuous fermentation operations over long durations can be achieved.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: March 13, 2018
    Assignee: Synata Bio Inc.
    Inventor: Robert Hickey
  • Patent number: 9913881
    Abstract: The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or activity of NPP1 or a mutant thereof, or a mutant NPP4 modified to exhibit ATP hydrolase activity similar to the hydrolase activity of NPP1.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: March 13, 2018
    Assignee: Yale University
    Inventors: Demetrios Braddock, Ronald Albright
  • Patent number: 9907839
    Abstract: Methods of treating glycogen storage disease type II, by administering acid ?-glucosidase, are described, as are compositions for use in treatment of glycogen storage disease type II.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: March 6, 2018
    Assignee: Duke University
    Inventor: Yuan-Tsong Chen
  • Patent number: 9909143
    Abstract: This disclosure describes a cell that includes an engineered subcellular compartment that generally includes a proteinaceous shell that includes at least one bacterial microcompartment (BMC) polypeptide. In some embodiments, the engineered subcellular compartment can further include one or more targeted enzymes. We further describe methods of making and using such cells.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: March 6, 2018
    Inventors: Claudia Margarete Schmidt-Dannert, Swati Choudhary Saurkar, Maureen Blacker Quin, Mark Anton Held
  • Patent number: 9901626
    Abstract: A method is disclosed to dissolve protein deposited in muscle. The method includes the step of administering an effective amount of an agent selected from the group consisting of fibrinolytics, proteolytics, photolytic and magnelytic agents.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: February 27, 2018
    Inventor: G. Blair Lamb
  • Patent number: 9902984
    Abstract: The present application discloses a method of making a mixture of 2?-FL and DFL in high yield by culturing, with lactose, a genetically modified cell having a recombinant gene that encodes a single fucosyl transferase. The resulting mixture of 2?-FL and DFL can be subjected to hydrolysis initiated by an acid or mediated by a fucosidase to produce fucose in high yields.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: February 27, 2018
    Assignee: GLYCOM A/S
    Inventors: Gyula Dekany, Pauline Peltier-Pain, Dóra Molnár-Gábor, Markus Hederos
  • Patent number: 9902945
    Abstract: The present invention relates to a conjugate of cell penetrating peptide and an active ingredient; and its use. Specifically, a conjugate including a cell penetrating peptide which is a peptide comprising any one amino acid sequence of SEQ ID NO: 1 to SEQ ID NO: 156, a fragment of any one sequence of SEQ ID NO: 1 to SEQ ID NO: 156, or a peptide having above 80% homology with the above-mentioned sequence; and a composition comprising the same are disclosed.
    Type: Grant
    Filed: September 17, 2013
    Date of Patent: February 27, 2018
    Assignee: GEMVAX & KAEL CO., LTD.
    Inventor: Sang Jae Kim
  • Patent number: 9902977
    Abstract: Disclosed herein is a bioenergy production system with reduced carbon dioxide emissions and process wastes; including a process for producing a bioalcohol and a biogas by subjecting a biomass, such as: herbaceous and woody plants, fruit pulp, freshwater and sea algae, grains, aerobic and anaerobic sludge, saccharides, polyols and carbohydrates, to a combined process of a biosaccharification/alcohol fermentation, including a biomass pretreatment process; and a process for producing a methane biogas with a reduced level of carbon dioxide and hydrogen sulfide, via an algae cultivation process with a view to purifying the carbon dioxide and hydrogen sulfide contained in the biogas; wherein, when the algae to be cultivated is microalgae, biodiesel is produced by subjecting the harvested microalgae to a biodiesel manufacturing process while recycling the glycerol and the saccharide-containing waste produced as byproducts to the biosaccharification/alcohol fermentation process, and when the algae to be cultivated is
    Type: Grant
    Filed: August 26, 2014
    Date of Patent: February 27, 2018
    Inventors: Kwang-Hee Lim, Kisay Lee, Young-Soon Um, Min-Woo Lee
  • Patent number: 9895427
    Abstract: Compositions and methods for treating or preventing E. coli infections are provided. The compositions can be formulated as pharmaceutical compositions or as disinfectants, sanitizers, detergents or antiseptics, and can be used to eradicate or reduce E. coli populations and thereby treat or prevent infection by E. coli. The compositions include one or more digestive enzymes, e.g., one or more protease, lipases, and amylases. Methods of use of the compositions are also provided.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: February 20, 2018
    Assignee: GALENAGEN, LLC
    Inventors: Joan M. Fallon, Matthew Heil, James J. Fallon
  • Patent number: 9896708
    Abstract: To provide a polypeptide having heparosan-glucuronate 5-epimerase activity, whereby means for producing a polysaccharide in which hexuronic acid residues has been epimerized is provided. Through screening of Achatina fulica cDNA library, a DNA encoding a polypeptide of heparosan-glucuronate 5-epimerase is obtained. The epimerase acts on glucuronic acid residues of N-acetyl heparosan and/or iduronic acid residues of completely desulfated N-acetylated heparin. The polypeptide encoded by the DNA is expressed by insect cells, to thereby yield the polypeptide having heparosan-glucuronate 5-epimerase activity. By bringing the polypeptide into contact with N-acetyl heparosan or completely desulfated N-acetylated heparin, a polysaccharide in which hexuronic acid residues has been epimerized is yielded.
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: February 20, 2018
    Inventors: Hideo Mochizuki, Kiwamu Yamagishi, Kiyoshi Suzuki, Yeong Shik Kim
  • Patent number: 9890395
    Abstract: Disclosed herein are methods and compositions for inactivating a FUT8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: February 13, 2018
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Trevor Collingwood, Gregory J. Cost
  • Patent number: 9884897
    Abstract: It has been believed that promoting the assembly of polysomes composed of many ribosomes attached to mRNA is very effective for highly efficient protein synthesis. However, the mechanism for p180 protein's capability of promoting polysome formation has been yet to be elucidated. The inventors of the present application newly discovered SF3b4 protein as a protein that specifically interacts with the coiled-coil domain of p180 protein, a responsible region for its capability of promoting polysome formation, and which is capable of promoting mRNA localization to an endoplasmic reticulum (ER). The inventors also found that, in cells capable of highly expressing both p180 protein and a protein promoting mRNA localization to an endoplasmic reticulum (ER) (e.g., SF3b4 protein), the mRNA localization to the endoplasmic reticulum can be significantly elevated so that the secretory capacity in cultured cells can be enhanced.
    Type: Grant
    Filed: March 26, 2014
    Date of Patent: February 6, 2018
    Inventors: Tomonori Ueno, Yuki Taga, Kiyoko Goto, Yuko Kaku
  • Patent number: 9885063
    Abstract: A process is provided for fermenting CO-containing gaseous substrates in a low phosphate medium. The process includes blending a liquid medium that includes at least one transition metal element with a liquid medium that includes at least at least one other transition metal element and one non-metal element to provide a fermentation medium. The process is effective for preventing precipitation of one or more transition metal elements with one or more non-metal elements. The fermentation medium used in the process is prepared in a way that requires significantly lower amounts of water and reduced levels of phosphate.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: February 6, 2018
    Inventors: Ryan H. Senaratne, Peter Simpson Bell, Song Liu, Syrona R. Scott
  • Patent number: 9873665
    Abstract: Since biomass is always accompanied by caustic inorganic materials, we have found that the formation of the anion salt of ?-hydroxysulfonic acid represent the largest “loss” of the ?-hydroxysulfonic acid in the potential reversible acid pretreatment process. By titrating the ?-hydroxysulfonic acid salt with strong mineral acid and then reverting the alfa-hydroxysulfonic acid as its primary components, the acid components can be recovered substantially quantitatively.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: January 23, 2018
    Inventors: Robert Lawrence Blackbourn, Paul Richard Weider, Dennis Shane Boriski
  • Patent number: 9872887
    Abstract: This disclosure provides extracellular matrix-binding synthetic peptidoglycans comprised of one or more synthetic peptides conjugated to a glycan and methods of their use.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: January 23, 2018
    Assignee: Purdue Research Foundation
    Inventors: Alyssa Panitch, John Eric Paderi, Shaili Sharma, Katherine Allison Stuart, Nelda Marie Vazquez-Portalatin
  • Patent number: 9868944
    Abstract: The present invention provides stable dried reaction mixtures, methods for their preparation, methods for their use, and kits comprising them. The stable dried reaction mixtures are useful in many recombinant DNA techniques, especially nucleic acid amplification by the polymerase chain reaction (PCR).
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: January 16, 2018
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Tomas R. Martinez, Edward S. Smith
  • Patent number: 9868973
    Abstract: A method for optimizing post-translational modifications of recombinant proteins expressed in living cells is described. More particularly, a method for modulation of host proteins in living cells that control PTMs on recombinant proteins is described that has particularly useful applications in developing manufacturing process changes or in biosimilar development. The goal of this modulation is to produce a recipe for production of a recombinant protein in the new process or in the biosimilar that will produce a targeted PTM profile in the resulting protein product. In the method one or more modulators are selected, as from a modulator library, which affect the activity of host proteins. These modulators are added to media during production such that the resulting product matches the PTMs of the reference product.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: January 16, 2018
    Assignee: STC Biologics, Inc.
    Inventors: Magdalena Leszcyniecka, Sergey Shulga-Morskoy
  • Patent number: 9867337
    Abstract: A consumer product for supplementing carbon dioxide is provided with delayed activation control in the form of a clamp. A bag, having a top and a bottom seal and a filter, contains a mycelial mass prepared under sterile laboratory conditions using aseptic techniques. The bag may be selectively clamped at various locations on its exterior. During manufacturing, the mycelial mass is sealed away from the air exchange portal by the clamp. The manipulation delays the optimized carbon dioxide generation and extends the product shelf-life significantly. The fungi are utilized on-demand by removal of the clamp and carbon dioxide flows from the product. Consumers will place the product near indoor plants. The precise clamping method delays the expiration of the product for storage and shipping optimization. The clamp is relocated to the top of the bag in order to provide a hanger for the carbon dioxide generator above plant level.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: January 16, 2018
    Inventors: Glen Babcock, Wendy Babcock Garrett
  • Patent number: 9863886
    Abstract: A sensor system, and a method of detecting a target analyte, comprises a chemically functionalized block copolymer, and a target analyte. The block copolymer exhibits a color change in the visible spectrum upon exposure to the target analyte.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: January 9, 2018
    Assignees: University of Maryland, College Park, The United States of America as Represented by the Secretary of the Army
    Inventors: Peter Kofinas, Omar B. Ayyub, Jennifer W. Sekowski, Ta-I Yang
  • Patent number: 9862935
    Abstract: Provided is a novel bacteriophage ?CJ20 (KCCM11362P). In addition, the present invention relates to an antibacterial composition including the bacteriophage ?CJ20 (KCCM11362P) as an active ingredient. Further, the present invention is a method of preventing and/or treating infectious diseases by enterotoxigenic Escherichia coli in animals except for humans using the bacteriophage ?CJ20 (KCCM11362P) or the antibacterial composition containing the bacteriophage ?CJ20 (KCCM11362P) as an active ingredient.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: January 9, 2018
    Inventors: Eun Mi Shin, Gi Duk Bae, Jae Won Kim