Patents by Examiner Karen Cochrane Carlson
  • Patent number: 9765120
    Abstract: The present invention relates to a cobalamin acquisition protein, compositions containing the cobalamin acquisition protein, and the use of such compositions.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: September 19, 2017
    Assignee: Wood Hole Oceanographic Institution
    Inventors: Makoto Saito, Erin M. Bertrand
  • Patent number: 9757433
    Abstract: The present invention relates to modified angiotensin converting enzyme 2 (ACE2) polypeptides and pharmaceutical and analytical uses thereof. In particular, the present invention relates to Zn2+ depleted-, Zn2+ free-, mixed metal- and metal ion substituted-ACE2 as well as methods for the manufacture of these variants and uses thereof, such as therapeutic and analytic uses of these ACE2 variants.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: September 12, 2017
    Assignee: Apeiron Biologicals AG
    Inventors: Hans Loibner, Bernhard Peball, Manfred Schuster, Stefan Stranner
  • Patent number: 9758550
    Abstract: The present invention relates to a cobalamin acquisition protein, compositions containing the cobalamin acquisition protein, and the use of such compositions.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: September 12, 2017
    Assignee: Woods Hole Oceanographic Institution
    Inventors: Makoto Saito, Erin M. Bertrand
  • Patent number: 9750196
    Abstract: Carbon dioxide benefits plants in restricted indoor growing areas. Plants will deplete carbon dioxide levels in an indoor environment over time. The present invention provides a process design, system, and apparatus for a controlled, non-electrical, non-heat generating, non-mechanical, production source of CO2. The source of CO2 is fungi inoculated into a scientifically sterilized, enclosed growth medium prepared in a laboratory setting. The fungi is provided with an optimum food source from which the fungi may produce CO2 for at least six months. The CO2 produced is passively transferred from the fungi growing environment to an indoor plant growing environment under the optimization of the present invention. The transfer is non-electrical and preferably occurs through a gaseous interchange portal system which provides an interface between the fungi's enclosed plastic bag and the surrounding plant-growing environment.
    Type: Grant
    Filed: February 22, 2011
    Date of Patent: September 5, 2017
    Inventors: Glen Babcock, Wendy Babcock Garrett
  • Patent number: 9744219
    Abstract: The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or activity of NPP1 or a mutant thereof, or a mutant NPP4 modified to exhibit ATP hydrolase activity similar to the hydrolase activity of NPP1.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: August 29, 2017
    Assignee: Yale University
    Inventors: Demetrios Braddock, Ronald Albright
  • Patent number: 9738884
    Abstract: The present invention provides a therapeutic agent for epithelial and endothelial injury, and in particular, for epithelial and endothelial microinjury, and the like. The therapeutic agent according to the present invention comprises, for example, a peptide of the following (a), (b), etc., a derivative thereof, or their salt: (a) a peptide comprising the amino acid sequence shown in any one of SEQ ID NOS: 10, 4, 12 and 6; or (b) a peptide comprising the amino acid sequence shown in any one of SEQ ID NOS: 16, 18, 20 and 22.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: August 22, 2017
    Assignee: NIHON UNIVERSITY
    Inventors: Chiaki Hidai, Hisataka Kitano, Atsushi Mamiya
  • Patent number: 9732310
    Abstract: The present invention relates to novel subtilase variants exhibiting alterations relative to the parent subtilase in one or more properties including: Wash performance, thermal stability, storage stability or catalytic activity. The variants of the invention are suitable for use in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: August 15, 2017
    Assignee: NOVOZYMES A/S
    Inventors: Henriette Draborg, Peter Kamp Hansen, Mads Eskelund Bjornvad, Mads Norregaard-Madsen, Mikael Mikkelsen
  • Patent number: 9732373
    Abstract: Provided herein are isolated polynucleotide encoding modified click beetle luciferase polypeptides that have enhanced luminescence and longer wavelength near-infrared signals. The disclosure also relates to near-infrared bioluminescence systems that include said modified click beetle luciferase polypeptides and novel luciferin derivatives, as well as methods of using said modified click beetle luciferase polypeptides and bioluminescence systems.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: August 15, 2017
    Assignee: Promega Corporation
    Inventors: Lance P. Encell, Mary P. Hall, Keith V. Wood, Monika G. Wood
  • Patent number: 9732363
    Abstract: The present invention provides a growth method for a microbe which can enhance the growth of the microbe without removing growth inhibitors from a saccharified solution. The growth method for a microbe comprises the steps of: obtaining a mixed saccharified solution by diluting the saccharified solution containing a growth inhibitor which inhibits the growth of the microbe with a sugar solution having a smaller growth inhibitor concentration than that of the saccharified solution such that the growth inhibitor concentration is decreased; and allowing the microbe to grow by adding the microbe to the mixed saccharified solution.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: August 15, 2017
    Assignee: HONDA MOTOR CO., LTD.
    Inventors: Yoshiki Tsuchida, Norihiko Tsukagoshi, Masaki Ueyama
  • Patent number: 9732362
    Abstract: The present invention relates to processes for recovering butanol produced in a fermentative process using, for example, an ethanol production plant which has been reversibly-retrofitted for butanol production, that is, the ethanol production plant may be converted for butanol production, but can also revert to an ethanol production. The present invention also relates to processes for recovering butanol produced in a fermentative process in a butanol production plant that may be converted to ethanol production plant.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: August 15, 2017
    Assignee: Butamax Advanced Biofuels LLC
    Inventors: Steven Christopher Barr, Robert W. Sylvester, Joseph J. Zaher
  • Patent number: 9732127
    Abstract: The invention relates to intracellular lipid binding proteins that bind retinoids and/or dye ligands and that are modified to transmit or emit light at a variety of different wavelengths.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: August 15, 2017
    Assignee: Board of Trustees of Michigan State University
    Inventors: Babak Borhan, James Geiger, Wenjing Wang, Chrysoula Vasileiou, Kin Sing Lee, Tetyana Berbasova
  • Patent number: 9732357
    Abstract: The invention provides a new expression system comprising a mammalian selectable marker that promotes desirable post-translational modifications of glycoproteins. In particular, the invention includes methods and compositions for optimal recombinant protein expression in mammalian cells by employing a selection marker system based on GPT genes of mammalian origin. The invention includes methods that facilitate selectivity and enhanced expression copies as well as protein yield of recombinant proteins in mammalian cells, and methods of using GPT expression systems.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: August 15, 2017
    Assignee: REGENERON PHARMACEUTICALS
    Inventors: Dipali Deshpande, Darya Burakov, Gang Chen, James Fandl
  • Patent number: 9724378
    Abstract: A fusion protein including granzyme B, a cell penetrating peptide, a cleavage site, and a targeting moiety, a composition for cell membrane penetration comprising the fusion protein, and an anticancer composition comprising the fusion protein.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: August 8, 2017
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Jae Il Lee, Hye Yoon Kang, Dongkyu Shin, Jung Min Kim, Jungmin Lee
  • Patent number: 9725491
    Abstract: The present invention provides methods for antigen and/or bioactive molecule delivery to antigen presenting cells utilizing ASC specks as vehicles; 1) the ASC speck composition is made of ASC protein(s) and the antigen and/or bioactive molecule(s) purified from cells as a compact micro-spherical structure; 2) purified micro-spherical ASC speck delivery vehicles are stable at 37° C. for more than 30 days; and 3) antigen and/or bioactive molecules carried by ASC specks can be efficiently phagocytosed by antigen presenting cells and their degradation in the lysosome allows antigen processing and presentation.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: August 8, 2017
    Assignee: Bogazici Universitesi
    Inventors: Ali Can Sahillioglu, Nesrin Ozoren
  • Patent number: 9719095
    Abstract: Disclosed herein are an expression vector capable of expressing myrcene, an Escherichia coli strain transformed with the vector and having improved capability of producing myrcene and a method for producing myrcene and a method for recycling glycerol using the same. In an aspect, the transformed Escherichia coli strain of the present disclosure can produce myrcene with high purity on a large scale using glycerol or glucose as a carbon source. Also, the Escherichia coli strain of the present disclosure is economical and environment-friendly because it can produce high value-added myrcene using waste glycerol as a carbon source. In addition, the strongly volatile myrcene can be produced and isolated at the same time.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: August 1, 2017
    Assignee: Korea Institute of Science and Technology
    Inventors: Han Min Woo, Eun Mi Kim, Youngsoon Um, Gyeongtaek Gong, Sun Mi Lee, Yunje Kim
  • Patent number: 9719128
    Abstract: The present invention features methods for selective lysis of endogenous cells in a biological sample. In preferred embodiments, the methods of the invention comprise contacting the biological sample with lysis solution, and subjecting the mixture to ultrasound, thereby selectively lysing the endogenous cells in the biological sample. The invention also features a lysis solution comprising Saponin and Proteinase.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: August 1, 2017
    Assignee: AdvanDx, Inc.
    Inventors: Martin Fuchs, Michelle Meltzer
  • Patent number: 9718866
    Abstract: The invention relates to a peptidomimetic of an NPC-1 epitope on the MUC5AC protein which is differentially expressed in pancreatic and colorectal cancer, and diagnostic and therapeutic usages. Further, antibodies that selectively bind the NPC-1 epitope peptidomimetics and may be used in diagnostic and therapeutic methods.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: August 1, 2017
    Assignee: Precision Biologics, Inc.
    Inventor: Xue-Ping Wang
  • Patent number: 9714293
    Abstract: The present invention relates generally to glutamine-free cell culture media supplemented with asparagine. The invention further concerns the production of recombinant proteins, such as antibodies, in asparagine-supplemented glutamine-free mammalian cell culture.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: July 25, 2017
    Assignee: GENENTECH, INC.
    Inventors: Martin Gawlitzek, Shun Luo, Christina Teresa Bevilacqua
  • Patent number: 9708602
    Abstract: The invention relates to a method and a prokaryotic cell for identifying a compound, which interferes with ribosome biogenesis, assembly and/or degradation. The cell expresses a first fusion protein comprising a first ribosomal protein, an amino acid linker and a first fluorescent protein, and a second fusion protein comprising a second ribosomal protein, an amino acid linker and a second fluorescent protein. The invention further relates to a gene construct comprising a first element encoding a first ribosomal protein fused to a first fluorescent protein by an amino acid linker, and a second element encoding a second ribosomal protein fused to a second fluorescent protein by an amino acid linker.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: July 18, 2017
    Assignee: UNIVERSITAET KONSTANZ
    Inventors: Rainer Nikolay, Elke Deuerling
  • Patent number: 9707294
    Abstract: The invention includes a magnetic nanoparticle molecular delivery vehicle to be used for transfection and delivery of therapeutic molecules across cell membranes and to specific sites in the body, using magnetic forces and ultrasound.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: July 18, 2017
    Assignee: Hidaca Limited
    Inventors: James Xing, Jie Chen