Abstract: The present invention relates to carriers, conjugate and pharmaceutical compositions and their use to increase the potency of drugs and to modify the pharmacokinetics of compounds. More particularly, the present invention relates to conjugates comprising the carrier described herein and their use in the treatment and diagnostic of cancer.
Abstract: Disclosed are novel peptides that are useful, for example, for detecting target proteins having a ?-sheet secondary structure which may be associated with a disease, and for diagnosing and treating such a disease. Related methods and kits also are disclosed.
Type:
Grant
Filed:
June 9, 2014
Date of Patent:
July 4, 2017
Assignee:
SYSTEM OF SYSTEMS ANALYTICS, INC.
Inventors:
D. Roxanne Duan, Jonathan R. Moll, Alan Rudolph, Renee Wegrzyn
Abstract: Method for producing a fibroin powder from silk products or filaments without sericin and dyes having the following phases: a) introduction of products or filaments into a very tightly-woven sealed bag with high filtering capacity to allow the treatment liquid but not the silk fibrils to exit; b) introduction of the bag into a tank with fresh and hot water with a mixer, in which soda is added to the water for a time of some hours; c) a rinsing phase of which the last is made with acetic acid in such a way as to make the fiber acceptable to the cutis as originally; d) phase of centrifugation and drying tumbler; e) tumbling phase, first opening the bags to throw away the material dried in the tumblers by pulverizing the fiber with a homogenous fragmentation in such a way as to keep the fibrils whole.
Type:
Grant
Filed:
June 26, 2012
Date of Patent:
July 4, 2017
Assignee:
AL.PRE.TEC. SRL ALLERGY PREVENTION TECHNOLOGY ITALIA
Abstract: The invention provides a cyclic polypeptide of Formula I (SEQ ID NO: 1): X1-R-X3-X4-L-S-X7-X8-X9-X10-X11-X12-X13??I or an amide, an ester or a salt thereof, or a bioconjugate thereof, wherein X1, X3, X4, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor.
Type:
Grant
Filed:
December 9, 2015
Date of Patent:
June 20, 2017
Assignee:
NOVARTIS AG
Inventors:
Frederic Zecri, Philipp Grosche, Kayo Yasoshima, Hongjuan Zhao, Jun Yuan, Aimee Richardson Usera, Changgang Lou, Aaron Kanter, Alexandra Marshall Bruce, Carla Guimaraes
Abstract: The present invention includes a novel class of highly specific protease inhibitors. In one embodiment, the inhibitors of the invention are ?-helical in structure. In another embodiment, the present invention represents the first demonstration of a highly specific cysteine protease inhibitor.
Type:
Grant
Filed:
April 26, 2013
Date of Patent:
June 6, 2017
Assignee:
The Trustees of the University of Pennsylvania
Abstract: The present invention relates to complexes of transcription factor decoys, their delivery to bacteria and their formulation. In particular, the present invention resides in an antibacterial complex comprising a nucleic acid sequence and one or more delivery moieties selected from quaternary amine compounds; bis-aminoalkanes and unsaturated derivatives thereof, wherein the amino component of the aminoalkane is an amino group forming part of a heterocyclic ring; and an antibacterial peptide.
Abstract: ?-Hairpin peptidomimetics of the general formula cyclo(-Tyr1-His2-Xaa3-Cys4-Ser5-Xaa6-DPro7-Xaa8-Arg9-Tyr10-Cys11-Tyr12-Xaa13-Xaa14-Xaa15-Pro16-), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with Xaa3, Xaa6, Xaa8 Xaa13, Xaa14 and Xaa15 being amino acid residues of certain types which are defined in the description and the claims, have favorable pharmacological properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immunosuppression; or during apheresis collections of peripheral blood stem cells and/or as agents to induce mobilization of stem cells to regulate tissue repair. These peptidomimetics can be manufactured by a process which is based on a mixed solid-and solution phase synthetic strategy.
Type:
Grant
Filed:
June 6, 2012
Date of Patent:
April 11, 2017
Assignee:
POLYPHOR AG
Inventors:
Frank Otto Gombert, Daniel Obrecht, Alexander Lederer, Johann Zimmermann, Christian Oefner
Abstract: The disclosure provides directly conjugated polysaccharide vaccine molecules and methods related thereto.
Type:
Grant
Filed:
July 11, 2012
Date of Patent:
April 11, 2017
Assignees:
The General Hospital Corporation, The United States, as represented by the secretary, Department of Health and Human Services, International Centre for Diarrhoeal Disease Research, Bangladesh
Inventors:
Edward T. Ryan, Pavol Kovac, Firdausi Qadri, Peng Xu, Stephen B. Calderwood, Willie Frank Vann, Dwight Christopher Peterson
Abstract: This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-1) receptor, e.g. a GLP-1 fragment or analog thereof.
Type:
Grant
Filed:
April 10, 2008
Date of Patent:
April 11, 2017
Assignees:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, CHILDREN'S HOSPITAL OF PHILADELPHIA
Inventors:
Doris Stoffers, Diva D. De Leon, Charles Stanley
Abstract: An antimicrobial composition comprises at least one or more organic acid or salt in water, one or more antimicrobial agent which has limited water-solubility. The composition contains high active content and is stable for long period of time.
Type:
Grant
Filed:
March 13, 2015
Date of Patent:
March 28, 2017
Assignee:
Solenis Technologies, L.P.
Inventors:
Zhaoqing Liu, Corinne E. Consalo, John S. Chapman
Abstract: The peptides described herein can function as carrier peptides. These peptides can associate with (e.g., non-covalently bind) biologically active molecules or imaging agents to transport the biologically active molecules or imaging across the blood-brain barrier. In some cases, such transport may increase the effectiveness of the biological molecules or imaging agents.
Type:
Grant
Filed:
May 19, 2014
Date of Patent:
March 21, 2017
Assignee:
Mayo Foundation for Medical Education and Research
Inventors:
Geoffry L. Curran, Gobinda Sarkar, Joseph F. Poduslo, Robert B. Jenkins, Val J. Lowe, Erik W. Mahlum
Abstract: This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.
Type:
Grant
Filed:
April 17, 2014
Date of Patent:
March 21, 2017
Assignee:
C3 JIAN, LLC
Inventors:
Randal H. Eckert, Chris Kaplan, Jian He, Daniel K. Yarbrough, Maxwell Anderson, Jee-Hyun Sim
Abstract: The present disclosure provides conjugate structures and compound structures used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.
Type:
Grant
Filed:
May 5, 2015
Date of Patent:
February 28, 2017
Assignee:
Redwood Bioscience, Inc.
Inventors:
Romas Alvydas Kudirka, Aaron Edward Albers, David Rabuka
Abstract: The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator (uPA), to activatable antibodies and other larger molecules that include the cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator, and to methods of making and using these polypeptides that include a cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator in a variety of therapeutic, diagnostic and prophylactic indications.
Type:
Grant
Filed:
January 30, 2015
Date of Patent:
February 7, 2017
Assignee:
CYTOMX THERAPEUTICS, INC.
Inventors:
Stephen James Moore, Margaret Thy Luu Nguyen, Daniel R. Hostetter, Olga Vasiljeva
Abstract: The present invention provides compositions and methods for inducing an immune response in a subject. In particular, the present invention provides compositions comprising immunostimulatory ligands (ISL) and methods of inducing an immune response in a subject therewith. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.
Type:
Grant
Filed:
January 27, 2014
Date of Patent:
January 31, 2017
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventors:
Joseph Holoshitz, Song Ling, Xiujun Pi, Denise de Almeida, Chaim Gilon, Amnon Hoffman
Abstract: A variety of compositions that include a metal oxide, films and batteries comprising one or more of the compositions, and methods of making the same.
Type:
Grant
Filed:
March 27, 2012
Date of Patent:
January 31, 2017
Assignee:
Massachusetts Institute of Technology
Inventors:
Ki Tae Nam, Chung-Yi Chiang, Angela M. Belcher
Abstract: The present invention provides a novel fusion polypeptide containing a catalytic portion of NPP1 fused to a targeting moiety, nucleic acids encoding the fusion polypeptide, a vector containing the nucleic acid integrated thereinto, a host cell transformed with the vector and pharmaceutical compositions comprising the fusion polypeptide.
Type:
Grant
Filed:
August 1, 2014
Date of Patent:
January 10, 2017
Assignee:
ALEXION PHARMACEUTICALS, INC.
Inventors:
Anthony Quinn, Alex J. Harvey, Zhinan Xia
Abstract: A peptide or peptidomimetic comprising the amino acid sequence of the second helix of a STAT protein, or a variant of such sequence, wherein the peptide or peptidomimetic comprises about 40 or fewer amino acids and binds to a STAT protein, as well as a method of inhibiting a STAT protein in a cell, a method of treating or preventing a disease associated with STAT overexpression in a host, and related compounds, compositions, and methods.
Type:
Grant
Filed:
May 30, 2008
Date of Patent:
January 10, 2017
Assignee:
The United States of America, as represented by the Secretary, Department of Health & Human Services
Inventors:
Nadya I. Tarasova, Olga Timofeeva, Vadim Gaponenko, Christopher J. Michejda, Maria Michejda, Alan O. Perantoni, Sergey G. Tarasov