Patents Examined by Kathleen Kerr Bragdon
  • Patent number: 7629308
    Abstract: The present invention relates to the polypeptides known as muscle calcineurin interacting proteins (MCIPs). These molecules binding to calcineurin and, in so doing, modulate its functions, which includes phosphate removal as part of a pathway coupling Ca2+ to cellular responses in muscle. MCIPs form a physical complex with the catalytic subunit of calcineurin, and increased levels of MCIPs correspond to a reduced ability of calcineurin to stimulate transcription of certain target genes. Methods to exploit these observation are provided and include screening for modulators of MCIP expression and binding to calcineurin, methods of diagnosis of MCIP defects, and methods for treating cardiomyopathies, including cardiac hypertrophy.
    Type: Grant
    Filed: February 13, 2001
    Date of Patent: December 8, 2009
    Assignee: Board of Regents, The University of Texas System
    Inventors: R. Sanders Williams, Beverly Rothermel
  • Patent number: 7462460
    Abstract: The present invention provides methods for identifying evolutionarily significant polynucleotide and polypeptide sequences in human and/or non-human primates which may be associated with a physiological condition, such as enhanced resistance to HCV infection. The invention also provides methods for identifying evolutionarily significant polynucleotides with mutations that are correlated with susceptibility to diseases, such as BRCA1 exon 11. The methods employ comparison of human and non-human primate sequences using statistical methods. Sequences thus identified may be useful as host therapeutic targets and/or in screening assays.
    Type: Grant
    Filed: February 15, 2005
    Date of Patent: December 9, 2008
    Assignee: Evolutionary Genomics, Inc.
    Inventors: Walter Messier, James Sikela
  • Patent number: 7452859
    Abstract: The instant invention provides for proteins, polypeptides, nucleic acid sequences, constructs, expression vectors, host cells, pharmaceutical compositions of, and methods for using human placental bikunin, serine protease inhibitor domains, and fragments thereof.
    Type: Grant
    Filed: March 27, 2006
    Date of Patent: November 18, 2008
    Assignee: Aerovance, Inc.
    Inventors: Paul P. Tamburini, Gary Davis, Katherine A. Delaria, Christopher W. Marlor, Daniel K. Muller
  • Patent number: 7452693
    Abstract: Genetic and biochemical characterization of the leinamycin biosynthesis gene cluster from Streptomyces atroolivaceus S-140 revealed two PKS genes, lnmI and lnmJ, that encode six PKS modules, none of which contains a cognate AT domain. The AT activity is provided in trans by a discrete protein, LnmG, which loads the malonyl coenzyme A extender unit onto the ACP domains of all six PKS modules. This finding provides a basis for methods of engineering modular polyketide synthases and polyketide synthase/nonribosomal peptide synthetases.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: November 18, 2008
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ben Shen, Yi-Qiang Cheng, Gong-Li Tang
  • Patent number: 7445915
    Abstract: The present invention provides a polypeptide comprising an amino acid sequence in which at least one amino acid is deleted, substituted or added in an amino acid sequence of isopropylmalate isomerase derived from a microorganism belonging to coryneform bacteria, wherein a coryneform bacterium which produces the polypeptide comprising the amino acid sequence as the sole isopropylmalate isomerase exhibits a partial leucine requirement in a minimal medium; a DNA encoding the polypeptide, a recombinant DNA comprising the DNA, a microorganism transformed with the recombinant DNA, and a process for producing an L-amino acid using the microorganism.
    Type: Grant
    Filed: March 19, 2003
    Date of Patent: November 4, 2008
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Masato Ikeda, Mikiro Hayashi, Junko Ohnishi, Satoshi Mitsuhashi, Hiroshi Mizoguchi, Satoshi Nakagawa
  • Patent number: 7439337
    Abstract: The present invention is a kit and method for purifying a protein of interest.
    Type: Grant
    Filed: August 2, 2007
    Date of Patent: October 21, 2008
    Assignee: Rutgers, the State University of New Jersey
    Inventor: William W. Ward
  • Patent number: 7432102
    Abstract: An objective of the present invention is to provide a method for producing substance PF1022 derivatives, in particular PF1022-220 and PF1022-260, by a direct fermentation method, and a transformant to be used for this method. According to the present invention, there is provided a transformant producing substance FF1022 derivatives, which can be obtained by introducing a genes involved in a biosynthetic pathway from chorismic acid to p-aminophenylpyruvic acid, including a papA gene encoding 4-amino-4-deoxychorismate synthase. which gene comprises the DNA sequence encoding the amino acid sequence of SEQ ID NO: 2; a papB gene encoding 4-amino-4-deoxyclaismate mutase, which gene comprises the DNA sequence encoding the amino acid sequence of SEQ ID NO: 4; and a papC gene encoding 4-amino-4-deoxyprepbenate dehydrogenase, which gene comprises the DNA sequence encoding the amino acid sequence of SEQ ID NO: 6, into a phenylalanine auxotrophic host induced from an organism that produces a substance PF1022.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: October 7, 2008
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Koji Yanai, Naomi Sumida, Manabu Watanabe, Tatsuki Moriya, Takeshi Murakami
  • Patent number: 7425625
    Abstract: Protein engineered CrtO ketolases isolated from Rhodococcus erythropolis AN12 are provided having increased carotenoid ketolase activity. Methods using the present CrtO ketolases are also provided for increasing ketocarotenoid production in suitable production hosts.
    Type: Grant
    Filed: June 8, 2005
    Date of Patent: September 16, 2008
    Assignee: E.I. du Pont de Nemours and Company
    Inventors: Xiao-Song Tang, Qiong Cheng, Luan Tao, Joanne Y. Shyr
  • Patent number: 7423136
    Abstract: The present invention relates to the production process of biotin by fermentation using genetically engineered microorganisms, including Escherichia coli and Pseudomonas mutabilis, and DNA sequences and vectors to be used in such process.
    Type: Grant
    Filed: October 19, 2005
    Date of Patent: September 9, 2008
    Assignee: Stephen F. Austin State University
    Inventors: Beatrice A. Clack, Alan B. Youngblood
  • Patent number: 7420038
    Abstract: FP-1 is a protein that is specifically expressed in the follicular papilla of the hair follicle. The nucleic acid and amino acid sequences of FP-1, as well as antibodies that specifically bind FP-1 are provided. In addition, methods of isolating follicular papilla cells and methods of modulating hair growth are also disclosed.
    Type: Grant
    Filed: February 21, 2007
    Date of Patent: September 2, 2008
    Assignee: New York University
    Inventors: Tung-Tien Sun, Qiong Cao
  • Patent number: 7420033
    Abstract: The present invention is directed to a composition consisting of a series of novel biologically active 33-mer peptides.
    Type: Grant
    Filed: February 22, 2007
    Date of Patent: September 2, 2008
    Assignee: Agennix, Inc.
    Inventors: Atul Varadhachary, Peter Glynn, Karel Petrak, Jose Engelmayer
  • Patent number: 7417120
    Abstract: The present invention describes methods of producing milligram quantities of three forms of purified Stat1 protein from recombinant DNA constructs. In addition, the Stat proteins may be isolated in their phosphorylated or nonphosphorylated forms (Tyr 701). The proteins can be produced in baculovirus infected insect cells, or E. coli. A compact domain in the amino terminus of Stat1? was isolated and found to enhance DNA binding due to its ability to interact with a neighboring Stat protein. A relatively protease-resistant recombinant truncated form of the Stat protein was isolated in 40-50 mg quantities. Purification of the Stat proteins were performed after modifying specific cysteine residues of the Stat proteins to prevent aggregation. Activated EGF-receptor partially purified from membranes by immunoprecipitation was shown to be capable of in vitro catalysis of the phosphorylation of the tyrosine residue of Stat1 known to be phosphorylated in vivo.
    Type: Grant
    Filed: January 19, 2006
    Date of Patent: August 26, 2008
    Assignee: The Rockefeller University
    Inventors: Uwe Vinkemeier, James E. Darnell, Jr.
  • Patent number: 7407807
    Abstract: The invention describes a method for producing a chimaeric human papillomavirus (HPV) L1 polypeptide containing a heterologous peptide, and in particular, a HPV L2 peptide. The method comprises the steps of introducing a DNA sequence coding for the heterologous peptide into a DNA sequence coding for the L1 polypeptide; introducing the DNA sequence including the sequences for the L1 polypeptide and heterologous peptide into a host cell in which the DNA sequence can be expressed; causing expression of the DNA sequence; and recovering the resulting chimaeric L1 polypeptide which includes the heterologous peptide. Typically, the nucleotides encoding the heterologous peptide replace the nucleotides of the L1 polypeptide at the point of insertion. The invention also describes a vector for use in the method, a host cell containing the vector, and a vaccine including the chimaeric HPV L1 polypeptide produced according to the method.
    Type: Grant
    Filed: May 19, 2003
    Date of Patent: August 5, 2008
    Assignee: University of Cape Town
    Inventors: Arvind Devshi Varsani, Edward Peter Rybicki
  • Patent number: 7407786
    Abstract: New lipase enzymes (both nucleic acids and polypeptides) are provided. Compositions which include these polypeptides, proteins, nucleic acids, recombinant cells, as well as methods involving the enzymes, antibodies to the enzymes, and methods of using the enzymes are also provided.
    Type: Grant
    Filed: August 17, 2004
    Date of Patent: August 5, 2008
    Assignee: Codexis, Inc.
    Inventors: Lorraine J. Giver, Jeremy Minshull, Kurt Vogel
  • Patent number: 7399489
    Abstract: Novel formulations containing exendins, exendin agonists and/or exendin analogs are provided.
    Type: Grant
    Filed: November 10, 2005
    Date of Patent: July 15, 2008
    Assignee: Amylin Pharmaceuticals, Inc.
    Inventors: Orville G. Kolterman, Andrew A. Young, James J. L'Italien
  • Patent number: 7390891
    Abstract: Disclosed are nucleic acid molecules encoding polypeptides of the telomerase complex. Also disclosed are methods of preparing the nucleic acid molecules and polypeptides, and methods of using these molecules.
    Type: Grant
    Filed: October 16, 1997
    Date of Patent: June 24, 2008
    Assignee: Amgen Inc.
    Inventors: Lea Anne Harrington, Murray O. Robinson
  • Patent number: 7358088
    Abstract: The present invention is directed to novel peptides and compositions capable of modulating apoptosis in cells, and to methods of modulating apoptosis employing the novel peptides and compositions of the invention. In one aspect, the invention is directed to a novel peptide designated the “GD domain,” which is essential both to Bak's interaction with Bcl-xL, and to Bak's cell killing function. Methods of identifying agonists or antagonists of GD domain function are provided. The GD domain is responsible for mediating key protein/protein interactions of significance to the actions of multiple cell death regulatory molecules.
    Type: Grant
    Filed: August 10, 2006
    Date of Patent: April 15, 2008
    Assignee: ImmunoGen, Inc.
    Inventors: Thomas D. Chittenden, Robert J. Lutz
  • Patent number: 7348416
    Abstract: The present invention provides a method for enriching cell surface proteins by oxidizing glycosylated protein with periodate. The present invention further provides that the cell surface proteins are obtained from intact cells either from cell lines or from tissues. The present invention provides a method not only capable of obtaining increased quantities of the cell surface proteins, but also capable of obtaining a wide ranges of proteins that are not detectable by other means.
    Type: Grant
    Filed: November 19, 2004
    Date of Patent: March 25, 2008
    Assignee: Applera Corporation
    Inventors: Bruno Domon, Ian McCaffery, Terence Ryan
  • Patent number: 7345158
    Abstract: The present invention provides the novel L-NAME-related actin cytoskeletal protein (LACS) and genes encoding the protein.
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: March 18, 2008
    Assignee: Anges MG, Inc.
    Inventors: Kensuke Egashira, Shujiro Inoue
  • Patent number: 7314917
    Abstract: The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: January 1, 2008
    Assignee: Regents of the University of Minnesota
    Inventor: Gary L. Nelsestuen