Abstract: In accordance with the present invention there is provided a suturing device. The suturing device includes a length of suture that will be delivered to the site of the PFO and placed through the tissue adjacent the opening to close the PFO. As described in greater detail below, the suture is advanced through the tissue surrounding the opening by a pair of needles that penetrate the tissue adjacent to the opening. A knot is then loosely tied with the length of suture and advanced to the site of the PFO. The tails of the suture extending from the knot are then cut and removed. It is also contemplated that a pre-formed or pre-tied knot may be disposed on the device, wherein after deployment of the suture through the tissue adjacent to the PFO and removal of the device a loop of suture having a pre-tied knot will remain, wherein the pre-tied knot may then be tightened to close the PFO. Further still it is contemplated that other means may be utilized to retain the sutures.

Abstract: A skin incision device has a casing with a bottom surface and a slot formed therein, a cover positioned on the casing and slidable in a direction toward the bottom surface, a blade positioned in the casing adjacent the slot, an actuator cooperative to a position between the cover and interior of the casing, and a carriage. The actuator engages the blade by its horizontal displacement triggered by slidable movement of the cover toward the bottom surface of the casing. The carriage element guides movement of the blade between a pre-actuated position and a post-actuated position. The blade extends outwardly of the bottom surface with a fixed depth of cut during a horizontal movement of the blade through the slot.

Abstract: Suturing instruments in accordance with the invention are dimensioned and configured to apply sutures to approximate, ligate, or fixate tissue in, for example, open, mini-incision, trans-vaginal, laparoscopic, or endoscopic surgical procedures. In some embodiments, the suturing instruments include a distal portion that is deflectably and/or pivotally coupled to the remainder of the instrument for improved maneuverability and functionality during surgery. In other embodiments, the suturing instruments are capable of housing multiple needle and suture assemblies and/or reloading the needle and suture assembly without removing the instrument from the surgical site.

Abstract: Forceps with a pair of scissor-like arms that are pivotally connected to each other and that continue past the pivot to form a catheter guide. At least two and preferably three bends are disposed in the arms immediately before the pivot, which allow the medical professional to place the guiding end of the forceps in the correct place while maintaining good visual contact with the patient's vocal cords. An alternative embodiment provides a fourth bend near the guiding end of the forceps that allows for easier insertion of a catheter in some patients, such as children.

Abstract: The proximal actuator is operable with various medical devices which have one tube or wire axially movable with respect to another tube or wire (e.g., a guide wire operable within an actuation sleeve). The actuator includes a deployment handle which is transversely or laterally (not axially) removably attachable. The actuator includes first retaining device (e.g., spring clip grip) removably attachable to the actuation sleeve and second retaining device removably attachable to the wire member. The second retainer moves relative to the first retainer such that the sleeve slides over the wire thereby moving a medical device at the distal end of the system. The handle may have a grip and a sleeve defining an aperture and a sliding member in the sleeve. The slide member is rotatably mounted to one retainer and is threadably mounted to the other retainer such that upon rotation, one moves with respect to the other.

Abstract: An endovascular stapler for securing an endograft to a vessel is disclosed. The stapler includes a staple housing adapted for storing at least one staple therein. The staple housing having an exit area for discharge of the at least one staple therethrough. The stapler also includes an actuating assembly adapted for discharging the at least one staple through the exit area and a displacement mechanism in operative association with the staple housing near the exit area. The displacement member is operative for pushing the exit area against the endograft when discharging the at least one staple therethrough. The displacement mechanism may comprise a balloon adapted to be inflated and deflated positioned near the exit area. The unbent staples may be shaped as elongate W shapes, or may alternatively be straight wire segments. The staples may be bent upon discharge.

Abstract: The present invention is directed to various systems for repairing tissue within the heart of a patient. The mitral valve repair system of the present invention comprises a guide catheter having a proximal end, a distal end, and at least one internal lumen formed therein, a therapy catheter capable of applying a suture to the tissue, and a fastener catheter capable of attaching a fastener to the suture. The therapy catheter and the fastener catheter are capable of traversing the internal lumen of the guide catheter. In addition, the present invention discloses various methods for repairing tissue within the heart of a patient.

Abstract: A deployment device for anchoring a suture to a suture anchoring device, which is made from a helically coiled member, includes a winding tube for winding a suture around the coiled member in a helical path such that the suture is attached to at least one turn of the coiled member. A support mechanism is also provided for supporting the suture anchoring device during the winding of the suture around the coiled member. The deployment device can be used for anchoring a string and the like to any helically coiled member.

Abstract: A fresh donor tissue valve isolation annulus size comprising a handle and trigger or crank knob manipulated by the user moves a movable probe into proximity with a stationary probe so that the probes can be inserted into the tissue valve lumen. The user releases the trigger or crank, and a biasing mechanism urges the movable probe away from the stationary probe until the resistance presented by the valve annulus equals the biasing force. A gage coupled to the movable probe displays a measure of the valve annulus diameter as a function of the distance that the movable probe moves away from the stationary probe until restrained from further movement by the fresh tissue valve annulus.

Abstract: Apparatus and method are provided for treatment of a bifurcation of a body lumen. The apparatus includes an elongated catheter body having a proximal end and a distal end. A balloon is associated with the distal end of the balloon catheter. The balloon includes a main vessel balloon for treating a main vessel of the bifurcation, and a branch vessel balloon for treating a branch vessel of the bifurcation. The branch vessel balloon includes an accordion configuration capable of being expanded from an unexpanded collapsed accordion configuration to an expanded accordion configuration extending into the branch vessel.

Abstract: A vessel filter comprising a first region and a second region wherein the filter is movable between a collapsed position for delivery to the vessel and an expanded position for placement within the vessel. A first region has a filter portion having a converging region at a first end portion to direct particles toward the center of the filter and the second region is flared in the expanded position to have a transverse dimension increasing toward a second end portion opposite the first end portion. The second region includes a vessel engaging portion at the second end portion. The second region includes a plurality of spaced apart struts with adjacent struts being joined.

Abstract: A pull-locking rotational action needle driver that comprises an ergonomically designed handle and an integrated locking system that permits left and right handed surgeons to perform the surgical suturing procedure in a less complicated and more secure way by allowing more control over the suturing needle and the area to be stitched, even when the suturing area is small, deep, and/or restricted.

Abstract: A surgical clip having a sliding state and a crimped state is adapted for use in a surgical procedure initially to slide along suture ends to an operative position and ultimately to crimp the suture ends at the operative position. a sub straight, bendable between the sliding state and the crimped state carries at least one coating having either lubricious or traction enhancing properties. A second coating can be added to form a coating laminate with the outer coating having lubricious properties facilitating the sliding state and the inner coating having traction enhancing properties facilitating thee crimped state.

Abstract: The device is formed from a multi-stranded micro-cable having a plurality of flexible strands of a shape memory material and at least one radiopaque strand. The strands can be made of a shape memory nickel titanium alloy, that is highly flexible at a temperature appropriate for introduction into the body via a catheter, and that after placement will take on the therapeutic shape. The radiopaque strand can have a core strand with a plurality of intermittently spaced apart enlarged radiopaque portions that may be a plurality of beads of radiopaque material spaced apart and mounted on the core strand, or a plurality of coils intermittently wound about and spaced apart on the core strand. A polyhedral occlusive device is also provided, adapted to be inserted into a portion of a vasculature for occluding a portion of the vasculature, for use in interventional therapy and vascular surgery.

Abstract: An automatic safe disposable blood sampling device includes a casing with a launching chamber formed therein. The launching chamber has a lancet needle-exiting hole at a front end thereof; a lancet needle arranged inside the launching chamber; a spring; a launching mechanism composed of the spring and a catch-launching mechanism; a press-launching mechanism provided on the casing; and a self-locking mechanism composed of barbs provided on the press-launching mechanism and self-locking hooks or notches provided on the casing which engage corresponding barbs. When pressed, the press-launching mechanism triggers the catch-launching mechanism, to disengage the lancet needle from the casing. The spring pushes the lancet needle so as to launch the lancet needle. During forward movement of the press-launching mechanism, the barbs pass across the self-locking hooks or notches. In the process of retraction, the barbs are locked with the self-locking hooks or notches and cannot return to their initial states.

Abstract: An intervertebral distraction tool has a clamshell head with upper and lower halves, each having a curvate outer surface and a flat inner surface. The distal side of the head is hinged so that the head opens and closes from the proximal side of the head. The hinge is a separating hinge that allows the halves to not only angulate with respect to one another about the hinge axis, but also to vertically separate from one another at the hinge. A distraction separator has decreasing taper at its distal end and a longitudinal bore that accommodates the elongate shaft of the trial so that the separator can be moved longitudinally relative to the shaft. Upon forward movement of the separator, the tapered upper and lower surfaces engage the flat inner surfaces of the head, causing the halves to angulate about the hinge axis of the head, thereby opening the head.

Abstract: The present invention relates to a decompression-compensating instrument for use in intraocular surgery, wherein a perfusate is supplied to an affected part of an eye via a supply channel at a predetermined pressure, and the perfusate is aspirated via an aspiration channel together with the affected tissues that are to be removed, the decompression-compensating instrument supplying the perfusate into the affected part when the internal pressure of the affected part is excessively lowered, and being constructed so as to be connectable to a point midway along the supply channel and comprising a storage-member that forms a chamber that is closable except for an opening from which the perfusate to be supplied to the supply channel flows, the capacity of the storage member being 7 cm3 to 22 cm3.

Abstract: The present invention provides a novel and most useful working tool for a resectoscope, adapted to side-to-side resection of biological tissue using predetermined lateral movement. Said resectoscope is adapted to either cold or hot resection and is either flexible or rigid. The present invention also provides for a suitable cutting member assembly and to a method useful for lateral resection.

Abstract: Custom-length self-expanding stent delivery systems and methods enable precise control of prosthesis position during deployment. The stent delivery systems carry multiple stent segments and include a stent bumper for helping control the axial position of the stent segments during deployment. This enables the deployment of multiple prostheses at a target site with precision and predictability, preventing stent segment recoil and ejection from the delivery device and thus eliminating excessive spacing or overlap between prostheses. In particular embodiments, the prostheses of the invention are deployed in stenotic lesions in coronary or peripheral arteries or in other vascular locations.

Abstract: A device is provided for use with a body fluid sampling device for extracting bodily fluid from an anatomical feature. The device comprises a cartridge having a plurality of cavities. The device may include a plurality of penetrating members each at least partially contained in the cavities of the cartridge wherein the penetrating members are slidably movable to extend outward from openings on the cartridge to penetrate tissue. The device may also include a plurality of analyte detecting members and a plurality of chambers. Each chamber may be associated with one of the cavities, the chambers positioned along an outer periphery of the cartridge, wherein at least one of said analyte detecting members forms a portion of one wall of one of said plurality of chambers. In one embodiment, the device may also include a fluid spreader positioned over at least a portion of said analyte detecting member to urge fluid toward one of the detecting members.