Abstract: This invention relates to a two-part system useful for treating proteinaceous substrates. The two-part system has a first part comprising a water-soluble/dispersible reactive polyimido compound and a second part comprising a nucleophilic catalytic agent. The polyimido compounds may be selected from the group consisting of polysuccinimide compounds, polyglutimide compounds, and copolymers of thereof. The polyimido compound may also comprise a functionalizing moiety that provides functionality to the polyimido compound and is preferably derived from a nucleophilic moiety selected from the group consisting of amines, alcohols, phenols, thiols, and carboxylates; and a water-solubilizing/dispersing moiety that provides water-solubility and/or water-dispersibility to the polyimido compound and is preferably derived from a nucleophilic moiety selected from the group consisting of amines, alcohols, phenols, thiols, and carboxylates.

Abstract: The invention is directed to a filamentous porous film that can act as a support for cellular attachment, growth and organization. The film is formed from filaments which define a matrix structure with pores.

Abstract: The invention relates to laminate plastics, preferably in the form of tubes, having an inner layer of thermoplastic and an outer layer of typically fiber-reinforced reaction resins, and is characterized in that the curing of the reaction resins is effected by light curing at temperatures between approximately 20 and 60° C.

Abstract: An anhydrous lotion composition for killing viruses and bacteria in addition to imparting a soft, lubricious, lotion-like feel when applied to tissue paper and tissue paper treated with such lotion compositions are disclosed. The antiviral action of the lotion is due to the addition of an organic acid such as citric acid or salicylic acid. The antibacterial action is due to the addition of antibacterial agents such as TRICLOSAN®. The solubilization of the antiviral and antibacterial agents within the lotion matrix is aided by the addition of hydrophilic solvents and hydrophilic surfactants. The lubricious lotions also contain a plastic or fluid skin conditioning agent such as petrolatum, an optional immobilizing agent such as a fatty alcohol or fatty acid to immobilize the skin conditioning agent on the surface of the tissue paper web and a hydrophilic surfactant to improve wettability when applied to toilet tissue.

Abstract: An improved method for the manufacture of transdermal drug delivery devices comprising liquid dispersions of a liquid in an aqueous or nonaqueous matrix is disclosed. More particularly, the invention relates to preventing the formation of a crystalline structure in such liquid dispersions by annealing films and laminates in-line immediately following film formation and/or lamination during the manufacture of these devices.

Abstract: A hydrogel wound dressing which is highly absorptive, contours to a wound site and maintains the wound in a moist state to promote healing thereof.

Abstract: Deodorant granulate for lining ashtrays for receiving tobacco ash, including an active component. The active component includes perfume which is one of aromatic and suitable for use on the human body, high viscosity solvent with low evaporation, and undecylenic acid deodorant. The active component is incorporated into non-inflammable mineral granulates whose granularity is selected so as not to leave any trace of dust when used, and has a porosity that enables the mineral granulate to absorb at least 15 wt % of the active component, and to release the active component upon contact with a lit cigarette or cigar. Method for lining ashtrays.

Abstract: A form of administration for applying pharmaceutical substances, auxiliary substances and diagnostic agents including a flexible carrier which is water repellant or is rendered water repellant, having a preparation in the form of a lyophilizate adhering to the carrier. The preparation contains a medicament and a hydrophilic polymer which can swell or is water-soluble. During application, the preparation is detached from the carrier for the purpose of application by rehydration of the preparation on contact with liquid.

Abstract: Oral active agent delivery system having improved flow controllers. A hollow tubular member containing the active agent formulation and having a fluid passing controller is placed at one end into a fluid and at a second end into a patient's mouth. The active agent is delivered when the patient sips on the end of the chamber. The improved controllers prevent leakage of the active agent formulation.

Abstract: The present invention is directed to compositions, and methods for the delivery of drugs. Devices for the transdermal delivery of drugs are also provided. Specifically, the present invention relates to hydrogel compositions comprising water and a base mixture, in which the base mixture comprises: (i) a gelling agent consisting of methycellulose or at least one natural gum, or a mixture thereof; (ii) at least one natural gum: (iii) glucose; (iv) propylparaben; (v) methyl paraben; and (vi) sodium chloride. The compositions may further comprise pectin, glycolic, alcoholic or oil-based additives, a coloring, fragrance, or other pharmaceutically acceptable additive. The compositions may further comprise substituted ureas of the formula R—NH—CO—NH2 such as butylurea. The compositions may further comprise drugs such as hormones selected from progesterone, progestin, estrogen and testosterone. Methods for the treatment of disorders responsive to hormone therapy are also provided.

Abstract: A glass fiber chemical delivery system including water soluble fiberglass particles containing a chemical composition. The water soluble fiberglass particles may define pores in which the chemical composition is contained or the water soluble fiberglass particles may each define a hollow core containing the chemical composition. As the fiberglass particles dissolve in an aqueous environment, such as within cells of a blood vessel wall or in a reaction vessel, the chemical composition is released.

Abstract: Transdermal compositions, devices, and methods for the administration of a drug at reduced skin irritation levels are disclosed. More particularly, this invention relates to novel methods, compositions, and devices for the reduction or elimination of irritation or sensitization caused by an irritating or sensitizing drug when it is delivered transdermally. According to a preferred embodiment, transdermal administration of a drug salt of a non-zwitterionic drug is disclosed wherein the drug salt comprises a combination of surface activity and a low octanol-water partition coefficient. Such drug salts have been found to reduce irritation or sensitization to the drug being delivered while achieving therapeutically effective transdermal fluxes.

Abstract: The present invention relates to breathable perspiration pads such as underarm-, wrist- and head-perspiration pads, collar inserts, and shoe inserts, having a breathable backsheet, and an odor control system. The combination of breathability and the odor control system delivers an improved odor control performance of the perspiration pad.

Abstract: The present invention relates to a process and a device for the production of a flat administration form comprising a preparation that contains pharmaceutical active substances. The flowable preparation is conveyed to an applicator unit (12) by means of a metering pump, and flows through a distribution chamber (2) having a distribution plate (3) provided with passages (4). This application device (12) transfers the preparation onto a layer of the flat administration form (6,11) which is therefor contacted with the distribution plate (3) for a short time.

Abstract: The invention relates to an Oral Delayed Immediate Release formulation comprising a compressed core containing one or more active substances surrounded with a coating, wherein release of active substance from the core is caused by rupture of the coating after a definite lag-time, said core comprising one or more immediate release carriers and having no substantial swelling properties upon exposure to gastrointestinal fluids. The invention further relates to formulations containing an Immediate Release formulation combined with one or more Oral Delayed Immediate Release formulations with different lag-times and to a method of preparing an Oral Delayed Immediate Release formulation.

Abstract: A laminated deodorant filter medium is constituted by a plurality of laminate units laminated together; each of which includes a fiber web constituted by a connecting portion and a resin-aggregating portion, both of which are made of a hotmelt resin, and a deodorant particle firmly attached to one surface of the fiber web by way of the resin-aggregating portion. Employable as the deodorant particle is at least two kinds of deodorant particles including an acidic odor deodorant particle, an alkaline odor deodorant particle, and a physically adsorbing particle. As the resin-aggregating portion is formed at a part where a hotmelt nonwoven fabric and the deodorant particle are in contact with each other, the deodorant particle can be firmly attached to the fiber web as a single layer without using a binder, whereby a deodorant filter medium having a low pressure loss and high efficiency can be obtained.

Abstract: Improved deodorants for offensive odors are made by combinations in a suitable solvent or carrier of at least two aldehydes, preferably in the form of addition components, with at least one unsaturated compound. These combinations can be further improved by the addition of other ingredients such as acidic or basic compounds, antioxidants, surfactants, chelating agents, and antimicrobial agents.

Abstract: Disclosed are anhydrous antiperspirant gel-solid stick compositions which comprise a particulate antiperspirant active; a solid non-polymeric gellant that is substantially free of dibenzylidene alditol, n-acyl amino acid derivatives, organic polymeric gellants, and inorganic thickening agents; and an anhydrous liquid carrier having an average solubility parameter of from about 3 to about 13 (cal/cm3)0.5 wherein the composition has a visible residue index of from about 11 to about 30 L-value, a product hardness of from about 500 gram-force to about 5,000 gram-force, a ratio of an elastic to viscous moduli of from about 0.1 to about 100. The refractive indices of the particulate antiperspirant active, solid non-polymeric gellant, and anhydrous liquid carrier are not matched. The solid non-polymeric gellant is preferably a crystalline material having an average particle size of less than about 1 &mgr;m, and/or has an elongated particle morphology having an aspect ratio of greater than about 2.

Abstract: An antimicrobial multi-layer island dressing including an inner absorbent assembly having a first layer comprising a wound contacting non-absorbent, non-adhering porous polymeric film which is impregnated with a broad spectrum antimicrobial agent, a second layer comprising a semipermeable continuous polymeric film joined to the first layer to form a sealed interior reservoir compartment, an absorbent material positioned within the interior reservoir compartment to collect discharged exudate from a wound, and an outer layer extending beyond the peripheral edges of the inner absorbent assembly, the outer layer having at least a portion coated with an adhesive material for adhering the island dressing to the wound area. The preferred antimicrobial agent is 2,4,4′-trichloro-2′-hydroxydiphenyl ether and may be present in an amount from about 0.01 to about 25 percent by weight of film material.

Abstract: A gum growth pad (10) comprising has a nonporous first layer (12). An and an absorbent second layer (14) is placed upon the nonporous first layer (12). A gum tissue growth medication (16) in a liquid form is may be impregnated within the absorbent second layer (14) and then dried. A semi-permeable third layer (18) covers the absorbent second layer (14) with the dried gum tissue growth medication (16). A facility (20) is for sealing the nonporous first layer (12) to the semi-permeable third layer (18) about a periphery thereof.