Abstract: The present disclosure provides a metering mechanism for an injection device. The mechanism comprises an actuating element for setting or discharging a dose from the injection device, a piston rod for producing an advance movement for dispensing a dose, a piston rod sleeve in which the piston rod is accommodated such that the piston rod can be non-rotatably connected to the piston rod sleeve, and a coupling element with which the actuating element and the piston rod sleeve can be coupled for discharge of the dose set with the actuating element. To prevent underdosage, the piston rod comprises a stop and the coupling element comprises a counter-stop which move relative to each other at least during setting of a dose and which abut each other in a maximum dose stop position, thereby preventing further setting of a dose.

Abstract: A pericardial puncture device includes an introducer, a needle, and an actuator. The introducer has a lumen and extends between an introducer proximal portion defining an introducer proximal end and an introducer distal portion defining an introducer distal end. The needle is received in the lumen and extends between a needle proximal portion and a needle distal portion having a sharp distal tip. The needle is movable from a retracted configuration to an advanced configuration. In the retracted configuration, the sharp distal tip is within the lumen and shy of the introducer distal end. In the advanced configuration, the sharp distal tip outside of the lumen and proud of the introducer distal end. The actuator includes a handle that is rotatable in a first direction with respect to the introducer to drive movement of the needle from the retracted configuration towards the advanced configuration.

Abstract: A device for connection to a medical connector, the device includes a cap having an annular wall having an exterior wall surface and an interior wall surface including a plurality of inwardly extending protrusions sized and shaped to frictionally engage a male luer, and a peelable seal. The cap configured to define a chamber to contain an absorbent material and disinfectant or antimicrobial agent. The cap includes one or more threads adapted to engage with a female luer connector. The cap is adapted to engage a male luer connector in a press-fit connection. The peelable seal prevents the disinfectant or the antimicrobial agent from exiting the chamber. Also described are methods of disinfecting a medical connector, and apparatuses comprising a device for disinfecting a medical connector.

Abstract: Elongate blood flash flow paths can be detrimental to the operation of catheter placement systems by delaying the indication time, reducing the efficacy of the vacuum, or increasing the chance of clotting. Catheter placement systems with reduced blood flash fluid paths include blood flash indicators having a proximally slidable syringe barrel and plunger that is fixedly attached to the system housing. By reversing the operation of the blood flash indicator syringe, the clinician maintains the advantages of a visual and tactile feedback while shortening the blood flow path between the needle tip and syringe barrel. Catheter placement systems also include a needle interface structure configured to further shorten the blood flash fluid path.

Abstract: A cartridge unit for a drug delivery device is provided, comprising: a cartridge unit guide feature, the cartridge unit guide feature being provided to mechanically cooperate with a housing guide feature provided on a housing to establish a guiding interface in order to guide relative movement of the cartridge unit and the housing when attaching the cartridge unit to the housing, wherein the cartridge unit guide feature is provided with at least one cartridge unit interface feature, wherein the cartridge unit interface feature is adapted to establish a further interface with the housing.

Abstract: Injection devices include a cap for removing a needle shield cap from a product container, and methods for assembling such injection devices, involve providing a cap that includes an engagement element for use in removing the needle shield cap from the product container when the cap is removed from the injection device.

Abstract: Provided is a connection member which is not limited by the material, the tube thickness, the tube diameter or the like of a suction tube and a discharge tube to be connected to a pump, and can eliminate troubles in the tube attachment. A connection member includes: a pump attachment part; a tube connecting part; and a flow passage defining part. At least a portion of each of the suction passage section and the discharge passage section of the flow passage defining part includes membranes deformable due to pressures of the liquid flowing in the suction passage section and the discharge passage section. The flow passage defining part has a shape allowing the flow passage defining part to be attached in an arrangement that the membranes face sensors for detecting a flow state of the liquid flowing in the suction passage section and the discharge passage section by deformation of the membranes.

Abstract: A cartridge assembly for a drug delivery device is described. The cartridge assembly includes a cartridge containing a drug, the cartridge including a dispensing end; a cartridge holder, the cartridge holder defining an interior cartridge holding section, where the cartridge is arranged within the cartridge holding section; and a fixing feature. The fixing feature includes a fixing surface, in particular a radially oriented surface, which is arranged to abut a cartridge surface of the cartridge, in particular a radially oriented surface, to prevent removal of the cartridge from the cartridge holder such that the cartridge is permanently secured in the cartridge holder.

Abstract: A cartridge assembly for a drug delivery device is described. The cartridge assembly includes (i) a cartridge containing a drug, the cartridge including a dispensing end; (ii) a cartridge holder, the cartridge holder defining an interior cartridge holding section, in which the cartridge is arranged within the cartridge holding section; and (iii) a fixing member. The fixing member includes a fixing surface arranged to abut a cartridge surface of the cartridge, in particular a radially oriented surface. The cartridge surface is a proximal surface which faces away from the dispensing end of the cartridge, and the cartridge surface is arranged between the dispensing end of the cartridge and the end opposite of the dispensing end. The fixing member includes a securing surface which is arranged to abut a holder surface of the cartridge holder. Further, a drug delivery device and a method for assembling the cartridge assembly are described.

Abstract: A cannula cartridge for receiving a cannula includes a needle assembly, a cannula and a protector. The needle assembly is movable within the protector between first and second positions. In the first position the needle is covered by the protector and a retainer of the protector engages an engagement element of the needle hub by a form fit connection. In the second position the needle at least partially extends from the protector. An inserter can move the needle assembly between the first position and to the second position and then back to the first position. The retainer and the engagement element are configured such that a holding force of the retainer is overcome by applying forces parallel to the axis of the needle. An inventive kit that includes an inserter and a driver for moving the needle assembly and a method of manufacturing the cannula cartridge are also disclosed.

Abstract: Disclosed is an applicator, and a handle for an applicator. The applicator has at least one barrel and a piston moveable within the at least one barrel to stroke between a variable first position and a second position. In use, movement of the piston towards the first position can draw a first fluid into the barrel, and movement of the piston towards the second position can force the first fluid out of the barrel. The barrel has at least one fluid inlet valve to allow the fluid to flow into the at least one barrel at least under action of the piston, and at least one fluid outlet valve to allow the first fluid to flow out of the at least one barrel at least under action of the piston. A handle has a piston actuator assembly, housed at least in part within a body of the handle, operable to move the piston towards the second position to dispense the first fluid from the applicator.

Abstract: A medical injection system adapted for a single-handed injection, the medical injection device comprising a gas compartment configured to contain a gas, the gas compartment comprising a piston, a reservoir intended to contain a drug composition, the reservoir having a proximal portion and a distal portion provided with a fluid exit configured to receive an injection needle, wherein the piston can move proximally between a distal position defining a first volume of the gas compartment to a proximal position defining a second volume of the gas compartment smaller than the first volume, and wherein the gas compartment is in gas communication with the reservoir in order to force the drug composition through the fluid exit, when the piston is moved proximally.