Abstract: Systems and methods for computer-assisted systems using robotic technology are described. For example, this disclosure describes systems and methods that can be used in various contexts such as, but not limited to, minimally invasive computer-assisted tele-operated surgery using robotic technology. The disclosure describes instruments and mechanisms for actuating and controlling the motions of such instruments. The instruments and actuator mechanisms may be used in medical operations and non-medical operations.

Abstract: Disclosed herein is a screw-in lead implantable in the pericardium of a patient heart and a system for delivering such leads to an implantation location. The leads include a helical tip electrode and a curvate body including a defibrillator coil with improved contact between the defibrillator coil and the patient heart. The delivery system includes a delivery catheter and lead receiving sheath disposed within the catheter. A fixation tine is disposed on one of the delivery catheter and the lead receiving sheath such that the delivery system may be anchored into the pericardium during fixation of the screw-in lead. In certain implementations, an implantable sleeve receives the leads to bias the defibrillator coil against the patient heart.

Abstract: A method, including receiving a unipolar ECG signal from the location in the heart from a selected one electrode of a pair of electrodes, computing a local unipolar minimum derivative of the unipolar signal at a plurality of times of occurrences of the local unipolar minimum derivative, identifying candidate time of occurrences of the plurality of times of occurrences of the local unipolar minimum derivative as candidate annotations of the time of activation of the myocardium, extracting features for each of the candidate annotations, assigning a confidence level based on a feature value for each of the candidate annotations, eliminating candidate annotations that have a confidence level below a threshold and generating a local activation time map using the remaining candidate annotations.

Abstract: In one example, a method includes selecting, by one or more processors and based on a representation of sensed electrical signals for a particular patient and a plurality of representations of sensed electrical signals for a plurality of other patients, a combination of electrodes of a plurality of combinations of one or more implantable electrodes for delivery of electrical stimulation to the particular patient.

Abstract: A blood pump system for persistently increasing the overall diameter and lumen diameter of peripheral veins and arteries by persistently increasing the speed of blood and the wall shear stress in a peripheral vein or artery for a period of time sufficient to result in a persistent increase in the overall diameter and lumen diameter of the vessel is provided. The blood pump system includes a blood pump, blood conduit(s), a control system with optional sensors, and a power source. The pump system is configured to connect to the vascular system in a patient and pump blood at a desired rate and pulsatility. The pumping of blood is monitored and adjusted, as necessary, to maintain the desired elevated blood speed, wall shear stress, and desired pulsatility in the target vessel to optimize the rate and extent of persistent increase in the overall diameter and lumen diameter of the target vessel.

Abstract: A system includes an interface and a processor. The interface is configured to receive an electrogram acquired in a heart of a patient. The processor is configured to (i) estimate a level of injury current present in the electrogram, and (ii) based on the estimated level of injury current, decide whether to use the electrogram in a subsequent analysis.

Abstract: A biopotential measurement device including a plurality of sensing electrodes and a controller is described. The plurality of sensing electrodes is adapted to measure one or more biopotential signals when the plurality of sensing electrodes is worn. The controller is coupled to the plurality of sensing electrodes and memory that stores instructions that when executed by the controller cause the biopotential measurement device to perform operations. The operations include collecting electrical signals over a first time period, each of the electrical signals associated with at least one of the plurality of sensing electrodes, mixing the electrical signals to generate a biopotential dataset that includes permutations of the electrical signals, and identifying a target biopotential signal included in the one or more biopotential signals based, at least in part, on the biopotential dataset.

Abstract: In one embodiment the invention provides a process of capturing a biopotential signal at a surface of a body using a sensor receiver which forms a first signal connection the body wherein one or more parameters of impedance of the first signal connection are unknown. The process comprises receiving the biopotential signal at an output of a first signal channel having a first transfer function which is dependent on the one of more unknown first impedance parameters. The process also comprises receiving the biopotential signal at an output of a second signal channel having a second transfer function dependent on the one of more unknown first impedance parameters. The process also comprises deriving a set of relations for the biopotential signal.

Abstract: Disclosed is a portable electrocardiogram measuring device for calculating one or more electrocardiogram leads according to an embodiment of the present disclosure. The device may include: a main measurement unit comprising a first electrode, a second electrode, and one or more processors; and a sub measurement unit comprising a third electrode, in which the one or more processors measure an electrocardiogram, by receiving electrical signals from at least two electrodes in a measurable state and by calculating different types of electrocardiogram leads based on the number of electrodes in the measurable state and an attachment position of electrodes.

Abstract: A neurostimulation system configured for providing neurostimulation therapy to a patient. A user customizes a pulse pattern on a pulse-by-pulse basis. Electrical stimulation energy is delivered to at least one electrode in accordance with the customized pulse pattern.

Abstract: Systems are provided for generating data representing electromagnetic states of a heart for medical, scientific, research, and/or engineering purposes. The systems generate the data based on source configurations such as dimensions of, and scar or fibrosis or pro-arrhythmic substrate location within, a heart and a computational model of the electromagnetic output of the heart. The systems may dynamically generate the source configurations to provide representative source configurations that may be found in a population. For each source configuration of the electromagnetic source, the systems run a simulation of the functioning of the heart to generate modeled electromagnetic output (e.g., an electromagnetic mesh for each simulation step with a voltage at each point of the electromagnetic mesh) for that source configuration.

Abstract: In one embodiment, a method to detect noise levels in electrocardiogram (ECG) signals. The method includes connecting to at least three sensing electrodes and obtaining a signal from each of the at least three sensing electrodes. The method also includes defining at least three channels between the at least three electrodes and obtaining heart data for a predetermined time period from the at least three channels wherein the heart data includes heart rate and QRS width. The method further includes comparing the heart data of each of the at least three channels to a consistency threshold.

Abstract: In an example, a method includes receiving a cardiac signal that is sensed by an electrode at a tissue location inside the heart. Fractionations are identified in the cardiac signal. The fractionations identified at the tissue location are compared between first and second cardiac cycles of the cardiac signal. Based on the comparing, a likelihood is estimated, that the tissue location is causing a stable arrhythmia. Based on the estimated likelihood, the tissue location is indicated to a user as likely to be causing the stable arrhythmia.

Abstract: Body-worn systems and methods for continuously monitoring a patient for cardiac electrical signals and identifying rhythm abnormalities including atrial fibrillation.

Abstract: This application provides a method and apparatus of analyzing the ECG frequency parameters with applications for the diagnosis of ST-segment elevation myocardial infarction (STEMI) diseases, which relates to the interdisciplinary field of biomedical and science engineering. The method includes obtaining ECG signals from subjects through the designed electrodes; calculating ECG frequency domain parameters of the subjects based on the proposed power spectrum model and getting the analytical validation results after studying and verifying the parameters; generating indicators based on the analytical validation results, which could be potentially used as alternative indicators for STEMI diagnosis; and alerting when the indicators meet preset abnormal conditions. The present embodiment is a powerful tool to diagnose STEMI diseases faster and more effectively and helps patients receive timely assistance and treatment.

Abstract: Medical apparatus includes a probe with a basket assembly at its distal end, including a plurality of resilient spines with multiple electrodes arrayed along a length of each of the spines. Processing circuitry is configured to acquire a first bipolar electrical signal from the tissue between first and second electrodes at first and second locations along a first spine of the basket assembly, and to acquire a second bipolar electrical signal from the tissue between the first electrode and a third electrode in a third location on a second spine of the basket assembly, and to interpolate, based on the first and second bipolar electrical signals, a vectorial electrical property of the tissue along an axis that passes through the first location and between the second and third locations.

Abstract: An operating room cable assembly for an electrical stimulation system that includes a lead connector having a housing, a lead lumen extending inwardly from a first opening in the housing and configured and arranged to receive a portion of a lead or lead extension, and a contact assembly disposed within the housing and configured and arranged to move relative to the housing. The contact assembly is configured and arranged to move to a load position and is biased to return to a lock position. The contact assembly includes of contacts that are configured and arranged to engage a portion of any lead or lead extension within the lead lumen when the contact assembly is in the lock position and to disengage from the portion of the lead or lead extension within the lead lumen when the contact assembly is in the load position.

Abstract: A medical implant is in the form of an implantable pulse generator. The implantable pulse generator includes a housing and a socket arranged on the housing for receiving an end portion of a lead. The socket provides a strain relief for the lead. The strain relief forms a sleeve which surrounds a through-opening for receiving the lead. A seal protrudes from an inner side of the sleeve facing the through-opening and is designed to sealably close the through-opening when no lead is inserted into the through-opening.

Abstract: A method to provide feedback, coaching, and ECG analysis during a cardiac event. A rescuer would typically be attempting cardiopulmonary resuscitation (CPR) and/or administering an electrical shock from a defibrillator and/or collecting electrocardiogram (ECG) data. The method includes a step of providing a data-generation device (e.g., a camera) and computing components. The computer is used to calculate distances on the fly using data generated by the data-generation device, such as a camera, that may be in motion. The method uses the computer to calculate movement of the chest of a patient and to assess outcomes. When CPR contaminates an ECG, the computer removes the unwanted contamination so that proper guidance to the rescuer can be delivered during CPR.

Abstract: The invention provides a body-worn monitor that measures a patient's vital signs (e.g. blood pressure, SpO2, heart rate, respiratory rate, and temperature) while simultaneously characterizing their activity state (e.g. resting, walking, convulsing, falling). The body-worn monitor processes this information to minimize corruption of the vital signs by motion-related artifacts. A software framework generates alarms/alerts based on threshold values that are either preset or determined in real time. The framework additionally includes a series of ‘heuristic’ rules that take the patient's activity state and motion into account, and process the vital signs accordingly. These rules, for example, indicate that a walking patient is likely breathing and has a regular heart rate, even if their motion-corrupted vital signs suggest otherwise.