Patents Examined by Kevin Bates
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Patent number: 12070509Abstract: Nucleotides encoding a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein are provided herein. Also describe are mRNA constructs that can be used to express CFTR protein in vitro or in vivo. The mRNA constructs can be formulated in a lipid formulation and administered via inhalation to treat cystic fibrosis.Type: GrantFiled: April 30, 2021Date of Patent: August 27, 2024Assignee: Arcturus Therapeutics, Inc.Inventors: Carlos G. Perez-Garcia, Kiyoshi Tachikawa, Daiki Matsuda, Padmanabh Chivukula, Priya Prakash Karmali, Yanjie Bao, Jerel Boyd Lee Vega, Rajesh Mukthavaram, Amit Sagi
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Patent number: 12037596Abstract: Compositions and methods are provided for modifying a rat genomic locus of interest using a large targeting vector (LTVEC) comprising various endogenous or exogenous nucleic acid sequences as described herein. Compositions and methods for generating a genetically modified rat comprising one or more targeted genetic modifications in their germline are also provided. Compositions and methods are provided which comprise a genetically modified rat or rat cell comprising a targeted genetic modification in the rat interleukin-2 receptor gamma locus, the rat ApoE locus, the rat Rag2 locus, the rat Rag1 locus and/or the rat Rag2/Rag1 locus. The various methods and compositions provided herein allows for these modified loci to be transmitted through the germline.Type: GrantFiled: March 9, 2021Date of Patent: July 16, 2024Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Jeffrey D. Lee, Alexander O. Mujica, Wojtek Auerbach, Ka-Man Venus Lai, David M. Valenzuela, George D. Yancopoulos
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Patent number: 10212460Abstract: Embodiments are directed towards managing play of at least one stream of digital content to reduce a time to a first frame or seek frame within the content by playing unencrypted portions of the digital content received at a client device at least until key negotiations and decryption actions are completed for corresponding encrypted digital content, at which point play is switched to the decrypted content in a seamless manner. In one embodiment, the unencrypted content is at a lower quality, resolution, or bit rate than the encrypted content. In one embodiment, the at least one stream is a stream of content that includes at least a first portion that is unencrypted, and a second portion that is encrypted. In another embodiment, the at least one stream includes a first stream that is unencrypted and played until a second, encrypted, stream is readied for play.Type: GrantFiled: June 29, 2012Date of Patent: February 19, 2019Assignee: GOOGLE LLCInventors: David Kimbal Dorwin, Hugh Finnan
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Patent number: 10148540Abstract: An anomaly detection system is able to detect spatial and temporal environment anomalies and spatial and temporal behavior anomalies, and monitor servers for anomalous characteristics of the environment and behavior. If metrics and/or characteristics associated with a given server are beyond a certain threshold, an alert is generated. Among other options, the alert can take the form of a heat map or a cluster cohesiveness report.Type: GrantFiled: July 31, 2015Date of Patent: December 4, 2018Assignee: SPLUNK INC.Inventor: Toufic Boubez
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Patent number: 10122599Abstract: A method and apparatus is disclosed herein for dynamically scaling application performance analysis completeness based on available system resources. In one embodiment, the method comprises monitoring incoming network traffic and a rate at which the traffic is being analyzed and dynamically adjusting application performance analysis completeness, the analysis being performed on the observed network traffic.Type: GrantFiled: October 19, 2012Date of Patent: November 6, 2018Assignee: AIRMAGNET, INC.Inventors: John Monk, Dan Prescott, Robert Vogt, Bruce Kosbab
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Patent number: 10110003Abstract: A system with three distinct but integral aspects for an effective energy optimization solution is disclosed. First, the system comprises a Smart Energy Load Center (SELC) adjacent to an energy generation facility (e.g., a wind farm) to limit or to entirely eliminate energy losses in transit and to reduce transmission and distribution infrastructure costs, and to eliminate energy handling costs reflected in relatively higher retail energy rates, compared to lower wholesale energy rates. Second, the system comprises methods to split existing energy consuming gadgets/gizmos (e.g., personal computers—PCs) into two sets of parts and moves the bigger set of the parts to the SELC without compromising the original functionality of the gadgets/gizmos. Thirdly, the system utilizes the material reduction and increased design features and cost savings yielded by the economies of scale offered by PCs residing at the SELC (Remote PC Warehouse) and harnesses the residual energy contained in the digital information.Type: GrantFiled: April 30, 2010Date of Patent: October 23, 2018Inventor: James R. Stalker
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Patent number: 10110714Abstract: A network access device (NAD) receives a UDP packet from a client to be transmitted to a management server over Internet, the UDP packet including a management message. The NAD is one of NADs managed by the management server. The NAD determines whether the management server is reachable using a UDP protocol. The NAD transmits the UDP packet to the management server using the UDP protocol over the Internet if it is determined that the management server is reachable using the UDP protocol. Otherwise, the NAD extracts a UDP payload from the UDP packet, encapsulates the UDP payload within an HTTP POST request, and transmits the HTTP POST request having the UDP payload encapsulated therein to the management server using a HTTP protocol over the Internet.Type: GrantFiled: December 9, 2015Date of Patent: October 23, 2018Assignee: CISCO TECHNOLOGY, INC.Inventors: Clifford A. Frey, John Bicket, Kevin Paul Herbert, Varun Sagar Malhotra, Benjamin A. Chambers
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Patent number: 10110412Abstract: A system and method for leveraging grid computing for node based interactive workflows is disclosed. A server system spawns a server process that receives node graph data and input attributes from a computing device, processes the data, caches the processed data, and transmits the processed data over a network to a computing device. The computing device runs a node graph application instance comprising proxy nodes configured to initiate a request to process node graph data at the server system. The server processed node graph data is displayed on the computing device. A plurality of computing devices may collaborate on a complex node graph where the node graph data processing is distributed over a plurality of servers.Type: GrantFiled: March 15, 2013Date of Patent: October 23, 2018Assignee: DISNEY ENTERPRISES, INC.Inventors: Jonathan Geibel, Evan Goldberg, Jay Steele
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Patent number: 10103960Abstract: An anomaly detection system is able to detect spatial and temporal environment anomalies and spatial and temporal behavior anomalies, and monitor servers for anomalous characteristics of the environment and behavior. If metrics and/or characteristics associated with a given server are beyond a certain threshold, an alert is generated. Among other options, the alert can take the form of a heat map or a cluster cohesiveness report.Type: GrantFiled: December 23, 2014Date of Patent: October 16, 2018Assignee: SPLUNK INC.Inventor: Toufic Boubez
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Patent number: 10097631Abstract: In one embodiment, a method includes receiving a first document including at least one content item and an interactive feature which allows users to post comments or additional content in response to the content item. The first document is associated with at least one entity, and is provided from a first web domain. A second document is selected from a second web domain, where the second document has a common content item with the first document, is also associated with the entity, and has its own interactive feature for user posts. A user post is received in connection with the first document, and the interactive features of the first document and the second document are synchronized so that the user post appears in both documents at substantially the same time.Type: GrantFiled: July 17, 2015Date of Patent: October 9, 2018Assignee: Facebook, Inc.Inventors: Ashoat Tevosyan, Holly Marie Ormseth, Amy Mercy Hwang, Varun Vikram Bhartia, Alan Grant McConnell, Todd Michael Hamilton
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Patent number: 10091049Abstract: Methods, systems, and devices are described for managing network communications. A traffic manager module may receive a script over a management plane of a packet core, interpret the script to identify a traffic management policy; and dynamically modify at least one aspect of a proxy connection over a bearer plane of the packet core at the traffic manager module based on the identified traffic management policy.Type: GrantFiled: August 19, 2013Date of Patent: October 2, 2018Assignee: F5 Networks, Inc.Inventors: John Giacomoni, Manish Vachharajani, Mark Terrel
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Patent number: 10075388Abstract: Method for an application client (C) and an application server (S) to negotiate quality parameters of a path (P) within a communication network (NAC, NMC, NB, NMS, NAS) connecting them. The method comprises the application client (C) sending to the application server (S) a request containing an identifier of a resource and said application server (S) sending at least an answer containing data associated to said resource to the application client (C). This request and this answer are transmitted through the path (P). The method is characterized in that the identifier specifies that the at least one answer should be compliant to a quality-aware protocol and contain quality parameters to be enforced by network nodes along the path (P).Type: GrantFiled: December 23, 2010Date of Patent: September 11, 2018Assignee: Alcatel LucentInventor: Jose Javier Garcia Aranda
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Patent number: 10069933Abstract: A network-configuring system creates stable virtual interfaces for groups of neighboring network nodes. During operation, the system can obtain network-neighborhood information from one or more network neighbors. This network-neighborhood information includes duplex-neighborhood information that indicates at least a set of neighboring devices to the network neighbor, and a set of remote network nodes which are accessible via a respective neighbor. The system can use the network-neighborhood information to determine one or more groups of network neighbors with common network characteristics, such that a respective group includes one or more mutually-connected network peers. The system can then define a virtual interface for a respective group of stable network neighbors, such that the virtual interface's member nodes include the local network node and the respective group's mutually-connected network peers.Type: GrantFiled: October 23, 2014Date of Patent: September 4, 2018Assignee: Cisco Technology, Inc.Inventors: Ignacio Solis, Glenn C. Scott
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Patent number: 10069941Abstract: Embodiments are directed to a cluster of nodes configured to run one or more services. A gateway on each node is configured to provide communication between the node and clients. The gateways manage filters designated by the clients, wherein the filters are named based upon a naming format used to name the services. The gateways receive configuration updates broadcast by a failover manager. The configuration updates comprise service endpoint changes for services running on the nodes. The gateways provide notifications to clients when a filter name matches at least a portion of a service name in a configuration update. The configuration updates identify a configuration version, and the gateways may provide notifications with endpoint information from more than one configuration update version. Notifications may be configured to be sent only when the endpoint for a primary replica of a service has changed.Type: GrantFiled: September 23, 2015Date of Patent: September 4, 2018Assignee: MICROSOFT TECHNOLOGY LICENSING, LLCInventors: Alex Wun, Vipul A. Modi, Lu Xun, Mansoor Mohsin
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Patent number: 10057202Abstract: A method for managing personal communication data, wherein the personal communication data including a plurality of chat histories from a plurality of chat applications is provided. The method may include converting a first chat history from a first application and a second chat history from a second application into an integrated unified format, whereby the second application is different from the first application. The method may also include storing the integrated unified format into an indexed storage. The method may further include providing a user interface (UI) to access the integrated unified format via the indexed storage.Type: GrantFiled: June 4, 2015Date of Patent: August 21, 2018Assignee: International Business Machines CorporationInventors: Su Liu, Michael S. Ly, Robert K. Sloan
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Patent number: 10051025Abstract: Methods, systems, and devices are described for estimating packet loss during media streaming over a data connection. A media player requests segments of an adaptive media stream and monitors variance in the amounts of data received. Increased variance in the amounts of data received can be directly correlated to a higher packet loss experienced by the data connection. The media player can use the estimated packet loss to adapt subsequent segment requests, or to otherwise subsequent behavior by the media player.Type: GrantFiled: December 31, 2013Date of Patent: August 14, 2018Assignee: DISH TECHNOLOGIES L.L.C.Inventor: Mark B. Hurst
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Patent number: 10051074Abstract: Methods and devices for managing devices not directly accessible to device management server are provided. A device for communicating a Location Update Alert message to a Device Management (DM) Server via a DM Gateway includes a memory for storing code of a DM client and a plurality of DM MOs, each of the plurality of DM MOs including one or more nodes, a processor for executing the code of the DM client stored in the memory, a communications unit for receiving and sending messages for the DM client, and the DM client for communicating a Location Update Alert message to the DM Server via the DM Gateway upon detecting a change in an address of the device, based on a LocationUpdate node of at least one of the plurality of DM MOs.Type: GrantFiled: March 21, 2011Date of Patent: August 14, 2018Assignee: SAMSUNG ELECTRONICS CO, LTD.Inventors: Kong Posh Bhat, Nhut Nguyen
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Patent number: 10044629Abstract: Dynamically determined time-to-live (TTL) values for responses to requests for resource records associated with domain names are provided herein. A resource record is selected from a group of available resource records associated with a domain name based on a resource record request. A TTL value is dynamically determined based on health check data for the selected resource record. The dynamically determined TTL value reduces connection failures and limits unnecessary computing resource use by using health check data to represent a confidence that an endpoint is still available and functioning properly.Type: GrantFiled: September 22, 2014Date of Patent: August 7, 2018Assignee: Amazon Technologies, Inc.Inventor: James Brendan Raftery
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Patent number: 10044881Abstract: A relay apparatus connected to service providing apparatuses respectively providing services and a communication apparatus that includes an additional-information storage unit configured to store additional information associated with the service and identification information, comprises: a receiving unit configured to receive notification including the service and the user identification information from the communication apparatus; a generating unit generating an output command for outputting, to the relay apparatus, the additional information stored in the additional-information storage unit corresponding to the service and the identification information included in the notification; an output commanding unit transmitting the output command to the communication apparatus; an acquiring unit acquiring the additional information output in response to the output command; a first communication unit configured to perform communication with the service providing apparatus using the acquired additional informationType: GrantFiled: October 28, 2011Date of Patent: August 7, 2018Assignee: BROTHER KOGYO KABUSHIKI KAISHAInventors: Toyoshi Inoue, Takeshi Nagasaki, Yusuke Shimada, Satoshi Watanabe, Katsuaki Ito, Hirokazu Banno, Kazutaka Yamamoto
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Patent number: 10033788Abstract: A method and a system for smooth streaming of media content in a distributed content delivery network, including encoding original media files; providing the encoded original media files to an indexer entity; calculating, the indexer entity, index jump tables for all the encoded original media files; ingesting the index jump tables and the encoded original media files to an origin server; requesting an end user to a SSS a stream fragment; retrieving, the SSS from the origin server, a specific index jump table associated to the requested stream fragment, and using the table to find out and retrieve, from the origin Server, a needed encoded original media file block; and retrieving, the SSS, the requested stream fragment out of the encoded media file block, and sending the requested stream fragment to the end user.Type: GrantFiled: December 24, 2014Date of Patent: July 24, 2018Assignee: TELEFONICA DIGITAL ESPAÑA, S.L.U.Inventors: Armando Antonio Garcia-Mendoza Sanchez, Antoni Silvestre Padros, José Carlos Pujol Alcolado, Jorge Hernández Pablo